-
1
-
-
0031465594
-
TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis
-
doi: 10.1074/jbc.272.51.32401
-
Chicheportiche Y, Bourdon PR, Xu H, Hsu Y, Scott H, Hession C, et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem (1997) 272:32401-10. doi: 10.1074/jbc.272.51.32401
-
(1997)
J Biol Chem
, vol.272
, pp. 32401-32410
-
-
Chicheportiche, Y.1
Bourdon, P.R.2
Xu, H.3
Hsu, Y.4
Scott, H.5
Hession, C.6
-
2
-
-
18244380611
-
A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis
-
doi:10.1016/S1074-7613(01)00232-1
-
Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner V, et al. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity (2001) 15:837-46. doi:10.1016/S1074-7613(01)00232-1
-
(2001)
Immunity
, vol.15
, pp. 837-846
-
-
Wiley, S.R.1
Cassiano, L.2
Lofton, T.3
Davis-Smith, T.4
Winkles, J.A.5
Lindner, V.6
-
3
-
-
0032752353
-
The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration
-
doi:10.1074/jbc.274.46.33166
-
Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SY, Peifley KA, et al. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem (1999) 274:33166-76. doi:10.1074/jbc.274.46.33166
-
(1999)
J Biol Chem
, vol.274
, pp. 33166-33176
-
-
Meighan-Mantha, R.L.1
Hsu, D.K.2
Guo, Y.3
Brown, S.A.4
Feng, S.Y.5
Peifley, K.A.6
-
4
-
-
0033843466
-
The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas
-
doi:10.1016/S0002-9440(10)64996-6
-
Feng SY, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, et al. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. Am J Pathol (2000) 156:1253-61. doi:10.1016/S0002-9440(10)64996-6
-
(2000)
Am J Pathol
, vol.156
, pp. 1253-1261
-
-
Feng, S.Y.1
Guo, Y.2
Factor, V.M.3
Thorgeirsson, S.S.4
Bell, D.W.5
Testa, J.R.6
-
5
-
-
33744944082
-
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human
-
doi:10.1074/jbc.M601553200
-
Bossen C, Ingold K, Tardivel A, Bodmer JL, Gaide O, Hertig S, et al. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem (2006) 281:13964-71. doi:10.1074/jbc.M601553200
-
(2006)
J Biol Chem
, vol.281
, pp. 13964-13971
-
-
Bossen, C.1
Ingold, K.2
Tardivel, A.3
Bodmer, J.L.4
Gaide, O.5
Hertig, S.6
-
6
-
-
42949160019
-
The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting
-
doi:10.1038/nrd2488
-
Winkles JA. The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting. Nat Rev Drug Discov (2008) 7:411-25. doi:10.1038/nrd2488
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 411-425
-
-
Winkles, J.A.1
-
7
-
-
80054865852
-
TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses
-
doi:10.1111/j.1600-065X.2011.01054.x
-
Burkly LC, Michaelson JS, Zheng TS. TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses. Immunol Rev (2011) 244:99-114. doi:10.1111/j.1600-065X.2011.01054.x
-
(2011)
Immunol Rev
, vol.244
, pp. 99-114
-
-
Burkly, L.C.1
Michaelson, J.S.2
Zheng, T.S.3
-
8
-
-
33750300516
-
Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and NF-kappaB and correlate with poor patient outcome
-
doi:10.1158/0008-5472.CAN-06-0418
-
Tran NL, McDonough WS, Savitch BA, Fortin SP, Winkles JA, Symons M, et al. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and NF-kappaB and correlate with poor patient outcome. Cancer Res (2006) 66:9535-42. doi:10.1158/0008-5472.CAN-06-0418
-
(2006)
Cancer Res
, vol.66
, pp. 9535-9542
-
-
Tran, N.L.1
McDonough, W.S.2
Savitch, B.A.3
Fortin, S.P.4
Winkles, J.A.5
Symons, M.6
-
9
-
-
74549220324
-
Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms
-
doi:10.1158/1078-0432.CCR-09-1929
-
Culp PA, Choi D, Zhang Y, Yin J, Seto P, Ybarra SE, et al. Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms. Clin Cancer Res (2010) 16:497-508. doi:10.1158/1078-0432.CCR-09-1929
-
(2010)
Clin Cancer Res
, vol.16
, pp. 497-508
-
-
Culp, P.A.1
Choi, D.2
Zhang, Y.3
Yin, J.4
Seto, P.5
Ybarra, S.E.6
-
10
-
-
84862698136
-
Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion
-
doi:10.1016/j.ajpath.2012.03.026
-
Whitsett TG, Cheng E, Inge L, Asrani K, Jameson NM, Hostetter G, et al. Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. Am J Pathol (2012) 181:111-20. doi:10.1016/j.ajpath.2012.03.026
-
(2012)
Am J Pathol
, vol.181
, pp. 111-120
-
-
Whitsett, T.G.1
Cheng, E.2
Inge, L.3
Asrani, K.4
Jameson, N.M.5
Hostetter, G.6
-
11
-
-
84875219244
-
The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma treatment
-
doi:10.1038/jid.2012.402
-
Zhou H, Ekmekcioglu S, Marks JW, Mohamedali KA, Asrani K, Phillips KK, et al. The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma treatment. J Invest Dermatol (2013) 133:1052-62. doi:10.1038/jid.2012.402
-
(2013)
J Invest Dermatol
, vol.133
, pp. 1052-1062
-
-
Zhou, H.1
Ekmekcioglu, S.2
Marks, J.W.3
Mohamedali, K.A.4
Asrani, K.5
Phillips, K.K.6
-
12
-
-
84875000590
-
Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb
-
doi:10.1007/s00432-012-1332-x
-
Chao DT, Su M, Tanlimco S, Sho M, Choi D, Fox M, et al. Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb. J Cancer Res Clin Oncol (2013) 139:315-25. doi:10.1007/s00432-012-1332-x
-
(2013)
J Cancer Res Clin Oncol
, vol.139
, pp. 315-325
-
-
Chao, D.T.1
Su, M.2
Tanlimco, S.3
Sho, M.4
Choi, D.5
Fox, M.6
-
13
-
-
84882702583
-
Roles of fibroblast growth factor-inducible 14 in hepatocellular carcinoma
-
doi:10.7314/APJCP.2013.14.6.3509
