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Volumn 61, Issue 7, 2012, Pages 1895-1902

Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 finnish men

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GLUCOSE; GLUTAMINE; HISTIDINE; INSULIN; ISOLEUCINE; LEUCINE; MESSENGER RNA; TYROSINE;

EID: 84863205594     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1378     Document Type: Article
Times cited : (217)

References (50)
  • 1
    • 0016419551 scopus 로고
    • Amino acid metabolism in man
    • Felig P. Amino acid metabolism in man. Annu Rev Biochem 1975;44:933-955
    • (1975) Annu Rev Biochem , vol.44 , pp. 933-955
    • Felig, P.1
  • 2
    • 0017341329 scopus 로고
    • Regulation by insulin of amino acid release and protein turnover in the perfused rat hemicorpus
    • Jefferson LS, Li JB, Rannels SR. Regulation by insulin of amino acid release and protein turnover in the perfused rat hemicorpus. J Biol Chem 1977;252:1476-1483 (Pubitemid 8047757)
    • (1977) Journal of Biological Chemistry , vol.252 , Issue.4 , pp. 1476-1483
    • Jefferson, L.S.1    Li, J.B.2    Rannels, S.R.3
  • 3
    • 0032932849 scopus 로고    scopus 로고
    • Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise
    • DOI 10.2337/diabetes.48.5.949
    • Biolo G, Williams BD, Fleming RY, Wolfe RR. Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise. Diabetes 1999;48:949-957 (Pubitemid 29226339)
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 949-957
    • Biolo, G.1    Williams, B.D.2    Fleming, R.Y.D.3    Wolfe, R.R.4
  • 6
    • 63449111894 scopus 로고    scopus 로고
    • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
    • Newgard CB, An J, Bain JR, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009;9:311-326
    • (2009) Cell Metab , vol.9 , pp. 311-326
    • Newgard, C.B.1    An, J.2    Bain, J.R.3
  • 7
    • 24744457955 scopus 로고    scopus 로고
    • Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein activity
    • Doi M, Yamaoka I, Nakayama M, Mochizuki S, Sugahara K, Yoshizawa F. Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity. J Nutr 2005;135:2103-2108 (Pubitemid 41298372)
    • (2005) Journal of Nutrition , vol.135 , Issue.9 , pp. 2103-2108
    • Doi, M.1    Yamaoka, I.2    Nakayama, M.3    Mochizuki, S.4    Sugahara, K.5    Yoshizawa, F.6
  • 8
    • 34447574828 scopus 로고    scopus 로고
    • Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis
    • DOI 10.1152/ajpendo.00609.2006
    • Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F. Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 2007;292:E1683-E1693 (Pubitemid 47084704)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.292 , Issue.6
    • Doi, M.1    Yamaoka, I.2    Nakayama, M.3    Sugahara, K.4    Yoshizawa, F.5
  • 11
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • Wang TJ, Larson MG, Vasan RS, et al. Metabolite profiles and the risk of developing diabetes. Nat Med 2011;17:448-453
    • (2011) Nat Med , vol.17 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3
  • 12
    • 74749092317 scopus 로고    scopus 로고
    • Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes
    • Menge BA, Schrader H, Ritter PR, et al. Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes. Regul Pept 2010;160:75-80
    • (2010) Regul Pept , vol.160 , pp. 75-80
    • Menge, B.A.1    Schrader, H.2    Ritter, P.R.3
  • 13
    • 78650732495 scopus 로고    scopus 로고
    • Plasma metabolomic profiles reflective of glucose homeostasis in nondiabetic and type 2 diabetic obese African-American women
    • Fiehn O, Garvey WT, Newman JW, Lok KH, Hoppel CL, Adams SH. Plasma metabolomic profiles reflective of glucose homeostasis in nondiabetic and type 2 diabetic obese African-American women. PLoS ONE 2010;5:e15234
    • (2010) PLoS ONE , vol.5
    • Fiehn, O.1    Garvey, W.T.2    Newman, J.W.3    Lok, K.H.4    Hoppel, C.L.5    Adams, S.H.6
  • 14
    • 0026519615 scopus 로고
    • Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: Role of amino acid availability
    • Flakoll PJ, Wentzel LS, Rice DE, Hill JO, Abumrad NN. Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: role of amino acid availability. Diabetologia 1992;35:357-366
    • (1992) Diabetologia , vol.35 , pp. 357-366
    • Flakoll, P.J.1    Wentzel, L.S.2    Rice, D.E.3    Hill, J.O.4    Abumrad, N.N.5
  • 15
    • 0023579118 scopus 로고
    • Decreased uptake of glucose by human forearm during infusion of leucine, isoleucine, or threonine
    • Schwenk WF, Haymond MW. Decreased uptake of glucose by human forearm during infusion of leucine, isoleucine, or threonine. Diabetes 1987;36:199-204 (Pubitemid 18025321)
    • (1987) Diabetes , vol.36 , Issue.2 , pp. 199-204
    • Schwenk, W.F.1    Haymond, M.W.2
  • 16
    • 0026025025 scopus 로고
    • The effects of euglycemic hyperinsulinemia and amino acid infusion on regional and whole body glucose disposal in man
    • Pisters PW, Restifo NP, Cersosimo E, Brennan MF. The effects of euglycemic hyperinsulinemia and amino acid infusion on regional and whole body glucose disposal in man. Metabolism 1991;40:59-65
    • (1991) Metabolism , vol.40 , pp. 59-65
    • Pisters, P.W.1    Restifo, N.P.2    Cersosimo, E.3    Brennan, M.F.4
  • 17
    • 0026635421 scopus 로고
    • Effects of infused amino acids on glucose production and utilization in healthy human subjects
    • Tappy L, Acheson K, Normand S, et al. Effects of infused amino acids on glucose production and utilization in healthy human subjects. Am J Physiol 1992;262:E826-E833
    • (1992) Am J Physiol , vol.262
    • Tappy, L.1    Acheson, K.2    Normand, S.3
  • 18
    • 69549097700 scopus 로고    scopus 로고
    • Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women
    • Huffman KM, Shah SH, Stevens RD, et al. Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care 2009;32:1678-1683
    • (2009) Diabetes Care , vol.32 , pp. 1678-1683
    • Huffman, K.M.1    Shah, S.H.2    Stevens, R.D.3
  • 19
    • 79959453305 scopus 로고    scopus 로고
    • Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism
    • Macotela Y, Emanuelli B, Bång AM, et al. Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS ONE 2011;6:e21187
    • (2011) PLoS ONE , vol.6
    • Macotela, Y.1    Emanuelli, B.2    Bång, A.M.3
  • 20
    • 31544440119 scopus 로고    scopus 로고
    • Potential importance of leucine in treatment of obesity and the metabolic syndrome
    • Layman DK, Walker DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr 2006;136(Suppl.):319S-323S (Pubitemid 43156532)
    • (2006) Journal of Nutrition , vol.136 , Issue.1
    • Layman, D.K.1    Walker, D.A.2
  • 21
    • 0028117586 scopus 로고
    • Protein content of the diabetic diet
    • Henry RR. Protein content of the diabetic diet. Diabetes Care 1994;17:1502-1513 (Pubitemid 24369743)
    • (1994) Diabetes Care , vol.17 , Issue.12 , pp. 1502-1513
    • Henry, R.R.1
  • 23
    • 63349087565 scopus 로고    scopus 로고
    • Genome-wide association studies in type 2 diabetes
    • McCarthy MI, Zeggini E. Genome-wide association studies in type 2 diabetes. Curr Diab Rep 2009;9:164-171
    • (2009) Curr Diab Rep , vol.9 , pp. 164-171
    • McCarthy, M.I.1    Zeggini, E.2
  • 24
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • DIAGRAM Consortium; GIANT Consortium; Global BPgen Consortium; Anders Hamsten on behalf of Procardis Consortium; MAGIC investigators
    • Dupuis J, Langenberg C, Prokopenko I, et al.; DIAGRAM Consortium; GIANT Consortium; Global BPgen Consortium; Anders Hamsten on behalf of Procardis Consortium; MAGIC investigators. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010;42:105-116
    • (2010) Nat Genet , vol.42 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3
  • 25
    • 75749091912 scopus 로고    scopus 로고
    • Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    • GIANT consortium; MAGIC investigators
