Induction of Parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene

Journal of Neuroscience Research

Volumn 88, Issue 8, 2010, Pages 1804-1811

  Morimoto, Nobutoshi ^a   Nagai, Makiko ^a   Miyazaki, Kazunori ^a   Ohta, Yasuyuki ^a   Kurata, Tomoko ^a   Takehisa, Yasushi ^a   Ikeda, Yoshio ^a   Matsuura, Tohru ^a   Asanuma, Masato ^a   Abe, Koji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Amyotrophic lateral sclerosis; DJ 1; PAG608; Parkinson's disease; PINK1

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DJ 1 PROTEIN; PROTEIN P53;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; FEMALE; GENE; GENE MUTATION; GENE TRANSLOCATION; HISTOPATHOLOGY; MALE; MOTONEURON; MOUSE; NONHUMAN; PAG608 GENE; PARKINSONISM; PATHOGENESIS; PINK1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SPINAL CORD; SPINAL CORD NERVE CELL; WESTERN BLOTTING;

ANIMALS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURONS; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PROTEIN KINASES; SPINAL CORD; SUPEROXIDE DISMUTASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77952348304     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22341     Document Type: Article

References (49)

1. Abe K, Pan LH, Watanabe M, Kato T, Itoyama Y. 1995. Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis. Neurosci Lett 199:152-154.
2. Abeliovich A, Flint Beal M. 2006. Parkinsonism genes: culprits and clues. J Neurochem 99:1062-1072.
3. Andreassen OA, Ferrante RJ, Klivenyi P, Klein AM, Dedeoglu A, Albers DS, Kowall NW, Beal MF. 2001. Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid. Exp Neurol 168:356-363. (Pubitemid 32289771)
4. Aoki M, Ogasawara M, Matsubara Y, Narisawa K, Nakamura S, Itoyama Y, Abe K. 1993. Mild ALS in Japan associated with novel SOD mutation. Nat Genet 5:323-324. (Pubitemid 23351300)
5. Asanuma M, Miyazaki I, Ogawa N. 2003. Dopamine- or L-DOPAinduced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease. Neurotox Res 5:165-176.
6. Bai Q, Mullett SJ, Garver JA, Hinkle DA, Burton EA. 2006. Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons. Brain Res 1113:33-44. (Pubitemid 44396950)
7. Barbeito LH, Pehar M, Cassina P, Vargas MR, Peluffo H, Viera L, Estevez AG, Beckman JS. 2004. A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. Brain Res Brain Res Rev 47:263-274. (Pubitemid 39574324)
8. Bendotti C, Calvaresi N, Chiveri L, Prelle A, Moggio M, Braga M, Silani V, De Biasi S. 2001. Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity. J Neurol Sci 191:25-33. (Pubitemid 33035892)
9. Bove J, Prou D, Perier C, Przedborski S. 2005. Toxin-induced models of Parkinson's disease. NeuroRx 2:484-494.
10. Bowling AC, Barkowski EE, McKenna-Yasek D, Sapp P, Horvitz HR, Beal MF, Brown RH Jr. 1995. Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis. J Neurochem 64:2366-2369.
11. de la Monte SM, Sohn YK, Ganju N, Wands JR. 1998. P53- and CD95-associated apoptosis in neurodegenerative diseases. Lab Invest 78:401-411. (Pubitemid 28207853)
12. Duke DC, Moran LB, Pearce RK, Graeber MB. 2007. The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability. Neurogenetics 8:83-94.
13. Eve DJ, Dennis JS, Citron BA. 2007. Transcription factor p53 in degenerating spinal cords. Brain Res 1150:174-181.
14. Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Kruger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C. 2007. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci 27:12413-12418. (Pubitemid 350085485)
15. Fan J, Ren H, Jia N, Fei E, Zhou T, Jiang P, Wu M, Wang G. 2008. DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J Biol Chem 283:4022-4030.
16. Gillardon F, Spranger M, Tiesler C, Hossmann KA. 1999. Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia. Brain Res Mol Brain Res 73:138-143.
17. Gonzalez de Aguilar JL, Gordon JW, Rene F, de Tapia M, Lutz-Bucher B, Gaiddon C, Loeffler JP. 2000. Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway. Neurobiol Dis 7:406-415.
18. Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, Caliendo J, Hentati A, Kwon YW, Deng HX 1994. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264:1772-1775. (Pubitemid 24227760)
19. Hermann DM, Kuroiwa T, Hata R, Gillardon F, Ito U, Mies G. 2001. Expression of redox factor-1, p53-activated gene 608 and caspase-3 messenger RNAs following repeated unilateral common carotid artery occlusion in gerbils - relationship to delayed cell injury and secondary failure of energy state. Neuroscience 102:779-787. (Pubitemid 32155875)
20. Higashi Y, Asanuma M, Miyazaki I, Haque ME, Fujita N, Tanaka K, Ogawa N. 2002. The p53-activated gene, PAG608, requires a zinc finger domain for nuclear localization and oxidative stress-induced apoptosis. J Biol Chem 277:42224-42232. (Pubitemid 35257542)
21. Hoepken HH, Gispert S, Morales B, Wingerter O, Del Turco D, Mulsch A, Nussbaum RL, Muller K, Drose S, Brandt U, Deller T, Wirth B, Kudin AP, Kunz WS, Auburger G. 2007. Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis 25:401-411. (Pubitemid 46124020)
