Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1057-1066

  Bayrak, Hacer ^a   Demirbas, Ahmet ^a   Karaoglu, Sengül Alpay ^b   Demirbas, Neslihan ^a  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

^b RECEP TAYYIP ERDOGAN UNIVERSITY   (Turkey)

Author keywords

1,2,4 Triazole; 1,3,4 Oxadiazole; 1,3,4 Thiadiazole; Antimicrobial activity; Isonicotinic acid hydrazide

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 2 (4 MORPHOLINO)ETHYLAMINE; 2 [(4 METHYLPIPERAZIN 1 YL)AMINOMETHYL] 4 PHENYL 5 PYRIDIN 4 YL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 2 [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO] N' (PYRIDIN 2 YLMETHYLENE) ACETOHYDRAZIDE; 2 [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO] N' (PYRIDIN 3 YLMETHYLENE) ACETOHYDRAZIDE; 2 [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO] N' (PYRIDIN 4 YLMETHYLENE) ACETOHYDRAZIDE; 2 [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]ACETOHYDRAZIDE; 2 ISONICOTINOYL N PHENYLHYDRAZINE CARBOTHIOAMIDE; 3 ISOBUTYLTHIO 4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOLE; 3 METHYLTHIO 4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOLE; 4 (4 METHYLPHENYL) 5 [[(4 PHENYL 5 PYRIDINE 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]METHYL] 4H 1,2,4 TRIAZOLE 3 THIOL; 4 PHENYL 2 [[(2 MORPHOLIN 4 YLETHYL)AMINO]METHYL] 5 PYRIDIN 4 YL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 PHENYL 5 PYRIDIN 4 YL 2 [[(4 [[(4 PHENYL 5 PYRIDINE 4 YL 3 THIOXO 2,4 DIHYDRO 3H 1,2,4 TRIAZOL 2 YL)METHYL]AMINO]PIPERAZIN 1 YL)AMINO]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOLE 3 THIOL; 5 [[(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]METHYL] 1,3,4 OXADIAZOLE 2 THIOL; 5 [[(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]METHYL] 2 (4 METHYLPHENYL)AMINO 1,3,4 THIADIAZOLE; 5 [[(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]METHYL] 2(4 METHYLPHENYL) 2 METHYLAMINO 1,3,4 THIADIAZOLE; 5 [[(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]METHYL] 3 [[(2 MORPHOLIN 4 YLETHYL)AMINO]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 [[(4 PHENYL 5 PYRIDINE 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]METHYL] 4 (4 METHYL PHENYL) 2 [(4 METHYLPIPERAZIN 1 YL)METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; ETHYL [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]ACETATE; MANNICH BASE; N (4 METHYLPHENYL) 2 [[(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]ACETYL] HYDRAZINECARBOTHIOAMIDE; N' [(2 HYDROXYPHENYL)METHYLENE] 2 [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL) THIO]ACETOHYDRAZIDE; N' [(2,6 DICHLOROPHENYL)METHYLENE] 2 [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL) THIO]ACETOHYDRAZIDE; N' [(3,4 DIHYDROXYPHENYL)METHYLENE] 2 [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL) THIO]ACETOHYDRAZIDE; N' [(4 FLUOROPHENYL)METHYLENE] 2 [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO] ACETOHYDRAZIDE; N' [(4 METHOXYPHENYL)METHYLENE] 2 [(4 PHENYL 5 PYRIDIN 4 YL 4H 1,2,4 TRIAZOL 3 YL)THIO]ACETOHYDRAZIDE; SCHIFF BASE; THIOSEMICARBAZIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTI-INFECTIVE AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MANNICH BASES; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; SCHIFF BASES; SPECTROPHOTOMETRY, INFRARED; TRIAZOLES;

EID: 60549092516     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.06.019     Document Type: Article

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