Yeast replicative aging: A paradigm for defining conserved longevity interventions

FEMS Yeast Research

Volumn 14, Issue 1, 2014, Pages 148-159

  Wasko, Brian M ^a   Kaeberlein, Matt ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Caenorhabditis elegans; Caloric restriction; Calorie restriction; Replicative life span; Target of rapamycin; Yeast

Indexed keywords

ADENYLATE KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN SCH9; S6 KINASE; SIRTUIN 1; SIRTUIN 2; TRANSCRIPTION FACTOR GCN4; TUNICAMYCIN; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; AGING; AMINO ACID METABOLISM; ARTICLE; ASYMMETRIC CELL DIVISION; AUTOPHAGY; CELL GROWTH; CELL METABOLISM; CELL STRESS; DIET RESTRICTION; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; GENE OVEREXPRESSION; HISTONE ACETYLATION; LIFE EXTENSION; LIFESPAN; LIPID METABOLISM; LONGEVITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUTRIENT AVAILABILITY; OPEN READING FRAME; OXIDATIVE STRESS; PROTEIN AGGREGATION; REPLICATIVE LIFE SPAN; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; TELOMERE; ANIMAL; BIOLOGICAL MODEL; CAENORHABDITIS ELEGANS; DROSOPHILA; PHYSIOLOGY; RODENT;

CAENORHABDITIS ELEGANS; EUKARYOTA; RODENTIA; SACCHAROMYCETALES;

ANIMALS; CAENORHABDITIS ELEGANS; DROSOPHILA; MODELS, BIOLOGICAL; RODENTIA; SACCHAROMYCES CEREVISIAE;

EID: 84893772201     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/1567-1364.12104     Document Type: Article

References (151)

