AKT hyperactivation confers a Th1 phenotype in thymic Treg cells deficient in TGF-β receptor II signaling

European Journal of Immunology

Volumn 44, Issue 2, 2014, Pages 521-532

  Liu, Yun ^a   Xu, Yingqian ^a   Sun, Jiabin ^a   Ma, Aihui ^a   Zhang, Feng ^a   Xia, Suhua ^a   Xu, Guiqin ^a   Liu, Yongzhong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

AKT; Stability; TGF ; Thymus; Treg cells

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; PROTEIN KINASE B; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BONE MARROW TRANSPLANTATION; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; TH1 CELL; THYMOCYTE; THYMUS;

AKT; STABILITY; TGF-Β; THYMUS; TREG CELLS;

ANIMALS; BONE MARROW TRANSPLANTATION; CD4-POSITIVE T-LYMPHOCYTES; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; INFLAMMATION; INTERFERON-GAMMA; MICE; MICE, INBRED C57BL; PHENOTYPE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; THYMUS GLAND; TRANSFORMING GROWTH FACTOR BETA;

EID: 84893583910     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201243291     Document Type: Article

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