-
1
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 2003;100(7):3983-8.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.7
, pp. 3983-3988
-
-
Al-hajj, M.1
Wicha, M.S.2
Benito-hernandez, A.3
-
2
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature. 2004;432(7015):396-401.
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 396-401
-
-
Singh, S.K.1
Hawkins, C.2
Clarke, I.D.3
-
3
-
-
33846100356
-
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
-
O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007;445(7123):106-10.
-
(2007)
Nature
, vol.445
, Issue.7123
, pp. 106-110
-
-
O'Brien, C.A.1
Pollett, A.2
Gallinger, S.3
Dick, J.E.4
-
4
-
-
34547193404
-
Phenotypic characterization of human colorectal cancer stem cells
-
Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2007;104(24):10158-63.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.24
, pp. 10158-10163
-
-
Dalerba, P.1
Dylla, S.J.2
Park, I.K.3
-
5
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444(7120):756-60.
-
(2006)
Nature
, vol.444
, Issue.7120
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
-
6
-
-
33847052127
-
Identification of pancreatic cancer stem cells
-
Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res. 2007;67(3):1030-7.
-
(2007)
Cancer Res
, vol.67
, Issue.3
, pp. 1030-1037
-
-
Li, C.1
Heidt, D.G.2
Dalerba, P.3
-
7
-
-
33846512398
-
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
-
Prince ME, Sivanandan R, Kaczorowski A, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A. 2007;104(3):973-8.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.3
, pp. 973-978
-
-
Prince, M.E.1
Sivanandan, R.2
Kaczorowski, A.3
-
8
-
-
38349183668
-
Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia
-
Hong D, Gupta R, Ancliff P, et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science. 2008;319(5861):336-9.
-
(2008)
Science
, vol.319
, Issue.5861
, pp. 336-339
-
-
Hong, D.1
Gupta, R.2
Ancliff, P.3
-
9
-
-
3943088431
-
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
-
Jamieson CH, Ailles LE, Dylla SJ, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004;351(7):657-67.
-
(2004)
N Engl J Med
, vol.351
, Issue.7
, pp. 657-667
-
-
Jamieson, C.H.1
Ailles, L.E.2
Dylla, S.J.3
-
10
-
-
79958043675
-
-
based on November 2011 SEER data submission, posted to the SEER web site, 2012 ed. Bethesda: National Cancer Institute; 2012
-
Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA. SEER Cancer Statistics Review, 1975-2009 (Vintage 2009 Populations). http://seer.cancer.gov/csr/1975_2009_pops09/, based on November 2011 SEER data submission, posted to the SEER web site, 2012 ed. Bethesda: National Cancer Institute; 2012.
-
SEER Cancer Statistics Review, 1975-2009 (Vintage 2009 Populations)
-
-
Howlader, N.1
Noone, A.M.2
Krapcho, M.3
Neyman, N.4
Aminou, R.5
Altekruse, S.F.6
Kosary, C.L.7
Ruhl, J.8
Tatalovich, Z.9
Cho, H.10
Mariotto, A.11
Eisner, M.P.12
Lewis, D.R.13
Chen, H.S.14
Feuer, E.J.15
Cronin, K.A.16
-
11
-
-
39149086121
-
Stems cells and the pathways to aging and cancer
-
Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell. 2008;132(4):681-96.
-
(2008)
Cell
, vol.132
, Issue.4
, pp. 681-696
-
-
Rossi, D.J.1
Jamieson, C.H.2
Weissman, I.L.3
-
12
-
-
56349149675
-
Miscreant myeloproliferative disorder stem cells
-
Jamieson CH, Barroga CF, Vainchenker WP. Miscreant myeloproliferative disorder stem cells. Leukemia. 2008;22(11):2011-9.
-
(2008)
Leukemia
, vol.22
, Issue.11
, pp. 2011-2019
-
-
Jamieson, C.H.1
Barroga, C.F.2
Vainchenker, W.P.3
-
13
-
-
0017785769
-
Primary bioassay of human tumor stem cells
-
Hamburger AW, Salmon SE. Primary bioassay of human tumor stem cells. Science. 1977;197(4302):461-3.
-
(1977)
Science
, vol.197
, Issue.4302
, pp. 461-463
-
-
Hamburger, A.W.1
Salmon, S.E.2
-
14
-
-
77955512077
-
Understanding the cancer stem cell
-
Bomken S, Fiser K, Heidenreich O, Vormoor J. Understanding the cancer stem cell. Br J Cancer. 2010;103(4):439-45.
-
(2010)
Br J Cancer
, vol.103
, Issue.4
, pp. 439-445
-
-
Bomken, S.1
Fiser, K.2
Heidenreich, O.3
Vormoor, J.4
-
15
-
-
33746498580
-
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
-
Krivtsov AV, Twomey D, Feng Z, et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature. 2006;442(7104):818-22.
-
(2006)
Nature
, vol.442
, Issue.7104
, pp. 818-822
-
-
Krivtsov, A.V.1
Twomey, D.2
Feng, Z.3
-
16
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3(7):730-7.
-
(1997)
Nat Med
, vol.3
, Issue.7
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
17
-
-
0030988803
-
Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo
-
Blair A, Hogge DE, Ailles LE, et al. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood. 1997;89(9):3104-12.
