Effect of protein disulfide isomerase chaperone activity inhibition on tissue factor activity

Journal of Thrombosis and Haemostasis

Volumn 8, Issue 8, 2010, Pages 1863-1865

  Raturi, A ^a   Ruf, W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR; CHAPERONE; PROTEIN DISULFIDE ISOMERASE;

ANTICOAGULATION; CONTROLLED STUDY; ENZYME ACTIVITY; KERATINOCYTE; LETTER; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION;

ANIMALS; BIOCHEMISTRY; CATTLE; HUMANS; IONS; MOLECULAR CHAPERONES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLSERINES; PROTEIN DISULFIDE-ISOMERASES; THROMBOPLASTIN; THROMBOSIS;

EID: 77958522684     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2010.03918.x     Document Type: Letter

References (14)

1. Ahamed J, Versteeg HH, Kerver M, Chen VM, Mueller BM, Hogg PJ, Ruf W. Disulfide isomerization switches tissue factor from coagulation to cell signaling. Proc Natl Acad Sci USA 2006, 103:13932-7.
2. Chen VM, Ahamed J, Versteeg HH, Berndt MC, Ruf W, Hogg PJ. Evidence for activation of tissue factor by an allosteric disulfide bond. Biochemistry 2006, 45:12020-8.
3. Chen VM, Hogg PJ. Allosteric disulfide bonds in thrombosis and thrombolysis. J Thromb Haemost 2006, 4:2533-41.
4. Rehemtulla A, Ruf W, Edgington TS. The integrity of the Cys186-Cys209 bond of the second disulfide loop of tissue factor is required for binding of factor VII. J Biol Chem 1991, 266:10294-9.
5. Liang HP, Hogg PJ. Critical importance of the cell system when studying tissue factor de-encryption. Blood 2008, 112:912-13.
6. Pendurthi UR, Ghosh S, Mandal SK, Rao LV. Tissue factor activation: is disulfide bond switching a regulatory mechanism? Blood 2007, 110:3900-8.
7. Reinhardt C, von Bruhl ML, Manukyan D, Grahl L, Lorenz M, Altmann B, Dlugai S, Hess S, Konrad I, Orschiedt L, Mackman N, Ruddock L, Massberg S, Engelmann B. Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation. J Clin Invest 2008, 118:1110-22.
8. Cho J, Furie BC, Coughlin SR, Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest 2008, 118:1123-31.
9. Versteeg HH, Ruf W. Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity. J Biol Chem 2007, 282:25416-24.
10. Persson E. Protein disulfide isomerase has no stimulatory chaperone effect on factor X activation by factor VIIa-soluble tissue factor. Thromb Res 2008, 123:171-6.
11. Kothari H, Sen P, Pendurthi UR, Rao LV. Bovine protein disulfide isomerase-enhanced tissue factor coagulant function: is phospholipid contaminant in it the real culprit? Blood 2008, 111:3295-6.
12. Klappa P, Ruddock LW, Darby NJ, Freedman RB. The b' domain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins. EMBO J 1998, 17:927-35.
13. Bajaj SP, Schmidt AE, Agah S, Bajaj MS, Padmanabhan K. High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa. J Biol Chem 2006, 281:24873-88.