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Volumn 181, Issue 1, 2014, Pages 1-8

Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; PROTEIN; PROTEIN 53BP1; UNCLASSIFIED DRUG;

EID: 84893659031     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR13572.1     Document Type: Review
Times cited : (116)

References (98)
  • 1
    • 0026733077 scopus 로고
    • The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxiatelangiectasia
    • Pandita TK, Hittelman WN. The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxiatelangiectasia. Radiat Res 1992; 131(2):214-23.
    • (1992) Radiat Res , vol.131 , Issue.2 , pp. 214-223
    • Pandita, T.K.1    Hittelman, W.N.2
  • 2
    • 0026663777 scopus 로고
    • Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells
    • Pandita TK, Hittelman WN. Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells. Radiat Res 1992; 130(1):94-103.
    • (1992) Radiat Res , vol.130 , Issue.1 , pp. 94-103
    • Pandita, T.K.1    Hittelman, W.N.2
  • 3
    • 33751568508 scopus 로고    scopus 로고
    • The cellular control of DNA double-strand breaks
    • Scott SP, Pandita TK. The cellular control of DNA double-strand breaks. J Cell Biochem 2006; 99(6):1463-75.
    • (2006) J Cell Biochem , vol.99 , Issue.6 , pp. 1463-1475
    • Scott, S.P.1    Pandita, T.K.2
  • 4
    • 63249124451 scopus 로고    scopus 로고
    • Chromatin remodeling finds its place in the DNA double-strand break response
    • Pandita TK, Richardson C. Chromatin remodeling finds its place in the DNA double-strand break response. Nucleic Acids Res 2009; 37(5):1363-77.
    • (2009) Nucleic Acids Res , vol.37 , Issue.5 , pp. 1363-1377
    • Pandita, T.K.1    Richardson, C.2
  • 7
    • 0033855389 scopus 로고    scopus 로고
    • Mechanisms of DNA doublestrand break repair and their potential to induce chromosomal aberrations
    • Pfeiffer P, Goedecke W, Obe G. Mechanisms of DNA doublestrand break repair and their potential to induce chromosomal aberrations. Mutagenesis 2000; 15(4):289-302.
    • (2000) Mutagenesis , vol.15 , Issue.4 , pp. 289-302
    • Pfeiffer, P.1    Goedecke, W.2    Obe, G.3
  • 8
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009; 461(7267):1071-8.
    • (2009) Nature , vol.461 , Issue.7267 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 9
    • 58549092574 scopus 로고    scopus 로고
    • DNA repair deficiency and neurological disease
    • McKinnon PJ. DNA repair deficiency and neurological disease. Nat Rev Neurosci. 2009; 10(2):100-12.
    • (2009) Nat Rev Neurosci , vol.10 , Issue.2 , pp. 100-112
    • McKinnon, P.J.1
  • 10
    • 84882718761 scopus 로고    scopus 로고
    • The logic and mechanism of homologous recombination partner choice
    • Hong S, Sung Y, Yu M, Lee M, Kleckner N, Kim KP. The logic and mechanism of homologous recombination partner choice. Molecular Cell 2013; 51(4):440-53.
    • (2013) Molecular Cell , vol.51 , Issue.4 , pp. 440-453
    • Hong, S.1    Sung, Y.2    Yu, M.3    Lee, M.4    Kleckner, N.5    Kim, K.P.6
  • 11
    • 0036480427 scopus 로고    scopus 로고
    • Double-strand breaks and translocations in cancer
    • Elliott B, Jasin M. Double-strand breaks and translocations in cancer. Cell Mol Life Sci 2002; 59(2):373-85.
    • (2002) Cell Mol Life Sci , vol.59 , Issue.2 , pp. 373-385
    • Elliott, B.1    Jasin, M.2
  • 12
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber MR. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 2010; 79:181-211.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 13
    • 0038700698 scopus 로고    scopus 로고
    • Molecular views of recombination proteins and their control
    • West SC. Molecular views of recombination proteins and their control. Nature reviews Molecular cell Biology 2003; 4(6):435-45.
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.6 , pp. 435-445
    • West, S.C.1
  • 14
    • 33747889217 scopus 로고    scopus 로고
    • Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
    • Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst) 2006; 5(9-10):1021-9.
    • (2006) DNA Repair (Amst) , vol.5 , Issue.9-10 , pp. 1021-1029
    • Sonoda, E.1    Hochegger, H.2    Saberi, A.3    Taniguchi, Y.4    Takeda, S.5
  • 15
    • 0032518657 scopus 로고    scopus 로고
    • Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
    • Sonoda E, Sasaki MS, Buerstedde JM, Bezzubova O, Shinohara A, Ogawa H, et al. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J 1998; 17(2): 598-608.
