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Volumn 114, Issue 4, 2014, Pages 689-705

MicroRNA regulation and cardiac calcium signaling: Role in cardiac disease and therapeutic potential

Author keywords

gene expression; microRNA

Indexed keywords

GENE EXPRESSION; MICRORNA;

EID: 84894473134     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.114.301798     Document Type: Review
Times cited : (120)

References (121)
  • 1
    • 0035966319 scopus 로고    scopus 로고
    • Micrornas: Tiny regulators with great potential
    • Ambros V. microRNAs: Tiny regulators with great potential. Cell. 2001;107:823-826
    • (2001) Cell , vol.107 , pp. 823-826
    • Ambros, V.1
  • 4
    • 81355123438 scopus 로고    scopus 로고
    • Evolution of microRNA diversity and regulation in animals
    • Berezikov E. Evolution of microRNA diversity and regulation in animals. Nat Rev Genet. 2011;12:846-860
    • (2011) Nat Rev Genet , vol.12 , pp. 846-860
    • Berezikov, E.1
  • 8
    • 27744537851 scopus 로고    scopus 로고
    • Human RISC couples microRNA biogenesis and posttranscriptional gene silencing
    • Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell. 2005;123:631-640
    • (2005) Cell , vol.123 , pp. 631-640
    • Gregory, R.I.1    Chendrimada, T.P.2    Cooch, N.3    Shiekhattar, R.4
  • 9
    • 60149088848 scopus 로고    scopus 로고
    • Origins and Mechanisms of miRNAs and siRNAs
    • Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell. 2009;136:642-655
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 10
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120:15-20
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 11
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-Transcriptional regulation by microRNAs: Are the answers in sight?
    • Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-Transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet. 2008;9:102-114
    • (2008) Nat Rev Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 12
    • 33846277696 scopus 로고    scopus 로고
    • Repression of protein synthesis by miRNAs: How many mechanisms?
    • Pillai RS, Bhattacharyya SN, Filipowicz W. Repression of protein synthesis by miRNAs: How many mechanisms? Trends Cell Biol. 2007;17:118-126
    • (2007) Trends Cell Biol , vol.17 , pp. 118-126
    • Pillai, R.S.1    Bhattacharyya, S.N.2    Filipowicz, W.3
  • 13
    • 33644768174 scopus 로고    scopus 로고
    • Control of translation and mRNA degradation by miRNAs and siRNAs
    • Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 2006;20:515-524
    • (2006) Genes Dev , vol.20 , pp. 515-524
    • Valencia-Sanchez, M.A.1    Liu, J.2    Hannon, G.J.3    Parker, R.4
  • 15
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008;456:980-984
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1    Gross, C.2    Fiedler, J.3
  • 18
    • 84870241098 scopus 로고    scopus 로고
    • Altered sarcoplasmic reticulum calcium cycling-Targets for heart failure therapy
    • Kho C, Lee A, Hajjar RJ. Altered sarcoplasmic reticulum calcium cycling-Targets for heart failure therapy. Nat Rev Cardiol. 2012;9:717-733
    • (2012) Nat Rev Cardiol , vol.9 , pp. 717-733
    • Kho, C.1    Lee, A.2    Hajjar, R.J.3
  • 19
    • 3543134142 scopus 로고    scopus 로고
    • Novel therapeutic approaches for heart failure by normalizing calcium cycling
    • Wehrens XH, Marks AR. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov. 2004;3:565-573
