A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: Activation of AKT via MTORC2

Journal of Biological Chemistry

Volumn 286, Issue 9, 2011, Pages 7182-7189

  Murata, Hitoshi ^a   Sakaguchi, Masakiyo ^a   Jin, Yu ^a   Sakaguchi, Yoshihiko ^b   Futami, Jun Ichiro ^c   Yamada, Hidenori ^c   Kataoka, Ken ^a   Huh, Nam Ho ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b UNIVERSITY OF MIYAZAKI   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AKT ACTIVATION; AKT PHOSPHORYLATION; CELL MOTILITY; COMMON FEATURES; CYTOSOLIC; CYTOTOXIC AGENTS; KINASE ACTIVITY; MAMMALIAN TARGET; MITOCHONDRIAL FUNCTION; NEURONAL CELL; OVER-EXPRESSION; PARKINSON DISEASE; PHOSPHATIDYLINOSITOL 3-KINASE; SPECIFIC COMPONENT;

ACTIVATION ANALYSIS; CELL DEATH; DISEASES; ENZYMES; GENES; MAMMALS; PARKS; PHOSPHORYLATION;

MITOCHONDRIA;

BRPK; CHAPERONE; CYTOTOXIC AGENT; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PARKINSON DISEASE ASSOCIATED KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PINK1; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CELL MOTILITY; CELL PROTECTION; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE LOSS; HUMAN; HUMAN CELL; MITOCHONDRION; NERVE CELL NECROSIS; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CYTOSOL; GENE EXPRESSION; HUMANS; MALE; MITOCHONDRIA; NEUROBLASTOMA; OXIDATIVE STRESS; PARKINSON DISEASE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 79953185407     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.179390     Document Type: Article

References (41)

