메뉴 건너뛰기




Volumn 40, Issue 1, 2010, Pages 4-11

Neurodegenerative disorders: Insights from the nematode Caenorhabditis elegans

Author keywords

Alzheimer's disease; Amyotrophic lateral sclerosis; C. elegans; Huntington's disease; Neurodegeneration; Parkinson's disease; Protein aggregation; Spinal muscular atrophy; Toxicity

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; COPPER ZINC SUPEROXIDE DISMUTASE; DJ 1 PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; HEAT SHOCK TRANSCRIPTION FACTOR 1; HUNTINGTIN; LEUCINE RICH REPEAT KINASE 2; MEMBRANE PROTEIN; PRESENILIN 1; PRESENILIN 2; PROTEIN PARK1; PROTEIN PARK11; PROTEIN PARK13; PROTEIN PARK2; PROTEIN PARK5; PROTEIN PARK6; PROTEIN PARK9; SOMATOMEDIN C; SURVIVAL MOTOR NEURON PROTEIN 1; SURVIVAL MOTOR NEURON PROTEIN 2; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 77955841798     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.05.012     Document Type: Review
Times cited : (82)

References (109)
  • 1
    • 20444375511 scopus 로고    scopus 로고
    • Proteolytic mechanisms in necrotic cell death and neurodegeneration
    • Artal-Sanz M., Tavernarakis N. Proteolytic mechanisms in necrotic cell death and neurodegeneration. FEBS Lett. 2005, 579:3287-3296.
    • (2005) FEBS Lett. , vol.579 , pp. 3287-3296
    • Artal-Sanz, M.1    Tavernarakis, N.2
  • 2
    • 67349229369 scopus 로고    scopus 로고
    • Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in Caenorhabditis elegans
    • Arya U., et al. Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in Caenorhabditis elegans. Exp. Gerontol. 2009, 44:462-466.
    • (2009) Exp. Gerontol. , vol.44 , pp. 462-466
    • Arya, U.1
  • 3
    • 77950188650 scopus 로고    scopus 로고
    • Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models
    • Asikainen S., et al. Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models. J. Mol. Neurosci. 2010, 41:210-218.
    • (2010) J. Mol. Neurosci. , vol.41 , pp. 210-218
    • Asikainen, S.1
  • 4
  • 5
    • 33644830913 scopus 로고    scopus 로고
    • Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity
    • Bates E.A., et al. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. J. Neurosci. 2006, 26:2830-2838.
    • (2006) J. Neurosci. , vol.26 , pp. 2830-2838
    • Bates, E.A.1
  • 6
    • 69949170793 scopus 로고    scopus 로고
    • The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies
    • Bauer P.O., Nukina N. The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies. J. Neurochem. 2009, 110:1737-1765.
    • (2009) J. Neurochem. , vol.110 , pp. 1737-1765
    • Bauer, P.O.1    Nukina, N.2
  • 7
    • 56049100463 scopus 로고    scopus 로고
    • A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau
    • Brandt R., et al. A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiol. Aging 2009, 30:22-33.
    • (2009) Neurobiol. Aging , vol.30 , pp. 22-33
    • Brandt, R.1
  • 8
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974, 77:71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 9
    • 57649207934 scopus 로고    scopus 로고
    • Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan
    • Briese M., et al. Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan. Hum. Mol. Genet. 2009, 18:97-104.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 97-104
    • Briese, M.1
  • 10
    • 33747053662 scopus 로고    scopus 로고
    • Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model
    • Brignull H.R., et al. Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model. J. Neurosci. 2006, 26:7597-7606.
    • (2006) J. Neurosci. , vol.26 , pp. 7597-7606
    • Brignull, H.R.1
  • 11
    • 0028812820 scopus 로고
    • Mutations of the presenilin I gene in families with early-onset Alzheimer's disease
    • Campion D., et al. Mutations of the presenilin I gene in families with early-onset Alzheimer's disease. Hum. Mol. Genet. 1995, 4:2373-2377.
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 2373-2377
    • Campion, D.1
  • 12
    • 17644392138 scopus 로고    scopus 로고
    • Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans
    • Cao S., et al. Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans. J. Neurosci. 2005, 25:3801-3812.
    • (2005) J. Neurosci. , vol.25 , pp. 3801-3812
    • Cao, S.1
  • 13
    • 67650566385 scopus 로고    scopus 로고
    • Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease
    • Carnemolla A., et al. Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease. J. Biol. Chem. 2009, 284:18167-18173.
