Antimycobacterial activity of new 3-substituted 5-(pyridin-4-yl)-3H-1,3,4- oxadiazol-2-one and 2-thione derivatives. Preliminary molecular modeling investigations

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 11, 2005, Pages 3797-3809

  Mamolo, Maria Grazia ^a   Zampieri, Daniele ^a   Vio, Luciano ^a   Fermeglia, Maurizio ^a   Ferrone, Marco ^a   Pricl, Sabrina ^a   Scialino, Giuditta ^a   Banfi, Elena ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Antimycobacterial; Biological activity; Molecular modeling; Synthesis

Indexed keywords

3 (2 METHYLPIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (2 METHYLPIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (3 METHYLPIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (3 METHYLPIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (3,4 DIHYDRO 1H ISOQUINOLIN 2 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (3,4 DIHYDRO 1H ISOQUINOLIN 2 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (4 ACETYLPIPERAZIN 1 YLMETHYL) 5 (PYRIDIN 4 YL) 3H 1,3,4 OXADIAZOL 2 ONE; 3 (4 ACETYLPIPERAZIN 1 YLMETHYL) 5 (PYRIDIN 4 YL) 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (4 BENZYLPIPERAZIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (4 BENZYLPIPERAZIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (4 BENZYLPIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (4 BENZYLPIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (4 METHYLPIPERAZIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (4 METHYLPIPERAZIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (4 METHYLPIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (4 METHYLPIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (AZEPAN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (AZEPAN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (MORPHOLINO 4 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (MORPHOLINO 4 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 3 (PIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOL 2 ONE; 3 (PIPERIDIN 1 YLMETHYL) 5 PYRIDIN 4 YL 3H 1,3,4 OXADIAZOLE 2 THIONE; 5 (PYRIDIN 4 YL 3 THIOMORPHOLIN 4 YLMETHYL) 3H 1,3,4 OXADIAZOL 2 ONE; 5 (PYRIDIN 4 YL 3 THIOMORPHOLIN 4 YLMETHYL) 3H 1,3,4 OXADIAZOLE 2 THIONE; ANTIMYCOBACTERIAL AGENT; CYTOCHROME P450; ISONIAZID; OFLOXACIN; OXADIAZOLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR INTERACTION; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SUBSTITUTION REACTION;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 18144398613     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.03.013     Document Type: Article

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