MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Belevych, Andriy E ^a,b,c   Sansom, Sarah E ^a   Terentyeva, Radmila ^d   Ho, Hsiang Ting ^a,b,c   Nishijima, Yoshinori ^a,b,c   Martin, Mickey M ^a   Jindal, Hitesh K ^d   Rochira, Jennifer A ^d   Kunitomo, Yukiko ^d   Abdellatif, Maha ^e   Carnes, Cynthia A ^a,b,c   Elton, Terry S ^a,b,c   Györke, Sandor ^a,b,c   Terentyev, Dmitry ^d  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d BROWN UNIVERSITY   (United States)

^e RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; MESSENGER RNA; MICRORNA; MICRORNA 1; MICRORNA 133; PHOSPHOPROTEIN PHOSPHATASE 2A; RYANODINE RECEPTOR 2; UNCLASSIFIED DRUG; BETA ADRENERGIC RECEPTOR; CALCIUM; ISOPRENALINE; MIRN1 MICRORNA, HUMAN; MIRN133 MICRORNA, HUMAN; PHOSPHATASE; RYANODINE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HEART FAILURE; MOLECULAR PATHOLOGY; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; CATALYSIS; DOG; ELECTROPHYSIOLOGY; ENZYME ACTIVE SITE; GENETICS; HEART ARRHYTHMIA; HEART VENTRICLE; HUMAN; METABOLISM; METHODOLOGY; MUSCLE CELL; PATHOLOGY; PHOSPHORYLATION; REPORTER GENE; SARCOPLASMIC RETICULUM;

ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM; CATALYSIS; CATALYTIC DOMAIN; DOGS; ELECTROPHYSIOLOGY; GENES, REPORTER; HEART FAILURE; HEART VENTRICLES; HUMANS; ISOPROTERENOL; MICRORNAS; MODELS, BIOLOGICAL; MUSCLE CELLS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, BETA; RNA, MESSENGER; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM;

EID: 82755165053     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028324     Document Type: Article

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