    • (1998) EMBO J , vol.17 , Issue.2 , pp. 598-608
    • Sonoda, E.1    Sasaki, M.S.2    Buerstedde, J.M.3    Bezzubova, O.4    Shinohara, A.5    Ogawa, H.6
  • 16
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004; 73:39-85.
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 17
    • 18444418299 scopus 로고    scopus 로고
    • Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells
    • Li L, Zou L. Sensing, signaling, and responding to DNA damage: organization of the checkpoint pathways in mammalian cells. J Cell Biochem 2005; 94(2):298-306.
    • (2005) J Cell Biochem , vol.94 , Issue.2 , pp. 298-306
    • Li, L.1    Zou, L.2
  • 19
    • 34248202517 scopus 로고    scopus 로고
    • Tying the loose ends together in DNA double strand break repair with 53BP1
    • Adams MM, Carpenter PB. Tying the loose ends together in DNA double strand break repair with 53BP1. Cell Div 2006; 1:19.
    • (2006) Cell Div , vol.1 , pp. 19
    • Adams, M.M.1    Carpenter, P.B.2
  • 20
    • 0036902410 scopus 로고    scopus 로고
    • 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
    • DiTullio RA, Jr., Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nature Cell Biol 2002; 4(12):998-1002.
    • (2002) Nature Cell Biol , vol.4 , Issue.12 , pp. 998-1002
    • DiTullio Jr., R.A.1    Mochan, T.A.2    Venere, M.3    Bartkova, J.4    Sehested, M.5    Bartek, J.6
  • 21
    • 0037772381 scopus 로고    scopus 로고
    • Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability
    • Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, et al. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem 2003; 278(17): 14971-7.
    • (2003) J Biol Chem , vol.278 , Issue.17 , pp. 14971-14977
    • Morales, J.C.1    Xia, Z.2    Lu, T.3    Aldrich, M.B.4    Wang, B.5    Rosales, C.6
  • 23
    • 84876855215 scopus 로고    scopus 로고
    • RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
    • Chapman JR, Barral P, Vannier JB, Borel V, Steger M, Tomas-Loba A, et al. RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Molecular Cell 2013; 49(5):858-71.
    • (2013) Molecular Cell , vol.49 , Issue.5 , pp. 858-871
    • Chapman, J.R.1    Barral, P.2    Vannier, J.B.3    Borel, V.4    Steger, M.5    Tomas-Loba, A.6
  • 24
    • 33845666681 scopus 로고    scopus 로고
    • Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
    • Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, et al. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 2006; 127(7):1361-73.
    • (2006) Cell , vol.127 , Issue.7 , pp. 1361-1373
    • Botuyan, M.V.1    Lee, J.2    Ward, I.M.3    Kim, J.E.4    Thompson, J.R.5    Chen, J.6
  • 25
    • 4444336414 scopus 로고    scopus 로고
    • The Tudor tandem of 53BP1: A new structural motif involved in DNA and RG-rich peptide binding
    • Epub 2004/09/03
    • Charier G, Couprie J, Alpha-Bazin B, Meyer V, Quemeneur E, Guerois R, et al. The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding. Structure 2004; 12(9):1551-62. Epub 2004/09/03.
    • (2004) Structure , vol.12 , Issue.9 , pp. 1551-1562
    • Charier, G.1    Couprie, J.2    Alpha-Bazin, B.3    Meyer, V.4    Quemeneur, E.5    Guerois, R.6
  • 26
    • 57749086992 scopus 로고    scopus 로고
    • Dimethyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage
    • Greeson NT, Sengupta R, Arida AR, Jenuwein T, Sanders SL. Dimethyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage. J Biol Chem 2008; 283(48):33168-74.
    • (2008) J Biol Chem , vol.283 , Issue.48 , pp. 33168-33174
    • Greeson, N.T.1    Sengupta, R.2    Arida, A.R.3    Jenuwein, T.4    Sanders, S.L.5
  • 27
    • 33645502395 scopus 로고    scopus 로고
    • Tudor, MBT and chromo domains gauge the degree of lysine methylation
    • Kim J, Daniel J, Espejo A, Lake A, Krishna M, Xia L, et al. Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO reports 2006; 7(4):397-403.
