Synthesis and biological evaluation of novel oxadiazole derivatives: A new class of thymidine phosphorylase inhibitors as potential anti-tumor agents

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 3, 2014, Pages 1008-1015

  Shahzad, Sohail Anjum ^a   Yar, Muhammad ^b   Bajda, Marek ^c,d   Jadoon, Bushra ^a   Khan, Zulfiqar Ali ^e   Naqvi, Syed Ali Raza ^e   Shaikh, Ahson Jabbar ^a   Hayat, Khizar ^a   Mahmmod, Adeem ^a   Mahmood, Nasir ^f   Filipek, Sławomir ^c  

^a COMSATS Institute of Information Technology ^*  (Pakistan)

^b Process and Energy Systems Engineering Center PRESTIGE   (Pakistan)

^c UNIVERSITY OF WARSAW   (Poland)

^d JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^e GOVERNMENT COLLEGE UNIVERSITY   (Pakistan)

^f UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

Author keywords

1,3,4 Oxadiazole 2 thione; Angiogenesis; Anti cancer activity; Mannich bases; Thymidine phosphorylase inhibitors

Indexed keywords

1,3,4 OXADIAZOLE 2 THIONE DERIVATIVE; 1,3,4 OXADIAZOLE DERIVATIVE; 3 (2 METHOXYPHENYLAMINOMETHYL) 5 (PHENYL) 1,3,4 OXADIAZOLINE 2 THIONE; 3 (3'' METHOXYPHENYLAMINOMETHYL) 5 (PHENYL) 1,3,4 OXADIAZOLINE 2 THIONE; 3 (3'',4'' DIMETHYLPHENYLAMINOMETHYL) 5 (PHENYL) 1,3,4 OXADIAZOLINE 2 THIONE; 3 (4 BROMOPHENYLAMINOMETHYL) 5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOLINE 2 THIONE; ANTINEOPLASTIC AGENT; THYMIDINE PHOSPHORYLASE; THYMIDINE PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

1,3,4-OXADIAZOLE-2-THIONE; ANGIOGENESIS; ANTI-CANCER ACTIVITY; MANNICH BASES; THYMIDINE PHOSPHORYLASE INHIBITORS;

ANTINEOPLASTIC AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; OXADIAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE PHOSPHORYLASE;

EID: 84892809650     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.043     Document Type: Article

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