-
(1997)
Blood
, vol.89
, Issue.9
, pp. 3104-3112
-
-
Blair, A.1
Hogge, D.E.2
Ailles, L.E.3
-
18
-
-
62649139996
-
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation
-
Abrahamsson AE, Geron I, Gotlib J, et al. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A. 2009;106(10):3925-9.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.10
, pp. 3925-3929
-
-
Abrahamsson, A.E.1
Geron, I.2
Gotlib, J.3
-
19
-
-
80052468964
-
Stem cell gene expression programs influence clinical outcome in human leukemia
-
Eppert K, Takenaka K, Lechman ER, et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med. 2011;17(9):1086-93.
-
(2011)
Nat Med
, vol.17
, Issue.9
, pp. 1086-1093
-
-
Eppert, K.1
Takenaka, K.2
Lechman, E.R.3
-
20
-
-
84859854912
-
A clinically relevant population of leukemic CD34+ CD38-cells in acute myeloid leukemia
-
Gerber JM, Smith BD, Ngwang B, et al. A clinically relevant population of leukemic CD34+ CD38-cells in acute myeloid leukemia. Blood. 2012;119:3571-7.
-
(2012)
Blood
, vol.119
, pp. 3571-3577
-
-
Gerber, J.M.1
Smith, B.D.2
Ngwang, B.3
-
21
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367(6464):645-8.
-
(1994)
Nature
, vol.367
, Issue.6464
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
-
22
-
-
0037059012
-
Preferential induction of apoptosis for primary human leukemic stem cells
-
Guzman ML, Swiderski CF, Howard DS, et al. Preferential induction of apoptosis for primary human leukemic stem cells. Proc Natl Acad Sci U S A. 2002;99(25):16220-5.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.25
, pp. 16220-16225
-
-
Guzman, M.L.1
Swiderski, C.F.2
Howard, D.S.3
-
23
-
-
42949104680
-
Diagnosis and prognosis in acute myeloid leukemia-the art of distinction
-
Lowenberg B. Diagnosis and prognosis in acute myeloid leukemia-the art of distinction. N Engl J Med. 2008;358(18):1960-2.
-
(2008)
N Engl J Med
, vol.358
, Issue.18
, pp. 1960-1962
-
-
Lowenberg, B.1
-
24
-
-
0032188805
-
The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties
-
Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998;92(7):2322-33.
-
(1998)
Blood
, vol.92
, Issue.7
, pp. 2322-2333
-
-
Grimwade, D.1
Walker, H.2
Oliver, F.3
-
25
-
-
55549101623
-
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
-
Ley TJ, Mardis ER, Ding L, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature. 2008;456(7218):66-72.
-
(2008)
Nature
, vol.456
, Issue.7218
, pp. 66-72
-
-
Ley, T.J.1
Mardis, E.R.2
Ding, L.3
-
26
-
-
42949083345
-
MicroRNA expression in cytogenetically normal acute myeloid leukemia
-
Marcucci G, Radmacher MD, Maharry K, et al. MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med. 2008;358(18):1919-28.
-
(2008)
N Engl J Med
, vol.358
, Issue.18
, pp. 1919-1928
-
-
Marcucci, G.1
Radmacher, M.D.2
Maharry, K.3
-
27
-
-
42949142189
-
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
-
Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med. 2008;358(18):1909-18.
-
(2008)
N Engl J Med
, vol.358
, Issue.18
, pp. 1909-1918
-
-
Schlenk, R.F.1
Dohner, K.2
Krauter, J.3
-
28
-
-
0036786901
-
The World Health Organization (WHO) classification of the myeloid neoplasms
-
Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002;100(7):2292-302.
-
(2002)
Blood
, vol.100
, Issue.7
, pp. 2292-2302
-
-
Vardiman, J.W.1
Harris, N.L.2
Brunning, R.D.3
-
30
-
-
0017653321
-
Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
-
Fialkow PJ, Jacobson RJ, Papayannopoulou T. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med. 1977;63(1):125-30.
-
(1977)
Am J Med
, vol.63
, Issue.1
, pp. 125-130
-
-
Fialkow, P.J.1
Jacobson, R.J.2
Papayannopoulou, T.3
-
31
-
-
84861839077
-
Estimations of the increasing prevalence and plateau prevalence of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy
-
Huang X, Cortes J, Kantarjian H. Estimations of the increasing prevalence and plateau prevalence of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Cancer. 2012;118: 3123-7.
-
(2012)
Cancer
, vol.118
, pp. 3123-3127
-
-
Huang, X.1
Cortes, J.2
Kantarjian, H.3
-
32
-
-
78049528573
-
Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre Stop Imatinib (STIM) trial
-
Mahon FX, Rea D, Guilhot J, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010;11(11):1029-35.
-
(2010)
Lancet Oncol
, vol.11
, Issue.11
, pp. 1029-1035
-
-
Mahon, F.X.1
Rea, D.2
Guilhot, J.3
-
33
-
-
84859643082
-
Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms
-
Deshpande A, Reddy MM, Schade GO, et al. Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms. Leukemia. 2012;26:708-15.
-
(2012)
Leukemia
, vol.26
, pp. 708-715
-
-
Deshpande, A.1
Reddy, M.M.2
Schade, G.O.3
-
34
-
-
79959463542
-
Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia
-
van Delft FW, Horsley S, Colman S, et al. Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia. Blood. 2011;117:6247-54.