    • Saxena R, Hivert MF, Langenberg C, et al.; GIANT consortium; MAGIC investigators. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010;42:142-148
    • (2010) Nat Genet , vol.42 , pp. 142-148
    • Saxena, R.1    Hivert, M.F.2    Langenberg, C.3
  • 26
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    • MAGIC investigators; GIANT Consortium
    • Voight BF, Scott LJ, Steinthorsdottir V, et al.; MAGIC investigators; GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010;42:579-589
    • (2010) Nat Genet , vol.42 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3
  • 27
    • 65549163338 scopus 로고    scopus 로고
    • Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
    • Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M. Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes 2009;58:1212-1221
    • (2009) Diabetes , vol.58 , pp. 1212-1221
    • Stancáková, A.1    Javorský, M.2    Kuulasmaa, T.3    Haffner, S.M.4    Kuusisto, J.5    Laakso, M.6
  • 28
    • 0242300698 scopus 로고    scopus 로고
    • Follow-up report on the diagnosis of diabetes mellitus
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • Genuth S, Alberti KG, Bennett P, et al.; Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003;26:3160-3167
    • (2003) Diabetes Care , vol.26 , pp. 3160-3167
    • Genuth, S.1    Alberti, K.G.2    Bennett, P.3
  • 29
    • 70349324702 scopus 로고    scopus 로고
    • High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism
    • Lond
    • Soininen P, Kangas AJ, Würtz P, et al. High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst (Lond) 2009;134:1781-1785
    • (2009) Analyst , vol.134 , pp. 1781-1785
    • Soininen, P.1    Kangas, A.J.2    Würtz, P.3
  • 30
    • 78650665228 scopus 로고    scopus 로고
    • Metabonomic, transcriptomic, and genomic variation of a population cohort
    • Inouye M, Kettunen J, Soininen P, et al. Metabonomic, transcriptomic, and genomic variation of a population cohort. Mol Syst Biol 2010;6:441
    • (2010) Mol Syst Biol , vol.6 , pp. 441
    • Inouye, M.1    Kettunen, J.2    Soininen, P.3
  • 31
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
    • DOI 10.2337/diacare.22.9.1462
    • Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-1470 (Pubitemid 29418240)
    • (1999) Diabetes Care , vol.22 , Issue.9 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 32
    • 77951221352 scopus 로고    scopus 로고
    • A re-annotation pipeline for Illumina BeadArrays: Improving the interpretation of gene expression data
    • Barbosa-Morais NL, Dunning MJ, Samarajiwa SA, et al. A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data. Nucleic Acids Res 2010;38:e17
    • (2010) Nucleic Acids Res , vol.38
    • Barbosa-Morais, N.L.1    Dunning, M.J.2    Samarajiwa, S.A.3
  • 33
    • 78650483491 scopus 로고    scopus 로고
    • Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips
    • Shi W, Oshlack A, Smyth GK. Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips. Nucleic Acids Res 2010;38:e204
    • (2010) Nucleic Acids Res , vol.38
    • Shi, W.1    Oshlack, A.2    Smyth, G.K.3
  • 34
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995;57:289-300
    • (1995) J R Stat Soc Ser B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 35
    • 49449083937 scopus 로고    scopus 로고
    • Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
    • Shaham O, Wei R, Wang TJ, et al. Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol 2008;4:214
    • (2008) Mol Syst Biol , vol.4 , pp. 214
    • Shaham, O.1    Wei, R.2    Wang, T.J.3
  • 36
    • 0029924108 scopus 로고    scopus 로고
    • Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity
    • Luzi L, Castellino P, DeFronzo RA. Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity. Am J Physiol 1996;270:E273-E281
    • (1996) Am J Physiol , vol.270
    • Luzi, L.1    Castellino, P.2    DeFronzo, R.A.3
  • 37
    • 0016166002 scopus 로고
    • Metabolic fate of leucine: A significant sterol precursor in adipose tissue and muscle