1. Aguilaniu H, Gustafsson L, Rigoulet M & Nystrom T (2003) Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 299: 1751-1753.
2. Alvers AL, Wood MS, Hu D, Kaywell AC, Dunn WA Jr & Aris JP (2009a) Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 5: 847-849.
3. Alvers AL, Fishwick LK, Wood MS, Hu D, Chung HS, Dunn WA Jr & Aris JP (2009b) Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell 8: 353-369.
4. Anisimov VN, Zabezhinski MA, Popovich IG et al. (2011) Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle 10: 4230-4236.
5. Apfeld J, O'Connor G, McDonagh T, DiStefano PS & Curtis R (2004) The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev 18: 3004-3009.
6. Ashrafi K, Lin SS, Manchester JK & Gordon JI (2000) Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14: 1872-1885.
7. Barros MH, Bandy B, Tahara EB & Kowaltowski AJ (2004) Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. J Biol Chem 279: 49883-49888.
8. Bass TM, Weinkove D, Houthoofd K, Gems D & Partridge L (2007) Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev 128: 546-552.
9. Bilinski T, Zadrag-Tecza R & Bartosz G (2012) Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast. FEMS Yeast Res 12: 97-101.
10. Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A & Partridge L (2010) Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 11: 35-46.
11. Bonawitz ND, Chatenay-Lapointe M, Pan Y & Shadel GS (2007) Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab 5: 265-277.
12. Burnett C, Valentini S, Cabreiro F et al. (2011) Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477: 482-485.
13. Cafferkey R, Young PR, McLaughlin MM et al. (1993) Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol Cell Biol 13: 6012-6023.
14. Cafferkey R, McLaughlin MM, Young PR, Johnson RK & Livi GP (1994) Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs. Gene 141: 133-136.
15. Chiocchetti A, Zhou J, Zhu H et al. (2007) Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Exp Gerontol 42: 275-286.
16. Cohen A, Ross L, Nachman I & Bar-Nun S (2012) Aggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assays. PLoS ONE 7: e44785.
17. Cuervo AM (2008) Autophagy and aging: keeping that old broom working. Trends Genet 24: 604-612.
18. Curran SP & Ruvkun G (2007) Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 3: e56.
19. Dang W, Steffen KK, Perry R et al. (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459: 802-807.
20. Delaney JR, Murakami CJ, Olsen B, Kennedy BK & Kaeberlein M (2011a) Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell Cycle 10: 156-165.
21. Delaney JR, Sutphin GL, Dulken B et al. (2011b) Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell 10: 1089-1091.
22. Delaney JR, Ahmed U, Chou A et al. (2013a) Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell 12: 156-166.
23. Delaney JR, Murakami C, Chou A et al. (2013b) Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Exp Gerontol 48: 1006-1013.
24. Dillin A, Hsu AL, Arantes-Oliveira N et al. (2002) Rates of behavior and aging specified by mitochondrial function during development. Science 298: 2398-2401.
25. Donmez G & Guarente L (2010) Aging and disease: connections to sirtuins. Aging Cell 9: 285-290.
26. Egilmez NK & Jazwinski SM (1989) Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae. J Bacteriol 171: 37-42.
27. Eisenberg T, Knauer H, Schauer A et al. (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11: 1305-1314.
28. Erjavec N & Nystrom T (2007) Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae. P Natl Acad Sci USA 104: 10877-10881.
29. Erjavec N, Larsson L, Grantham J & Nystrom T (2007) Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. Genes Dev 21: 2410-2421.
30. Erjavec N, Cvijovic M, Klipp E & Nystrom T (2008) Selective benefits of damage partitioning in unicellular systems and its effects on aging. P Natl Acad Sci USA 105: 18764-18769.
31. Fabrizio P, Pletcher SD, Minois N, Vaupel JW & Longo VD (2004) Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. FEBS Lett 557: 136-142.
32. Finkel T, Deng CX & Mostoslavsky R (2009) Recent progress in the biology and physiology of sirtuins. Nature 460: 587-591.
33. Flatt T (2011) Survival costs of reproduction in Drosophila. Exp Gerontol 46: 369-375.
34. Gershon H & Gershon D (2000) The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review. Mech Ageing Dev 120: 1-22.
35. Guarente L (2011) Sirtuins, aging, and metabolism. Cold Spring Harb Symp Quant Biol 76: 81-90.
36. Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G & Lee SS (2005) A systematic RNAi screen for longevity genes in C. elegans. Genes Dev 19: 1544-1555.
37. Hansen M, Hsu AL, Dillin A & Kenyon C (2005) New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet 1: 119-128.
38. Hansen M, Taubert S, Crawford D, Libina N, Lee SJ & Kenyon C (2007) Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6: 95-110.
39. Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M & Kenyon C (2008) A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4: e24.
40. Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298-300.
41. Harman D (2006) Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci 1067: 10-21.
42. Harrison DE, Strong R, Sharp ZD et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460: 392-395.
43. Hartwell LH & Unger MW (1977) Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division. J Cell Biol 75: 422-435.
44. Heitman J, Movva NR & Hall MN (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253: 905-909.
45. Helliwell SB, Wagner P, Kunz J, Deuter-Reinhard M, Henriquez R & Hall MN (1994) TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol Cell 5: 105-118.
46. Hempenstall S, Page MM, Wallen KR & Selman C (2012) Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice. Mech Ageing Dev 133: 37-45.
47. Henderson KA & Gottschling DE (2008) A mother's sacrifice: what is she keeping for herself? Curr Opin Cell Biol 20: 723-728.
48. Hinnebusch AG (2005) Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol 59: 407-450.
49. Houtkooper RH, Mouchiroud L, Ryu D et al. (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497: 451-457.
50. Howitz KT, Bitterman KJ, Cohen HY et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196.
51. Hughes AL & Gottschling DE (2012) An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature 492: 261-265.
52. Jia K, Chen D & Riddle DL (2004) The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131: 3897-3906.
53. Jiang JC, Jaruga E, Repnevskaya MV & Jazwinski SM (2000) An intervention resembling caloric restriction prolongs life span and retards aging in yeast. FASEB J 14: 2135-2137.
54. Jiang JC, Wawryn J, Shantha Kumara HM & Jazwinski SM (2002) Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast. Exp Gerontol 37: 1023-1030.
55. Johnson SC, Rabinovitch PS & Kaeberlein M (2013) mTOR is a key modulator of ageing and age-related disease. Nature 493: 338-345.
56. Jorgensen P, Nishikawa JL, Breitkreutz BJ & Tyers M (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297: 395-400.
57. Jorgensen P, Rupes I, Sharom JR, Schneper L, Broach JR & Tyers M (2004) A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev 18: 2491-2505.
58. Kaeberlein M (2008) Cell biology: a molecular age barrier. Nature 454: 709-710.
59. Kaeberlein M (2010) Lessons on longevity from budding yeast. Nature 464: 513-519.
60. Kaeberlein M (2013) Longevity and aging. F1000Prime Rep 5: 5.
61. Kaeberlein M, McVey M & Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13: 2570-2580.
62. Kaeberlein M, Kirkland KT, Fields S & Kennedy BK (2004) Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2: E296.
63. Kaeberlein M, Kirkland KT, Fields S & Kennedy BK (2005a) Genes determining replicative life span in a long-lived genetic background. Mech Ageing Dev 126: 491-504.
64. Kaeberlein M, Hu D, Kerr EO et al. (2005b) Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 1: e69.
65. Kaeberlein M, Powers RW 3rd, Steffen KK et al. (2005c) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310: 1193-1196.
66. Kaeberlein M, McDonagh T, Heltweg B et al. (2005d) Substrate specific activation of sirtuins by resveratrol. J Biol Chem 280: 17038-17045.
67. Kaeberlein TL, Smith ED, Tsuchiya M et al. (2006) Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5: 487-494.
68. Kanfi Y, Naiman S, Amir G et al. (2012) The sirtuin SIRT6 regulates lifespan in male mice. Nature 483: 218-221.
69. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V & Benzer S (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14: 885-890.
70. Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL & Kockel L (2010) With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab 11: 453-465.
71. Keith CT & Schreiber SL (1995) PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 270: 50-51.
72. Kennedy BK, Austriaco NR Jr & Guarente L (1994) Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol 127: 1985-1993.
73. Kennedy BK, Gotta M, Sinclair DA et al. (1997) Redistribution of silencing proteins from telomeres to the nucleolus ia associated with extension of life span in S. cerevisiae. Cell 89: 381-391.
74. Kennedy BK, Steffen KK & Kaeberlein M (2007) Ruminations on dietary restriction and aging. Cell Mol Life Sci 64: 1323-1328.
75. Khazaeli AA, Tatar M, Pletcher SD & Curtsinger JW (1997) Heat-induced longevity extension in Drosophila. I. Heat treatment, mortality, and thermotolerance. J Gerontol A Biol Sci Med Sci 52: B48-B52.
76. Kim S, Benguria A, Lai CY & Jazwinski SM (1999) Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol Biol Cell 10: 3125-3136.
77. Kirchman PA & Botta G (2007) Copper supplementation increases yeast life span under conditions requiring respiratory metabolism. Mech Ageing Dev 128: 187-195.