    • (2006) EMBO Reports , vol.7 , Issue.4 , pp. 397-403
    • Kim, J.1    Daniel, J.2    Espejo, A.3    Lake, A.4    Krishna, M.5    Xia, L.6
  • 28
    • 59449094470 scopus 로고    scopus 로고
    • An oligomerized 53BP1 tudor domain suffices for recognition of DNA doublestrand breaks
    • Zgheib O, Pataky K, Brugger J, Halazonetis TD. An oligomerized 53BP1 tudor domain suffices for recognition of DNA doublestrand breaks. Molecular Cellular Biology 2009; 29(4):1050-8.
    • (2009) Molecular Cellular Biology , vol.29 , Issue.4 , pp. 1050-1058
    • Zgheib, O.1    Pataky, K.2    Brugger, J.3    Halazonetis, T.D.4
  • 29
    • 2642542643 scopus 로고    scopus 로고
    • A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
    • Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, et al. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Development 2004; 18(11):1251-62.
    • (2004) Genes Development , vol.18 , Issue.11 , pp. 1251-1262
    • Schotta, G.1    Lachner, M.2    Sarma, K.3    Ebert, A.4    Sengupta, R.5    Reuter, G.6
  • 30
    • 0141815630 scopus 로고    scopus 로고
    • Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA
    • Iwabuchi K, Basu BP, Kysela B, Kurihara T, Shibata M, Guan D, et al. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J Biol Chem 2003; 278(38): 36487-95.
    • (2003) J Biol Chem , vol.278 , Issue.38 , pp. 36487-36495
    • Iwabuchi, K.1    Basu, B.P.2    Kysela, B.3    Kurihara, T.4    Shibata, M.5    Guan, D.6
  • 33
    • 84865364870 scopus 로고    scopus 로고
    • Playing the end game: DNA double-strand break repair pathway choice
    • Chapman JR, Taylor MR, Boulton SJ. Playing the end game: DNA double-strand break repair pathway choice. Molecular Cell 2012; 47(4):497-510.
    • (2012) Molecular Cell , vol.47 , Issue.4 , pp. 497-510
    • Chapman, J.R.1    Taylor, M.R.2    Boulton, S.J.3
  • 34
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 2005; 123(7):1213-26.
    • (2005) Cell , vol.123 , Issue.7 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 36
    • 0037378527 scopus 로고    scopus 로고
    • P53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
    • Ward IM, Minn K, van Deursen J, Chen J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Molecular Cell Biol 2003; 23(7):2556-63.
    • (2003) Molecular Cell Biol , vol.23 , Issue.7 , pp. 2556-2563
    • Ward, I.M.1    Minn, K.2    Van Deursen, J.3    Chen, J.4
  • 37
    • 77949708459 scopus 로고    scopus 로고
    • Regulation of chromatin architecture by the PWWP domaincontaining DNA damage-responsive factor EXPAND1/MUM1
    • Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, et al. Regulation of chromatin architecture by the PWWP domaincontaining DNA damage-responsive factor EXPAND1/MUM1. Molecular Cell 2010; 37(6):854-64.
    • (2010) Molecular Cell , vol.37 , Issue.6 , pp. 854-864
    • Huen, M.S.1    Huang, J.2    Leung, J.W.3    Sy, S.M.4    Leung, K.M.5    Ching, Y.P.6
  • 38
    • 79955502009 scopus 로고    scopus 로고
    • Regulation of DNA end joining resection and immunoglobulin class switch recombination by 53BP1
    • Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, et al. Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Molecular Cell 2011; 42(3):319-29.
    • (2011) Molecular Cell , vol.42 , Issue.3 , pp. 319-329
    • Bothmer, A.1    Robbiani, D.F.2    Di Virgilio, M.3    Bunting, S.F.4    Klein, I.A.5    Feldhahn, N.6
  • 39
    • 77951057068 scopus 로고    scopus 로고
    • 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
    • Bothmer A, Robbiani DF, Feldhahn N, Gazumyan A, Nussenzweig A, Nussenzweig MC. 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med 2010; 207(4):855-65.
    • (2010) J Exp Med , vol.207 , Issue.4 , pp. 855-865
    • Bothmer, A.1    Robbiani, D.F.2    Feldhahn, N.3    Gazumyan, A.4    Nussenzweig, A.5    Nussenzweig, M.C.6
  • 40
    • 59849089955 scopus 로고    scopus 로고
    • Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    • Mahaney BL, Meek K, Lees-Miller SP. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J 2009; 417(3):639-50.
    • (2009) Biochem J , vol.417 , Issue.3 , pp. 639-650
    • Mahaney, B.L.1    Meek, K.2    Lees-Miller, S.P.3
  • 41
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington LS, Gautier J. Double-strand break end resection and repair pathway choice. Annu Rev Genet 2011; 45:247-71.