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 565-573
    • Wehrens, X.H.1    Marks, A.R.2
  • 20
    • 79959950762 scopus 로고    scopus 로고
    • Novel therapeutic targets for the treatment of heart failure
    • Tamargo J, López-Sendón J. Novel therapeutic targets for the treatment of heart failure. Nat Rev Drug Discov. 2011;10:536-555
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 536-555
    • Tamargo, J.1    López-Sendón, J.2
  • 21
    • 0033636778 scopus 로고    scopus 로고
    • Junctophilins: A novel family of junctional membrane complex proteins
    • Takeshima H, Komazaki S, Nishi M, Iino M, Kangawa K. Junctophilins: A novel family of junctional membrane complex proteins. Mol Cell. 2000;6:11-22
    • (2000) Mol Cell , vol.6 , pp. 11-22
    • Takeshima, H.1    Komazaki, S.2    Nishi, M.3    Iino, M.4    Kangawa, K.5
  • 22
    • 34248584090 scopus 로고    scopus 로고
    • Inositol trisphosphate receptor Ca2+ release channels
    • Foskett JK, White C, Cheung KH, Mak DO. Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev. 2007;87:593-658
    • (2007) Physiol Rev , vol.87 , pp. 593-658
    • Foskett, J.K.1    White, C.2    Cheung, K.H.3    Mak, D.O.4
  • 24
    • 84859910744 scopus 로고    scopus 로고
    • Ca(2+) signaling: An outlook on the characterization of Ca(2+) channels and their importance in cellular functions
    • Karlstad J, Sun Y, Singh BB. Ca(2+) signaling: An outlook on the characterization of Ca(2+) channels and their importance in cellular functions. Adv Exp Med Biol. 2012;740:143-157
    • (2012) Adv Exp Med Biol , vol.740 , pp. 143-157
    • Karlstad, J.1    Sun, Y.2    Singh, B.B.3
  • 25
    • 84870241098 scopus 로고    scopus 로고
    • Altered sarcoplasmic reticulum calcium cycling-Targets for heart failure therapy
    • Kho C, Lee A, Hajjar RJ. Altered sarcoplasmic reticulum calcium cycling-Targets for heart failure therapy. Nat Rev Cardiol. 2012;9:717-733
    • (2012) Nat Rev Cardiol , vol.9 , pp. 717-733
    • Kho, C.1    Lee, A.2    Hajjar, R.J.3
  • 26
    • 79960044552 scopus 로고    scopus 로고
    • CaMKII in myocardial hypertrophy and heart failure
    • Anderson ME, Brown JH, Bers DM. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol. 2011;51:468-473
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 468-473
    • Anderson, M.E.1    Brown, J.H.2    Bers, D.M.3
  • 27
    • 0037162697 scopus 로고    scopus 로고
    • Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    • Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, Olson EN. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell. 2002;110:479-488
    • (2002) Cell , vol.110 , pp. 479-488
    • Zhang, C.L.1    McKinsey, T.A.2    Chang, S.3    Antos, C.L.4    Hill, J.A.5    Olson, E.N.6
  • 28
    • 74049097964 scopus 로고    scopus 로고
    • Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70
    • Peng W, Zhang Y, Zheng M, Cheng H, Zhu W, Cao CM, Xiao RP. Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70. Circ Res. 2010;106:102-110
    • (2010) Circ Res , vol.106 , pp. 102-110
    • Peng, W.1    Zhang, Y.2    Zheng, M.3    Cheng, H.4    Zhu, W.5    Cao, C.M.6    Xiao, R.P.7
  • 30
    • 84875224962 scopus 로고    scopus 로고
    • Ca2+/Calmodulin-dependent protein kinase II d mediates myocardial ischemia/reperfusion injury through nuclear factor-?B
