Functional characterization of the promoter region of the human EVI1 gene in acute myeloid leukemia: RUNX1 and ELK1 directly regulate its transcription

Oncogene

Volumn 32, Issue 16, 2013, Pages 2069-2078

  Maicas, M ^a   Vazquez I ^a   Vicente, C ^a   Garcia Sanchez M A ^a   Marcotegui, N ^a   Urquiza, L ^a   Calasanz, M J ^a   Odero, M D ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

AML; ELK1; EVI1; promoter; RUNX1

Indexed keywords

LUCIFERASE; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR RUNX1;

ACETYLATION; ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CPG ISLAND; DOWN REGULATION; EVI1 GENE; GENE CONTROL; GENE OVEREXPRESSION; GENE SILENCING; HEMATOPOIESIS; HUMAN; HUMAN CELL; MEGAKARYOCYTE; MOLECULAR MECHANICS; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; UPREGULATION;

ACETYLATION; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DNA-BINDING PROTEINS; ETS-DOMAIN PROTEIN ELK-1; HISTONES; HUMANS; LEUKEMIA, MYELOID, ACUTE; MEGAKARYOCYTES; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84876675153     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.222     Document Type: Article

References (36)

1. Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S et al. Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell 2008; 3: 207-220.
2. Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, Perkins A et al. Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J 2005; 24: 1976-1987.
3. Shimizu S, Nagasawa T, Katoh O, Komatsu N, Yokota J, Morishita K. EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation. Biochem Biophys Res Commun 2002; 292: 609-616.
4. Dohner H, Estey EH, Amadori S, Appelbaum FR, Buchner T, Burnett AK et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115: 453-474.
5. Lugthart S, van Drunen E, van Norden Y, van Hoven A, Erpelinck CA, Valk PJ et al. High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. Blood 2008; 111: 4329-4337.
6. Haas K, Kundi M, Sperr WR, Esterbauer H, Ludwig WD, Ratei R et al. Expression and prognostic significance of different mRNA 5'-end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission duration. Genes Chromosomes Cancer 2008; 47: 288-298.
7. Groschel S, Lugthart S, Schlenk RF, Valk PJ, Eiwen K, Goudswaard C et al. High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities. J Clin Oncol 2010; 28: 2101-2107.
8. Vazquez I, Maicas M, Cervera J, Agirre X, Marin-Bejar O, Marcotegui N et al. Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia. Haematologica 96: 1448-1456.
9. Wieser R. The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions. Gene 2007; 396: 346-357.
10. Nucifora G, Laricchia-Robbio L, Senyuk V. EVI1 and hematopoietic disorders: history and perspectives. Gene 2006; 368: 1-11.
11. Laricchia-Robbio L, Fazzina R, Li D, Rinaldi CR, Sinha KK, Chakraborty S et al. Point mutations in two EVI1 Zn fingers abolish EVI1-GATA1 interaction and allow ery-throid differentiation of murine bone marrow cells. Mol Cell Biol 2006; 26: 7658-7666.
12. Laricchia-Robbio L, Premanand K, Rinaldi CR, Nucifora G. EVI1 Impairs myelopoi-esis by deregulation of PU.1 function. Cancer Res 2009; 69: 1633-1642.
13. Senyuk V, Sinha KK, Li D, Rinaldi CR, Yanamandra S, Nucifora G. Repression of RUNX1 activity by EVI1: a new role of EVI1 in leukemogenesis. Cancer Res 2007; 67: 5658-5666.
14. Vazquez I, Maicas M, Cervera J, Agirre X, Marin-Bejar O, Marcotegui N et al. Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia. Haematologica 2011; 96: 1448-1456.
15. Arai S, Yoshimi A, Shimabe M, Ichikawa M, Nakagawa M, Imai Y et al. Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells. Blood 2010; 117: 6304-6314.
16. Fujiwara T, O'Geen H, Keles S, Blahnik K, Linnemann AK, Kang YA et al. Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell 2009; 36: 667-681.
17. Oakford PC, James SR, Qadi A, West AC, Ray SN, Bert AG et al. Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1. Leuk Res 2010; 34: 1203-1213.
18. Mikhail FM, Sinha KK, Saunthararajah Y, Nucifora G. Normal and transforming functions of RUNX1: a perspective. J Cell Physiol 2006; 207: 582-593.
19. Gaidzik VI, Bullinger L, Schlenk RF, Zimmermann AS, Rock J, Paschka P et al. RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group. J Clin Oncol 2011; 29: 1364-1372.
20. Elagib KE, Racke FK, Mogass M, Khetawat R, Delehanty LL, Goldfarb AN. RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation. Blood 2003; 101: 4333-4341.
21. Pencovich N, Jaschek R, Tanay A, Groner Y. Dynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line models. Blood 2011; 117: e1-14.
22. Bingemann SC, Konrad TA, Wieser R. Zinc finger transcription factor ecotropic viral integration site 1 is induced by all-trans retinoic acid (ATRA) and acts as a dual modulator of the ATRA response. FEBS J 2009; 276: 6810-6822.
23. Aytekin M, Vinatzer U, Musteanu M, Raynaud S, Wieser R. Regulation of the expression of the oncogene EVI1 through the use of alternative mRNA 5'-ends. Gene 2005; 356: 160-168.
24. Goldfarb AN. Megakaryocytic programming by a transcriptional regulatory loop: a circle connecting RUNX1, GATA-1, and P-TEFb. J Cell Biochem 2009; 107: 377-382.
25. Terui K, Takahashi Y, Kitazawa J, Toki T, Yokoyama M, Ito E. Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin. Tohoku J Exp Med 2000; 192: 259-273.
26. Osato M. Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene 2004; 23: 4284-4296.
27. Zhang L, Li Z, Yan J, Pradhan P, Corpora T, Cheney MD et al. Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit. J Biol Chem 2003; 278: 33097-33104.
28. Langabeer SE, Gale RE, Rollinson SJ, Morgan GJ, Linch DC. Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7. Genes Chromosomes Cancer 2002; 34: 24-32.
29. Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T et al. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2 alphaB gene associated with myeloblastic leukemias. Blood 1999; 93: 1817-1824.
30. Yordy JS, Muise-Helmericks RC. Signal transduction and the Ets family of transcription factors. Oncogene 2000; 19: 6503-6513.
31. Wasylyk B, Hahn SL, Giovane A. The Ets family of transcription factors. Eur J Biochem 1993; 211: 7-18.
32. Yasar D, Karadogan I, Alanoglu G, Akkaya B, Luleci G, Salim O et al. Array comparative genomic hybridization analysis of adult acute leukemia patients. Cancer Genet Cytogenet 2010; 197: 122-129.
33. Cruzalegui FH, Cano E, Treisman R. ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry. Oncogene 1999; 18: 7948-7957.
34. Garcia J, de Gunzburg J, Eychene A, Gisselbrecht S, Porteu F. Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1-and Rap1-B-Raf-dependent pathways. Mol Cell Biol 2001; 21: 2659-2670.
35. Biggs JR, Peterson LF, Zhang Y, Kraft AS, Zhang DE. AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex. Mol Cell Biol 2006; 26: 7420-7429.
36. Fernandez-Alvarez A, Soledad Alvarez M, Cucarella C, Casado M. Characterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifs. J Biol Chem 2010; 285: 11765-11774.