Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 8, 2013, Pages 2286-2297

  Du, Qian Ru ^a   Li, Dong Dong ^a   Pi, Ya Zhou ^a   Li, Jing Ran ^a   Sun, Jian ^a   Fang, Fei ^a   Zhong, Wei Qing ^b   Gong, Hai Bin ^c   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

1,3,4 Oxadiazoles; Anticancer activities; Metronidazole; Thymidylate synthase; X ray crystallography

Indexed keywords

1,3,4 OXADIAZOLE THIOETHER DERIVATIVE; 2 (2 CHLOROPYRIDIN 4 YL) 5 [[2 (2 METHYL 5 NITRO 1HIMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOLE; 2 (3,5 DIMETHOXYPHENYL) 5 [[2 (2 METHYL 5-NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOLE; 2 (4 CHLOROPHENYL) 5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOLE; 2 (4 FLUOROPHENYL) 5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOLE; 2 (4 ISOPROPYLPHENYL) 5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOLE; 2 (FURAN 2 YL) 5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOLE; 2 [4 (TERT BUTYL)PHENYL] 5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOLE; 2 [5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOL 2 YL]PHENOL; 2 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL)THIO] 5 (PYRIDIN 4 YL] 1,3,4 OXADIAZOLE; 2 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 5 (NAPHTHALEN 1 YL) 1,3,4 OXADIAZOLE; 2 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 5 (NAPHTHALEN 2 YL) 1,3,4 OXADIAZOLE; 2 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 5 (PYRIDIN 2 YL) 1,3,4 OXADIAZOLE; 2 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 5 (THIOPHEN 2 YL) 1,3,4 OXADIAZOLE; 2 [[2 (2 METHYL 5 NITRO 1H-IMIDAZOL 1 YL)ETHYL]THIO] 5 (3,4,5 TRIMETHOXYPHENYL) 1,3,4 OXADIAZOLE; 2 METHYL 6 [5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOL 2 YL]PHENOL; 4 [5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOL 2 YL]PYRIDIN 2 AMINE; 5 [5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOL 2 YL]PYRIDIN-2-AMINE; 5 METHOXY 2 [5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOL 2 YL]PHENOL; 5 METHYL 2 [5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOL 2 YL]PHENOL; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; FLUOROURACIL; N,N DIMETHYL 4 [5 [[2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]THIO] 1,3,4 OXADIAZOL 2 YL]ANILINE; PEMETREXED; RALTITREXED; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL STRAIN; CANCER CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG TARGETING; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; OXADIAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; THYMIDYLATE SYNTHASE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 84875734003     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.02.008     Document Type: Article

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