    • Ling H, Gray CB, Zambon AC, Grimm M, Gu Y, Dalton N, Purcell NH, Peterson K, Brown JH. Ca2+/Calmodulin-dependent protein kinase II d mediates myocardial ischemia/reperfusion injury through nuclear factor-?B. Circ Res. 2013;112:935-944
    • (2013) Circ Res , vol.112 , pp. 935-944
    • Ling, H.1    Gray, C.B.2    Zambon, A.C.3    Grimm, M.4    Gu, Y.5    Dalton, N.6    Purcell, N.H.7    Peterson, K.8    Brown, J.H.9
  • 31
    • 79955605472 scopus 로고    scopus 로고
    • Multiple facets of NF-?B in the heart: To be or not to NF-?B
    • Gordon JW, Shaw JA, Kirshenbaum LA. Multiple facets of NF-?B in the heart: To be or not to NF-?B. Circ Res. 2011;108:1122-1132
    • (2011) Circ Res , vol.108 , pp. 1122-1132
    • Gordon, J.W.1    Shaw, J.A.2    Kirshenbaum, L.A.3
  • 32
    • 14644414790 scopus 로고    scopus 로고
    • Protein kinase cascade in the regulation of cardiac hypertrophy
    • Dorn II GW, Force T. Protein kinase cascade in the regulation of cardiac hypertrophy. J Clin Invest. 2005;115:527-537
    • (2005) J Clin Invest , vol.115 , pp. 527-537
    • Dorn II, G.W.1    Force, T.2
  • 34
    • 57749121689 scopus 로고    scopus 로고
    • Microrna-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
    • Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, Bassel-Duby R, Olson EN. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 2008;22:3242-3254
    • (2008) Genes Dev , vol.22 , pp. 3242-3254
    • Liu, N.1    Bezprozvannaya, S.2    Williams, A.H.3    Qi, X.4    Richardson, J.A.5    Bassel-Duby, R.6    Olson, E.N.7
  • 39
    • 70350353082 scopus 로고    scopus 로고
    • MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction
    • Dong S, Cheng Y, Yang J, Li J, Liu X, Wang X, Wang D, Krall TJ, Delphin ES, Zhang C. MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J Biol Chem. 2009;284:29514-29525
    • (2009) J Biol Chem , vol.284 , pp. 29514-29525
    • Dong, S.1    Cheng, Y.2    Yang, J.3    Li, J.4    Liu, X.5    Wang, X.6    Wang, D.7    Krall, T.J.8    Delphin, E.S.9    Zhang, C.10
  • 42
    • 79957631904 scopus 로고    scopus 로고
    • The role of microRNA in modulating myocardial ischemia-reperfusion injury
    • Ye Y, Perez-Polo JR, Qian J, Birnbaum Y. The role of microRNA in modulating myocardial ischemia-reperfusion injury. Physiol Genomics. 2011;43:534-542
    • (2011) Physiol Genomics , vol.43 , pp. 534-542
    • Ye, Y.1    Perez-Polo, J.R.2    Qian, J.3    Birnbaum, Y.4
  • 43
    • 65249185780 scopus 로고    scopus 로고
    • Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    • Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 2009;104:879-886
    • (2009) Circ Res , vol.104 , pp. 879-886
    • Rane, S.1    He, M.2    Sayed, D.3    Vashistha, H.4    Malhotra, A.5    Sadoshima, J.6    Vatner, D.E.7    Vatner, S.F.8    Abdellatif, M.9
  • 44
    • 77953782181 scopus 로고    scopus 로고
    • MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand
    • Sayed D, He M, Hong C, Gao S, Rane S, Yang Z, Abdellatif M. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem. 2010;285:20281-20290
    • (2010) J Biol Chem , vol.285 , pp. 20281-20290
    • Sayed, D.1    He, M.2    Hong, C.3    Gao, S.4    Rane, S.5    Yang, Z.6    Abdellatif, M.7
  • 45
    • 77957935805 scopus 로고    scopus 로고
    • MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury
    • Wang X, Zhang X, Ren XP, Chen J, Liu H, Yang J, Medvedovic M, Hu Z, Fan GC. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Circulation. 2010;122:1308-1318
