Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

Nature Medicine

Volumn 7, Issue 9, 2001, Pages 1048-1051

  Sonoshita, Masahiro ^a,b   Takaku, Kazuaki ^a,b   Sasaki, Nobuya ^a   Sugimoto, Yukihiko ^b   Ushikubi, Fumitaka ^c   Narumiya, Shuh ^b   Oshima, Masanobu ^b   Taketo, Makoto M ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CYCLIC AMP; CYCLOOXYGENASE 2; PROSTAGLANDIN E RECEPTOR; VASCULOTROPIN;

ADENOMATOUS POLYP; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARACHIDONIC ACID METABOLISM; ARTICLE; CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; GASTROINTESTINAL POLYPOSIS; GENE DELETION; GENE DISRUPTION; INTESTINE POLYP; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ADENOMA; ADENOMATOUS POLYPOSIS COLI; ANIMALS; CYCLOOXYGENASE 2; DINOPROSTONE; ENDOTHELIAL GROWTH FACTORS; HOMOZYGOTE; ISOENZYMES; LYMPHOKINES; MICE; MICE, KNOCKOUT; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, PROSTAGLANDIN; RECEPTORS, PROSTAGLANDIN E; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034796261     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0901-1048     Document Type: Article

References (26)

1. Cyclooxygenase-2 inhibitors in tumorigenesis. Part I
2. Cyclooxygenase-2 inhibitors in tumorigenesis. Part II
3. Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis
4. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
5. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
6. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
7. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer
8. Δ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
9. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
10. Aspirin, NSAIDS, and colon cancer prevention: Mechanisms?
11. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
12. International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes
13. Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract
14. 3
15. Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice
16. 2 in human prostatic carcinoma cells
17. 2, and nonsteroidal anti-inflammatory drugs
18. Host cyclooxygenase-2 modulates carcinoma growth
19. 2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells
20. New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
21. Laminin and collagen IV subunit distribution in normal and neoplastic tissues of colorectum and breast
22. 2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis
23. Self-promotion? Intimate connections between APC and prostaglandin H synthase-2
24. 1 in colon carcinogenesis
25. Frequent β-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis
26. 2 gene