-
(2011)
Blood
, vol.117
, pp. 6247-6254
-
-
van Delft, F.W.1
Horsley, S.2
Colman, S.3
-
35
-
-
78751644099
-
Genetic variegation of clonal architecture and propagating cells in leukaemia
-
Anderson K, Lutz C, van Delft FW, et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature. 2011;469(7330):356-61.
-
(2011)
Nature
, vol.469
, Issue.7330
, pp. 356-361
-
-
Anderson, K.1
Lutz, C.2
van Delft, F.W.3
-
36
-
-
78751661556
-
Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
-
Notta F, Mullighan CG, Wang JC, et al. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature. 2011;469(7330):362-7.
-
(2011)
Nature
, vol.469
, Issue.7330
, pp. 362-367
-
-
Notta, F.1
Mullighan, C.G.2
Wang, J.C.3
-
37
-
-
0242361142
-
Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia
-
Chessells JM, Veys P, Kempski H, et al. Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia. Br J Haematol. 2003;123(3):396-405.
-
(2003)
Br J Haematol
, vol.123
, Issue.3
, pp. 396-405
-
-
Chessells, J.M.1
Veys, P.2
Kempski, H.3
-
38
-
-
33846242910
-
Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia
-
Cox CV, Martin HM, Kearns PR, et al. Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia. Blood. 2007;109(2):674-82.
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 674-682
-
-
Cox, C.V.1
Martin, H.M.2
Kearns, P.R.3
-
39
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306(5694):269-71.
-
(2004)
Science
, vol.306
, Issue.5694
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
-
40
-
-
34547780475
-
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
-
O'Neil J, Grim J, Strack P, et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med. 2007;204(8):1813-24.
-
(2007)
J Exp Med
, vol.204
, Issue.8
, pp. 1813-1824
-
-
O'Neil, J.1
Grim, J.2
Strack, P.3
-
41
-
-
78650333573
-
NOTCH mutations as prognostic markers in T-ALL
-
Ferrando A. NOTCH mutations as prognostic markers in T-ALL. Leukemia. 2010;24(12):2003-4.
-
(2010)
Leukemia
, vol.24
, Issue.12
, pp. 2003-2004
-
-
Ferrando, A.1
-
42
-
-
70449671729
-
Direct inhibition of the NOTCH transcription factor complex
-
Moellering RE, Cornejo M, Davis TN, et al. Direct inhibition of the NOTCH transcription factor complex. Nature. 2009;462(7270):182-8.
-
(2009)
Nature
, vol.462
, Issue.7270
, pp. 182-188
-
-
Moellering, R.E.1
Cornejo, M.2
Davis, T.N.3
-
43
-
-
78650068497
-
Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance
-
Chiu PP, Jiang H, Dick JE. Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance. Blood. 2010;116(24):5268-79.
-
(2010)
Blood
, vol.116
, Issue.24
, pp. 5268-5279
-
-
Chiu, P.P.1
Jiang, H.2
Dick, J.E.3
-
44
-
-
84863088013
-
NOTCH1 signaling drives human T-cell acute lymphoblastic leukemia initiating cell survival and self-renewal
-
Ma W, Gutierrez A, Goff DJ, et al. NOTCH1 signaling drives human T-cell acute lymphoblastic leukemia initiating cell survival and self-renewal. PLoS One. 2012;7:e39725.
-
(2012)
PLoS One
, vol.7
, pp. e39725
-
-
Ma, W.1
Gutierrez, A.2
Goff, D.J.3
-
45
-
-
77956331142
-
Notch signaling in the regulation of stem cell self-renewal and differentiation
-
Liu J, Sato C, Cerletti M, Wagers A. Notch signaling in the regulation of stem cell self-renewal and differentiation. Curr Top Dev Biol. 2010;92:367-409.
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 367-409
-
-
Liu, J.1
Sato, C.2
Cerletti, M.3
Wagers, A.4
-
46
-
-
13944261231
-
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
-
Conboy IM, Conboy MJ, Wagers AJ, et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433(7027):760-4.
-
(2005)
Nature
, vol.433
, Issue.7027
, pp. 760-764
-
-
Conboy, I.M.1
Conboy, M.J.2
Wagers, A.J.3
-
47
-
-
20144370145
-
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
-
Duncan AW, Rattis FM, DiMascio LN, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005;6(3):314-22.
-
(2005)
Nat Immunol
, vol.6
, Issue.3
, pp. 314-322
-
-
Duncan, A.W.1
Rattis, F.M.2
DiMascio, L.N.3
-
48
-
-
0037737728
-
A role for Wnt signalling in self-renewal of haematopoietic stem cells
-
Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003;423(6938):409-14.
-
(2003)
Nature
, vol.423
, Issue.6938
, pp. 409-414
-
-
Reya, T.1
Duncan, A.W.2
Ailles, L.3
-
49
-
-
10244224027
-
Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord blood
-
Haddad R, Guardiola P, Izac B, et al. Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord blood. Blood. 2004;104(13):3918-26.