-
Li N, Hu WJ, Shi J, Xue J, Guo WX, Zhang Y, et al. Roles of fibroblast growth factor-inducible 14 in hepatocellular carcinoma. Asian Pac J Cancer Prev (2013) 14:3509-14. doi:10.7314/APJCP.2013.14.6.3509
-
(2013)
Asian Pac J Cancer Prev
, vol.14
, pp. 3509-3514
-
-
Li, N.1
Hu, W.J.2
Shi, J.3
Xue, J.4
Guo, W.X.5
Zhang, Y.6
-
14
-
-
84874618380
-
Functional expression of TWEAK and the receptor Fn14 in human malignant ovarian tumors: possible implication for ovarian tumor intervention
-
doi:10.1371/journal.pone.0057436
-
Gu L, Dai L, Cao C, Zhu J, Ding C, Xu HB, et al. Functional expression of TWEAK and the receptor Fn14 in human malignant ovarian tumors: possible implication for ovarian tumor intervention. PLoS One (2013) 8:e57436. doi:10.1371/journal.pone.0057436
-
(2013)
PLoS One
, vol.8
-
-
Gu, L.1
Dai, L.2
Cao, C.3
Zhu, J.4
Ding, C.5
Xu, H.B.6
-
15
-
-
77952892382
-
Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway
-
doi:10.1074/jbc.M110.131979
-
Brown SA, Ghosh A, Winkles JA. Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. J Biol Chem (2010) 285:17432-41. doi:10.1074/jbc.M110.131979
-
(2010)
J Biol Chem
, vol.285
, pp. 17432-17441
-
-
Brown, S.A.1
Ghosh, A.2
Winkles, J.A.3
-
16
-
-
77956406117
-
Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappaB pathway
-
doi:10.4049/jimmunol.0903555
-
Roos C, Wicovsky A, Muller N, Salzmann S, Rosenthal T, Kalthoff H, et al. Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappaB pathway. J Immunol (2010) 185:1593-605. doi:10.4049/jimmunol.0903555
-
(2010)
J Immunol
, vol.185
, pp. 1593-1605
-
-
Roos, C.1
Wicovsky, A.2
Muller, N.3
Salzmann, S.4
Rosenthal, T.5
Kalthoff, H.6
-
17
-
-
84858627919
-
Cellular inhibitors of apoptosis are global regulators of NF-kappaB and MAPK activation by members of the TNF family of receptors
-
doi:10.1126/scisignal.2001878
-
Varfolomeev E, Goncharov T, Maecker H, Zobel K, Komuves LG, Deshayes K, et al. Cellular inhibitors of apoptosis are global regulators of NF-kappaB and MAPK activation by members of the TNF family of receptors. Sci Signal (2012) 5:ra22. doi:10.1126/scisignal.2001878
-
(2012)
Sci Signal
, vol.5
-
-
Varfolomeev, E.1
Goncharov, T.2
Maecker, H.3
Zobel, K.4
Komuves, L.G.5
Deshayes, K.6
-
18
-
-
35348860287
-
Identification of Fn14/TWEAK receptor as a potential therapeutic target in esophageal adenocarcinoma
-
doi:10.1002/ijc.22898
-
Watts GS, Tran NL, Berens ME, Bhattacharyya AK, Nelson MA, Montgomery EA, et al. Identification of Fn14/TWEAK receptor as a potential therapeutic target in esophageal adenocarcinoma. Int J Cancer (2007) 121:2132-9. doi:10.1002/ijc.22898
-
(2007)
Int J Cancer
, vol.121
, pp. 2132-2139
-
-
Watts, G.S.1
Tran, N.L.2
Berens, M.E.3
Bhattacharyya, A.K.4
Nelson, M.A.5
Montgomery, E.A.6
-
19
-
-
51049115805
-
The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity
-
doi:10.1158/1541-7786.MCR-08-0005
-
Willis AL, Tran NL, Chatigny JM, Charlton N, Vu H, Brown SA, et al. The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity. Mol Cancer Res (2008) 6:725-34. doi:10.1158/1541-7786.MCR-08-0005
-
(2008)
Mol Cancer Res
, vol.6
, pp. 725-734
-
-
Willis, A.L.1
Tran, N.L.2
Chatigny, J.M.3
Charlton, N.4
Vu, H.5
Brown, S.A.6
-
20
-
-
80755144050
-
Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome
-
doi:10.1093/carcin/bgr182
-
Huang M, Narita S, Tsuchiya N, Ma Z, Numakura K, Obara T, et al. Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome. Carcinogenesis (2011) 32:1589-96. doi:10.1093/carcin/bgr182
-
(2011)
Carcinogenesis
, vol.32
, pp. 1589-1596
-
-
Huang, M.1
Narita, S.2
Tsuchiya, N.3
Ma, Z.4
Numakura, K.5
Obara, T.6
-
21
-
-
84878668685
-
TWEAK-independent Fn14 self-association and NF-kappaB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domain
-
doi:10.1371/journal.pone.0065248
-
Brown SA, Cheng E, Williams MS, Winkles JA. TWEAK-independent Fn14 self-association and NF-kappaB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domain. PLoS One (2013) 8:e65248. doi:10.1371/journal.pone.0065248
-
(2013)
PLoS One
, vol.8
-
-
Brown, S.A.1
Cheng, E.2
Williams, M.S.3
Winkles, J.A.4
-
22
-
-
0037377706
-
The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors
-
doi:10.1016/S0002-9440(10)63927-2
-
Tran NL, McDonough WS, Donohue PJ, Winkles JA, Berens TJ, Ross KR, et al. The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors. Am J Pathol (2003) 162:1313-21. doi:10.1016/S0002-9440(10)63927-2
-
(2003)
Am J Pathol
, vol.162
, pp. 1313-1321
-
-
Tran, N.L.1
McDonough, W.S.2
Donohue, P.J.3
Winkles, J.A.4
Berens, T.J.5
Ross, K.R.6
-
23
-
-
28344457483
-
TWEAK attenuates the transition from innate to adaptive immunity
-
doi:10.1016/j.cell.2005.09.022
-
Maecker H, Varfolomeev E, Kischkel F, Lawrence D, LeBlanc H, Lee W, et al. TWEAK attenuates the transition from innate to adaptive immunity. Cell (2005) 123:931-44. doi:10.1016/j.cell.2005.09.022
-
(2005)
Cell
, vol.123
, pp. 931-944
-
-
Maecker, H.1
Varfolomeev, E.2
Kischkel, F.3
Lawrence, D.4
LeBlanc, H.5
Lee, W.6
-
24
-
-
31144452060
-
Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells
-
Campbell S, Burkly LC, Gao HX, Berman JW, Su L, Browning B, et al. Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells. J Immunol (2006) 176:1889-98.
