Differences in phosphodiesterase 3A and 3B expression after ischemic insult

Neuroscience Research

Volumn 75, Issue 4, 2013, Pages 340-348

  Mitome Mishima, Yumiko ^a   Miyamoto, Nobukazu ^a   Tanaka, Ryota ^a   Oishi, Hidenori ^a   Arai, Hajime ^a   Hattori, Nobutaka ^a   Urabe, Takao ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute cerebral infarction; Astrocyte; CAMP responsive element binding protein; Ischemic boundary zone; Oligodendrocyte progenitor cell; Phosphodiesterase type 3B

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; PHOSPHODIESTERASE 3A; PHOSPHODIESTERASE 3B; PHOSPHODIESTERASE III; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; C57BL 6 MOUSE; CORPUS CALLOSUM; ENDOTHELIUM CELL; FOREBRAIN; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CELL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REPERFUSION; STEM CELL; TRANSIENT ISCHEMIC ATTACK;

ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD11B; BRAIN; CALCIUM-BINDING PROTEINS; CELL COUNT; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; CORPUS CALLOSUM; CREB-BINDING PROTEIN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLIAL FIBRILLARY ACIDIC PROTEIN; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; PHOSPHOPYRUVATE HYDRATASE; PHOSPHORYLATION; REPERFUSION;

EID: 84876144541     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2013.02.006     Document Type: Article

References (31)

1. Ballif B.A., Blenis J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ. 2001, 12:397-408.
2. Beavo J.A. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev. 1995, 75:725-748.
3. Choi J.M., Shin H.K., Kim K.Y., Lee J.H., Hong K.W. Neuroprotective effect of cilostazol against focal cerebral ischemia via antiapoptotic action in rats. J. Pharmacol. Exp. Ther. 2002, 300:787-793.
4. Degerman E., Ahmad F., Chung Y.W., Guirguis E., Omar B., Stenson L., Manganiello V. From PDE3B to the regulation of energy homeostasis. Curr. Opin. Pharmacol. 2011, 11:676-682.
5. Degerman E., Belfrage P., Manganiello V.C. Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3). J. Biol. Chem. 1997, 272:6823-6826.
6. Dewar D., Underhill S.M., Goldberg M.P. Oligodendrocytes and ischemic brain injury. J. Cereb. Blood Flow Metab. 2003, 23:263-274.
7. Eddleston M., Mucke L. Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience 1993, 54:15-36.
8. Gao Y.A., Gao G., Long C.X., Han S., Zu P.Y., Fang L., Li J.F. Enhanced phosphorylation of cyclic AMP response element binding protein in the brain of mice following repetitive hypoxic exposure. Biochem. Biophys. Res. Commun. 2006, 340:661-667.
9. Gresele P., Momi S., Falcinelli E. Anti-platelet therapy: phosphodiesterase inhibitors. Br. J. Clin. Pharmacol. 2011, 72:634-646.
10. Hara H., Huang P.L., Panahian N., Fishman M.C., Moskowitz M.A. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J. Cereb. Blood Flow Metab. 1996, 16:605-611.
11. Hara T., Hamada J., Yano S., Morioka M., Kai Y., Ushio Y. CREB is required for acquisition of ischemic tolerance in gerbil hippocampal CA1 region. J. Neurochem. 2003, 86:805-814.
12. Jeon Y.H., Heo Y.S., Kim C.M., Hyun Y.L., Lee T.G., Ro S., Cho J.M. Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development. Cell. Mol. Life Sci. 2005, 62:1198-1220.
13. Kambayashi J., Liu Y.G., Sun B., Shakur Y., Yoshitake M., Czerwiec F. Cilostazol as a unique antithrombotic agent. Curr. Pharm. Des. 2003, 9:2289-2302.
14. Lee J.H., Lee Y.K., Ishikawa M., Koga K., Fukunaga M., Miyakoda G., Mori T., Hosokawa T., Hong K.W. Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats-an MRI study. Brain Res. 2003, 994:91-98.
15. Lee J.H., Park S.Y., Lee W.S., Hong K.W. Lack of antiapoptotic effects of antiplatelet drug, aspirin and clopidogrel, and antioxidant, MCI-186, against focal ischemic brain damage in rats. Neurol. Res. 2005, 27:483-492.
16. Miyamoto N., Tanaka R., Shimosawa T., Yatomi Y., Fujita T., Hattori N., Urabe T. Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice. J. Cereb. Blood Flow Metab. 2009, 29:1769-1779.
17. Miyamoto N., Tanaka R., Shimura H., Watanabe T., Mori H., Onodera M., Mochizuki H., Hattori N., Urabe T. Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain. J. Cereb. Blood Flow Metab. 2010, 30:299-310.
18. Moskowitz M.A., Lo E.H., Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron 2010, 67:181-198.
19. Nikpour M., Sadeghian H., Saberi M.R., Nick R.S., Seyedi S.M., Hosseini A., Parsaee H., Bozorg A.T. Design, synthesis and biological evaluation of 6-(benzyloxy)-4-methylquinolin-2(1H)-one derivatives as PDE3 inhibitors. Bioorg. Med. Chem. 2010, 18:855-862.
20. Shin H.K., Lee H.R., Lee D.H., Hong K.W., Lee J.H., Park S.Y., Lee S.J., Lee J.S., Lee W.S., Rhim B.Y., Kim C.D. Cilostazol enhances neovascularization in the mouse hippocampus after transient forebrain ischemia. J. Neurosci. Res. 2010, 88:2228-2238.
21. Stoll G., Jander S., Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog. Neurobiol. 1998, 56:149-171.
22. Tanaka K., Nogawa S., Ito D., Suzuki S., Dembo T., Kosakai A., Fukuuchi Y. Phosphorylation of cyclic adenosine monophosphate response element binding protein in oligodendrocytes in the corpus callosum after focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 2001, 21:1177-1188.
23. Tanaka K., Nogawa S., Suzuki S., Dembo T., Kosakai A. Upregulation of oligodendrocyte progenitor cells associated with restoration of mature oligodendrocytes and myelination in peri-infarct area in the rat brain. Brain Res. 2003, 989:172-179.
24. Tanaka Y., Tanaka R., Liu M., Hattori N., Urabe T. Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia. Neuroscience 2010, 171:1367-1376.
25. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 1998, 20:709-726.
26. Thompson P.E., Manganiello V., Degerman E. Re-discovering PDE3 inhibitors-new opportunities for a long neglected target. Curr. Top. Med. Chem. 2007, 7:421-436.
27. Walton M., Sirimanne E., Williams C., Gluckman P., Dragunow M. The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair. Brain Res. Mol. Brain Res. 1996, 43:21-29.
28. Watanabe T., Zhang N., Liu M., Tanaka R., Mizuno Y., Urabe T. Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion. Stroke 2006, 37:1539-1545.
29. Yan C., Miller C.L., Abe F Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart. Circ. Res. 2007, 100:489-501.
30. Zhang N., Komine-Kobayashi M., Tanaka R., Liu M.Z., Mizuno Y., Urabe T. Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke 2005, 36:2220-2225.
31. Zhang N., Miyamoto N., Tanaka R., Mochizuki H., Hattori N., Urabe T. Activation of tyrosine hydroxylase prevents pneumonia in a rat chronic cerebral hypoperfusion model. Neuroscience 2009, 158:665-672.