Thymidine phosphorylase from Escherichia coli: Tight-binding inhibitors as enzyme active-site titrants

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 21, Issue 1, 2006, Pages 69-73

  Gbaj, Abdul ^a   Edwards, Philip N ^a   Reigan, Philip ^a   Freeman, Sally ^a   Jaffar, Mohammed ^a   Douglas, Kenneth T ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Angiogenesis; Anticancer drugs; Inhibitors; Stoichiometric inhibition; Thymidine phosphorylase; Transition state inhibitor

Indexed keywords

5 CHLORO 6 (2 IMINOPYRROLIDIN 1 YL)METHYLURACIL; 6 (2 IMINOIMIDAZOL 1 YL)METHYL 5 BROMOURACIL; 6 (2 IMINOIMIDAZOL 1 YL)METHYL 5 CHLOROURACIL; PYRIMIDINE; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG; URACIL DERIVATIVE; DEOXYURIDINE; ENZYME INHIBITOR; RECOMBINANT PROTEIN; THYMIDINE;

ANGIOGENESIS; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ESCHERICHIA COLI; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; PROTEIN BINDING;

ESCHERICHIA COLI;

BINDING SITES; DEOXYURIDINE; ENZYME INHIBITORS; ESCHERICHIA COLI; MODELS, MOLECULAR; PROTEIN BINDING; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE PHOSPHORYLASE;

EID: 33646099832     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360500424010     Document Type: Article

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