    • (2009) J. Biol. Chem. , vol.284 , pp. 18167-18173
    • Carnemolla, A.1
  • 14
    • 0036544654 scopus 로고    scopus 로고
    • Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1
    • Cartegni L., Krainer A.R. Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1. Nat. Genet. 2002, 30:377-384.
    • (2002) Nat. Genet. , vol.30 , pp. 377-384
    • Cartegni, L.1    Krainer, A.R.2
  • 15
    • 0025328345 scopus 로고
    • The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans
    • Chalfie M., Wolinsky E. The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans. Nature 1990, 345:410-416.
    • (1990) Nature , vol.345 , pp. 410-416
    • Chalfie, M.1    Wolinsky, E.2
  • 16
    • 52449095571 scopus 로고    scopus 로고
    • Modeling spinal muscular atrophy in Drosophila
    • Chang H., et al. Modeling spinal muscular atrophy in Drosophila. PLoS ONE 2008, 15:e3209.
    • (2008) PLoS ONE , vol.15
    • Chang, H.1
  • 17
    • 33748792821 scopus 로고    scopus 로고
    • Opposing activities protect against age-onset proteotoxicity
    • Cohen E., et al. Opposing activities protect against age-onset proteotoxicity. Science 2006, 313:1604-1610.
    • (2006) Science , vol.313 , pp. 1604-1610
    • Cohen, E.1
  • 18
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy
    • Conway K.A., et al. Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:571-576.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 571-576
    • Conway, K.A.1
  • 19
    • 33746533924 scopus 로고    scopus 로고
    • Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
    • Cooper A.A., et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 2006, 313:324-328.
    • (2006) Science , vol.313 , pp. 324-328
    • Cooper, A.A.1
  • 20
    • 0030130574 scopus 로고    scopus 로고
    • The neurobiology of childhood spinal muscular atrophy
    • Crawford T.O., Pardo C.A. The neurobiology of childhood spinal muscular atrophy. Neurobiol. Dis. 1996, 3:97-110.
    • (1996) Neurobiol. Dis. , vol.3 , pp. 97-110
    • Crawford, T.O.1    Pardo, C.A.2
  • 21
    • 0031057003 scopus 로고    scopus 로고
    • Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis
    • Cudkowicz M.E., et al. Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Ann. Neurol. 1997, 41:210-221.
    • (1997) Ann. Neurol. , vol.41 , pp. 210-221
    • Cudkowicz, M.E.1
  • 22
    • 0034639940 scopus 로고    scopus 로고
    • A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes
    • Culetto E., Sattelle D.B. A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes. Hum. Mol. Genet. 2000, 9:869-877.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 869-877
    • Culetto, E.1    Sattelle, D.B.2
  • 23
    • 0027333449 scopus 로고
    • Apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor
    • Daigle I., Li C. apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:12045-12049.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 12045-12049
    • Daigle, I.1    Li, C.2
  • 24
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    • DiFiglia M., et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 1997, 277:1990-1993.
    • (1997) Science , vol.277 , pp. 1990-1993
    • DiFiglia, M.1
  • 25
    • 0026464566 scopus 로고
    • Molecular genetics of cell death in the nematode Caenorhabditis elegans
    • Driscoll M. Molecular genetics of cell death in the nematode Caenorhabditis elegans. J. Neurobiol. 1992, 23:1327-1351.
    • (1992) J. Neurobiol. , vol.23 , pp. 1327-1351
    • Driscoll, M.1
  • 26
    • 0033524413 scopus 로고    scopus 로고
    • Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron
    • Faber P.W., et al. Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:179-184.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 179-184
    • Faber, P.W.1
  • 27
    • 0037168585 scopus 로고    scopus 로고
    • Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity
    • Faber P.W., et al. Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:17131-17136.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 17131-17136
    • Faber, P.W.1
  • 28
    • 0036154959 scopus 로고    scopus 로고
    • Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy
    • Feldkotter M., et al. Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy. Am. J. Hum. Genet. 2002, 70:358-368.
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 358-368
    • Feldkotter, M.1
  • 29
    • 0037047163 scopus 로고    scopus 로고
    • Interaction of intracellular beta amyloid peptide with chaperone proteins
    • Fonte V., et al. Interaction of intracellular beta amyloid peptide with chaperone proteins. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:9439-9444.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 9439-9444
    • Fonte, V.1
  • 30
    • 38149110518 scopus 로고    scopus 로고
    • Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein
    • Fonte V., et al. Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein. J. Biol. Chem. 2008, 283:784-791.