-
(2004)
Blood
, vol.104
, Issue.13
, pp. 3918-3926
-
-
Haddad, R.1
Guardiola, P.2
Izac, B.3
-
50
-
-
77449121923
-
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
-
Butler JM, Nolan DJ, Vertes EL, et al. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell. 2010;6(3):251-64.
-
(2010)
Cell Stem Cell
, vol.6
, Issue.3
, pp. 251-264
-
-
Butler, J.M.1
Nolan, D.J.2
Vertes, E.L.3
-
51
-
-
79952217210
-
Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells
-
Varnum-Finney B, Halasz LM, Sun M, et al. Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest. 2011;121(3):1207-16.
-
(2011)
J Clin Invest
, vol.121
, Issue.3
, pp. 1207-1216
-
-
Varnum-finney, B.1
Halasz, L.M.2
Sun, M.3
-
52
-
-
84855370035
-
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
-
Wang L, Lawrence MS, Wan Y, et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011;365(26):2497-506.
-
(2011)
N Engl J Med
, vol.365
, Issue.26
, pp. 2497-2506
-
-
Wang, L.1
Lawrence, M.S.2
Wan, Y.3
-
53
-
-
46749145421
-
CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment
-
Patten PE, Buggins AG, Richards J, et al. CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment. Blood. 2008;111(10):5173-81.
-
(2008)
Blood
, vol.111
, Issue.10
, pp. 5173-5181
-
-
Patten, P.E.1
Buggins, A.G.2
Richards, J.3
-
54
-
-
77957366071
-
Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription
-
Buggins AG, Pepper C, Patten PE, et al. Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription. Cancer Res. 2010;70(19):7523-33.
-
(2010)
Cancer Res
, vol.70
, Issue.19
, pp. 7523-7533
-
-
Buggins, A.G.1
Pepper, C.2
Patten, P.E.3
-
55
-
-
0028947580
-
Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice
-
Skoda RC, Tsai SF, Orkin SH, Leder P. Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. J Exp Med. 1995;181(5):1603-13.
-
(1995)
J Exp Med
, vol.181
, Issue.5
, pp. 1603-1613
-
-
Skoda, R.C.1
Tsai, S.F.2
Orkin, S.H.3
Leder, P.4
-
56
-
-
0022380768
-
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
-
Adams JM, Harris AW, Pinkert CA, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985;318(6046):533-8.
-
(1985)
Nature
, vol.318
, Issue.6046
, pp. 533-538
-
-
Adams, J.M.1
Harris, A.W.2
Pinkert, C.A.3
-
57
-
-
33646339095
-
MYC levels govern hematopoietic tumor type and latency in transgenic mice
-
Smith DP, Bath ML, Metcalf D, et al. MYC levels govern hematopoietic tumor type and latency in transgenic mice. Blood. 2006;108(2):653-61.
-
(2006)
Blood
, vol.108
, Issue.2
, pp. 653-661
-
-
Smith, D.P.1
Bath, M.L.2
Metcalf, D.3
-
58
-
-
79952830167
-
Myc roles in hematopoiesis and leukemia
-
Delgado MD, Leon J. Myc roles in hematopoiesis and leukemia. Genes Cancer. 2010;1(6):605-16.
-
(2010)
Genes Cancer
, vol.1
, Issue.6
, pp. 605-616
-
-
Delgado, M.D.1
Leon, J.2
-
59
-
-
67649861052
-
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
-
Chen Y, Hu Y, Zhang H, et al. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet. 2009;41(7):783-92.
-
(2009)
Nat Genet
, vol.41
, Issue.7
, pp. 783-792
-
-
Chen, Y.1
Hu, Y.2
Zhang, H.3
-
60
-
-
33646546386
-
The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
-
Jamieson CH, Gotlib J, Durocher JA, et al. The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A. 2006;103(16):6224-9.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.16
, pp. 6224-6229
-
-
Jamieson, C.H.1
Gotlib, J.2
Durocher, J.A.3
-
61
-
-
79952437988
-
Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia
-
Samanta A, Perazzona B, Chakraborty S, et al. Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia. Leukemia. 2011;25(3):463-72.
-
(2011)
Leukemia
, vol.25
, Issue.3
, pp. 463-472
-
-
Samanta, A.1
Perazzona, B.2
Chakraborty, S.3
-
62
-
-
84859865097
-
Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice
-
Walz C, Ahmed W, Lazarides K, et al. Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice. Blood. 2012;119(15):3550-60.
-
(2012)
Blood
, vol.119
, Issue.15
, pp. 3550-3560
-
-
Walz, C.1
Ahmed, W.2
Lazarides, K.3
-
63
-
-
84864567410
-
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
-
Tanaka S, Miyagi S, Sashida G, et al. Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood. 2012;120:1107-17.
-
(2012)
Blood
, vol.120
, pp. 1107-1117
-
-
Tanaka, S.1
Miyagi, S.2
Sashida, G.3
-
64
-
-
77950287628
-
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML
-
Wang Y, Krivtsov AV, Sinha AU, et al. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010;327(5973):1650-3.
-
(2010)
Science
, vol.327
, Issue.5973
, pp. 1650-1653
-
-
Wang, Y.1
Krivtsov, A.V.2
Sinha, A.U.3
-
65
-
-
20844463226
-
Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli
-
Holtz MS, Forman SJ, Bhatia R. Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli. Leukemia. 2005;19(6):1034-41.