    • (2010) Circulation , vol.122 , pp. 1308-1318
    • Wang, X.1    Zhang, X.2    Ren, X.P.3    Chen, J.4    Liu, H.5    Yang, J.6    Medvedovic, M.7    Hu, Z.8    Fan, G.C.9
  • 46
    • 80051802344 scopus 로고    scopus 로고
    • MicroRNA-24 regulates vascularity after myocardial infarction
    • Fiedler J, Jazbutyte V, Kirchmaier BC, et al. MicroRNA-24 regulates vascularity after myocardial infarction. Circulation. 2011;124:720-730
    • (2011) Circulation , vol.124 , pp. 720-730
    • Fiedler, J.1    Jazbutyte, V.2    Kirchmaier, B.C.3
  • 49
    • 37349042225 scopus 로고    scopus 로고
    • Emerging role of microRNAs in cardiovascular biology
    • Latronico MV, Catalucci D, Condorelli G. Emerging role of microRNAs in cardiovascular biology. Circ Res. 2007;101:1225-1236
    • (2007) Circ Res , vol.101 , pp. 1225-1236
    • Latronico, M.V.1    Catalucci, D.2    Condorelli, G.3
  • 51
    • 72149133679 scopus 로고    scopus 로고
    • MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction
    • Bostjancic E, Zidar N, Stajer D, Glavac D. MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction. Cardiology. 2010;115:163-169
    • (2010) Cardiology , vol.115 , pp. 163-169
    • Bostjancic, E.1    Zidar, N.2    Stajer, D.3    Glavac, D.4
  • 53
    • 61949226650 scopus 로고    scopus 로고
    • Mir-1 overexpression enhances Ca2+ release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2
    • Terentyev D, Belevych AE, Terentyeva R, Martin MM, Malana GE, Kuhn DE, Abdellatif M. miR-1 overexpression enhances Ca2+ release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2. Circ Res. 2009;104:514-521
    • (2009) Circ Res , vol.104 , pp. 514-521
    • Terentyev, D.1    Belevych, A.E.2    Terentyeva, R.3    Martin, M.M.4    Malana, G.E.5    Kuhn, D.E.6    Abdellatif, M.7
  • 55
    • 52449116560 scopus 로고    scopus 로고
    • MicroRNAs: Novel regulators in cardiac development and disease
    • Thum T, Catalucci D, Bauersachs J. MicroRNAs: Novel regulators in cardiac development and disease. Cardiovasc Res. 2008;79:562-570
    • (2008) Cardiovasc Res , vol.79 , pp. 562-570
    • Thum, T.1    Catalucci, D.2    Bauersachs, J.3
  • 56
    • 52449122650 scopus 로고    scopus 로고
    • Control of cardiac excitability by microRNAs
    • Yang B, Lu Y, Wang Z. Control of cardiac excitability by microRNAs. Cardiovasc Res. 2008;79:571-580
    • (2008) Cardiovasc Res , vol.79 , pp. 571-580
    • Yang, B.1    Lu, Y.2    Wang, Z.3
  • 59
    • 34547895472 scopus 로고    scopus 로고
    • Time course of changes in the expression of DHPR RyR(2) and SERCA2 after myocardial infarction in the rat left ventricle
    • Sallinen P, Mänttäri S, Leskinen H, Ilves M, Ruskoaho H, Saarela S. Time course of changes in the expression of DHPR, RyR(2), and SERCA2 after myocardial infarction in the rat left ventricle. Mol Cell Biochem. 2007;303:97-103
    • (2007) Mol Cell Biochem , vol.303 , pp. 97-103
    • Sallinen, P.1    Mänttäri, S.2    Leskinen, H.3    Ilves, M.4    Ruskoaho, H.5    Saarela, S.6
  • 60
    • 84867339835 scopus 로고    scopus 로고
    • MicroRNAs and cardiac sarcoplasmic reticulum calcium ATPase-2 in human myocardial infarction: Expression and bioinformatic analysis
    • Boštjančič E, Zidar N, Glavač D. MicroRNAs and cardiac sarcoplasmic reticulum calcium ATPase-2 in human myocardial infarction: Expression and bioinformatic analysis. BMC Genomics. 2012;13:552