    • (2011) Annu Rev Genet , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 42
    • 6344264992 scopus 로고    scopus 로고
    • DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains
    • Yu X, Chen J. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 2004; 24(21): 9478-86.
    • (2004) Mol Cell Biol , vol.24 , Issue.21 , pp. 9478-9486
    • Yu, X.1    Chen, J.2
  • 43
    • 67349246802 scopus 로고    scopus 로고
    • CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    • Yun MH, Hiom K. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 2009; 459(7245):460-3.
    • (2009) Nature , vol.459 , Issue.7245 , pp. 460-463
    • Yun, M.H.1    Hiom, K.2
  • 44
    • 53649090109 scopus 로고    scopus 로고
    • DNA helicases Sgs1 and BLM promote DNA double-strand break resection
    • Gravel S, Chapman JR, Magill C, Jackson SP. DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev 2008; 22(20):2767-72.
    • (2008) Genes Dev , vol.22 , Issue.20 , pp. 2767-2772
    • Gravel, S.1    Chapman, J.R.2    Magill, C.3    Jackson, S.P.4
  • 45
    • 79951688343 scopus 로고    scopus 로고
    • BLM-DNA2-RPA-MRN and EXO1-BLM-RPAMRN constitute two DNA end resection machineries for human DNA break repair
    • Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, Wyman C, et al. BLM-DNA2-RPA-MRN and EXO1-BLM-RPAMRN constitute two DNA end resection machineries for human DNA break repair. Genes Development. 2011; 25(4):350-62.
    • (2011) Genes Development , vol.25 , Issue.4 , pp. 350-362
    • Nimonkar, A.V.1    Genschel, J.2    Kinoshita, E.3    Polaczek, P.4    Campbell, J.L.5    Wyman, C.6
  • 46
    • 0035099044 scopus 로고    scopus 로고
    • BRCA2 is required for homology-directed repair of chromosomal breaks
    • Moynahan ME, Pierce AJ, Jasin M. BRCA2 is required for homology-directed repair of chromosomal breaks. Molecular Cell 2001; 7(2):263-72.
    • (2001) Molecular Cell , vol.7 , Issue.2 , pp. 263-272
    • Moynahan, M.E.1    Pierce, A.J.2    Jasin, M.3
  • 47
    • 0031472370 scopus 로고    scopus 로고
    • Association of BRCA1 with Rad51 in mitotic and meiotic cells
    • Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 1997; 88(2):265-75.
    • (1997) Cell , vol.88 , Issue.2 , pp. 265-275
    • Scully, R.1    Chen, J.2    Plug, A.3    Xiao, Y.4    Weaver, D.5    Feunteun, J.6
  • 48
    • 0033590171 scopus 로고    scopus 로고
    • BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene
    • Snouwaert JN, Gowen LC, Latour AM, Mohn AR, Xiao A, DiBiase L, et al. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene. Oncogene 1999; 18(55):7900-7.
    • (1999) Oncogene , vol.18 , Issue.55 , pp. 7900-7907
    • Snouwaert, J.N.1    Gowen, L.C.2    Latour, A.M.3    Mohn, A.R.4    Xiao, A.5    Dibiase, L.6
  • 50
    • 0035874894 scopus 로고    scopus 로고
    • Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation
    • Moynahan ME, Cui TY, Jasin M. Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation. Cancer Research 2001; 61(12): 4842-50.
    • (2001) Cancer Research , vol.61 , Issue.12 , pp. 4842-4850
    • Moynahan, M.E.1    Cui, T.Y.2    Jasin, M.3
  • 51
    • 0037115914 scopus 로고    scopus 로고
    • Homologous repair of DNA damage and tumorigenesis: The BRCA connection
    • Jasin M. Homologous repair of DNA damage and tumorigenesis: the BRCA connection. Oncogene 2002; 21(58):8981-93.
    • (2002) Oncogene , vol.21 , Issue.58 , pp. 8981-8993
    • Jasin, M.1
  • 52
    • 33745200945 scopus 로고    scopus 로고
    • Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2
    • Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, et al. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Molecular Cell 2006; 22(6):719-29.