-
(2005)
Leukemia
, vol.19
, Issue.6
, pp. 1034-1041
-
-
Holtz, M.S.1
Forman, S.J.2
Bhatia, R.3
-
66
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
Copland M, Hamilton A, Elrick LJ, et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood. 2006;107(11):4532-9.
-
(2006)
Blood
, vol.107
, Issue.11
, pp. 4532-4539
-
-
Copland, M.1
Hamilton, A.2
Elrick, L.J.3
-
67
-
-
0037421968
-
Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo
-
Karnauskas R, Niu Q, Talapatra S, et al. Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo. Oncogene. 2003;22(5):688-98.
-
(2003)
Oncogene
, vol.22
, Issue.5
, pp. 688-698
-
-
Karnauskas, R.1
Niu, Q.2
Talapatra, S.3
-
68
-
-
0345144023
-
High levels of BAX, low levels of MRP-1, and high platelets are independent predictors of response to imatinib in myeloid blast crisis of CML
-
Lange T, Gunther C, Kohler T, et al. High levels of BAX, low levels of MRP-1, and high platelets are independent predictors of response to imatinib in myeloid blast crisis of CML. Blood. 2003;101(6):2152-5.
-
(2003)
Blood
, vol.101
, Issue.6
, pp. 2152-2155
-
-
Lange, T.1
Gunther, C.2
Kohler, T.3
-
69
-
-
84861385403
-
Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia
-
Zhang H, Li H, Ho N, et al. Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia. Mol Cell Biol. 2012;32(10):1776-87.
-
(2012)
Mol Cell Biol
, vol.32
, Issue.10
, pp. 1776-1787
-
-
Zhang, H.1
Li, H.2
Ho, N.3
-
70
-
-
84862777672
-
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
-
Ng KP, Hillmer AM, Chuah CT, et al. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat Med. 2012;18(4):521-8.
-
(2012)
Nat Med
, vol.18
, Issue.4
, pp. 521-528
-
-
Ng, K.P.1
Hillmer, A.M.2
Chuah, C.T.3
-
71
-
-
0036153470
-
High Bad and Bax mRNA expression correlate with negative outcome in acute myeloid leukemia (AML)
-
Kohler T, Schill C, Deininger MW, et al. High Bad and Bax mRNA expression correlate with negative outcome in acute myeloid leukemia (AML). Leukemia. 2002;16(1):22-9.
-
(2002)
Leukemia
, vol.16
, Issue.1
, pp. 22-29
-
-
Kohler, T.1
Schill, C.2
Deininger, M.W.3
-
72
-
-
16444375702
-
Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia
-
Packham G, Stevenson FK. Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia. Immunology. 2005;114(4):441-9.
-
(2005)
Immunology
, vol.114
, Issue.4
, pp. 441-449
-
-
Packham, G.1
Stevenson, F.K.2
-
73
-
-
55749105701
-
Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers
-
Pepper C, Lin TT, Pratt G, et al. Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers. Blood. 2008;112(9):3807-17.
-
(2008)
Blood
, vol.112
, Issue.9
, pp. 3807-3817
-
-
Pepper, C.1
Lin, T.T.2
Pratt, G.3
-
74
-
-
20044372326
-
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
-
Messmer BT, Messmer D, Allen SL, et al. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest. 2005;115(3):755-64.
-
(2005)
J Clin Invest
, vol.115
, Issue.3
, pp. 755-764
-
-
Messmer, B.T.1
Messmer, D.2
Allen, S.L.3
-
75
-
-
84865861478
-
Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia
-
Billard C. Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia. Leukemia. 2012;26:2032-8.
-
(2012)
Leukemia
, vol.26
, pp. 2032-2038
-
-
Billard, C.1
-
76
-
-
33644525274
-
Gene expression changes associated with progression and response in chronic myeloid leukemia
-
Radich JP, Dai H, Mao M, et al. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2006;103(8):2794-9.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.8
, pp. 2794-2799
-
-
Radich, J.P.1
Dai, H.2
Mao, M.3
-
77
-
-
36649002031
-
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
-
Zhao C, Blum J, Chen A, et al. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007;12(6):528-41.
-
(2007)
Cancer Cell
, vol.12
, Issue.6
, pp. 528-541
-
-
Zhao, C.1
Blum, J.2
Chen, A.3
-
78
-
-
50649118068
-
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
-
Dierks C, Beigi R, Guo GR, et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell. 2008;14(3):238-49.
-
(2008)
Cancer Cell
, vol.14
, Issue.3
, pp. 238-249
-
-
Dierks, C.1
Beigi, R.2
Guo, G.R.3
-
79
-
-
64749091867
-
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
Zhao C, Chen A, Jamieson CH, et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009;458(7239):776-9.
-
(2009)
Nature
, vol.458
, Issue.7239
, pp. 776-779
-
-
Zhao, C.1
Chen, A.2
Jamieson, C.H.3
-
80
-
-
56649114489
-
BCR-ABL-transformed GMP as myeloid leukemic stem cells
-
Minami Y, Stuart SA, Ikawa T, et al. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008;105(46):17967-72.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.46
, pp. 17967-17972
-
-
Minami, Y.1
Stuart, S.A.2
Ikawa, T.3
-
81
-
-
33947267129
-
Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells
-
Moore MA, Dorn DC, Schuringa JJ, et al. Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells. Exp Hematol. 2007;35(4 Suppl 1): 105-16.