78. Kirchman PA, Kim S, Lai CY & Jazwinski SM (1999) Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics 152: 179-190.
79. Kirkwood TB (1977) Evolution of ageing. Nature 270: 301-304.
80. Klass MR (1977) Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech Ageing Dev 6: 413-429.
81. Knorre DA, Kulemzina IA, Sorokin MI, Kochmak SA, Bocharova NA, Sokolov SS & Severin FF (2010) Sir2-dependent daughter-to-mother transport of the damaged proteins in yeast is required to prevent high stress sensitivity of the daughters. Cell Cycle 9: 4501-4505.
82. Kobayashi T & Ganley AR (2005) Recombination regulation by transcription-induced cohesin dissociation in rDNA repeats. Science 309: 1581-1584.
83. Kraakman L, Lemaire K, Ma P et al. (1999) A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol Microbiol 32: 1002-1012.
84. Lai CY, Jaruga E, Borghouts C & Jazwinski SM (2002) A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae. Genetics 162: 73-87.
85. Lakowski B & Hekimi S (1998) The genetics of caloric restriction in Caenorhabditis elegans. P Natl Acad Sci USA 95: 13091-13096.
86. Lam YT, Aung-Htut MT, Lim YL, Yang H & Dawes IW (2011) Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells. Free Radic Biol Med 50: 963-970.
87. Lamming DW, Ye L, Katajisto P et al. (2012) Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335: 1638-1643.
88. Li H, Tsang CK, Watkins M, Bertram PG & Zheng XF (2006) Nutrient regulates Tor1 nuclear localization and association with rDNA promoter. Nature 442: 1058-1061.
89. Liao CY, Rikke BA, Johnson TE, Diaz V & Nelson JF (2010) Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell 9: 92-95.
90. Lin SJ, Defossez PA & Guarente L (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128.
91. Lin SJ, Kaeberlein M, Andalis AA et al. (2002) Calorie restriction extends Saccharomyces cerevisiae life span by increasing respiration. Nature 418: 344-348.
92. Lin SS, Manchester JK & Gordon JI (2003) Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing. J Biol Chem 278: 13390-13397.
93. Lithgow GJ, White TM, Melov S & Johnson TE (1995) Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. P Natl Acad Sci USA 92: 7540-7544.
94. Longo VD & Fabrizio P (2002) Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans? Cell Mol Life Sci 59: 903-908.
95. Longo VD & Finch CE (2003) Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 299: 1342-1346.
96. Longo VD, Shadel GS, Kaeberlein M & Kennedy B (2012) Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab 16: 18-31.
97. Lu JY, Lin YY, Sheu JC et al. (2011) Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell 146: 969-979.
98. Mair W, Goymer P, Pletcher SD & Partridge L (2003) Demography of dietary restriction and death in Drosophila. Science 301: 1731-1733.
99. Masoro EJ (2005) Overview of caloric restriction and ageing. Mech Ageing Dev 126: 913-922.
100. McCay CM, Crowell MF & Maynard LA (1935) The effect of retarded growth upon the length of life and upon ultimate size. J Nutr 10: 63-79.
101. McFaline-Figueroa JR, Vevea J, Swayne TC et al. (2011) Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast. Aging Cell 10: 885-895.
102. McMurray MA & Thorner J (2009) Septins: molecular partitioning and the generation of cellular asymmetry. Cell Div 4: 18.
103. Medvedik O, Lamming DW, Kim KD & Sinclair DA (2007) MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol 5: e261.
104. Miceli MV, Jiang JC, Tiwari A, Rodriguez-Quinones JF & Jazwinski SM (2011) Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan. Front Genet 2: 102.
105. Miller RA, Harrison DE, Astle CM et al. (2011) Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 66: 191-201.
106. Molin M, Yang J, Hanzen S, Toledano MB, Labarre J & Nystrom T (2011) Life span extension and H(2)O(2) resistance elicited by caloric restriction require the peroxiredoxin Tsa1 in Saccharomyces cerevisiae. Mol Cell 43: 823-833.
107. Mortimer RK & Johnston JR (1959) Life span of individual yeast cells. Nature 183: 1751-1752.
108. Omodei D & Fontana L (2011) Calorie restriction and prevention of age-associated chronic disease. FEBS Lett 585: 1537-1542.
109. Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ & Kapahi P (2007) Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6: 111-119.
110. Paradis S, Ailion M, Toker A, Thomas JH & Ruvkun G (1999) A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 13: 1438-1452.
111. Partridge L, Gems D & Withers DJ (2005) Sex and death: what is the connection? Cell 120: 461-472.
112. Passtoors WM, Beekman M, Deelen J et al. (2013) Gene expression analysis of mTOR pathway: association with human longevity. Aging Cell 12: 24-31.
113. Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK & Fields S (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20: 174-184.
114. Rajawat YS, Hilioti Z & Bossis I (2009) Aging: central role for autophagy and the lysosomal degradative system. Ageing Res Rev 8: 199-213.
