메뉴 건너뛰기




Volumn 138, Issue 23, 2011, Pages 5257-5267

A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development

Author keywords

Axon outgrowth; Dendrite morphology; FOXO; Neurodevelopment; PTEN

Indexed keywords

DAF 18 PROTEIN; ISOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

EID: 80755184820     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.069062     Document Type: Article
Times cited : (51)

References (68)
  • 1
    • 33645362213 scopus 로고    scopus 로고
    • UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation
    • Adler, C. E., Fetter, R. D. and Bargmann, C. I. (2006). UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation. Nat. Neurosci. 9, 511-518.
    • (2006) Nat. Neurosci , vol.9 , pp. 511-518
    • Adler, C.E.1    Fetter, R.D.2    Bargmann, C.I.3
  • 2
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
    • Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B. and Cohen, P. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 7, 261-269.
    • (1997) Curr. Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 4
    • 0034743423 scopus 로고    scopus 로고
    • A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans
    • Altun-Gultekin, Z., Andachi, Y., Tsalik, E. L., Pilgrim, D., Kohara, Y. and Hobert, O. (2001). A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. Development 128, 1951-1969.
    • (2001) Development , vol.128 , pp. 1951-1969
    • Altun-Gultekin, Z.1    Andachi, Y.2    Tsalik, E.L.3    Pilgrim, D.4    Kohara, Y.5    Hobert, O.6
  • 6
    • 41849087003 scopus 로고    scopus 로고
    • FOXO animal models reveal a variety of diverse roles for FOXO transcription factors
    • Arden, K. C. (2008). FOXO animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene 27, 2345-2350.
    • (2008) Oncogene , vol.27 , pp. 2345-2350
    • Arden, K.C.1
  • 8
    • 0037323903 scopus 로고    scopus 로고
    • Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors
    • Birkenkamp, K. U. and Coffer, P. J. (2003). Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors. Biochem. Soc. Trans. 31, 292-297.
    • (2003) Biochem. Soc Trans , vol.31 , pp. 292-297
    • Birkenkamp, K.U.1    Coffer, P.J.2
  • 10
    • 0017076266 scopus 로고
    • The life cycle of the nematode Caenorhabditis elegans. I. Wild-type growth and reproduction
    • Byerly, L., Cassada, R. C. and Russell, R. L. (1976). The life cycle of the nematode Caenorhabditis elegans. I. Wild-type growth and reproduction. Dev. Biol. 51, 23-33.
    • (1976) Dev. Biol , vol.51 , pp. 23-33
    • Byerly, L.1    Cassada, R.C.2    Russell, R.L.3
  • 11
  • 12
    • 35148813033 scopus 로고    scopus 로고
    • Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans
    • Colon-Ramos, D. A., Margeta, M. A. and Shen, K. (2007). Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Science 318, 103-106.
    • (2007) Science , vol.318 , pp. 103-106
    • Colon-Ramos, D.A.1    Margeta, M.A.2    Shen, K.3
  • 13
    • 34247174760 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis
    • Cosker, K. E. and Eickholt, B. J. (2007). Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis. Biochem. Soc. Trans. 35, 207-210.
    • (2007) Biochem. Soc Trans , vol.35 , pp. 207-210
    • Cosker, K.E.1    Eickholt, B.J.2
  • 15
    • 0028807085 scopus 로고
    • The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
    • Dorman, J. B., Albinder, B., Shroyer, T. and Kenyon, C. (1995). The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141, 1399-1406.
    • (1995) Genetics , vol.141 , pp. 1399-1406
    • Dorman, J.B.1    Albinder, B.2    Shroyer, T.3    Kenyon, C.4
  • 17
    • 7444264727 scopus 로고    scopus 로고
    • Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo
    • Fraser, M. M., Zhu, X., Kwon, C. H., Uhlmann, E. J., Gutmann, D. H. and Baker, S. J. (2004). Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res. 64, 7773-7779.
    • (2004) Cancer Res , vol.64 , pp. 7773-7779
    • Fraser, M.M.1    Zhu, X.2    Kwon, C.H.3    Uhlmann, E.J.4    Gutmann, D.H.5    Baker, S.J.6
  • 18
    • 0032981396 scopus 로고    scopus 로고
    • Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene
    • Gil, E. B., Malone Link, E., Liu, L. X., Johnson, C. D. and Lees, J. A. (1999). Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene. Proc. Natl. Acad. Sci. USA 96, 2925-2930.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2925-2930
    • Gil, E.B.1    Malone Link, E.2    Liu, L.X.3    Johnson, C.D.4    Lees, J.A.5
  • 19
    • 18844472952 scopus 로고    scopus 로고
    • Expression of the PTEN tumour suppressor protein during human development
    • Gimm, O., Attie-Bitach, T., Lees, J. A., Vekemans, M. and Eng, C. (2000). Expression of the PTEN tumour suppressor protein during human development. Hum. Mol. Genet. 9, 1633-1639.
    • (2000) Hum. Mol. Genet , vol.9 , pp. 1633-1639
    • Gimm, O.1    Attie-Bitach, T.2    Lees, J.A.3    Vekemans, M.4    Eng, C.5
  • 20
    • 0042566203 scopus 로고    scopus 로고
    • The phosphatidylinositol-3 kinase (PI3K)-Akt pathway suppresses neurite branch formation in NGF-treated PC12 cells
    • Higuchi, M., Onishi, K., Masuyama, N. and Gotoh, Y. (2003). The phosphatidylinositol-3 kinase (PI3K)-Akt pathway suppresses neurite branch formation in NGF-treated PC12 cells. Genes Cells 8, 657-669.
    • (2003) Genes Cells , vol.8 , pp. 657-669
    • Higuchi, M.1    Onishi, K.2    Masuyama, N.3    Gotoh, Y.4
  • 21
    • 0030765073 scopus 로고    scopus 로고
    • Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene
    • Hobert, O., Mori, I., Yamashita, Y., Honda, H., Ohshima, Y., Liu, Y. and Ruvkun, G. (1997). Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 19, 345-357.
    • (1997) Neuron , vol.19 , pp. 345-357
    • Hobert, O.1    Mori, I.2    Yamashita, Y.3    Honda, H.4    Ohshima, Y.5    Liu, Y.6    Ruvkun, G.7
  • 22
    • 30444442827 scopus 로고    scopus 로고
    • Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain
    • Hoekman, M. F., Jacobs, F. M., Smidt, M. P. and Burbach, J. P. (2006). Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain. Gene Expr. Patterns 6, 134-140.
    • (2006) Gene Expr. Patterns , vol.6 , pp. 134-140
    • Hoekman, M.F.1    Jacobs, F.M.2    Smidt, M.P.3    Burbach, J.P.4
  • 23
    • 84971678127 scopus 로고
    • Genetic analysis of a large autosomal region in Caenorhabditis Elegans by the use of a free duplication
    • Howell, A. M., Gilmour, S. G., Mancebo, R. A. and Rose, A. M. (1987). Genetic analysis of a large autosomal region in Caenorhabditis Elegans by the use of a free duplication. Genet. Res. 49, 207-213.
    • (1987) Genet Res , vol.49 , pp. 207-213
    • Howell, A.M.1    Gilmour, S.G.2    Mancebo, R.A.3    Rose, A.M.4
  • 24
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • Jia, K., Chen, D. and Riddle, D. L. (2004). The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131, 3897-3906.
    • (2004) Development , vol.131 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 25
    • 78649793287 scopus 로고    scopus 로고
    • PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3-kinase and MAP kinase signaling
    • Jia, L., Ji, S., Maillet, J. C. and Zhang, X. (2010). PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3-kinase and MAP kinase signaling. J. Cell. Biochem. 111, 1390-1400.
    • (2010) J. Cell. Biochem , vol.111 , pp. 1390-1400
    • Jia, L.1    Ji, S.2    Maillet, J.C.3    Zhang, X.4
  • 26
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P. and Sabatini, D. M. (2002). mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163-175.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 27
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura, K. D., Tissenbaum, H. A., Liu, Y. and Ruvkun, G. (1997). daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946.
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.G.3
  • 29
    • 0036282745 scopus 로고    scopus 로고
    • Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery
    • Konishi, Y., Lehtinen, M., Donovan, N. and Bonni, A. (2002). Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol. Cell 9, 1005-1016.
    • (2002) Mol. Cell , vol.9 , pp. 1005-1016
    • Konishi, Y.1    Lehtinen, M.2    Donovan, N.3    Bonni, A.4
  • 31
    • 0242268407 scopus 로고    scopus 로고
    • MTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