    • (2008) J. Biol. Chem. , vol.283 , pp. 784-791
    • Fonte, V.1
  • 31
    • 0037106316 scopus 로고    scopus 로고
    • Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice
    • Fossale E., et al. Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice. Hum. Mol. Genet. 2002, 11:2233-2241.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2233-2241
    • Fossale, E.1
  • 32
    • 0036174010 scopus 로고    scopus 로고
    • Alpha-Synuclein is phosphorylated in synucleinopathy lesions
    • Fujiwara H., et al. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell Biol. 2002, 4:160-164.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 160-164
    • Fujiwara, H.1
  • 33
    • 33644850056 scopus 로고    scopus 로고
    • Progressive disruption of cellular protein folding in models of polyglutamine diseases
    • Gidalevitz T., et al. Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 2006, 311:1471-1474.
    • (2006) Science , vol.311 , pp. 1471-1474
    • Gidalevitz, T.1
  • 34
    • 62149129690 scopus 로고    scopus 로고
    • Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity
    • Gidalevitz T., et al. Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity. PLoS Genet. 2009, 5:e1000399.
    • (2009) PLoS Genet. , vol.5
    • Gidalevitz, T.1
  • 35
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease
    • Goedert M., Spillantini M.G. A century of Alzheimer's disease. Science 2006, 314:777-781.
    • (2006) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantini, M.G.2
  • 36
    • 0029909180 scopus 로고    scopus 로고
    • PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans
    • Goedert M., et al. PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans. J. Cell Sci. 1996, 109(Pt 11):2661-2672.
    • (1996) J. Cell Sci. , vol.109 , Issue.PART 11 , pp. 2661-2672
    • Goedert, M.1
  • 37
    • 54049141614 scopus 로고    scopus 로고
    • The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans
    • Gordon P., et al. The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans. Dev. Genes Evol. 2008, 218:541-551.
    • (2008) Dev. Genes Evol. , vol.218 , pp. 541-551
    • Gordon, P.1
  • 38
    • 65449156394 scopus 로고    scopus 로고
    • SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans
    • Guthrie C.R., et al. SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. Hum. Mol. Genet. 2009, 18:1825-1838.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1825-1838
    • Guthrie, C.R.1
  • 39
    • 38649084391 scopus 로고    scopus 로고
    • Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model
    • Hamamichi S., et al. Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:728-733.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 728-733
    • Hamamichi, S.1
  • 40
    • 77951558389 scopus 로고    scopus 로고
    • C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease
    • Harrington A.J., et al. C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease. Dev. Dyn. 2010, 239:1282-1295.
    • (2010) Dev. Dyn. , vol.239 , pp. 1282-1295
    • Harrington, A.J.1
  • 41
    • 67650727585 scopus 로고    scopus 로고
    • AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model
    • Hassan W.M., et al. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model. Hum. Mol. Genet. 2009, 18:2739-2747.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 2739-2747
    • Hassan, W.M.1
  • 42
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
    • Hutton M., et al. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 1998, 393:702-705.
    • (1998) Nature , vol.393 , pp. 702-705
    • Hutton, M.1
  • 43
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • Jackson G.R., et al. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 2002, 34:509-519.
    • (2002) Neuron , vol.34 , pp. 509-519
    • Jackson, G.R.1
  • 44
    • 67650383731 scopus 로고    scopus 로고
    • Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors
    • Jacobsen K.T., Iverfeldt K. Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors. Cell. Mol. Life Sci. 2009, 66:2299-2318.
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 2299-2318
    • Jacobsen, K.T.1    Iverfeldt, K.2
  • 45
    • 63049132756 scopus 로고    scopus 로고
    • Acetylation targets mutant huntingtin to autophagosomes for degradation
    • Jeong H., et al. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 2009, 137:60-72.
    • (2009) Cell , vol.137 , pp. 60-72
    • Jeong, H.1
  • 46
    • 69149102628 scopus 로고    scopus 로고
    • Repression of alpha-synuclein expression and toxicity by microRNA-7
    • Junn E., et al. Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:13052-13057.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 13052-13057
    • Junn, E.1
  • 47
    • 0037448540 scopus 로고    scopus 로고
    • Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
    • Kamath R.S., et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 2003, 421:231-237.