    • (2012) BMC Genomics , vol.13 , pp. 552
    • Boštjančič, E.1    Zidar, N.2    Glavač, D.3
  • 61
    • 33748587841 scopus 로고    scopus 로고
    • A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes
    • Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL, Thomson AM, Lim B, Rigoutsos I. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell. 2006;126:1203-1217
    • (2006) Cell , vol.126 , pp. 1203-1217
    • Miranda, K.C.1    Huynh, T.2    Tay, Y.3    Ang, Y.S.4    Tam, W.L.5    Thomson, A.M.6    Lim, B.7    Rigoutsos, I.8
  • 65
    • 34249279050 scopus 로고    scopus 로고
    • MicroRNA-133 controls cardiac hypertrophy
    • Carè A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007;13:613-618
    • (2007) Nat Med , vol.13 , pp. 613-618
    • Carè, A.1    Catalucci, D.2    Felicetti, F.3
  • 67
    • 78649843756 scopus 로고    scopus 로고
    • MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-Amplification loop promoting calcineurin/ NFAT signalling
    • da Costa Martins PA, Salic K, Gladka MM, et al. MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-Amplification loop promoting calcineurin/ NFAT signalling. Nat Cell Biol. 2010;12:1220-1227
    • (2010) Nat Cell Biol , vol.12 , pp. 1220-1227
    • Da Costa Martins, P.A.1    Salic, K.2    Gladka, M.M.3
  • 68
    • 22444437609 scopus 로고    scopus 로고
    • Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    • Zhao Y, Samal E, Srivastava D. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature. 2005;436:214-220
    • (2005) Nature , vol.436 , pp. 214-220
    • Zhao, Y.1    Samal, E.2    Srivastava, D.3
  • 69
    • 33847038668 scopus 로고    scopus 로고
    • MicroRNAs play an essential role in the development of cardiac hypertrophy
    • Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res. 2007;100:416-424
    • (2007) Circ Res , vol.100 , pp. 416-424
    • Sayed, D.1    Hong, C.2    Chen, I.Y.3    Lypowy, J.4    Abdellatif, M.5
  • 70
    • 84862801651 scopus 로고    scopus 로고
    • Mir-1 mediated suppression of Sorcin regulates myocardial contractility through modulation of Ca2+ signaling
    • Ali R, Huang Y, Maher SE, Kim RW, Giordano FJ, Tellides G, Geirsson A. miR-1 mediated suppression of Sorcin regulates myocardial contractility through modulation of Ca2+ signaling. J Mol Cell Cardiol. 2012;52:1027-1037
    • (2012) J Mol Cell Cardiol , vol.52 , pp. 1027-1037
    • Ali, R.1    Huang, Y.2    Maher, S.E.3    Kim, R.W.4    Giordano, F.J.5    Tellides, G.6    Geirsson, A.7
  • 73
  • 75
    • 58149143288 scopus 로고    scopus 로고
    • The emerging role of microRNAs in cardiac remodeling and heart failure
    • Divakaran V, Mann DL. The emerging role of microRNAs in cardiac remodeling and heart failure. Circ Res. 2008;103:1072-1083
    • (2008) Circ Res , vol.103 , pp. 1072-1083
    • Divakaran, V.1    Mann, D.L.2
  • 76
    • 84857582662 scopus 로고    scopus 로고
    • Differential expression of microRNAs in different disease states
    • Abdellatif M. Differential expression of microRNAs in different disease states. Circ Res. 2012;110:638-650
    • (2012) Circ Res , vol.110 , pp. 638-650
    • Abdellatif, M.1
  • 77
    • 84880816481 scopus 로고    scopus 로고
    • Therapeutic cardiac-Targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling
    • Karakikes I, Chaanine AH, Kang S, Mukete BN, Jeong D, Zhang S, Hajjar RJ, Lebeche D. Therapeutic cardiac-Targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling. J Am Heart Assoc. 2013;2:e000078
    • (2013) J Am Heart Assoc , vol.2
    • Karakikes, I.1    Chaanine, A.H.2    Kang, S.3    Mukete, B.N.4    Jeong, D.5    Zhang, S.6    Hajjar, R.J.7    Lebeche, D.8
  • 78
    • 84866552877 scopus 로고    scopus 로고
    • Mir-24 regulates junctophilin-2 expression in cardiomyocytes
    • Xu M, Wu HD, Li RC, et al. Mir-24 regulates junctophilin-2 expression in cardiomyocytes. Circ Res. 2012;111:837-841
    • (2012) Circ Res , vol.111 , pp. 837-841
    • Xu, M.1    Wu, H.D.2    Li, R.C.3
  • 79
    • 84874255537 scopus 로고    scopus 로고
    • In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice
    • Li RC, Tao J, Guo YB, et al. In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice. Circ Res. 2013;112:601-605
    • (2013) Circ Res , vol.112 , pp. 601-605
    • Li, R.C.1    Tao, J.2    Guo, Y.B.3
  • 80
    • 84861858796 scopus 로고    scopus 로고
    • Targeted deletion of microRNA-22 promotes stress-induced cardiac contractile dysfunction
    • Gurha P et al. Targeted deletion of microRNA-22 promotes stress-induced cardiac contractile dysfunction. Circulation. 2012; 125: 2751-61
    • (2012) Circulation , vol.125 , pp. 2751-61
    • Gurha, P.1
  • 82
    • 48849095818 scopus 로고    scopus 로고
    • Mirna expression in the failing human heart: Functional correlates
    • Sucharov C, Bristow MR, Port JD. miRNA expression in the failing human heart: Functional correlates. J Mol Cell Cardiol. 2008;45:185-192
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 185-192
    • Sucharov, C.1    Bristow, M.R.2    Port, J.D.3
  • 84
    • 79551689552 scopus 로고    scopus 로고
    • Regulation of cardiac microRNAs by serum response factor
    • Zhang X, Azhar G, Helms SA, Wei JY. Regulation of cardiac microRNAs by serum response factor. J Biomed Sci. 2011;18:15
    • (2011) J Biomed Sci , vol.18 , pp. 15
    • Zhang, X.1    Azhar, G.2    Helms, S.A.3    Wei, J.Y.4
  • 85
    • 33947522846 scopus 로고    scopus 로고
    • Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo
    • Willis MS, Ike C, Li L, Wang DZ, Glass DJ, Patterson C. Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo. Circ Res. 2007;100:456-459
    • (2007) Circ Res , vol.100 , pp. 456-459
    • Willis, M.S.1    Ike, C.2    Li, L.3    Wang, D.Z.4    Glass, D.J.5    Patterson, C.6
  • 86
    • 11144237310 scopus 로고    scopus 로고
    • Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I
    • Kedar V, McDonough H, Arya R, Li HH, Rockman HA, Patterson C. Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc Natl Acad Sci U S A. 2004;101:18135-18140
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 18135-18140
    • Kedar, V.1    McDonough, H.2    Arya, R.3    Li, H.H.4    Rockman, H.A.5    Patterson, C.6
  • 89
    • 80955158803 scopus 로고    scopus 로고
    • Posttransctiptional regulation of the beta-subunit of cardiac L-Type Ca2+ channels by microRNAs during long-Term exposure to isoproterenol in rats
    • Carrillo ED et al. Posttransctiptional regulation of the beta-subunit of cardiac L-Type Ca2+ channels by microRNAs during long-Term exposure to isoproterenol in rats. J Caridovasc Pharmacol. 2011; 58: 470-8
    • (2011) J Caridovasc Pharmacol , vol.58 , pp. 470-8
    • Carrillo, E.D.1
  • 91
    • 6344292527 scopus 로고    scopus 로고
    • What causes sudden death in heart failure?