115. Rizki G, Iwata TN, Li J et al. (2011) The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet 7: e1002235.
116. Robida-Stubbs S, Glover-Cutter K, Lamming DW et al. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab 15: 713-724.
117. Rogina B & Helfand SL (2004) Sir2 mediates longevity in the fly through a pathway related to calorie restriction. P Natl Acad Sci USA 101: 15998-16003.
118. Rogina B, Helfand SL & Frankel S (2002) Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science 298: 1745.
119. Rolland F, De Winde JH, Lemaire K, Boles E, Thevelein JM & Winderickx J (2000) Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process. Mol Microbiol 38: 348-358.
120. Sadeh A, Movshovich N, Volokh M, Gheber L & Aharoni A (2011) Fine-tuning of the Msn2/4-mediated yeast stress responses as revealed by systematic deletion of Msn2/4 partners. Mol Biol Cell 22: 3127-3138.
121. Salminen A & Kaarniranta K (2012) AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev 11: 230-241.
122. Salvi JS, Chan JN, Pettigrew C, Liu TT, Wu JD & Mekhail K (2013) Enforcement of a lifespan-sustaining distribution of Sir2 between telomeres, mating-type loci, and rDNA repeats by Rif1. Aging Cell 12: 67-75.
123. Sampaio-Marques B, Felgueiras C, Silva A et al. (2012) SNCA (alpha-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. Autophagy 8: 1494-1509.
124. Schleit J, Wasko BM & Kaeberlein M (2012) Yeast as a model to understand the interaction between genotype and the response to calorie restriction. FEBS Lett 586: 2868-2873.
125. Schleit J, Johnson SC, Bennett CF et al. (2013) Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell [Epub ahead of print].
126. Selman C, Tullet JM, Wieser D et al. (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326: 140-144.
127. Shama S, Lai CY, Antoniazzi JM, Jiang JC & Jazwinski SM (1998) Heat stress-induced life span extension in yeast. Exp Cell Res 245: 379-388.
128. Sharma PK, Agrawal V & Roy N (2011) Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae. Age (Dordr) 33: 143-154.
129. Shcheprova Z, Baldi S, Frei SB, Gonnet G & Barral Y (2008) A mechanism for asymmetric segregation of age during yeast budding. Nature 454: 728-734.
130. Sinclair DA & Guarente L (1997) Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91: 1033-1042.
131. Smith ED, Tsuchiya M, Fox LA et al. (2008) Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome Res 18: 564-570.
132. Stanfel MN, Shamieh LS, Kaeberlein M & Kennedy BK (2009) The TOR pathway comes of age. Biochim Biophys Acta 1790: 1067-1074.
133. Steffen KK, MacKay VL, Kerr EO et al. (2008) Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell 133: 292-302.
134. Steffen KK, McCormick MA, Pham KM et al. (2012) Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics 191: 107-118.
135. Steinkraus KA, Kaeberlein M & Kennedy BK (2008) Replicative aging in yeast: the means to the end. Annu Rev Cell Dev Biol 24: 29-54.
136. Stumpferl SW, Brand SE, Jiang JC et al. (2012) Natural genetic variation in yeast longevity. Genome Res 22: 1963-1973.
137. Sun J, Kale SP, Childress AM, Pinswasdi C & Jazwinski SM (1994) Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269: 18638-18645.
138. Tang F, Watkins JW, Bermudez M et al. (2008) A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery. Autophagy 4: 874-886.
139. Tissenbaum HA & Guarente L (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230.
140. Toda T, Cameron S, Sass P, Zoller M & Wigler M (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50: 277-287.
141. Toda T, Cameron S, Sass P & Wigler M (1988) SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev 2: 517-527.
142. Urban J, Soulard A, Huber A et al. (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 26: 663-674.
143. Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L & Muller F (2003) Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426: 620.
144. Vezina C, Kudelski A & Sehgal SN (1975) Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 28: 721-726.
145. Viswanathan M & Guarente L (2011) Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 477: E1-E2.
146. Wang X, Zuo X, Kucejova B & Chen XJ (2008) Reduced cytosolic protein synthesis suppresses mitochondrial degeneration. Nat Cell Biol 10: 1090-1097.
147. Weinberger M, Mesquita A, Caroll T et al. (2010) Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence. Aging 2: 709-726.
148. Wilkinson JE, Burmeister L, Brooks SV et al. (2012) Rapamycin slows aging in mice. Aging Cell 11: 675-682.
149. Woo DK & Poyton RO (2009) The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation. Exp Gerontol 44: 390-397.
150. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M & Sinclair D (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686-689.
151. Zhou KI, Pincus Z & Slack FJ (2011) Longevity and stress in Caenorhabditis elegans. Aging (Albany NY) 3: 733-753.