Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 5225-5233

  Manjunatha, K ^a   Poojary, Boja ^a   Lobo, Prajwal L ^a   Fernandes, Jennifer ^b   Kumari, N Suchetha ^c  

^a MANGALORE UNIVERSITY   (India)

^b Department of Pharmachemistry   (India)

^c NITTE DEEMED TO BE UNIVERSITY   (India)

Author keywords

1,3,4 Oxadiazol 2 thiones; 4 Methylthiophenyl; Anti inflammatory activity; Antimicrobial activity; Ibuprofen

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 (4 ETHOXYCABONYLPIPERADIN 1 YL)METHYL 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 (MORPHOLIN 4 YLMETHYL)1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 (PIPERAZIN 1 YLMETHYL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 (PIPERIDIN 1 YLMETHYL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 [(4 METHYLPIPERAZIN 1 YLMETHYL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 [[4 (2 ETHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 [[4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 [[4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 [[4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 [[4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 ISOBUTYLPHENYL)ETHYL 3 [[4 (4 NITROPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOBENZYL) 3 (MORPHOLIN 4 YLMETHYL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOBENZYL) 3 [[4 (2 ETHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOBENZYL) 3 [[4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOBENZYL) 3 [[4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOBENZYL) 3 [[4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOBENZYL) 3 [[4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOBENZYL) 3 [[4 (4 NITROPHENYL)PIPERAZIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOBENZYL) 3 [[4 ETHOXYCABONYLPIPERADIN 1 YL]METHYL] 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOPHENYL) 3 (PIPERIDIN 1 YLMETHYL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOPHENYL)ETHYL 3 (PIPERAZIN 1 YLMETHYL) 1,3,4 OXADIAZOLE 2(3H) THIONE; 5 (4 METHYLTHIOPHENYL)ETHYL 3 [(4 METHYLPIPERAZIN 1 YLMETHYL) 1,3,4 OXADIAZOLE 2(3H) THIONE; ANALGESIC AGENT; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CICLOPIROXOLAMINE; CIPROFLOXACIN; DICLOFENAC; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; FEMALE; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; MALE; MASS SPECTROMETRY; METHYLATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PAW EDEMA; PENICILLIUM MARNEFFEI; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; RAT; STAPHYLOCOCCUS AUREUS; THIN LAYER CHROMATOGRAPHY; TRICHOPHYTON MENTAGROPHYTES;

ANIMALS; ANTI-INFECTIVE AGENTS; CHROMATOGRAPHY, LIQUID; CHROMATOGRAPHY, THIN LAYER; DRUG EVALUATION, PRECLINICAL; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MICROBIAL SENSITIVITY TESTS; OXADIAZOLES;

EID: 77957825924     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.08.039     Document Type: Article

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