    • Tomaselli GF, Zipes DP. What causes sudden death in heart failure? Circ Res. 2004;95:754-763
    • (2004) Circ Res , vol.95 , pp. 754-763
    • Tomaselli, G.F.1    Zipes, D.P.2
  • 92
    • 56749178874 scopus 로고    scopus 로고
    • Targeting calcium handling in arrhythmias
    • Antoons G, Sipido KR. Targeting calcium handling in arrhythmias. Europace. 2008;10:1364-1369
    • (2008) Europace , vol.10 , pp. 1364-1369
    • Antoons, G.1    Sipido, K.R.2
  • 94
    • 79959419859 scopus 로고    scopus 로고
    • Cardiospecific microRNA plasma levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples
    • Gidlöf O, Andersson P, van Der Pals J, Götberg M, Erlinge D. Cardiospecific microRNA plasma levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples. Cardiology. 2011;118:217-226
    • (2011) Cardiology , vol.118 , pp. 217-226
    • Gidlöf, O.1    Andersson, P.2    Van Der Pals, J.3    Götberg, M.4    Erlinge, D.5
  • 95
    • 67649908891 scopus 로고    scopus 로고
    • MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bcl-2
    • Tang Y, Zheng J, Sun Y, Wu Z, Liu Z, Huang G. MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bcl-2. Int Heart J. 2009;50:377-387
    • (2009) Int Heart J. , vol.50 , pp. 377-387
    • Tang, Y.1    Zheng, J.2    Sun, Y.3    Wu, Z.4    Liu, Z.5    Huang, G.6
  • 97
    • 84855922902 scopus 로고    scopus 로고
    • Can we predict outcomes in atrial fibrillation?
    • Desai NR, Giugliano RP. Can we predict outcomes in atrial fibrillation? Clin Cardiol. 2012;35(Suppl 1):10-14
    • (2012) Clin Cardiol , vol.35 , Issue.SUPPL. 1 , pp. 10-14
    • Desai, N.R.1    Giugliano, R.P.2
  • 98
    • 84864586399 scopus 로고    scopus 로고
    • The multidimensional role of calcium in atrial fibrillation pathophysiology: Mechanistic insights and therapeutic opportunities
    • Nattel S, Dobrev D. The multidimensional role of calcium in atrial fibrillation pathophysiology: Mechanistic insights and therapeutic opportunities. Eur Heart J. 2012;33:1870-1877
    • (2012) Eur Heart J. , vol.33 , pp. 1870-1877
    • Nattel, S.1    Dobrev, D.2
  • 99
    • 79960985606 scopus 로고    scopus 로고
    • Recent advances in the molecular pathophysiology of atrial fibrillation
    • Wakili R, Voigt N, Kääb S, Dobrev D, Nattel S. Recent advances in the molecular pathophysiology of atrial fibrillation. J Clin Invest. 2011;121:2955-2968
    • (2011) J Clin Invest , vol.121 , pp. 2955-2968
    • Wakili, R.1    Voigt, N.2    Kääb, S.3    Dobrev, D.4    Nattel, S.5
  • 100
    • 58149345865 scopus 로고    scopus 로고
    • Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics
    • Dobrev D, Nattel S. Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics. J Cardiovasc Pharmacol. 2008;52:293-299
    • (2008) J Cardiovasc Pharmacol , vol.52 , pp. 293-299
    • Dobrev, D.1    Nattel, S.2
  • 101
    • 79951938038 scopus 로고    scopus 로고
    • Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation
    • Yue L, Xie J, Nattel S. Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res. 2011;89:744-753
    • (2011) Cardiovasc Res , vol.89 , pp. 744-753
    • Yue, L.1    Xie, J.2    Nattel, S.3
  • 102
    • 84877132387 scopus 로고    scopus 로고
    • MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation
    • Luo X, Pan Z, Shan H, et al. MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation. J Clin Invest. 2013;123:1939-1951
    • (2013) J Clin Invest , vol.123 , pp. 1939-1951