22. Kostic V, Gurney ME, Deng HX, Siddique T, Epstein CJ, Przedborski S. 1997. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Ann Neurol 41:497-504. (Pubitemid 27169189)
23. Lev N, Ickowicz D, Barhum Y, Melamed E, Offen D. 2009. DJ-1 Changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS. J Mol Neurosci 38:94-102.
24. Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK. 2006. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci 26:41-50. (Pubitemid 43089519)
25. Miki Y, Mori F, Nunomura J, Ookawa K, Yajima N, Yagihashi S, Wakabayashi K. 2009. Sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration: a TDP-43 immunohistochemical study. Neuropathology (In Press).
26. Miyazaki I, Asanuma M. 2009. Approaches to prevent dopamine quinone-induced neurotoxicity. Neurochem Res 34:698-706.
27. Mogi M, Kondo T, Mizuno Y, Nagatsu T. 2007. p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain. Neurosci Lett 414:94-97. (Pubitemid 46241643)
28. Muqit MM, Abou-Sleiman PM, Saurin AT, Harvey K, Gandhi S, Deas E, Eaton S, Payne Smith MD, Venner K, Matilla A, Healy DG, Gilks WP, Lees AJ, Holton J, Revesz T, Parker PJ, Harvey RJ, Wood NW, Latchman DS. 2006. Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem 98:156-169. (Pubitemid 43882941)
29. Murakami T, Nagai M, Miyazaki K, Morimoto N, Ohta Y, Kurata T, Takehisa Y, Kamiya T, Abe K. 2007. Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene. Brain Res 1150:182-189. (Pubitemid 46702112)
30. Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H. 1997. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 231:509-513. (Pubitemid 27214343)
31. Nair VD, McNaught KS, Gonzalez-Maeso J, Sealfon SC, Olanow CW. 2006. p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J Biol Chem 281:39550-39560. (Pubitemid 46041915)
32. Ohta Y, Nagai M, Nagata T, Murakami T, Nagano I, Narai H, Kurata T, Shiote M, Shoji M, Abe K. 2006. Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene. J Neurosci Res 84:980-992. (Pubitemid 44521042)
33. Prives C, Hall PA. 1999. The p53 pathway. J Pathol 187:112-126.
34. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX. 1993. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59-62. (Pubitemid 23087289)
35. Sakurai M, Kawamura T, Nishimura H, Suzuki H, Tezuka F, Abe K. 2009. Induction of Parkinson disease-related proteins in motor neurons after transient spinal cord ischemia in rabbits. J Cereb Blood Flow Metab 29:752-758.
36. Sasaki S, Tsutsumi Y, Yamane K, Sakuma H, Maruyama S. 1992. Sporadic amyotrophic lateral sclerosis with extensive neurological involvement. Acta Neuropathol 84:211-215.
37. Sasaki S, Aoki M, Nagai M, Kobayashi M, Itoyama Y. 2009. Mitochondrial alterations in transgenic mice with an H46R mutant Cu/Zn superoxide dismutase gene. J Neuropathol Exp Neurol 68:365-373.
38. Schapira AH. 2008. Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol 7:97-109. (Pubitemid 350251942)
39. Shaulsky G, Goldfinger N, Tosky MS, Levine AJ, Rotter V. 1991. Nuclear localization is essential for the activity of p53 protein. Oncogene 6:2055-2065. (Pubitemid 21924047)
40. Shieh SY, Ikeda M, Taya Y, Prives C. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334. (Pubitemid 27467963)
41. Shimizu M, Miyazaki I, Higashi Y, Eslava-Alva MJ, Diaz-Corrales FJ, Asanuma M, Ogawa N. 2008. Specific induction of PAG608 in cranial and spinal motor neurons of L-DOPA-treated parkinsonian rats. Neurosci Res 60:355-363.
42. Tomasevic G, Shamloo M, Israeli D, Wieloch T. 1999. Activation of p53 and its target genes p21(WAF1/Cip1) and PAG608/Wig-1 in ischemic preconditioning. Brain Res Mol Brain Res 70:304-313.
43. Tsuboi Y, Munemoto H, Ishikawa S, Matsumoto K, Iguchi-Ariga SM, Ariga H. 2008. DJ-1, a causative gene product of a familial form of Parkinson's disease, is secreted through microdomains. FEBS Lett 582:2643-2649.
44. Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, Albanese A, Nussbaum R, Gonzalez-Maldonado R, Deller T, Salvi S, Cortelli P, Gilks WP, Latchman DS, Harvey RJ, Dallapiccola B, Auburger G, Wood NW. 2004. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304:1158-1160. (Pubitemid 38661852)
45. Vargas MR, Pehar M, Cassina P, Beckman JS, Barbeito L. 2006. Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis. J Neurochem 97:687-696.
46. Varmeh-Ziaie S, Okan I, Wang Y, Magnusson KP, Warthoe P, Strauss M, Wiman KG. 1997. Wig-1, a new p53-induced gene encoding a zinc finger protein. Oncogene 15:2699-2704. (Pubitemid 27507617)
47. Warita H, Hayashi T, Murakami T, Manabe Y, Abe K. 2001. Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice. Brain Res Mol Brain Res 89:147-152. (Pubitemid 32322744)
48. Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL. 1995. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14:1105-1116.
49. Yanagisawa D, Kitamura Y, Inden M, Takata K, Taniguchi T, Morikawa S, Morita M, Inubushi T, Tooyama I, Taira T, Iguchi-Ariga SM, Akaike A, Ariga H. 2008. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. J Cereb Blood Flow Metab 28:563-578. (Pubitemid 351304267)