    • (2006) Molecular Cell , vol.22 , Issue.6 , pp. 719-729
    • Xia, B.1    Sheng, Q.2    Nakanishi, K.3    Ohashi, A.4    Wu, J.5    Christ, N.6
  • 53
    • 66349096607 scopus 로고    scopus 로고
    • PALB2 is an integral component of the BRCA complex required for homologous recombination repair
    • Sy SM, Huen MS, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci USA 2009; 106(17):7155-60.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.17 , pp. 7155-7160
    • Sy, S.M.1    Huen, M.S.2    Chen, J.3
  • 54
    • 77957804215 scopus 로고    scopus 로고
    • Human BRCA2 protein promotes RAD51 filament formation on RPA-covered singlestranded DNA
    • Liu J, Doty T, Gibson B, Heyer WD. Human BRCA2 protein promotes RAD51 filament formation on RPA-covered singlestranded DNA. Nat Struct Mol Biol 2010; 17(10):1260-2.
    • (2010) Nat Struct Mol Biol , vol.17 , Issue.10 , pp. 1260-1262
    • Liu, J.1    Doty, T.2    Gibson, B.3    Heyer, W.D.4
  • 55
    • 84875224166 scopus 로고    scopus 로고
    • Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
    • Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, et al. Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol 2013; 20(3):317-25.
    • (2013) Nat Struct Mol Biol , vol.20 , Issue.3 , pp. 317-325
    • Tang, J.1    Cho, N.W.2    Cui, G.3    Manion, E.M.4    Shanbhag, N.M.5    Botuyan, M.V.6
  • 56
    • 84876877091 scopus 로고    scopus 로고
    • A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
    • Escribano-Diaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkac J, et al. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Molecular cell 2013; 49(5):872-83.
    • (2013) Molecular Cell , vol.49 , Issue.5 , pp. 872-883
    • Escribano-Diaz, C.1    Orthwein, A.2    Fradet-Turcotte, A.3    Xing, M.4    Young, J.T.5    Tkac, J.6
  • 57
    • 77950958141 scopus 로고    scopus 로고
    • 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
    • Bunting SF, Callen E, Wong N, Chen HT, Polato F, Gunn A, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 2010; 141(2):243-54.
    • (2010) Cell , vol.141 , Issue.2 , pp. 243-254
    • Bunting, S.F.1    Callen, E.2    Wong, N.3    Chen, H.T.4    Polato, F.5    Gunn, A.6
  • 58
    • 77953291328 scopus 로고    scopus 로고
    • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    • Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol. 2010; 17(6):688-95.
    • (2010) Nat Struct Mol Biol , vol.17 , Issue.6 , pp. 688-695
    • Bouwman, P.1    Aly, A.2    Escandell, J.M.3    Pieterse, M.4    Bartkova, J.5    Van Der Gulden, H.6
  • 60
    • 66149114020 scopus 로고    scopus 로고
    • Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
    • Huertas P, Jackson SP. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J Biol Chem 2009; 284(14):9558-65.
    • (2009) J Biol Chem , vol.284 , Issue.14 , pp. 9558-9565
    • Huertas, P.1    Jackson, S.P.2
  • 61
    • 77955841149 scopus 로고    scopus 로고
    • Collaboration and competition between DNA double-strand break repair pathways
    • Kass EM, Jasin M. Collaboration and competition between DNA double-strand break repair pathways. FEBS Lett 2010; 584(17): 3703-8.
    • (2010) FEBS Lett , vol.584 , Issue.17 , pp. 3703-3708
    • Kass, E.M.1    Jasin, M.2
  • 62
    • 43149118369 scopus 로고    scopus 로고
    • Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair
    • Chen L, Nievera CJ, Lee AY, Wu X. Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. J Biol Chem 2008; 283(12):7713-20.
    • (2008) J Biol Chem , vol.283 , Issue.12 , pp. 7713-7720
    • Chen, L.1    Nievera, C.J.2    Lee, A.Y.3    Wu, X.4
  • 63
    • 57049124828 scopus 로고    scopus 로고
    • 53BP1 facilitates long-range DNA end-joining during V(D)J recombination
    • Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, et al. 53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature 2008; 456(7221):529-33.
    • (2008) Nature , vol.456 , Issue.7221 , pp. 529-533
    • Difilippantonio, S.1    Gapud, E.2    Wong, N.3    Huang, C.Y.4    Mahowald, G.5    Chen, H.T.6
  • 65
    • 47349107760 scopus 로고    scopus 로고
    • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    • Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Lobrich M, et al. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Molecular Cell 2008; 31(2):167-77.
    • (2008) Molecular Cell , vol.31 , Issue.2 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Lobrich, M.6
  • 66
    • 67749093497 scopus 로고    scopus 로고
    • The impact of heterochromatin on DSB repair
    • Goodarzi AA, Noon AT, Jeggo PA. The impact of heterochromatin on DSB repair. Biochem Soc Trans 2009; 37(Pt 3):569-76.