-
(2006)
J Immunol
, vol.176
, pp. 1889-1898
-
-
Campbell, S.1
Burkly, L.C.2
Gao, H.X.3
Berman, J.W.4
Su, L.5
Browning, B.6
-
25
-
-
24644478033
-
TWEAK induces liver progenitor cell proliferation
-
doi:10.1172/JCI23486
-
Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, et al. TWEAK induces liver progenitor cell proliferation. J Clin Invest (2005) 115:2330-40. doi:10.1172/JCI23486
-
(2005)
J Clin Invest
, vol.115
, pp. 2330-2340
-
-
Jakubowski, A.1
Ambrose, C.2
Parr, M.3
Lincecum, J.M.4
Wang, M.Z.5
Zheng, T.S.6
-
26
-
-
79954449374
-
The TWEAK/Fn14 pathway in tissue remodeling: for better or for worse
-
doi:10.1007/978-1-4419-6612-4_32
-
Burkly LC, Dohi T. The TWEAK/Fn14 pathway in tissue remodeling: for better or for worse. Adv Exp Med Biol (2011) 691:305-22. doi:10.1007/978-1-4419-6612-4_32
-
(2011)
Adv Exp Med Biol
, vol.691
, pp. 305-322
-
-
Burkly, L.C.1
Dohi, T.2
-
27
-
-
84864749264
-
The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases
-
doi:10.1189/jlb.0112042
-
Dohi T, Burkly LC. The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases. J Leukoc Biol (2012) 92:265-79. doi:10.1189/jlb.0112042
-
(2012)
J Leukoc Biol
, vol.92
, pp. 265-279
-
-
Dohi, T.1
Burkly, L.C.2
-
28
-
-
84885115695
-
The TWEAK-Fn14 system as a potential drug target
-
doi:10.1111/bph.12337
-
Wajant H. The TWEAK-Fn14 system as a potential drug target. Br J Pharmacol (2013) 170:748-64. doi:10.1111/bph.12337
-
(2013)
Br J Pharmacol
, vol.170
, pp. 748-764
-
-
Wajant, H.1
-
29
-
-
47949099098
-
Origin and physiological roles of inflammation
-
doi:10.1038/nature07201
-
Medzhitov R. Origin and physiological roles of inflammation. Nature (2008) 454:428-35. doi:10.1038/nature07201
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
-
30
-
-
66749134594
-
Targeting innate immunity protein kinase signalling in inflammation
-
doi:10.1038/nrd2829
-
Gaestel M, Kotlyarov A, Kracht M. Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Discov (2009) 8:480-99. doi:10.1038/nrd2829
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 480-499
-
-
Gaestel, M.1
Kotlyarov, A.2
Kracht, M.3
-
31
-
-
33749242814
-
Signalling platforms that modulate the inflammatory response: new targets for drug development
-
doi:10.1038/nrd2109
-
McCulloch CA, Downey GP, El-Gabalawy H. Signalling platforms that modulate the inflammatory response: new targets for drug development. Nat Rev Drug Discov (2006) 5:864-76. doi:10.1038/nrd2109
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 864-876
-
-
McCulloch, C.A.1
Downey, G.P.2
El-Gabalawy, H.3
-
33
-
-
72049094072
-
Global and regional causes of death
-
doi:10.1093/bmb/ldp028
-
Mathers CD, Boerma T, Ma FD. Global and regional causes of death. Br Med Bull (2009) 92:7-32. doi:10.1093/bmb/ldp028
-
(2009)
Br Med Bull
, vol.92
, pp. 7-32
-
-
Mathers, C.D.1
Boerma, T.2
Ma, F.D.3
-
34
-
-
77955487488
-
The science of stroke: mechanisms in search of treatments
-
doi:10.1016/j.neuron.2010.07.002
-
Moskowitz MA, Lo EH, Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron (2010) 67:181-98. doi:10.1016/j.neuron.2010.07.002
-
(2010)
Neuron
, vol.67
, pp. 181-198
-
-
Moskowitz, M.A.1
Lo, E.H.2
Iadecola, C.3
-
35
-
-
36249026451
-
TWEAK and the central nervous system
-
doi:10.1007/s12035-007-0024-z
-
Yepes M. TWEAK and the central nervous system. Mol Neurobiol (2007) 35:255-65. doi:10.1007/s12035-007-0024-z
-
(2007)
Mol Neurobiol
, vol.35
, pp. 255-265
-
-
Yepes, M.1
-
36
-
-
4644228323
-
Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration
-
doi:10.1523/JNEUROSCI.1089-04.2004
-
Potrovita I, Zhang W, Burkly L, Hahm K, Lincecum J, Wang MZ, et al. Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration. J Neurosci (2004) 24:8237-44. doi:10.1523/JNEUROSCI.1089-04.2004
-
(2004)
J Neurosci
, vol.24
, pp. 8237-8244
-
-
Potrovita, I.1
Zhang, W.2
Burkly, L.3
Hahm, K.4
Lincecum, J.5
Wang, M.Z.6
-
37
-
-
13244257271
-
A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia
-
doi:10.1016/S0002-9440(10)62273-0
-
Yepes M, Brown SA, Moore EG, Smith EP, Lawrence DA, Winkles JA. A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia. Am J Pathol (2005) 166:511-20. doi:10.1016/S0002-9440(10)62273-0
-
(2005)
Am J Pathol
, vol.166
, pp. 511-520
-
-
Yepes, M.1
Brown, S.A.2
Moore, E.G.3
Smith, E.P.4
Lawrence, D.A.5
Winkles, J.A.6
-
38
-
-
78650175484
-
Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death
-
doi:10.1016/j.neuroscience.2010.10.029
-
Haile WB, Echeverry R, Wu F, Guzman J, An J, Wu J, et al. Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death. Neuroscience (2010) 171:1256-64. doi:10.1016/j.neuroscience.2010.10.029
-
(2010)
Neuroscience
, vol.171
, pp. 1256-1264
-
-
Haile, W.B.1
Echeverry, R.2
Wu, F.3
Guzman, J.4
An, J.5
Wu, J.6
-
39
-
-
55649111573
-
Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke
-
doi:10.1016/j.jns.2008.08.005
-
Inta I, Frauenknecht K, Dorr H, Kohlhof P, Rabsilber T, Auffarth GU, et al. Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke. J Neurol Sci (2008) 275:117-20. doi:10.1016/j.jns.2008.08.005
-
(2008)
J Neurol Sci
, vol.275
, pp. 117-120
-
-
Inta, I.1
Frauenknecht, K.2
Dorr, H.3
Kohlhof, P.4
Rabsilber, T.5
Auffarth, G.U.6
-
40
-
-
33847209525
-
TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia
-
doi:10.1038/sj.jcbfm.9600368
-
Zhang X, Winkles JA, Gongora MC, Polavarapu R, Michaelson JS, Hahm K, et al. TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia. J Cereb Blood Flow Metab (2007) 27:534-44. doi:10.1038/sj.jcbfm.9600368
-
(2007)
J Cereb Blood Flow Metab
, vol.27
, pp. 534-544
-
-
Zhang, X.1
Winkles, J.A.2
Gongora, M.C.3
Polavarapu, R.4
Michaelson, J.S.5
Hahm, K.6
-
41
-
-
27744432820
-
Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through NF-kappaB pathway activation
-
doi:10.1523/JNEUROSCI.3382-05.2005
-