    • Rosenthal J, Angel A, Farkas J. Metabolic fate of leucine: a significant sterol precursor in adipose tissue and muscle. Am J Physiol 1974;226:411-418
    • (1974) Am J Physiol , vol.226 , pp. 411-418
    • Rosenthal, J.1    Angel, A.2    Farkas, J.3
  • 39
    • 45849128681 scopus 로고    scopus 로고
    • Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus
    • Kuzuya T, Katano Y, Nakano I, et al. Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus. Biochem Biophys Res Commun 2008;373:94-98
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 94-98
    • Kuzuya, T.1    Katano, Y.2    Nakano, I.3
  • 42
    • 0032988976 scopus 로고    scopus 로고
    • Role of glutamine in human carbohydrate metabolism in kidney and other tissues
    • DOI 10.1046/j.1523-1755.1999.055003778.x
    • Stumvoll M, Perriello G, Meyer C, Gerich J. Role of glutamine in human carbohydrate metabolism in kidney and other tissues. Kidney Int 1999;55:778-792 (Pubitemid 29100691)
    • (1999) Kidney International , vol.55 , Issue.3 , pp. 778-792
    • Stumvoll, M.1    Perriello, G.2    Meyer, C.3    Gerich, J.4
  • 43
    • 0029330329 scopus 로고
    • Regulation of gut glutamine metabolism: Role of hormones and cytokines
    • Abumrad NN, Kim S, Molina PE. Regulation of gut glutamine metabolism: role of hormones and cytokines. Proc Nutr Soc 1995l;54:525-533
    • (1995) Proc Nutr Soc , vol.54 , pp. 525-533
    • Abumrad, N.N.1    Kim, S.2    Molina, P.E.3
  • 44
    • 0030941820 scopus 로고    scopus 로고
    • Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study
    • Perseghin G, Ghosh S, Gerow K, Shulman GI. Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study. Diabetes 1997;46:1001-1009 (Pubitemid 27221001)
    • (1997) Diabetes , vol.46 , Issue.6 , pp. 1001-1009
    • Perseghin, G.1    Ghosh, S.2    Gerow, K.3    Shulman, G.I.4
  • 45
    • 0034616107 scopus 로고    scopus 로고
    • The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte
    • DOI 10.1074/jbc.275.14.10597
    • de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L. The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte. J Biol Chem 2000;275:10597-10603 (Pubitemid 30202126)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.14 , pp. 10597-10603
    • De La, I.N.1    Mukhtar, M.2    Seoane, J.3    Guinovart, J.J.4    Agius, L.5
  • 46
    • 50949132578 scopus 로고    scopus 로고
    • The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population
    • DESIR Study Group
    • Vaxillaire M, Cavalcanti-Proença C, Dechaume A, et al.; DESIR Study Group. The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Diabetes 2008;57:2253-2257
    • (2008) Diabetes , vol.57 , pp. 2253-2257
    • Vaxillaire, M.1    Cavalcanti-Proença, C.2    Dechaume, A.3
  • 48
    • 77951858557 scopus 로고    scopus 로고
    • Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans
    • MAGIC investigators
    • Ingelsson E, Langenberg C, Hivert MF, et al.; MAGIC investigators. Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes 2010;59:1266-1275
    • (2010) Diabetes , vol.59 , pp. 1266-1275
    • Ingelsson, E.1    Langenberg, C.2    Hivert, M.F.3
  • 49
    • 84856733126 scopus 로고    scopus 로고
    • Cellular characterization of the GCKR P446L variant associated with type 2 diabetes risk
    • Rees MG, Wincovitch S, Schultz J, et al. Cellular characterization of the GCKR P446L variant associated with type 2 diabetes risk. Diabetologia 2011;55:114-22
    • (2011) Diabetologia , vol.55 , pp. 114-122
    • Rees, M.G.1    Wincovitch, S.2    Schultz, J.3
  • 50
    • 79960895140 scopus 로고    scopus 로고
    • Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    • Kilpeläinen TO, Zillikens MC, Stančákova A, et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet 2011;43:753-760
    • (2011) Nat Genet , vol.43 , pp. 753-760
    • Kilpeläinen, T.O.1    Zillikens, M.C.2    Stančákova, A.3


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