Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4316-4322

  Li, Yao ^a   Luo, Yin ^a   Hu, Yang ^a   Zhu, Di Di ^a   Zhang, Shuai ^a   Liu, Zhi Jun ^a   Gong, Hai Bin ^b   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

Antibacterial activities; FabH inhibitors; Nitroimidazole; Oxadiazole

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 2 (2 METHOXYBENZYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (2 METHOXYPHENYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (3 BROMOBENZYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (3 BROMOPHENYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (3 FLUOROBENZYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (3 FLUOROPHENYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (3 METHOXYBENZYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (3 METHOXYPHENYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (4 BROMOBENZYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (4 BROMOPHENYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (4 CHLOROBENZYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (4 CHLOROPHENYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (4 FLUOROBENZYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 (4 FLUOROPHENYL) 5 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 1,3,4 OXADIAZOLE; 2 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 5 (2 METHYLBENZYL) 1,3,4 OXADIAZOLE; 2 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 5 (4 NITROBENZYL) 1,3,4 OXADIAZOLE; 2 [(2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)METHYL] 5 (4 NITROPHENYL) 1,3,4 OXADIAZOLE; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; KANAMYCIN; MOLECULAR SCAFFOLD; NITROIMIDAZOLE DERIVATIVE; SECNIDAZOLE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACETYLTRANSFERASES; ANTI-INFECTIVE AGENTS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FATTY ACID SYNTHETASE COMPLEX, TYPE II; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; NITROIMIDAZOLES; OXADIAZOLES; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 84863217489     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.050     Document Type: Article

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