    • (2009) Biochem Soc Trans , vol.37 , Issue.PART 3 , pp. 569-576
    • Goodarzi, A.A.1    Noon, A.T.2    Jeggo, P.A.3
  • 67
    • 75949122330 scopus 로고    scopus 로고
    • 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
    • Noon AT, Shibata A, Rief N, Lobrich M, Stewart GS, Jeggo PA, et al. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nature Cell Biology 2010; 12(2):177-84.
    • (2010) Nature Cell Biology , vol.12 , Issue.2 , pp. 177-184
    • Noon, A.T.1    Shibata, A.2    Rief, N.3    Lobrich, M.4    Stewart, G.S.5    Jeggo, P.A.6
  • 68
    • 79960055393 scopus 로고    scopus 로고
    • KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response
    • Goodarzi AA, Kurka T, Jeggo PA. KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat Struct Mol Biol 2011; 18(7): 831-9.
    • (2011) Nat Struct Mol Biol , vol.18 , Issue.7 , pp. 831-839
    • Goodarzi, A.A.1    Kurka, T.2    Jeggo, P.A.3
  • 69
    • 0031046294 scopus 로고    scopus 로고
    • A superfamily of conserved domains in DNA damageresponsive cell cycle checkpoint proteins
    • Bork P, Hofmann K, Bucher P, Neuwald AF, Altschul SF, Koonin EV. A superfamily of conserved domains in DNA damageresponsive cell cycle checkpoint proteins. Faseb J 1997; 11(1): 68-76.
    • (1997) Faseb J , vol.11 , Issue.1 , pp. 68-76
    • Bork, P.1    Hofmann, K.2    Bucher, P.3    Neuwald, A.F.4    Altschul, S.F.5    Koonin, E.V.6
  • 70
    • 0037099666 scopus 로고    scopus 로고
    • Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor
    • Derbyshire DJ, Basu BP, Serpell LC, Joo WS, Date T, Iwabuchi K, et al. Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor. EMBO 2002; 21(14):3863-72.
    • (2002) EMBO , vol.21 , Issue.14 , pp. 3863-3872
    • Derbyshire, D.J.1    Basu, B.P.2    Serpell, L.C.3    Joo, W.S.4    Date, T.5    Iwabuchi, K.6
  • 71
    • 34548771748 scopus 로고    scopus 로고
    • Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage
    • Munoz IM, Jowsey PA, Toth R, Rouse J. Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. Nucleic Acids Res 2007; 35(16):5312-22.
    • (2007) Nucleic Acids Res , vol.35 , Issue.16 , pp. 5312-5322
    • Munoz, I.M.1    Jowsey, P.A.2    Toth, R.3    Rouse, J.4
  • 72
    • 11244300690 scopus 로고    scopus 로고
    • Human PTIP facilitates ATMmediated activation of p53 and promotes cellular resistance to ionizing radiation
    • Jowsey PA, Doherty AJ, Rouse J. Human PTIP facilitates ATMmediated activation of p53 and promotes cellular resistance to ionizing radiation. J Biol Chem 2004; 279(53):55562-9.
    • (2004) J Biol Chem , vol.279 , Issue.53 , pp. 55562-55569
    • Jowsey, P.A.1    Doherty, A.J.2    Rouse, J.3
  • 73
    • 34547122520 scopus 로고    scopus 로고
    • PTIP associates with MLL3-and MLL4-containing histone H3 lysine 4 methyltransferase complex
    • Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, et al. PTIP associates with MLL3-and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 2007; 282(28): 20395-406.
    • (2007) J Biol Chem , vol.282 , Issue.28 , pp. 20395-20406
    • Cho, Y.W.1    Hong, T.2    Hong, S.3    Guo, H.4    Yu, H.5    Kim, D.6
  • 74
    • 34848880490 scopus 로고    scopus 로고
    • The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex
    • Epub 2007/10/11
    • Patel SR, Kim D, Levitan I, Dressler GR. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell 2007; 13(4):580-92. Epub 2007/10/11.
    • (2007) Dev Cell , vol.13 , Issue.4 , pp. 580-592
    • Patel, S.R.1    Kim, D.2    Levitan, I.3    Dressler, G.R.4
  • 75
    • 0142240342 scopus 로고    scopus 로고
    • BRCT repeats as phosphopeptide-binding modules involved in protein targeting
    • Manke IA, Lowery DM, Nguyen A, Yaffe MB. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 2003; 302(5645):636-9.