Polavarapu R, Gongora MC, Winkles JA, Yepes M. Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through NF-kappaB pathway activation. J Neurosci (2005) 25:10094-100. doi:10.1523/JNEUROSCI.3382-05.2005
-
(2005)
J Neurosci
, vol.25
, pp. 10094-10100
-
-
Polavarapu, R.1
Gongora, M.C.2
Winkles, J.A.3
Yepes, M.4
-
42
-
-
84859724482
-
Multiple sclerosis
-
doi:10.1172/JCI58649
-
Nylander A, Hafler DA. Multiple sclerosis. J Clin Invest (2012) 122:1180-8. doi:10.1172/JCI58649
-
(2012)
J Clin Invest
, vol.122
, pp. 1180-1188
-
-
Nylander, A.1
Hafler, D.A.2
-
43
-
-
80053300497
-
Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
-
doi:10.1111/j.1476-5381.2011.01302.x
-
Constantinescu CS, Farooqi N, O'Brien K, Gran B. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol (2011) 164:1079-106. doi:10.1111/j.1476-5381.2011.01302.x
-
(2011)
Br J Pharmacol
, vol.164
, pp. 1079-1106
-
-
Constantinescu, C.S.1
Farooqi, N.2
O'Brien, K.3
Gran, B.4
-
44
-
-
84861233384
-
Treatment update in multiple sclerosis
-
doi:10.1007/s11882-012-0256-5
-
Morris K, Yiannikas C. Treatment update in multiple sclerosis. Curr Allergy Asthma Rep (2012) 12:246-54. doi:10.1007/s11882-012-0256-5
-
(2012)
Curr Allergy Asthma Rep
, vol.12
, pp. 246-254
-
-
Morris, K.1
Yiannikas, C.2
-
45
-
-
84894346803
-
A further TWEAK to multiple sclerosis pathophysiology
-
doi: 10.1007/s12035-013-8490-y
-
Nazeri A, Heydarpour P, Sadaghiani S, Sahraian MA, Burkly LC, Bar-Or A. A further TWEAK to multiple sclerosis pathophysiology. Mol Neurobiol (2013). doi:10.1007/s12035-013-8490-y
-
(2013)
Mol Neurobiol
-
-
Nazeri, A.1
Heydarpour, P.2
Sadaghiani, S.3
Sahraian, M.A.4
Burkly, L.C.5
Bar-Or, A.6
-
46
-
-
84864446952
-
Animal models of multiple sclerosis: the good, the bad and the bottom line
-
doi:10.1038/nn.3168
-
Ransohoff RM. Animal models of multiple sclerosis: the good, the bad and the bottom line. Nat Neurosci (2012) 15:1074-7. doi:10.1038/nn.3168
-
(2012)
Nat Neurosci
, vol.15
, pp. 1074-1077
-
-
Ransohoff, R.M.1
-
47
-
-
27244442108
-
Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis
-
doi:10.1016/j.clim.2005.06.005
-
Desplat-Jego S, Creidy R, Varriale S, Allaire N, Luo Y, Bernard D, et al. Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis. Clin Immunol (2005) 117:15-23. doi:10.1016/j.clim.2005.06.005
-
(2005)
Clin Immunol
, vol.117
, pp. 15-23
-
-
Desplat-Jego, S.1
Creidy, R.2
Varriale, S.3
Allaire, N.4
Luo, Y.5
Bernard, D.6
-
48
-
-
12344315245
-
Targeting fibroblast growth factor-inducible-14 signaling protects from chronic relapsing experimental autoimmune encephalomyelitis
-
doi:10.1016/j.jneuroim.2004.10.001
-
Mueller AM, Pedre X, Kleiter I, Hornberg M, Steinbrecher A, Giegerich G. Targeting fibroblast growth factor-inducible-14 signaling protects from chronic relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol (2005) 159:55-65. doi:10.1016/j.jneuroim.2004.10.001
-
(2005)
J Neuroimmunol
, vol.159
, pp. 55-65
-
-
Mueller, A.M.1
Pedre, X.2
Kleiter, I.3
Hornberg, M.4
Steinbrecher, A.5
Giegerich, G.6
-
49
-
-
0036889706
-
TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity
-
doi:10.1016/S0165-5728(02)00368-5
-
Desplat-Jego S, Varriale S, Creidy R, Terra R, Bernard D, Khrestchatisky M, et al. TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity. J Neuroimmunol (2002) 133:116-23. doi:10.1016/S0165-5728(02)00368-5
-
(2002)
J Neuroimmunol
, vol.133
, pp. 116-123
-
-
Desplat-Jego, S.1
Varriale, S.2
Creidy, R.3
Terra, R.4
Bernard, D.5
Khrestchatisky, M.6
-
50
-
-
39849083749
-
TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model
-
doi:10.1016/j.jneuroim.2007.12.003
-
Iocca HA, Plant SR, Wang Y, Runkel L, O'Connor BP, Lundsmith ET, et al. TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model. J Neuroimmunol (2008) 194:97-106. doi:10.1016/j.jneuroim.2007.12.003
-
(2008)
J Neuroimmunol
, vol.194
, pp. 97-106
-
-
Iocca, H.A.1
Plant, S.R.2
Wang, Y.3
Runkel, L.4
O'Connor, B.P.5
Lundsmith, E.T.6
-
51
-
-
58149374594
-
Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: implications for inflammatory tissue injury
-
doi:10.1097/NEN.0b013e31818dab90
-
Serafini B, Magliozzi R, Rosicarelli B, Reynolds R, Zheng TS, Aloisi F. Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: implications for inflammatory tissue injury. J Neuropathol Exp Neurol (2008) 67:1137-48. doi:10.1097/NEN.0b013e31818dab90
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 1137-1148
-
-
Serafini, B.1
Magliozzi, R.2
Rosicarelli, B.3
Reynolds, R.4
Zheng, T.S.5
Aloisi, F.6
-
52
-
-
59649094164
-
Fn14-TRAIL, a chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis
-
doi:10.2353/ajpath.2009.080462
-
Razmara M, Hilliard B, Ziarani AK, Murali R, Yellayi S, Ghazanfar M, et al. Fn14-TRAIL, a chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis. Am J Pathol (2009) 174:460-74. doi:10.2353/ajpath.2009.080462
-
(2009)
Am J Pathol
, vol.174
, pp. 460-474
-
-
Razmara, M.1
Hilliard, B.2
Ziarani, A.K.3
Murali, R.4
Yellayi, S.5
Ghazanfar, M.6
-
53
-
-
0035863835
-
Roles of TNF-related apoptosis-inducing ligand in experimental autoimmune encephalomyelitis
-
Hilliard B, Wilmen A, Seidel C, Liu TS, Goke R, Chen Y. Roles of TNF-related apoptosis-inducing ligand in experimental autoimmune encephalomyelitis. J Immunol (2001) 166:1314-9.
-
(2001)
J Immunol
, vol.166
, pp. 1314-1319
-
-
Hilliard, B.1
Wilmen, A.2
Seidel, C.3
Liu, T.S.4
Goke, R.5
Chen, Y.6
-
54
-
-
84874754790
-
Amelioration of autoimmune neuroinflammation by the fusion molecule Fn14-TRAIL
-
doi:10.1186/1742-2094-10-36
-
Prinz-Hadad H, Mizrachi T, Irony-Tur-Sinai M, Prigozhina TB, Aronin A, Brenner T, et al. Amelioration of autoimmune neuroinflammation by the fusion molecule Fn14-TRAIL. J Neuroinflamm (2013) 10:36. doi:10.1186/1742-2094-10-36
-
(2013)
J Neuroinflamm
, vol.10
, pp. 36
-
-
Prinz-Hadad, H.1
Mizrachi, T.2
Irony-Tur-Sinai, M.3
Prigozhina, T.B.4
Aronin, A.5
Brenner, T.6
-
55
-
-
84870663366
-
When and where does rheumatoid arthritis begin?