    • Kwon, C. H., Zhu, X., Zhang, J. and Baker, S. J. (2003). mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc. Natl. Acad. Sci. USA 100, 12923-12928.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12923-12928
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3    Baker, S.J.4
  • 33
  • 35
    • 0035846601 scopus 로고    scopus 로고
    • Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
    • Lee, R. Y., Hench, J. and Ruvkun, G. (2001). Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11, 1950-1957.
    • (2001) Curr. Biol , vol.11 , pp. 1950-1957
    • Lee, R.Y.1    Hench, J.2    Ruvkun, G.3
  • 37
  • 39
    • 0030657540 scopus 로고    scopus 로고
    • An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • Lin, K., Dorman, J. B., Rodan, A. and Kenyon, C. (1997). daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-1322.
    • Science , vol.278 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 40
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • Lin, K., Hsin, H., Libina, N. and Kenyon, C. (2001). Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28, 139-145.
    • (2001) Nat. Genet , vol.28 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 41
    • 0037015269 scopus 로고    scopus 로고
    • TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
    • Long, X., Spycher, C., Han, Z. S., Rose, A. M., Muller, F. and Avruch, J. (2002). TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr. Biol. 12, 1448-1461.
    • (2002) Curr. Biol , vol.12 , pp. 1448-1461
    • Long, X.1    Spycher, C.2    Han, Z.S.3    Rose, A.M.4    Muller, F.5    Avruch, J.6
  • 42
    • 0029612196 scopus 로고
    • A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction
    • MacDougall, L. K., Domin, J. and Waterfield, M. D. (1995). A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Curr. Biol. 5, 1404-1415.
    • (1995) Curr. Biol , vol.5 , pp. 1404-1415
    • Macdougall, L.K.1    Domin, J.2    Waterfield, M.D.3
  • 43
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama, T. and Dixon, J. E. (1998). The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273, 13375-13378.
    • (1998) J. Biol. Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 45
    • 25844512127 scopus 로고    scopus 로고
    • Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18
    • Masse, I., Molin, L., Billaud, M. and Solari, F. (2005). Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18. Dev. Biol. 286, 91-101.
    • (2005) Dev. Biol , vol.286 , pp. 91-101
    • Masse, I.1    Molin, L.2    Billaud, M.3    Solari, F.4
  • 46
    • 0038245261 scopus 로고    scopus 로고
    • Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: Evidence for activation by anionic phospholipids
    • McConnachie, G., Pass, I., Walker, S. M. and Downes, C. P. (2003). Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. Biochem. J. 371, 947-955.
    • (2003) Biochem. J , vol.371 , pp. 947-955
    • McConnachie, G.1    Pass, I.2    Walker, S.M.3    Downes, C.P.4
  • 47
    • 0029050730 scopus 로고
    • Neural regulation of thermotaxis in Caenorhabditis elegans
    • Mori, I. and Ohshima, Y. (1995). Neural regulation of thermotaxis in Caenorhabditis elegans. Nature 376, 344-348.
    • (1995) Nature , vol.376 , pp. 344-348
    • Mori, I.1    Ohshima, Y.2
  • 48
    • 0029768753 scopus 로고    scopus 로고
    • A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    • Morris, J. Z., Tissenbaum, H. A. and Ruvkun, G. (1996). A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382, 536-539.
    • (1996) Nature , vol.382 , pp. 536-539
    • Morris, J.Z.1    Tissenbaum, H.A.2    Ruvkun, G.3
  • 49
    • 28044472729 scopus 로고    scopus 로고
    • Agingdependent and -independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans
    • Murakami, H., Bessinger, K., Hellmann, J. and Murakami, S. (2005). Agingdependent and -independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans. J. Neurosci. 25, 10894-10904.
    • (2005) J. Neurosci , vol.25 , pp. 10894-10904
    • Murakami, H.1    Bessinger, K.2    Hellmann, J.3    Murakami, S.4
  • 51
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulinlike metabolic and longevity signals in C. elegans
    • Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A. and Ruvkun, G. (1997). The Fork head transcription factor DAF-16 transduces insulinlike metabolic and longevity signals in C. elegans. Nature 389, 994-999.
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6    Ruvkun, G.7
  • 53
    • 0033151613 scopus 로고    scopus 로고
    • A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
    • Paradis, S., Ailion, M., Toker, A., Thomas, J. H. and Ruvkun, G. (1999). A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 13, 1438-1452.
    • (1999) Genes Dev , vol.13 , pp. 1438-1452
    • Paradis, S.1    Ailion, M.2    Toker, A.3    Thomas, J.H.4    Ruvkun, G.5
  • 55
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D. D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P. and Sabatini, D. M. (2004). Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302.
    • (2004) Curr. Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 56
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D. D., Guertin, D. A., Ali, S. M. and Sabatini, D. M. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 57
    • 0037428076 scopus 로고    scopus 로고
    • Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity
    • Shi, S. H., Jan, L. Y. and Jan, Y. N. (2003). Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell 112, 63-75.
    • (2003) Cell , vol.112 , pp. 63-75
    • Shi, S.H.1    Jan, L.Y.2    Jan, Y.N.3
  • 58
    • 12444296522 scopus 로고    scopus 로고
    • The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans
    • Solari, F., Bourbon-Piffaut, A., Masse, I., Payrastre, B., Chan, A. M. and Billaud, M. (2005). The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans. Oncogene 24, 20-27.
    • (2005) Oncogene , vol.24 , pp. 20-27
    • Solari, F.1    Bourbon-Piffaut, A.2    Masse, I.3    Payrastre, B.4    Chan, A.M.5    Billaud, M.6
  • 59
    • 33748295795 scopus 로고    scopus 로고
    • Insulin signaling in the central nervous system: Learning to survive
    • van der Heide, L. P., Ramakers, G. M. and Smidt, M. P. (2006). Insulin signaling in the central nervous system: learning to survive. Prog. Neurobiol. 79, 205-221.
    • (2006) Prog Neurobiol , vol.79 , pp. 205-221
    • van der Heide, L.P.1    Ramakers, G.M.2    Smidt, M.P.3
  • 60
    • 37149046442 scopus 로고    scopus 로고
    • Function of PTEN during the formation and maintenance of neuronal circuits in the brain
    • van Diepen, M. T. and Eickholt, B. J. (2008). Function of PTEN during the formation and maintenance of neuronal circuits in the brain. Dev. Neurosci. 30, 59-64.
    • (2008) Dev. Neurosci , vol.30 , pp. 59-64
    • van Diepen, M.T.1    Eickholt, B.J.2
  • 63
    • 79952114000 scopus 로고    scopus 로고
    • The neurodevelopmental implications of PI3K signaling
    • Waite, K. and Eickholt, B. J. (2010). The neurodevelopmental implications of PI3K signaling. Curr. Top. Microbiol. Immunol. 346, 245-265.
    • (2010) Curr. Top. Microbiol. Immunol , vol.346 , pp. 245-265
    • Waite, K.1    Eickholt, B.J.2
  • 64
    • 2942596447 scopus 로고    scopus 로고
    • Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans
    • Wenick, A. S. and Hobert, O. (2004). Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans. Dev. Cell 6, 757-770.
    • (2004) Dev. Cell , vol.6 , pp. 757-770
    • Wenick, A.S.1    Hobert, O.2
  • 66
    • 0142150016 scopus 로고    scopus 로고
    • Investigating C. elegans development through mosaic analysis
    • Yochem, J. and Herman, R. K. (2003). Investigating C. elegans development through mosaic analysis. Development 130, 4761-4768.
    • (2003) Development , vol.130 , pp. 4761-4768
    • Yochem, J.1    Herman, R.K.2
  • 67
  • 68
    • 60849109211 scopus 로고    scopus 로고
    • Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
    • Zhou, J., Blundell, J., Ogawa, S., Kwon, C. H., Zhang, W., Sinton, C., Powell, C. M. and Parada, L. F. (2009). Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J. Neurosci. 29, 1773-1783.
    • (2009) J. Neurosci , vol.29 , pp. 1773-1783
    • Zhou, J.1    Blundell, J.2    Ogawa, S.3    Kwon, C.H.4    Zhang, W.5    Sinton, C.6    Powell, C.M.7    Parada, L.F.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.