-
(2007)
Exp Hematol
, vol.35
, pp. 105-116
-
-
Moore, M.A.1
Dorn, D.C.2
Schuringa, J.J.3
-
82
-
-
0026504525
-
Homeobox genes and axial patterning
-
McGinnis W, Krumlauf R. Homeobox genes and axial patterning. Cell. 1992;68(2):283-302.
-
(1992)
Cell
, vol.68
, Issue.2
, pp. 283-302
-
-
McGinnis, W.1
Krumlauf, R.2
-
83
-
-
0030942488
-
Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis
-
Lawrence HJ, Helgason CD, Sauvageau G, et al. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood. 1997;89(6):1922-30.
-
(1997)
Blood
, vol.89
, Issue.6
, pp. 1922-1930
-
-
Lawrence, H.J.1
Helgason, C.D.2
Sauvageau, G.3
-
84
-
-
79959899727
-
Hox transcription factor regulation of adult bone-marrow-derived cell behaviour during tissue repair and regeneration
-
Mahdipour E, Mace KA. Hox transcription factor regulation of adult bone-marrow-derived cell behaviour during tissue repair and regeneration. Expert Opin Biol Ther. 2011;11(8):1079-90.
-
(2011)
Expert Opin Biol Ther
, vol.11
, Issue.8
, pp. 1079-1090
-
-
Mahdipour, E.1
Mace, K.A.2
-
85
-
-
0037673984
-
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
-
Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 2003;423(6937):255-60.
-
(2003)
Nature
, vol.423
, Issue.6937
, pp. 255-260
-
-
Lessard, J.1
Sauvageau, G.2
-
86
-
-
79957839752
-
Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells
-
Smith LL, Yeung J, Zeisig BB, et al. Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells. Cell Stem Cell. 2011;8(6):649-62.
-
(2011)
Cell Stem Cell
, vol.8
, Issue.6
, pp. 649-662
-
-
Smith, L.L.1
Yeung, J.2
Zeisig, B.B.3
-
87
-
-
79958083987
-
Notch-ing from T-cell to B-cell lymphoid malignancies
-
Mirandola L, Comi P, Cobos E, et al. Notch-ing from T-cell to B-cell lymphoid malignancies. Cancer Lett. 2011;308(1):1-13.
-
(2011)
Cancer Lett
, vol.308
, Issue.1
, pp. 1-13
-
-
Mirandola, L.1
Comi, P.2
Cobos, E.3
-
88
-
-
79956319072
-
Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies
-
Treanor LM, Volanakis EJ, Zhou S, et al. Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies. Blood. 2011;117(20):5453-62.
-
(2011)
Blood
, vol.117
, Issue.20
, pp. 5453-5462
-
-
Treanor, L.M.1
Volanakis, E.J.2
Zhou, S.3
-
89
-
-
35448967331
-
Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
-
Apperley JF. Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 2007;8(11):1018-29.
-
(2007)
Lancet Oncol
, vol.8
, Issue.11
, pp. 1018-1029
-
-
Apperley, J.F.1
-
90
-
-
77954219134
-
The bone marrow microenvironment as a sanctuary for minimal residual disease in CML
-
Nair RR, Tolentino J, Hazlehurst LA. The bone marrow microenvironment as a sanctuary for minimal residual disease in CML. Biochem Pharmacol. 2010;80(5):602-12.
-
(2010)
Biochem Pharmacol
, vol.80
, Issue.5
, pp. 602-612
-
-
Nair, R.R.1
Tolentino, J.2
Hazlehurst, L.A.3
-
91
-
-
0033568250
-
Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia
-
Holyoake T, Jiang X, Eaves C, Eaves A. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood. 1999;94(6):2056-64.
-
(1999)
Blood
, vol.94
, Issue.6
, pp. 2056-2064
-
-
Holyoake, T.1
Jiang, X.2
Eaves, C.3
Eaves, A.4
-
92
-
-
35948984135
-
Chemotherapy-resistant human AML stem cells home to and engraft within the bonemarrow endosteal region
-
Ishikawa F, Yoshida S, Saito Y, et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bonemarrow endosteal region. Nat Biotechnol. 2007;25(11):1315-21.
-
(2007)
Nat Biotechnol
, vol.25
, Issue.11
, pp. 1315-1321
-
-
Ishikawa, F.1
Yoshida, S.2
Saito, Y.3
-
93
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham SM, Jorgensen HG, Allan E, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99(1):319-25.
-
(2002)
Blood
, vol.99
, Issue.1
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
-
94
-
-
84862286978
-
Significance of CD44 and CD24 as cancer stem cell markers: An enduring ambiguity
-
Jaggupilli A, Elkord E. Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguity. Clin Dev Immunol. 2012;2012:708036.
-
(2012)
Clin Dev Immunol
, vol.2012
, pp. 708036
-
-
Jaggupilli, A.1
Elkord, E.2
-
95
-
-
33749521890
-
Requirement for CD44 in homing and engraftment of BCR-ABL- expressing leukemic stem cells
-
Krause DS, Lazarides K, von Andrian UH, Van Etten RA. Requirement for CD44 in homing and engraftment of BCR-ABL- expressing leukemic stem cells. Nat Med. 2006;12(10):1175-80.