-
doi:10.1016/j.jbspin.2012.09.004
-
Schaeverbeke T, Truchetet Mé, Richez C. When and where does rheumatoid arthritis begin? Joint Bone Spine (2012) 79:550-4. doi:10.1016/j.jbspin.2012.09.004
-
(2012)
Joint Bone Spine
, vol.79
, pp. 550-554
-
-
Schaeverbeke, T.1
Truchetet, Mé.2
Richez, C.3
-
56
-
-
84884905188
-
Genetics of rheumatoid arthritis-a comprehensive review
-
doi:10.1007/s12016-012-8346-7
-
Kurkó J, Besenyei T, Laki J, Glant TT, Mikecz K, Szekanecz Z. Genetics of rheumatoid arthritis-a comprehensive review. Clin Rev Allergy Immunol (2013) 45:170-9. doi:10.1007/s12016-012-8346-7
-
(2013)
Clin Rev Allergy Immunol
, vol.45
, pp. 170-179
-
-
Kurkó, J.1
Besenyei, T.2
Laki, J.3
Glant, T.T.4
Mikecz, K.5
Szekanecz, Z.6
-
57
-
-
84863861008
-
Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis
-
doi:10.1093/rheumatology/kes113
-
Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology (2012) 51(Suppl 5):v3-11. doi:10.1093/rheumatology/kes113
-
(2012)
Rheumatology
, vol.51
, Issue.SUPPL. 5
-
-
Choy, E.1
-
58
-
-
84876295703
-
Autoimmunity in rheumatoid arthritis: different antigens-common principles
-
doi:10.1136/annrheumdis-2012-202349
-
Trouw LA, Huizinga TW, Toes RE. Autoimmunity in rheumatoid arthritis: different antigens-common principles. Ann Rheum Dis (2013) 72(Suppl 2):ii132-6. doi:10.1136/annrheumdis-2012-202349
-
(2013)
Ann Rheum Dis
, vol.72
, Issue.SUPPL. 2
-
-
Trouw, L.A.1
Huizinga, T.W.2
Toes, R.E.3
-
59
-
-
84875687447
-
Biologic therapy for autoimmune diseases: an update
-
doi:10.1186/1741-7015-11-88
-
Rosman Z, Shoenfeld Y, Zandman-Goddard G. Biologic therapy for autoimmune diseases: an update. BMC Med (2013) 11:88. doi:10.1186/1741-7015-11-88
-
(2013)
BMC Med
, vol.11
, pp. 88
-
-
Rosman, Z.1
Shoenfeld, Y.2
Zandman-Goddard, G.3
-
60
-
-
73449109162
-
TWEAK and its receptor Fn14 in the synovium of patients with rheumatoid arthritis compared to psoriatic arthritis and its response to tumour necrosis factor blockade
-
doi:10.1136/ard.2008.090548
-
van Kuijk AW, Wijbrandts CA, Vinkenoog M, Zheng TS, Reedquist KA, Tak PP. TWEAK and its receptor Fn14 in the synovium of patients with rheumatoid arthritis compared to psoriatic arthritis and its response to tumour necrosis factor blockade. Ann Rheum Dis (2010) 69:301-4. doi:10.1136/ard.2008.090548
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 301-304
-
-
van Kuijk, A.W.1
Wijbrandts, C.A.2
Vinkenoog, M.3
Zheng, T.S.4
Reedquist, K.A.5
Tak, P.P.6
-
61
-
-
84883185923
-
TWEAK promotes osteoclastogenesis in rheumatoid arthritis
-
doi:10.1016/j.ajpath.2013.05.027
-
Park JS, Kwok SK, Lim MA, Oh HJ, Kim EK, Jhun JY, et al. TWEAK promotes osteoclastogenesis in rheumatoid arthritis. Am J Pathol (2013) 183:857-67. doi:10.1016/j.ajpath.2013.05.027
-
(2013)
Am J Pathol
, vol.183
, pp. 857-867
-
-
Park, J.S.1
Kwok, S.K.2
Lim, M.A.3
Oh, H.J.4
Kim, E.K.5
Jhun, J.Y.6
-
62
-
-
79953093604
-
TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis
-
doi:10.1186/ar3294
-
Dharmapatni AA, Smith MD, Crotti TN, Holding CA, Vincent C, Weedon HM, et al. TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis. Arthritis Res Ther (2011) 13:R51. doi:10.1186/ar3294
-
(2011)
Arthritis Res Ther
, vol.13
-
-
Dharmapatni, A.A.1
Smith, M.D.2
Crotti, T.N.3
Holding, C.A.4
Vincent, C.5
Weedon, H.M.6
-
63
-
-
45549101861
-
Relationship of serum TWEAK level to cytokine level, disease activity, and response to anti-TNF treatment in patients with rheumatoid arthritis
-
doi:10.1080/03009740801898608
-
Park MC, Chung SJ, Park YB, Lee SK. Relationship of serum TWEAK level to cytokine level, disease activity, and response to anti-TNF treatment in patients with rheumatoid arthritis. Scand J Rheumatol (2008) 37:173-8. doi:10.1080/03009740801898608
-
(2008)
Scand J Rheumatol
, vol.37
, pp. 173-178
-
-
Park, M.C.1
Chung, S.J.2
Park, Y.B.3
Lee, S.K.4
-
64
-
-
84865413742
-
TWEAK promotes the production of interleukin-17 in rheumatoid arthritis
-
doi:10.1016/j.cyto.2012.06.285
-
Park JS, Park MK, Lee SY, Oh HJ, Lim MA, Cho WT, et al. TWEAK promotes the production of interleukin-17 in rheumatoid arthritis. Cytokine (2012) 60:143-9. doi:10.1016/j.cyto.2012.06.285
-
(2012)
Cytokine
, vol.60
, pp. 143-149
-
-
Park, J.S.1
Park, M.K.2
Lee, S.Y.3
Oh, H.J.4
Lim, M.A.5
Cho, W.T.6
-
65
-
-
33746890880
-
TWEAK is a novel arthritogenic mediator
-
Perper SJ, Browning B, Burkly LC, Weng S, Gao C, Giza K, et al. TWEAK is a novel arthritogenic mediator. J Immunol (2006) 177:2610-20.
