Structural basis for non-competitive product inhibition in human thymidine phosphorylase: Implications for drug design

Biochemical Journal

Volumn 399, Issue 2, 2006, Pages 199-204

  El Omari, Kamel ^a   Bronckaers, Annelies ^b   Liekens, Sandra ^b   Pérez Pérez, Maria Jésus ^c   Balzarini, Jan ^b   Stammers, David K ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

Angiogenesis; Human thymidine phosphorylase; Product inhibition; Pyrimidine nucleoside phosphorylase; Structure; X ray crystallography

Indexed keywords

ANGIOGENESIS; HUMAN THYMIDINE PHOSPHORYLASE; PRODUCT INHIBITION; PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE;

CONFORMATIONS; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENZYME INHIBITION; HYDROGEN BONDS; REACTION KINETICS; X RAY CRYSTALLOGRAPHY;

ENZYMES;

ANGIOGENESIS INHIBITOR; ENZYME INHIBITOR; PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE; RIBOSE PHOSPHATE; THYMIDINE; THYMIDINE PHOSPHORYLASE; THYMINE;

ARTICLE; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME STRUCTURE; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; LIGANDS; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE PHOSPHORYLASE; THYMINE;

EID: 33750028028     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060513     Document Type: Article

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