Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs)

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 2902-2914

  Yamada, Roppei ^a   Cao, Xuefei ^a   Butkevich, Alexey N ^b   Millard, Melissa ^a   Odde, Srinivas ^a   Mordwinkin, Nick ^a   Gundla, Rambabu ^a   Zandi, Ebrahim ^c,d   Louie, Stan G ^a,d   Petasis, Nicos A ^b,d   Neamati, Nouri ^a,d  

^a University of Colorado Denver Anschutz Medical Campus   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLIC ACID DERIVATIVE; AMIDE; CARBAMIC ACID DERIVATIVE; COPPER ZINC SUPEROXIDE DISMUTASE; METHYL GROUP; N [2 (CYCLOHEXYLAMINO) 1 (4 METHOXYPHENYL) 2 OXOETHYL] N (3,5 DIMETHOXYPHENYL)PROPYNAMIDE; N [2 (CYCLOPENTYLAMINO) 1 (3 METHOXYPHENYL) 2 OXOETHYL] N [3 (TRIFLUOROMETHYL)PHENYL]PROPYNAMIDE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOINFORMATICS; CANCER CELL CULTURE; CELL CYCLE ARREST; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MELANOMA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; TREATMENT DURATION; TUMOR GROWTH;

ALKYNES; AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 9; CELL DIVISION; CELL LINE, TUMOR; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; OXIDATIVE STRESS; PROPIONATES; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79955409571     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101655d     Document Type: Article

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