-
(2006)
J Immunol
, vol.177
, pp. 2610-2620
-
-
Perper, S.J.1
Browning, B.2
Burkly, L.C.3
Weng, S.4
Gao, C.5
Giza, K.6
-
66
-
-
43049176840
-
Involvement of TWEAK/Fn14 interaction in the synovial inflammation of RA
-
doi:10.1093/rheumatology/ken006
-
Kamijo S, Nakajima A, Kamata K, Kurosawa H, Yagita H, Okumura K. Involvement of TWEAK/Fn14 interaction in the synovial inflammation of RA. Rheumatology (2008) 47:442-50. doi:10.1093/rheumatology/ken006
-
(2008)
Rheumatology
, vol.47
, pp. 442-450
-
-
Kamijo, S.1
Nakajima, A.2
Kamata, K.3
Kurosawa, H.4
Yagita, H.5
Okumura, K.6
-
67
-
-
33750350777
-
Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis
-
Kamata K, Kamijo S, Nakajima A, Koyanagi A, Kurosawa H, Yagita H, et al. Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis. J Immunol (2006) 177:6433-9.
-
(2006)
J Immunol
, vol.177
, pp. 6433-6439
-
-
Kamata, K.1
Kamijo, S.2
Nakajima, A.3
Koyanagi, A.4
Kurosawa, H.5
Yagita, H.6
-
68
-
-
84882854274
-
Safety, tolerability, pharmacokinetics, and pharmacodynamics of anti-TWEAK monoclonal antibody in patients with rheumatoid arthritis
-
doi:10.1016/j.clinthera.2013.06.008
-
Wisniacki N, Amaravadi L, Galluppi GR, Zheng TS, Zhang R, Kong J, et al. Safety, tolerability, pharmacokinetics, and pharmacodynamics of anti-TWEAK monoclonal antibody in patients with rheumatoid arthritis. Clin Ther (2013) 35:1137-49. doi:10.1016/j.clinthera.2013.06.008
-
(2013)
Clin Ther
, vol.35
, pp. 1137-1149
-
-
Wisniacki, N.1
Amaravadi, L.2
Galluppi, G.R.3
Zheng, T.S.4
Zhang, R.5
Kong, J.6
-
69
-
-
84871505213
-
Unmet medical needs in systemic lupus erythematosus
-
doi:10.1186/ar3919
-
Lateef A, Petri M. Unmet medical needs in systemic lupus erythematosus. Arthritis Res Ther (2012) 14(Suppl 4):S4. doi:10.1186/ar3919
-
(2012)
Arthritis Res Ther
, vol.14
, Issue.SUPPL. 4
-
-
Lateef, A.1
Petri, M.2
-
70
-
-
84862016703
-
Taming lupus-a new understanding of pathogenesis is leading to clinical advances
-
doi:10.1038/nm.2752
-
Liu Z, Davidson A. Taming lupus-a new understanding of pathogenesis is leading to clinical advances. Nat Med (2012) 18:871-82. doi:10.1038/nm.2752
-
(2012)
Nat Med
, vol.18
, pp. 871-882
-
-
Liu, Z.1
Davidson, A.2
-
71
-
-
84865391444
-
Role of TWEAK in lupus nephritis: a bench-to-bedside review
-
doi:10.1016/j.jaut.2012.05.003
-
Michaelson JS, Wisniacki N, Burkly LC, Putterman C. Role of TWEAK in lupus nephritis: a bench-to-bedside review. J Autoimmun (2012) 39:130-42. doi:10.1016/j.jaut.2012.05.003
-
(2012)
J Autoimmun
, vol.39
, pp. 130-142
-
-
Michaelson, J.S.1
Wisniacki, N.2
Burkly, L.C.3
Putterman, C.4
-
72
-
-
0037111246
-
The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells
-
Kaplan MJ, Lewis EE, Shelden EA, Somers E, Pavlic R, McCune WJ, et al. The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells. J Immunol (2002) 169:6020-9.
-
(2002)
J Immunol
, vol.169
, pp. 6020-6029
-
-
Kaplan, M.J.1
Lewis, E.E.2
Shelden, E.A.3
Somers, E.4
Pavlic, R.5
McCune, W.J.6
-
73
-
-
75649117077
-
Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study
-
doi:10.1186/ar2816
-
Schwartz N, Rubinstein T, Burkly LC, Collins CE, Blanco I, Su L, et al. Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study. Arthritis Res Ther (2009) 11:R143. doi:10.1186/ar2816
-
(2009)
Arthritis Res Ther
, vol.11
-
-
Schwartz, N.1
Rubinstein, T.2
Burkly, L.C.3
Collins, C.E.4
Blanco, I.5
Su, L.6
-
74
-
-
79251640587
-
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus
-
doi:10.1016/j.cyto.2010.11.012
-
Liu ZC, Zhou QL, Li XZ, Yang JH, Ao X, Veeraragoo P, et al. Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Cytokine (2011) 53:295-300. doi:10.1016/j.cyto.2010.11.012
-
(2011)
Cytokine
, vol.53
, pp. 295-300
-
-
Liu, Z.C.1
Zhou, Q.L.2
Li, X.Z.3
Yang, J.H.4
Ao, X.5
Veeraragoo, P.6
-
75
-
-
84856706706
-
Expression of human tumor necrosis factor-like weak inducer of apoptosis in patients with systemic lupus erythematosus
-
doi:10.1007/s10067-011-1865-4
-
Wang C, Chen LL, Pan HF, Leng RX, Qin WZ, Ye DQ. Expression of human tumor necrosis factor-like weak inducer of apoptosis in patients with systemic lupus erythematosus. Clin Rheumatol (2012) 31:335-9. doi:10.1007/s10067-011-1865-4
-
(2012)
Clin Rheumatol
, vol.31
, pp. 335-339
-
-
Wang, C.1
Chen, L.L.2
Pan, H.F.3
Leng, R.X.4
Qin, W.Z.5
Ye, D.Q.6
-
76
-
-
79955369269
-
Gene expression of TWEAK/Fn14 and IP-10/CXCR3 in glomerulus and tubulointerstitium of patients with lupus nephritis
-
doi:10.1111/j.1440-1797.2011.01449.x
-
Lu J, Kwan BC, Lai FM, Choi PC, Tam LS, Li EK, et al. Gene expression of TWEAK/Fn14 and IP-10/CXCR3 in glomerulus and tubulointerstitium of patients with lupus nephritis. Nephrology (2011) 16:426-32. doi:10.1111/j.1440-1797.2011.01449.x
-
(2011)
Nephrology
, vol.16
, pp. 426-432
-
-
Lu, J.1
Kwan, B.C.2
Lai, F.M.3
Choi, P.C.4
Tam, L.S.5
Li, E.K.6
-
77
-
-
80755189919
-
Correlations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and IL-8 with lupus nephritis
-
doi:10.1007/s10875-011-9555-1
-
El-Shehaby A, Darweesh H, El-Khatib M, Momtaz M, Marzouk S, El-Shaarawy N, et al. Correlations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and IL-8 with lupus nephritis. J Clin Immunol (2011) 31:848-56. doi:10.1007/s10875-011-9555-1
-
(2011)
J Clin Immunol
, vol.31
, pp. 848-856
-
-
El-Shehaby, A.1
Darweesh, H.2
El-Khatib, M.3
Momtaz, M.4
Marzouk, S.5
El-Shaarawy, N.6
-
78
-
-
84863644739
-
Urinary TWEAK level as a marker of lupus nephritis activity in 46 cases
-
doi:10.1155/2012/359647
-
Xuejing Z, Jiazhen T, Jun L, Xiangqing X, Shuguang Y, Fuyou L. Urinary TWEAK level as a marker of lupus nephritis activity in 46 cases. J Biomed Biotechnol (2012) 2012:359647. doi:10.1155/2012/359647
-
(2012)
J Biomed Biotechnol
, vol.2012
, pp. 359647
-
-
Xuejing, Z.1
Jiazhen, T.2
Jun, L.3
Xiangqing, X.4
Shuguang, Y.5
Fuyou, L.6
-
79
-
-
38849204911
-
TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus
-
Zhao Z, Burkly LC, Campbell S, Schwartz N, Molano A, Choudhury A, et al. TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus. J Immunol (2007) 179:7949-58.