    • (2003) Nature , vol.421 , pp. 231-237
    • Kamath, R.S.1
  • 48
    • 0041665176 scopus 로고    scopus 로고
    • A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy
    • Kashima T., Manley J.L. A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy. Nat. Genet. 2003, 34:460-463.
    • (2003) Nat. Genet. , vol.34 , pp. 460-463
    • Kashima, T.1    Manley, J.L.2
  • 49
    • 34548537573 scopus 로고    scopus 로고
    • A MicroRNA feedback circuit in midbrain dopamine neurons
    • Kim J., et al. A MicroRNA feedback circuit in midbrain dopamine neurons. Science 2007, 317:1220-1224.
    • (2007) Science , vol.317 , pp. 1220-1224
    • Kim, J.1
  • 50
    • 33845423002 scopus 로고    scopus 로고
    • Using Caenorhabditis elegans models of neurodegenerative disease to identify neuroprotective strategies
    • Kraemer B., Schellenberg G.D. Using Caenorhabditis elegans models of neurodegenerative disease to identify neuroprotective strategies. Int. Rev. Neurobiol. 2007, 77:219-246.
    • (2007) Int. Rev. Neurobiol. , vol.77 , pp. 219-246
    • Kraemer, B.1    Schellenberg, G.D.2
  • 51
    • 34548389257 scopus 로고    scopus 로고
    • SUT-1 enables tau-induced neurotoxicity in C. elegans
    • Kraemer B.C., Schellenberg G.D. SUT-1 enables tau-induced neurotoxicity in C. elegans. Hum. Mol. Genet. 2007, 16:1959-1971.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 1959-1971
    • Kraemer, B.C.1    Schellenberg, G.D.2
  • 52
    • 0042889049 scopus 로고    scopus 로고
    • Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
    • Kraemer B.C., et al. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:9980-9985.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 9980-9985
    • Kraemer, B.C.1
  • 53
    • 33646133424 scopus 로고    scopus 로고
    • Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans
    • Kraemer B.C., et al. Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans. Hum. Mol. Genet. 2006, 15:1483-1496.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1483-1496
    • Kraemer, B.C.1
  • 54
    • 33644849650 scopus 로고    scopus 로고
    • Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans
    • Kuwahara T., et al. Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans. J. Biol. Chem. 2006, 281:334-340.
    • (2006) J. Biol. Chem. , vol.281 , pp. 334-340
    • Kuwahara, T.1
  • 55
    • 52949083619 scopus 로고    scopus 로고
    • A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans
    • Kuwahara T., et al. A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans. Hum. Mol. Genet. 2008, 17:2997-3009.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 2997-3009
    • Kuwahara, T.1
  • 56
    • 0037971209 scopus 로고    scopus 로고
    • Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein
    • Lakso M., et al. Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein. J. Neurochem. 2003, 86:165-172.
    • (2003) J. Neurochem. , vol.86 , pp. 165-172
    • Lakso, M.1
  • 57
    • 0032497504 scopus 로고    scopus 로고
    • Parkinson's disease. First of two parts
    • Lang A.E., Lozano A.M. Parkinson's disease. First of two parts. N. Engl. J. Med. 1998, 339:1044-1053.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1044-1053
    • Lang, A.E.1    Lozano, A.M.2
  • 58
    • 0030981541 scopus 로고    scopus 로고
    • Correlation between severity and SMN protein level in spinal muscular atrophy
    • Lefebvre S., et al. Correlation between severity and SMN protein level in spinal muscular atrophy. Nat. Genet. 1997, 16:265-269.
    • (1997) Nat. Genet. , vol.16 , pp. 265-269
    • Lefebvre, S.1
  • 59
    • 0029906585 scopus 로고    scopus 로고
    • Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
    • Levitan D., et al. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:14940-14944.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 14940-14944
    • Levitan, D.1
  • 60
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
    • Link C.D. Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:9368-9372.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9368-9372
    • Link, C.D.1
  • 61
    • 33751397131 scopus 로고    scopus 로고
    • C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease
    • Link C.D. C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Exp. Gerontol. 2006, 41:1007-1013.
    • (2006) Exp. Gerontol. , vol.41 , pp. 1007-1013
    • Link, C.D.1
  • 62
    • 0035109444 scopus 로고    scopus 로고
    • Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
    • Link C.D., et al. Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol. Aging 2001, 22:217-226.