-
(2006)
Nat Med
, vol.12
, Issue.10
, pp. 1175-1180
-
-
Krause, D.S.1
Lazarides, K.2
von Andrian, U.H.3
Van Etten, R.A.4
-
96
-
-
33749515476
-
Targeting of CD44 eradicates human acute myeloid leukemic stem cells
-
Jin L, Hope KJ, Zhai Q, et al. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med. 2006;12(10):1167-74.
-
(2006)
Nat Med
, vol.12
, Issue.10
, pp. 1167-1174
-
-
Jin, L.1
Hope, K.J.2
Zhai, Q.3
-
97
-
-
42249103574
-
CXCR4 is required for the quiescence of primitive hematopoietic cells
-
Nie Y, Han YC, Zou YR. CXCR4 is required for the quiescence of primitive hematopoietic cells. J Exp Med. 2008;205(4):777-83.
-
(2008)
J Exp Med
, vol.205
, Issue.4
, pp. 777-783
-
-
Nie, Y.1
Han, Y.C.2
Zou, Y.R.3
-
98
-
-
33845445939
-
Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
-
Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity. 2006;25(6):977-88.
-
(2006)
Immunity
, vol.25
, Issue.6
, pp. 977-988
-
-
Sugiyama, T.1
Kohara, H.2
Noda, M.3
Nagasawa, T.4
-
99
-
-
84860767803
-
Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib
-
Weisberg E, Azab AK, Manley PW, et al. Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib. Leukemia. 2012;26:985-90.
-
(2012)
Leukemia
, vol.26
, pp. 985-990
-
-
Weisberg, E.1
Azab, A.K.2
Manley, P.W.3
-
100
-
-
38349086394
-
CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
-
Jin L, Tabe Y, Konoplev S, et al. CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol Cancer Ther. 2008;7(1):48-58.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.1
, pp. 48-58
-
-
Jin, L.1
Tabe, Y.2
Konoplev, S.3
-
101
-
-
84255197306
-
Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: Longterm observation of 1151 patients from the randomized CML Study IV
-
Fabarius A, Leitner A, Hochhaus A, et al. Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: longterm observation of 1151 patients from the randomized CML Study IV. Blood. 2011;118(26):6760-8.
-
(2011)
Blood
, vol.118
, Issue.26
, pp. 6760-6768
-
-
Fabarius, A.1
Leitner, A.2
Hochhaus, A.3
-
102
-
-
84872757839
-
New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing
-
Domenech E, Gomez-Lopez G, Gzlez-Pena D, et al. New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing. PLoS One. 2012;7(6):e38158.
-
(2012)
PLoS One
, vol.7
, Issue.6
, pp. e38158
-
-
Domenech, E.1
Gomez-lopez, G.2
Gzlez-pena, D.3
-
103
-
-
84863116398
-
Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
-
Marcucci G, Metzeler KH, Schwind S, et al. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol. 2012;30(7):742-50.
-
(2012)
J Clin Oncol
, vol.30
, Issue.7
, pp. 742-750
-
-
Marcucci, G.1
Metzeler, K.H.2
Schwind, S.3
-
104
-
-
84859837026
-
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
-
Harris WJ, Huang X, Lynch JT, et al. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell. 2012;21(4):473-87.
-
(2012)
Cancer Cell
, vol.21
, Issue.4
, pp. 473-487
-
-
Harris, W.J.1
Huang, X.2
Lynch, J.T.3
-
106
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006;5(9):769-84.
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.9
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
107
-
-
77952105211
-
Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
-
Zhang B, Strauss AC, Chu S, et al. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell. 2010;17(5):427-42.
-
(2010)
Cancer Cell
, vol.17
, Issue.5
, pp. 427-442
-
-
Zhang, B.1
Strauss, A.C.2
Chu, S.3
-
108
-
-
84863011183
-
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
-
Li L, Wang L, Li L, et al. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell. 2012;21(2):266-81.
-
(2012)
Cancer Cell
, vol.21
, Issue.2
, pp. 266-281
-
-
Li, L.1
Wang, L.2
Li, L.3
-
109
-
-
80054777860
-
Frequent EVI1 translocations in myeloid blast crisis CML that evolves through tyrosine kinase inhibitors
-
Paquette RL, Nicoll J, Chalukya M, et al. Frequent EVI1 translocations in myeloid blast crisis CML that evolves through tyrosine kinase inhibitors. Cancer Genet. 2011;204(7):392-7.
-
(2011)
Cancer Genet
, vol.204
, Issue.7
, pp. 392-397
-
-
Paquette, R.L.1
Nicoll, J.2
Chalukya, M.3
-
110
-
-
84876675153
-
Functional characterization of the promoter region of the human EVI1 gene in acute myeloid leukemia: RUNX1 and ELK1 directly regulate its transcription
-
Maicas M, Vazquez I, Vicente C, et al. Functional characterization of the promoter region of the human EVI1 gene in acute myeloid leukemia: RUNX1 and ELK1 directly regulate its transcription. Oncogene. 2013;32:2069-78.