-
(2007)
J Immunol
, vol.179
, pp. 7949-7958
-
-
Zhao, Z.1
Burkly, L.C.2
Campbell, S.3
Schwartz, N.4
Molano, A.5
Choudhury, A.6
-
80
-
-
68149180876
-
TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis
-
doi:10.1016/j.imlet.2009.06.010
-
Molano A, Lakhani P, Aran A, Burkly LC, Michaelson JS, Putterman C. TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis. Immunol Lett (2009) 125:119-28. doi:10.1016/j.imlet.2009.06.010
-
(2009)
Immunol Lett
, vol.125
, pp. 119-128
-
-
Molano, A.1
Lakhani, P.2
Aran, A.3
Burkly, L.C.4
Michaelson, J.S.5
Putterman, C.6
-
81
-
-
84866085652
-
Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis
-
doi:10.1016/j.clim.2012.08.008
-
Xia Y, Campbell SR, Broder A, Herlitz L, Abadi M, Wu P, et al. Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis. Clin Immunol (2012) 145:108-21. doi:10.1016/j.clim.2012.08.008
-
(2012)
Clin Immunol
, vol.145
, pp. 108-121
-
-
Xia, Y.1
Campbell, S.R.2
Broder, A.3
Herlitz, L.4
Abadi, M.5
Wu, P.6
-
82
-
-
84878353733
-
Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway
-
doi:10.1016/j.jaut.2013.03.002
-
Wen J, Xia Y, Stock A, Michaelson JS, Burkly LC, Gulinello M, et al. Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway. J Autoimmun (2013) 43:44-54. doi:10.1016/j.jaut.2013.03.002
-
(2013)
J Autoimmun
, vol.43
, pp. 44-54
-
-
Wen, J.1
Xia, Y.2
Stock, A.3
Michaelson, J.S.4
Burkly, L.C.5
Gulinello, M.6
-
84
-
-
80054686286
-
Tumor metastasis: molecular insights and evolving paradigms
-
doi:10.1016/j.cell.2011.09.024
-
Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 147:275-92. doi:10.1016/j.cell.2011.09.024
-
(2011)
Cell
, vol.147
, pp. 275-292
-
-
Valastyan, S.1
Weinberg, R.A.2
-
85
-
-
80053157914
-
Unravelling the complexity of metastasis-molecular understanding and targeted therapies
-
doi:10.1038/nrc3125
-
Sethi N, Kang Y. Unravelling the complexity of metastasis-molecular understanding and targeted therapies. Nat Rev Cancer (2011) 11:735-48. doi:10.1038/nrc3125
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 735-748
-
-
Sethi, N.1
Kang, Y.2
-
86
-
-
84858760109
-
Combining immunotherapy and targeted therapies in cancer treatment
-
doi:10.1038/nrc3237
-
Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer (2012) 12:237-51. doi:10.1038/nrc3237
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 237-251
-
-
Vanneman, M.1
Dranoff, G.2
-
87
-
-
79953271634
-
The evolving war on cancer
-
doi:10.1016/j.cell.2011.03.026
-
Haber DA, Gray NS, Baselga J. The evolving war on cancer. Cell (2011) 145:19-24. doi:10.1016/j.cell.2011.03.026
-
(2011)
Cell
, vol.145
, pp. 19-24
-
-
Haber, D.A.1
Gray, N.S.2
Baselga, J.3
-
88
-
-
84886412861
-
RG7212 anti-TWEAK mAb inhibits tumor growth through inhibition of tumor cell proliferation and survival signaling and by enhancing the host antitumor immune response
-
doi:10.1158/1078-0432.CCR-13-0405
-
Yin X, Luistro L, Zhong H, Smith M, Nevins T, Schostack K, et al. RG7212 anti-TWEAK mAb inhibits tumor growth through inhibition of tumor cell proliferation and survival signaling and by enhancing the host antitumor immune response. Clin Cancer Res (2013) 19:5686-98. doi:10.1158/1078-0432.CCR-13-0405
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5686-5698
-
-
Yin, X.1
Luistro, L.2
Zhong, H.3
Smith, M.4
Nevins, T.5
Schostack, K.6
-
89
-
-
84886404926
-
A first-in-human phase 1 monotherapy study of RG7212 (R), a novel monoclonal antibody targeting TWEAK signaling in patients with advanced solid tumors
-
doi:10.1016/S0959-8049(12)71828-2
-
Lassen U, Schellens JH, Siu LL, Jonker DJ, Sorensen M, Jarutat T, et al. A first-in-human phase 1 monotherapy study of RG7212 (R), a novel monoclonal antibody targeting TWEAK signaling in patients with advanced solid tumors. Eur J Cancer (2012) 48(Suppl 6):12. doi:10.1016/S0959-8049(12)71828-2
-
(2012)
Eur J Cancer
, vol.48
, Issue.SUPPL. 6
, pp. 12
-
-
Lassen, U.1
Schellens, J.H.2
Siu, L.L.3
Jonker, D.J.4
Sorensen, M.5
Jarutat, T.6
-
90
-
-
84885399010
-
Fn14-Trail effectively inhibits hepatocellular carcinoma growth
-
doi:10.1371/journal.pone.0077050
-
Aronin A, Amsili S, Prigozhina TB, Tzdaka K, Rachmilewitz J, Shani N, et al. Fn14-Trail effectively inhibits hepatocellular carcinoma growth. PLoS One (2013) 8:e77050. doi:10.1371/journal.pone.0077050
-
(2013)
PLoS One
, vol.8
-
-
Aronin, A.1
Amsili, S.2
Prigozhina, T.B.3
Tzdaka, K.4
Rachmilewitz, J.5
Shani, N.6
-
91
-
-
79960091768
-
Development of an Fn14 agonistic antibody as an anti-tumor agent
-
doi:10.4161/mabs.3.4.16090
-
Michaelson JS, Amatucci A, Kelly R, Su L, Garber E, Day ES, et al. Development of an Fn14 agonistic antibody as an anti-tumor agent. MAbs (2011) 3:362-75. doi:10.4161/mabs.3.4.16090
-
(2011)
MAbs
, vol.3
, pp. 362-375
-
-
Michaelson, J.S.1
Amatucci, A.2
Kelly, R.3
Su, L.4
Garber, E.5
Day, E.S.6
-
92
-
-
84863454553
-
The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft models
-
doi:10.4161/cbt.20564
-
Michaelson JS, Kelly R, Yang L, Zhang X, Wortham K, Joseph IB. The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft models. Cancer Biol Ther (2012) 13:812-21. doi:10.4161/cbt.20564
