The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans

NeuroToxicology

Volumn 41, Issue , 2014, Pages 28-43

  Estevez, Annette O ^a,e   Morgan, Kathleen L ^b,f   Szewczyk, Nathaniel J ^c,g   Gems, David ^d   Estevez, Miguel ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e Neurometrica   (United States)

^f IMMUNETRICS INC   (United States)

^g UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Amyotrophic lateral sclerosis; Insulin insulin like signaling; Neurodegeneration; PINK1; PTEN; Selenium

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; GLUTATHIONE; INSULIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE; PTEN INDUCED PUTATIVE KINASE 1; SELENIUM; SOMATOMEDIN; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; CAENORHABDITIS ELEGANS; CELL NUCLEUS; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GABAERGIC SYSTEM; MOTONEURON; MOTOR DYSFUNCTION; NERVE DEGENERATION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

AMYOTROPHIC LATERAL SCLEROSIS; INSULIN/INSULIN-LIKE SIGNALING; NEURODEGENERATION; PINK1; PTEN; SELENIUM;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; INSULIN; MOVEMENT; MUTATION; NEURODEGENERATIVE DISEASES; PROTEIN-SERINE-THREONINE KINASES; SELENIUM; SIGNAL TRANSDUCTION; SOMATOMEDINS; TIME FACTORS; TRACE ELEMENTS; TRANSCRIPTION FACTORS;

EID: 84892881367     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.12.012     Document Type: Article

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