MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury

Circulation

Volumn 122, Issue 13, 2010, Pages 1308-1318

  Wang, Xiaohong ^a   Zhang, Xiaowei ^a   Ren, Xiao Ping ^a   Chen, Jing ^a   Liu, Hongzhu ^a   Yang, Junqi ^a   Medvedovic, Mario ^a   Hu, Zhuowei ^b   Fan, Guo Chang ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

apoptosis; cardiomyocyte; microRNA; myocardial infarction; reperfusion injury

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CASPASE 3; FIBROBLAST GROWTH FACTOR RECEPTOR 2; LACTATE DEHYDROGENASE; LEUKEMIA INHIBITORY FACTOR RECEPTOR; MICRORNA; MICRORNA 494; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN; PROTEIN KINASE B; ROCK1 PROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; MIRN494 MICRORNA, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; GENE OVEREXPRESSION; GENE TARGETING; HEART INFARCTION SIZE; HEART INJURY; HEART MUSCLE CELL; HEART PROTECTION; ISCHEMIA; ISOLATED HEART; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TRANSGENICS; WILD TYPE; ANIMAL; DISEASE MODEL; GENETICS; HEART MUSCLE ISCHEMIA; METABOLISM; PATHOPHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; DISEASE MODELS, ANIMAL; MICE; MICE, TRANSGENIC; MICRORNAS; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY;

EID: 77957935805     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.964684     Document Type: Article

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