    • (2001) Neurobiol. Aging , vol.22 , pp. 217-226
    • Link, C.D.1
  • 63
    • 0037405291 scopus 로고    scopus 로고
    • Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model
    • Link C.D., et al. Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol. Aging 2003, 24:397-413.
    • (2003) Neurobiol. Aging , vol.24 , pp. 397-413
    • Link, C.D.1
  • 64
    • 0033607515 scopus 로고    scopus 로고
    • Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats
    • Liu F.H., et al. Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats. J. Biol. Chem. 1999, 274:34425-34432.
    • (1999) J. Biol. Chem. , vol.274 , pp. 34425-34432
    • Liu, F.H.1
  • 65
    • 0033033434 scopus 로고    scopus 로고
    • A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy
    • Lorson C.L., et al. A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:6307-6311.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 6307-6311
    • Lorson, C.L.1
  • 66
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group
    • MacDonald C.M.A., et al. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 1993, 72:971-983.
    • (1993) Cell , vol.72 , pp. 971-983
    • MacDonald, C.M.A.1
  • 67
    • 69249153430 scopus 로고    scopus 로고
    • The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42
    • McColl G., et al. The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42. J. Biol. Chem. 2009, 284:22697-22702.
    • (2009) J. Biol. Chem. , vol.284 , pp. 22697-22702
    • McColl, G.1
  • 68
    • 0029770683 scopus 로고    scopus 로고
    • Ptl-1, a Caenorhabditis elegans gene whose products are homologous to the tau microtubule-associated proteins
    • McDermott J.B., et al. ptl-1, a Caenorhabditis elegans gene whose products are homologous to the tau microtubule-associated proteins. Biochemistry 1996, 35:9415-9423.
    • (1996) Biochemistry , vol.35 , pp. 9415-9423
    • McDermott, J.B.1
  • 69
    • 0032718045 scopus 로고    scopus 로고
    • The Caenorhabditis elegans orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability
    • Miguel-Aliaga I., et al. The Caenorhabditis elegans orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability. Hum. Mol. Genet. 1999, 8:2133-2143.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 2133-2143
    • Miguel-Aliaga, I.1
  • 70
    • 26944463072 scopus 로고    scopus 로고
    • Progressive neurodegeneration in C. elegans model of tauopathy
    • Miyasaka T., et al. Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiol. Dis. 2005, 20:372-383.
    • (2005) Neurobiol. Dis. , vol.20 , pp. 372-383
    • Miyasaka, T.1
  • 71
    • 0036678146 scopus 로고    scopus 로고
    • The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    • Morley J.F., et al. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:10417-10422.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 10417-10422
    • Morley, J.F.1
  • 72
    • 23844511660 scopus 로고    scopus 로고
    • Synergistic defect in 60S ribosomal subunit assembly caused by a mutation of Rrs1p, a ribosomal protein L11-binding protein, and 3'-extension of 5S rRNA in Saccharomyces cerevisiae
    • Nariai M., et al. Synergistic defect in 60S ribosomal subunit assembly caused by a mutation of Rrs1p, a ribosomal protein L11-binding protein, and 3'-extension of 5S rRNA in Saccharomyces cerevisiae. Nucleic Acids Res. 2005, 33:4553-4562.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 4553-4562
    • Nariai, M.1
  • 73
    • 48649085488 scopus 로고    scopus 로고
    • P97 Homologs from Caenorhabditis elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat
    • Nishikori S., et al. p97 Homologs from Caenorhabditis elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat. Genes Cells 2008, 13:827-838.
    • (2008) Genes Cells , vol.13 , pp. 827-838
    • Nishikori, S.1
  • 74
    • 2342652188 scopus 로고    scopus 로고
    • Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
    • Nollen E.A., et al. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:6403-6408.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 6403-6408
    • Nollen, E.A.1
  • 75
    • 0034772838 scopus 로고    scopus 로고
    • Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans
    • Oeda T., et al. Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans. Hum. Mol. Genet. 2001, 10:2013-2023.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 2013-2023
    • Oeda, T.1
  • 76
    • 0032936755 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson's disease
    • Olanow C.W., Tatton W.G. Etiology and pathogenesis of Parkinson's disease. Annu. Rev. Neurosci. 1999, 22:123-144.