-
(2013)
Oncogene
, vol.32
, pp. 2069-2078
-
-
Maicas, M.1
Vazquez, I.2
Vicente, C.3
-
111
-
-
84870437993
-
RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with poor prognosis and up-regulation of lymphoid genes
-
Greif PA, Konstandin NP, Metzeler KH, et al. RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with poor prognosis and up-regulation of lymphoid genes. Haematologica. 2012;97:1909-15.
-
(2012)
Haematologica
, vol.97
, pp. 1909-1915
-
-
Greif, P.A.1
Konstandin, N.P.2
Metzeler, K.H.3
-
112
-
-
81555228423
-
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
-
Shen Y, Zhu YM, Fan X, et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood. 2011;118(20):5593-603.
-
(2011)
Blood
, vol.118
, Issue.20
, pp. 5593-5603
-
-
Shen, Y.1
Zhu, Y.M.2
Fan, X.3
-
113
-
-
84864031521
-
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia
-
Akalin A, Garrett-Bakelman FE, Kormaksson M, et al. Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet. 2012;8(6):e1002781.
-
(2012)
PLoS Genet
, vol.8
, Issue.6
, pp. e1002781
-
-
Akalin, A.1
Garrett-bakelman, F.E.2
Kormaksson, M.3
-
114
-
-
80052284526
-
Ten-eleven-translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
-
Ko M, Bandukwala HS, An J, et al. Ten-eleven-translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A. 2011;108(35):14566-71.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.35
, pp. 14566-14571
-
-
Ko, M.1
Bandukwala, H.S.2
An, J.3
-
115
-
-
2342565860
-
p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells
-
Salesse S, Dylla SJ, Verfaillie CM. p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells. Leukemia. 2004;18(4):727-33.
-
(2004)
Leukemia
, vol.18
, Issue.4
, pp. 727-733
-
-
Salesse, S.1
Dylla, S.J.2
Verfaillie, C.M.3
-
116
-
-
84875131206
-
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition
-
Goff DJ, Recart AC, Sadarangani A, et al. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013;12(3):316-28.
-
(2013)
Cell Stem Cell
, vol.12
, Issue.3
, pp. 316-328
-
-
Goff, D.J.1
Recart, A.C.2
Sadarangani, A.3
-
117
-
-
84555191727
-
Spliceosome mutations in hematopoietic malignancies
-
Hahn CN, Scott HS. Spliceosome mutations in hematopoietic malignancies. Nat Genet. 2012;44(1):9-10.
-
(2012)
Nat Genet
, vol.44
, Issue.1
, pp. 9-10
-
-
Hahn, C.N.1
Scott, H.S.2
-
119
-
-
84555171449
-
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
-
Quesada V, Conde L, Villamor N, et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet. 2012;44(1):47-52.
-
(2012)
Nat Genet
, vol.44
, Issue.1
, pp. 47-52
-
-
Quesada, V.1
Conde, L.2
Villamor, N.3
-
120
-
-
84862854953
-
Chronic lymphocytic leukemia with SF3B1 mutation
-
Quesada V, Ramsay AJ, Lopez-Otin C. Chronic lymphocytic leukemia with SF3B1 mutation. N Engl J Med. 2012;366(26):2530.
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2530
-
-
Quesada, V.1
Ramsay, A.J.2
Lopez-otin, C.3
-
121
-
-
57849136005
-
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling
-
Hartner JC, Walkley CR, Lu J, Orkin SH. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol. 2009;10(1):109-15.
-
(2009)
Nat Immunol
, vol.10
, Issue.1
, pp. 109-115
-
-
Hartner, J.C.1
Walkley, C.R.2
Lu, J.3
Orkin, S.H.4
-
122
-
-
70449584569
-
ADAR1 is required for hematopoietic progenitor cell survival via RNA editing
-
XuFeng R, Boyer MJ, Shen H, et al. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. Proc Natl Acad Sci U S A. 2009;106(42):17763-8.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.42
, pp. 17763-17768
-
-
XuFeng, R.1
Boyer, M.J.2
Shen, H.3
-
123
-
-
70349969478
-
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
-
Shah SP, Morin RD, Khattra J, et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature. 2009;461(7265):809-13.
-
(2009)
Nature
, vol.461
, Issue.7265
, pp. 809-813
-
-
Shah, S.P.1
Morin, R.D.2
Khattra, J.3
-
124
-
-
84872522380
-
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia
-
Jiang Q, Crews LA, Barrett CL, et al. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2013;110(3):1041-6.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.3
, pp. 1041-1046
-
-
Jiang, Q.1
Crews, L.A.2
Barrett, C.L.3
-
125
-
-
84873996576
-
Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice
-
Steinman RA, Yang Q, Gasparetto M, et al. Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice. Int J Cancer. 2013;132(8):1741-50.
-
(2013)
Int J Cancer
, vol.132
, Issue.8
, pp. 1741-1750
-
-
Steinman, R.A.1
Yang, Q.2
Gasparetto, M.3
-
126
-
-
84862649489
-
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons
-
Meyer KD, Saletore Y, Zumbo P, et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012;149(7):1635-46.
-
(2012)
Cell
, vol.149
, Issue.7
, pp. 1635-1646
-
-
Meyer, K.D.1
Saletore, Y.2
Zumbo, P.3
|