    • (2003) Science , vol.302 , Issue.5645 , pp. 636-639
    • Manke, I.A.1    Lowery, D.M.2    Nguyen, A.3    Yaffe, M.B.4
  • 76
    • 0142147272 scopus 로고    scopus 로고
    • The BRCT domain is a phospho-protein binding domain
    • Yu X, Chini CC, He M, Mer G, Chen J. The BRCT domain is a phospho-protein binding domain. Science 2003; 302(5645): 639-42.
    • (2003) Science , vol.302 , Issue.5645 , pp. 639-642
    • Yu, X.1    Chini, C.C.2    He, M.3    Mer, G.4    Chen, J.5
  • 77
    • 67650549751 scopus 로고    scopus 로고
    • PTIP regulates 53BP1 and SMC1 at the DNA damage sites
    • Wu J, Prindle MJ, Dressler GR, Yu X. PTIP regulates 53BP1 and SMC1 at the DNA damage sites. J Biol Chem 2009; 284(27): 18078-84.
    • (2009) J Biol Chem , vol.284 , Issue.27 , pp. 18078-18084
    • Wu, J.1    Prindle, M.J.2    Dressler, G.R.3    Yu, X.4
  • 78
    • 65149092552 scopus 로고    scopus 로고
    • Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage
    • Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem 2009; 284(11):7284-93.
    • (2009) J Biol Chem , vol.284 , Issue.11 , pp. 7284-7293
    • Gong, Z.1    Cho, Y.W.2    Kim, J.E.3    Ge, K.4    Chen, J.5
  • 79
    • 0026623241 scopus 로고
    • A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
    • Hardy CF, Sussel L, Shore D. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 1992; 6(5):801-14.
    • (1992) Genes Dev , vol.6 , Issue.5 , pp. 801-814
    • Hardy, C.F.1    Sussel, L.2    Shore, D.3
  • 80
    • 3543064379 scopus 로고    scopus 로고
    • Human Rif1 ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint
    • Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Development 2004; 18(17):2108-19.
    • (2004) Genes Development , vol.18 , Issue.17 , pp. 2108-2119
    • Silverman, J.1    Takai, H.2    Buonomo, S.B.3    Eisenhaber, F.4    De Lange, T.5
  • 81
    • 10344235232 scopus 로고    scopus 로고
    • Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules
    • Xu L, Blackburn EH. Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol 2004; 167(5):819-30.
    • (2004) J Cell Biol , vol.167 , Issue.5 , pp. 819-830
    • Xu, L.1    Blackburn, E.H.2
  • 82
    • 75549090255 scopus 로고    scopus 로고
    • Mammalian Rif1 contributes to replication stress survival and homology-directed repair
    • Buonomo SB, Wu Y, Ferguson D, de Lange T. Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol 2009; 187(3):385-98.
    • (2009) J Cell Biol , vol.187 , Issue.3 , pp. 385-398
    • Buonomo, S.B.1    Wu, Y.2    Ferguson, D.3    De Lange, T.4
  • 83
  • 84
    • 84876527317 scopus 로고    scopus 로고
    • RIF1 counteracts BRCA1-mediated end resection during DNA repair
    • Feng L, Fong KW, Wang J, Wang W, Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem 2013; 288(16):11135-43.
    • (2013) J Biol Chem , vol.288 , Issue.16 , pp. 11135-11143
    • Feng, L.1    Fong, K.W.2    Wang, J.3    Wang, W.4    Chen, J.5
  • 85
    • 84873526612 scopus 로고    scopus 로고
    • Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching
    • Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, et al. Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 2013; 339(6120):711-5.
    • (2013) Science , vol.339 , Issue.6120 , pp. 711-715
    • Di Virgilio, M.1    Callen, E.2    Yamane, A.3    Zhang, W.4    Jankovic, M.5    Gitlin, A.D.6
  • 86
    • 84866427034 scopus 로고    scopus 로고
    • Rif1 regulates the replication timing domains on the human genome
    • Yamazaki S, Ishii A, Kanoh Y, Oda M, Nishito Y, Masai H. Rif1 regulates the replication timing domains on the human genome. EMBO 2012; 31(18):3667-77.
    • (2012) EMBO , vol.31 , Issue.18 , pp. 3667-3677
    • Yamazaki, S.1    Ishii, A.2    Kanoh, Y.3    Oda, M.4    Nishito, Y.5    Masai, H.6
  • 87
    • 84866412836 scopus 로고    scopus 로고
    • Mouse Rif1 is a key regulator of the replicationtiming programme in mammalian cells
    • Cornacchia D, Dileep V, Quivy JP, Foti R, Tili F, Santarella-Mellwig R, et al. Mouse Rif1 is a key regulator of the replicationtiming programme in mammalian cells. EMBO 2012; 31(18): 3678-90.