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 123-144
    • Olanow, C.W.1    Tatton, W.G.2
  • 77
    • 16944366666 scopus 로고    scopus 로고
    • The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein
    • Ozelius L.J., et al. The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. Nat. Genet. 1997, 17:40-48.
    • (1997) Nat. Genet. , vol.17 , pp. 40-48
    • Ozelius, L.J.1
  • 78
    • 8844266996 scopus 로고    scopus 로고
    • Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
    • Paisan-Ruiz C., et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004, 44:595-600.
    • (2004) Neuron , vol.44 , pp. 595-600
    • Paisan-Ruiz, C.1
  • 79
    • 45449098044 scopus 로고    scopus 로고
    • Cytoplasmic expression of mouse prion protein causes severe toxicity in Caenorhabditis elegans
    • Park K.W., Li L. Cytoplasmic expression of mouse prion protein causes severe toxicity in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 2008, 372:697-702.
    • (2008) Biochem. Biophys. Res. Commun. , vol.372 , pp. 697-702
    • Park, K.W.1    Li, L.2
  • 80
    • 0035818590 scopus 로고    scopus 로고
    • Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
    • Parker J.A., et al. Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:13318-13323.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 13318-13323
    • Parker, J.A.1
  • 81
    • 16844375290 scopus 로고    scopus 로고
    • Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
    • Parker J.A., et al. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat. Genet. 2005, 37:349-350.
    • (2005) Nat. Genet. , vol.37 , pp. 349-350
    • Parker, J.A.1
  • 82
    • 35348913211 scopus 로고    scopus 로고
    • Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity
    • Parker J.A., et al. Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity. J. Neurosci. 2007, 27:11056-11064.
    • (2007) J. Neurosci. , vol.27 , pp. 11056-11064
    • Parker, J.A.1
  • 83
    • 0018238065 scopus 로고
    • Incidence, prevalence, and gene frequency studies of chronic childhood spinal muscular atrophy
    • Pearn J. Incidence, prevalence, and gene frequency studies of chronic childhood spinal muscular atrophy. J. Med. Genet. 1978, 15:409-413.
    • (1978) J. Med. Genet. , vol.15 , pp. 409-413
    • Pearn, J.1
  • 84
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M.H., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 85
    • 72749106042 scopus 로고    scopus 로고
    • VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease
    • Ruan Q., et al. VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiol. Dis. 2010, 37:330-338.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 330-338
    • Ruan, Q.1
  • 86
    • 67651171368 scopus 로고    scopus 로고
    • LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans
    • Saha S., et al. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J. Neurosci. 2009, 29:9210-9218.
    • (2009) J. Neurosci. , vol.29 , pp. 9210-9218
    • Saha, S.1
  • 87
    • 0034705224 scopus 로고    scopus 로고
    • Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans
    • Satyal S.H., et al. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:5750-5755.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 5750-5755
    • Satyal, S.H.1
  • 88
    • 0029784838 scopus 로고    scopus 로고
    • Amyloid beta-protein and the genetics of Alzheimer's disease
    • Selkoe D.J. Amyloid beta-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 1996, 271:18295-18298.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18295-18298
    • Selkoe, D.J.1
  • 89
    • 0035404388 scopus 로고    scopus 로고
    • A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study
    • Sharma N., et al. A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. Am. J. Pathol. 2001, 159:339-344.
    • (2001) Am. J. Pathol. , vol.159 , pp. 339-344
    • Sharma, N.1
  • 90
    • 8944241774 scopus 로고    scopus 로고
    • Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant
    • Sherrington R., et al. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum. Mol. Genet. 1996, 5:985-988.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 985-988
    • Sherrington, R.1
  • 91
    • 0242300619 scopus 로고    scopus 로고
    • Alpha-Synuclein locus triplication causes Parkinson's disease
    • Singleton A.B., et al. alpha-Synuclein locus triplication causes Parkinson's disease. Science 2003, 302:841.
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1
  • 92
    • 0032560487 scopus 로고    scopus 로고
    • Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
    • Spillantini M.G., et al. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:7737-7741.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 7737-7741
    • Spillantini, M.G.1
  • 93
    • 27944506923 scopus 로고    scopus 로고
    • A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress
    • Springer W., et al. A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Hum. Mol. Genet. 2005, 14:3407-3423.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 3407-3423
    • Springer, W.1
  • 94
    • 33748439489 scopus 로고    scopus 로고
    • An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity
    • Stanhill A., et al. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Mol. Cell 2006, 23:875-885.