    • Luo, X.1    Pan, Z.2    Shan, H.3
  • 103
    • 84867767699 scopus 로고    scopus 로고
    • Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation
    • Harada M, Luo X, Qi XY, et al. Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation. 2012;126:2051-2064
    • (2012) Circulation , vol.126 , pp. 2051-2064
    • Harada, M.1    Luo, X.2    Qi, X.Y.3
  • 104
    • 40749107501 scopus 로고    scopus 로고
    • Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis
    • Shi-Wen X, Leask A, Abraham D. Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev. 2008;19:133-144
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 133-144
    • Shi-Wen, X.1    Leask, A.2    Abraham, D.3
  • 106
    • 84887207559 scopus 로고    scopus 로고
    • Extracellular matrix secretion by cardiac fibroblasts: Role of microRNA-29band microRNA-30c
    • in press
    • Abonnenc M, Nabeebaccus AA, Mayr U, et al. Extracellular matrix secretion by cardiac fibroblasts: Role of microRNA-29band microRNA-30c. Circ Rres. 2013 in press
    • (2013) Circ Rres
    • Abonnenc, M.1    Nabeebaccus, A.A.2    Mayr, U.3
  • 109
    • 25444520537 scopus 로고    scopus 로고
    • Mir-15 and miR-16 induce apoptosis by targeting BCL2
    • Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005;102:13944-13949
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , pp. 13944-13949
    • Cimmino, A.1    Calin, G.A.2    Fabbri, M.3
  • 111
    • 66349123063 scopus 로고    scopus 로고
    • MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20
    • Ren XP, Wu J, Wang X, Sartor MA, Qian J, Jones K, Nicolaou P, Pritchard TJ, Fan GC. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation. 2009;119:2357-2366
    • (2009) Circulation , vol.119 , pp. 2357-2366
    • Ren, X.P.1    Wu, J.2    Wang, X.3    Sartor, M.A.4    Qian, J.5    Jones, K.6    Nicolaou, P.7    Pritchard, T.J.8    Fan, G.C.9
  • 112
    • 67649998366 scopus 로고    scopus 로고
    • MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice
    • Bonauer A, Carmona G, Iwasaki M, et al. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science. 2009;324:1710-1713
    • (2009) Science , vol.324 , pp. 1710-1713
    • Bonauer, A.1    Carmona, G.2    Iwasaki, M.3
  • 117
    • 84855244103 scopus 로고    scopus 로고
    • MicroRNA therapeutics in cardiovascular medicine
    • Thum T. MicroRNA therapeutics in cardiovascular medicine. EMBO Mol Med. 2012;4:3-14
    • (2012) EMBO Mol Med , vol.4 , pp. 3-14
    • Thum, T.1
  • 118
    • 33645135862 scopus 로고    scopus 로고
    • Anti-miRNA oligonucleotides (AMOs): Ammunition to target miRNAs implicated in human disease?
    • Weiler J, Hunziker J, Hall J. Anti-miRNA oligonucleotides (AMOs): Ammunition to target miRNAs implicated in human disease? Gene Ther. 2006;13:496-502
    • (2006) Gene Ther , vol.13 , pp. 496-502
    • Weiler, J.1    Hunziker, J.2    Hall, J.3
  • 119
    • 0037310844 scopus 로고    scopus 로고
    • LNA: A versatile tool for therapeutics and genomics
    • Petersen M, Wengel J. LNA: A versatile tool for therapeutics and genomics. Trends Biotechnol. 2003;21:74-81
    • (2003) Trends Biotechnol , vol.21 , pp. 74-81
    • Petersen, M.1    Wengel, J.2
  • 120
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells
    • Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells. Nat Methods. 2007;4:721-726
    • (2007) Nat Methods , vol.4 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3


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