1. Hardy, J., Cai, H., Cookson, M. R., Gwinn-Hardy, K., and Singleton, A. (2006) Ann. Neurol. 60, 389-398
2. Klein, C., and Schlossmacher, M. G. (2006) Nat. Clin. Pract. Neurol. 2, 136-146
3. Biskup, S., Gerlach, M., Kupsch, A., Reichmann, H., Riederer, P., Vieregge, P., Wüllner, U., and Gasser, T. (2008) J. Neurol. 255, Suppl. 5, 8-17
4. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047
5. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., and Shimizu, N. (1998) Nature 392, 605-608
6. Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C., Squitieri, F., Ibanez, P., Joosse, M., van Dongen, J. W., Vanacore, N., van Swieten, J. C., Brice, A., Meco, G., van Duijn, C. M., Oostra, B. A., and Heutink, P. (2003) Science 299, 256-259
7. Unoki, M., and Nakamura, Y. (2001) Oncogene 20, 4457-4465
8. Nakajima, A., Kataoka, K., Hong, M., Sakaguchi, M., and Huh, N. H. (2003) Cancer Lett. 201, 195-201
9. Strauss, K. M., Martins, L. M., Plun-Favreau, H., Marx, F. P., Kautzmann, S., Berg, D., Gasser, T., Wszolek, Z., Müller, T., Bornemann, A., Wolburg, H., Downward, J., Riess, O., Schulz, J. B., and Krüger, R. (2005) Hum. Mol. Genet. 14, 2099-2111
10. Zimprich, A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M., Lincoln, S., Kachergus, J., Hulihan, M., Uitti, R. J., Calne, D. B., Stoessl, A. J., Pfeiffer, R. F., Patenge, N., Carbajal, I. C., Vieregge, P., Asmus, F., Müller-Myhsok, B., Dickson, D. W., Meitinger, T., Strom, T. M., Wszolek, Z. K., and Gasser, T. (2004) Neuron 44, 601-607
11. Schapira, A. H., Cooper, J. M., Dexter, D., Jenner, P., Clark, J. B., and Marsden, C. D. (1989) Lancet 1, 1269
12. Greenamyre, J. T., Sherer, T. B., Betarbet, R., and Panov, A. V. (2001) IUBMB Life 52, 135-141
13. Valente, E. M., Salvi, S., Ialongo, T., Marongiu, R., Elia, A. E., Caputo, V., Romito, L., Albanese, A., Dallapiccola, B., and Bentivoglio, A. R. (2004) Ann. Neurol. 56, 336-341
14. Haque, M. E., Thomas, K. J., D'Souza, C., Callaghan, S., Kitada, T., Slack, R. S., Fraser, P., Cookson, M. R., Tandon, A., and Park, D. S. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 1716-1721
15. Deng, H., Jankovic, J., Guo, Y., Xie, W., and Le, W. (2005) Biochem. Biophys. Res. Commun. 337, 1133-1138
16. MacKeigan, J. P., Murphy, L. O., and Blenis, J. (2005) Nat. Cell Biol. 7, 591-600
17. Kitada, T., Pisani, A., Porter, D. R., Yamaguchi, H., Tscherter, A., Martella, G., Bonsi, P., Zhang, C., Pothos, E. N., and Shen, J. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 11441-11446
18. Gautier, C. A., Kitada, T., and Shen, J. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 11364-11369
19. Pridgeon, J. W., Olzmann, J. A., Chin, L. S., and Li, L. (2007) PLoS Biol. 5, e172
20. Beilina, A., Van Der Brug, M., Ahmad, R., Kesavapany, S., Miller, D. W., Petsko, G. A., and Cookson, M. R. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 5703-5708
21. Takatori, S., Ito, G., and Iwatsubo, T. (2008) Neurosci. Lett. 430, 13-17
22. Kessler, K. R., Hamscho, N., Morales, B., Menzel, C., Barrero, F., Vives, F., Gispert, S., and Auburger, G. (2005) J. Neural. Transm. 112, 1345-1353
23. Criscuolo, C., Volpe, G., De Rosa, A., Varrone, A., Marongiu, R., Mancini, P., Salvatore, E., Dallapiccola, B., Filla, A., Valente, E. M., and De Michele, G. (2006) Movement Disord. 21, 1265-1267
24. Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Science 307, 1098-1101
25. Hresko, R. C., and Mueckler, M. (2005) J. Biol. Chem. 280, 40406-40416
26. Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., and Su, B. (2006) Cell 127, 125-137
27. Pearce, L. R., Huang, X., Boudeau, J., Pawłowski, R., Wullschleger, S., Deak, M., Ibrahim, A. F., Gourlay, R., Magnuson, M. A., and Alessi, D. R. (2007) Biochem. J. 405, 513-522
28. Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J. H., Hsu, P. P., Bagley, A. F., Markhard, A. L., and Sabatini, D. M. (2006) Mol. Cell 22, 159-168
29. Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., and Hall, M. N. (2004) Nat. Cell Biol. 6, 1122-1128
30. Sarbassov, D. D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2004) Curr. Biol. 14, 1296-1302
31. Frias, M. A., Thoreen, C. C., Jaffe, J. D., Schroder, W., Sculley, T., Carr, S. A., and Sabatini, D. M. (2006) Curr. Biol. 16, 1865-1870
32. Wullschleger, S., Loewith, R., and Hall, M. N. (2006) Cell 124, 471-484
33. Bhaskar, P. T., and Hay, N. (2007) Dev. Cell 12, 487-502
34. Shiota, C., Woo, J. T., Lindner, J., Shelton, K. D., and Magnuson, M. A. (2006) Dev. Cell 11, 583-589
35. Guertin, D. A., Stevens, D. M., Thoreen, C. C., Burds, A. A., Kalaany, N. Y., Moffat, J., Brown, M., Fitzgerald, K. J., and Sabatini, D. M. (2006) Dev. Cell 11, 859-871
36. Dagda, R. K., Cherra, S. J., 3rd, Kulich, S. M., Tandon, A., Park, D., and Chu, C. T. (2009) J. Biol. Chem. 284, 13843-13855
37. Lin, W., and Kang, U. J. (2008) J. Neurochem. 106, 464-474
38. Masri, J., Bernath, A., Martin, J., Jo, O. D., Vartanian, R., Funk, A., and Gera, J. (2007) Cancer Res. 67, 11712-11720
39. Farkas, L. M., and Krieglstein, K. (2002) J. Neural. Transm. 109, 267-277
40. Ries, V., Henchcliffe, C., Kareva, T., Rzhetskaya, M., Bland, R., During, M. J., Kholodilov, N., and Burke, R. E. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 18757-18762
41. Yang, Y., Gehrke, S., Haque, M. E., Imai, Y., Kosek, J., Yang, L., Beal, M. F., Nishimura, I., Wakamatsu, K., Ito, S., Takahashi, R., and Lu, B. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 13670-13675