    • (2006) Mol. Cell , vol.23 , pp. 875-885
    • Stanhill, A.1
  • 95
    • 0033584258 scopus 로고    scopus 로고
    • The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity
    • Stege G.J., et al. The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity. Biochem. Biophys. Res. Commun. 1999, 262:152-156.
    • (1999) Biochem. Biophys. Res. Commun. , vol.262 , pp. 152-156
    • Stege, G.J.1
  • 96
    • 0034192462 scopus 로고    scopus 로고
    • A model for Niemann-Pick type C disease in the nematode Caenorhabditis elegans
    • Sym M., et al. A model for Niemann-Pick type C disease in the nematode Caenorhabditis elegans. Curr. Biol. 2000, 10:527-530.
    • (2000) Curr. Biol. , vol.10 , pp. 527-530
    • Sym, M.1
  • 97
    • 34347408041 scopus 로고    scopus 로고
    • Hook2 contributes to aggresome formation
    • Szebenyi G., et al. Hook2 contributes to aggresome formation. BMC Cell Biol. 2007, 8:19.
    • (2007) BMC Cell Biol. , vol.8 , pp. 19
    • Szebenyi, G.1
  • 98
    • 70350370787 scopus 로고    scopus 로고
    • What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?
    • Teschendorf D., Link C.D. What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?. Mol. Neurodegener. 2009, 4:38.
    • (2009) Mol. Neurodegener. , vol.4 , pp. 38
    • Teschendorf, D.1    Link, C.D.2
  • 99
    • 41949097891 scopus 로고    scopus 로고
    • C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging
    • van Ham T.J., et al. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet. 2008, 4:e1000027.
    • (2008) PLoS Genet. , vol.4
    • van Ham, T.J.1
  • 100
    • 35548950179 scopus 로고    scopus 로고
    • Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans
    • Voisine C., et al. Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. PLoS One 2007, 2:e504.
    • (2007) PLoS One , vol.2
    • Voisine, C.1
  • 101
    • 33644771265 scopus 로고    scopus 로고
    • Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin
    • Wang H., et al. Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin. Hum. Mol. Genet. 2006, 15:1025-1041.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1025-1041
    • Wang, H.1
  • 102
    • 58949099388 scopus 로고    scopus 로고
    • Effects of overexpression of huntingtin proteins on mitochondrial integrity
    • Wang H., et al. Effects of overexpression of huntingtin proteins on mitochondrial integrity. Hum. Mol. Genet. 2009, 18:737-752.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 737-752
    • Wang, H.1
  • 103
    • 59249098430 scopus 로고    scopus 로고
    • An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans
    • Wang J., et al. An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. PLoS Genet. 2009, 5:e1000350.
    • (2009) PLoS Genet. , vol.5
    • Wang, J.1
  • 104
    • 0002221492 scopus 로고
    • The structure of the nervous system of the nematode C. elegans
    • White J.G., et al. The structure of the nervous system of the nematode C. elegans. Philos. Trans. R. Soc. Lond. B Biol. Sci. 1986, 314:1-340.
    • (1986) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.314 , pp. 1-340
    • White, J.G.1
  • 105
    • 33845613251 scopus 로고    scopus 로고
    • Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    • Wu Y., et al. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J. Neurosci. 2006, 26:13102-13113.
    • (2006) J. Neurosci. , vol.26 , pp. 13102-13113
    • Wu, Y.1
  • 106
    • 77951975674 scopus 로고    scopus 로고
    • Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers
    • Wu Y., et al. Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers. Neurobiol. Aging 2010, 31:1055-1058.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1055-1058
    • Wu, Y.1
  • 107
    • 1642340527 scopus 로고    scopus 로고
    • Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation
    • Yamanaka K., et al. Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation. J. Struct. Biol. 2004, 146:242-250.
    • (2004) J. Struct. Biol. , vol.146 , pp. 242-250
    • Yamanaka, K.1
  • 108
    • 44349160257 scopus 로고    scopus 로고
    • Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans
    • Yun C., et al. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:7094-7099.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 7094-7099
    • Yun, C.1
  • 109
    • 8844233579 scopus 로고    scopus 로고
    • Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
    • Zimprich A., et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004, 44:601-607.
    • (2004) Neuron , vol.44 , pp. 601-607
    • Zimprich, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.