Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: Optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 13, 2004, Pages 3443-3450

  Yano, Shingo ^a   Kazuno, Hideki ^a   Sato, Tsutomu ^a   Suzuki, Norihiko ^a   Emura, Tomohiro ^a   Wierzba, Konstanty ^a   Yamashita, Jun Ichi ^a   Tada, Yukio ^a   Yamada, Yuji ^a   Fukushima, Masakazu ^a   Asao, Tetsuji ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

2 Deoxy 5 (trifluoromethyl) uridine (F3dThd); TAS 102; Thymidine phosphorylase inhibitor; TPI

Indexed keywords

AMIDE; GUANIDINE DERIVATIVE; METHYL GROUP; THYMIDINE PHOSPHORYLASE; TRIFLURIDINE; URACIL DERIVATIVE; URIDINE PHOSPHORYLASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; MOUSE; NONHUMAN; REACTION OPTIMIZATION;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; ENZYME INHIBITORS; HUMANS; HYDROCARBONS; INHIBITORY CONCENTRATION 50; METHANE; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDINE PHOSPHORYLASE; URACIL; URIDINE PHOSPHORYLASE;

EID: 2942608177     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.046     Document Type: Article

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