    • (2012) EMBO , vol.31 , Issue.18 , pp. 3678-3690
    • Cornacchia, D.1    Dileep, V.2    Quivy, J.P.3    Foti, R.4    Tili, F.5    Santarella-Mellwig, R.6
  • 88
    • 84878893538 scopus 로고    scopus 로고
    • 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
    • Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell 2013; 153(6):1266-80.
    • (2013) Cell , vol.153 , Issue.6 , pp. 1266-1280
    • Callen, E.1    Di Virgilio, M.2    Kruhlak, M.J.3    Nieto-Soler, M.4    Wong, N.5    Chen, H.T.6
  • 89
    • 2442707746 scopus 로고    scopus 로고
    • 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
    • Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB. 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol 2004; 5(5): 481-7.
    • (2004) Nat Immunol , vol.5 , Issue.5 , pp. 481-487
    • Manis, J.P.1    Morales, J.C.2    Xia, Z.3    Kutok, J.L.4    Alt, F.W.5    Carpenter, P.B.6
  • 90
    • 57049132043 scopus 로고    scopus 로고
    • 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
    • Dimitrova N, Chen YC, Spector DL, de Lange T. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature 2008; 456(7221):524-8.
    • (2008) Nature , vol.456 , Issue.7221 , pp. 524-528
    • Dimitrova, N.1    Chen, Y.C.2    Spector, D.L.3    De Lange, T.4
  • 91
    • 84857130477 scopus 로고    scopus 로고
    • Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair
    • Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, et al. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proc Natl Acad Sci USA 2012; 109(7):2455-60.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.7 , pp. 2455-2460
    • Oksenych, V.1    Alt, F.W.2    Kumar, V.3    Schwer, B.4    Wesemann, D.R.5    Hansen, E.6
  • 93
    • 31044432090 scopus 로고    scopus 로고
    • XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous endjoining
    • Ahnesorg P, Smith P, Jackson SP. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous endjoining. Cell 2006; 124(2):301-13.
    • (2006) Cell , vol.124 , Issue.2 , pp. 301-313
    • Ahnesorg, P.1    Smith, P.2    Jackson, S.P.3
  • 94
    • 31044440630 scopus 로고    scopus 로고
    • Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly
    • Buck D, Malivert L, de Chasseval R, Barraud A, Fondaneche MC, Sanal O, et al. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 2006; 124(2):287-99.
    • (2006) Cell , vol.124 , Issue.2 , pp. 287-299
    • Buck, D.1    Malivert, L.2    De Chasseval, R.3    Barraud, A.4    Fondaneche, M.C.5    Sanal, O.6
  • 95
    • 34248400443 scopus 로고    scopus 로고
    • Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells
    • Zha S, Alt FW, Cheng HL, Brush JW, Li G. Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci USA 2007; 104(11): 4518-23.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.11 , pp. 4518-4523
    • Zha, S.1    Alt, F.W.2    Cheng, H.L.3    Brush, J.W.4    Li, G.5
  • 96
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • Stavnezer J, Guikema JE, Schrader CE. Mechanism and regulation of class switch recombination. Annu Rev Immunol 2008; 26:261-92.
    • (2008) Annu Rev Immunol , vol.26 , pp. 261-292
    • Stavnezer, J.1    Guikema, J.E.2    Schrader, C.E.3
  • 97
    • 84870367600 scopus 로고    scopus 로고
    • 53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-kappaB through miR-146a
    • Li X, Xu B, Moran MS, Zhao Y, Su P, Haffty BG, et al. 53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-kappaB through miR-146a. Carcinogenesis 2012; 33(12): 2593-600.
    • (2012) Carcinogenesis , vol.33 , Issue.12 , pp. 2593-2600
    • Li, X.1    Xu, B.2    Moran, M.S.3    Zhao, Y.4    Su, P.5    Haffty, B.G.6
  • 98
    • 84863023461 scopus 로고    scopus 로고
    • 53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathway
    • Hong S, Li X, Zhao Y, Yang Q, Kong B. 53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathway. Oncol Rep 2012; 27(4):1251-7.
    • (2012) Oncol Rep , vol.27 , Issue.4 , pp. 1251-1257
    • Hong, S.1    Li, X.2    Zhao, Y.3    Yang, Q.4    Kong, B.5


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