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 812-821
-
-
Michaelson, J.S.1
Kelly, R.2
Yang, L.3
Zhang, X.4
Wortham, K.5
Joseph, I.B.6
-
93
-
-
84892158338
-
A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo
-
doi: 10.4161/mabs.26709
-
Trebing J, Lang I, Chopra M, Salzmann S, Moshir M, Silence K, et al. A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo. MAbs (2014) 6. doi:10.4161/mabs.26709
-
(2014)
MAbs
, vol.6
-
-
Trebing, J.1
Lang, I.2
Chopra, M.3
Salzmann, S.4
Moshir, M.5
Silence, K.6
-
94
-
-
84892183514
-
A phase I study of enavatuzumab (PDL192, ABT-361), a first-in-class human monoclonal antibody targeting TWEAK (tumor necrosis factor-like inducer of apoptosis) receptor, in patients with advanced solid tumors
-
Abstract C18. doi:10.1158/1535-7163.TARG-11-C18
-
Lam ET, Eckhardt SG, Messersmith W, Jimeno A, O'Bryant CL, Ramanathan RK, et al. A phase I study of enavatuzumab (PDL192, ABT-361), a first-in-class human monoclonal antibody targeting TWEAK (tumor necrosis factor-like inducer of apoptosis) receptor, in patients with advanced solid tumors. Mol Cancer Ther (2013) 10(Suppl 1):AbstractC18. doi:10.1158/1535-7163.TARG-11-C18
-
(2013)
Mol Cancer Ther
, vol.10
, Issue.SUPPL. 1
-
-
Lam, E.T.1
Eckhardt, S.G.2
Messersmith, W.3
Jimeno, A.4
O'Bryant, C.L.5
Ramanathan, R.K.6
-
95
-
-
79960124328
-
Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells
-
doi:10.1158/1535-7163.MCT-11-0161
-
Zhou H, Marks JW, Hittelman WN, Yagita H, Cheung LH, Rosenblum MG, et al. Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells. Mol Cancer Ther (2011) 10:1276-88. doi:10.1158/1535-7163.MCT-11-0161
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1276-1288
-
-
Zhou, H.1
Marks, J.W.2
Hittelman, W.N.3
Yagita, H.4
Cheung, L.H.5
Rosenblum, M.G.6
-
96
-
-
84880905289
-
Antitumor activity of a humanized, bivalent immunotoxin targeting Fn14-positive solid tumors
-
doi:10.1158/0008-5472.CAN-13-0187
-
Zhou H, Hittelman WN, Yagita H, Cheung LH, Martin SS, Winkles JA, et al. Antitumor activity of a humanized, bivalent immunotoxin targeting Fn14-positive solid tumors. Cancer Res (2013) 73:4439-50. doi:10.1158/0008-5472.CAN-13-0187
-
(2013)
Cancer Res
, vol.73
, pp. 4439-4450
-
-
Zhou, H.1
Hittelman, W.N.2
Yagita, H.3
Cheung, L.H.4
Martin, S.S.5
Winkles, J.A.6
-
97
-
-
36049022442
-
TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease
-
doi:10.1016/j.cyto.2007.09.007
-
Burkly LC, Michaelson JS, Hahm K, Jakubowski A, Zheng TS. TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease. Cytokine (2007) 40:1-16. doi:10.1016/j.cyto.2007.09.007
-
(2007)
Cytokine
, vol.40
, pp. 1-16
-
-
Burkly, L.C.1
Michaelson, J.S.2
Hahm, K.3
Jakubowski, A.4
Zheng, T.S.5
-
98
-
-
72449164564
-
Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function
-
doi:10.1158/1541-7786.MCR-09-0194
-
Fortin SP, Ennis MJ, Savitch BA, Carpentieri D, McDonough WS, Winkles JA, et al. Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function. Mol Cancer Res (2009) 7:1871-81. doi:10.1158/1541-7786.MCR-09-0194
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1871-1881
-
-
Fortin, S.P.1
Ennis, M.J.2
Savitch, B.A.3
Carpentieri, D.4
McDonough, W.S.5
Winkles, J.A.6
-
99
-
-
84876531010
-
The HER2-and heregulin-beta1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression
-
doi:10.1158/1541-7786.MCR-12-0542
-
Asrani K, Keri RA, Galisteo R, Brown SA, Morgan SJ, Ghosh A, et al. The HER2-and heregulin-beta1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression. Mol Cancer Res (2013) 11:393-404. doi:10.1158/1541-7786.MCR-12-0542
-
(2013)
Mol Cancer Res
, vol.11
, pp. 393-404
-
-
Asrani, K.1
Keri, R.A.2
Galisteo, R.3
Brown, S.A.4
Morgan, S.J.5
Ghosh, A.6
-
100
-
-
10844249434
-
Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice
-
doi:10.1158/0008-5472.CAN-04-1879
-
Ho DH, Vu H, Brown SA, Donohue PJ, Hanscom HN, Winkles JA. Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice. Cancer Res (2004) 64:8968-72. doi:10.1158/0008-5472.CAN-04-1879
-
(2004)
Cancer Res
, vol.64
, pp. 8968-8972
-
-
Ho, D.H.1
Vu, H.2
Brown, S.A.3
Donohue, P.J.4
Hanscom, H.N.5
Winkles, J.A.6
-
101
-
-
77649315474
-
Therapeutic targeting of TWEAK/Fnl4 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway
-
doi:10.1007/400_2008_18
-
Michaelson JS, Burkly LC. Therapeutic targeting of TWEAK/Fnl4 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway. Results Probl Cell Differ (2009) 49:145-60. doi:10.1007/400_2008_18
-
(2009)
Results Probl Cell Differ
, vol.49
, pp. 145-160
-
-
Michaelson, J.S.1
Burkly, L.C.2
-
102
-
-
0032993566
-
TWEAK can induce cell death via endogenous TNF and TNF receptor 1
-
doi:10.1002/(SICI)1521-4141(199906)29:06<1785::AID-IMMU1785>3.0.CO;2-U
-
Schneider P, Schwenzer R, Haas E, Muhlenbeck F, Schubert G, Scheurich P, et al. TWEAK can induce cell death via endogenous TNF and TNF receptor 1. Eur J Immunol (1999) 29:1785-92. doi:10.1002/(SICI)1521-4141(199906)29:06<1785::AID-IMMU1785>3.0.CO;2-U
-
(1999)
Eur J Immunol
, vol.29
, pp. 1785-1792
-
-
Schneider, P.1
Schwenzer, R.2
Haas, E.3
Muhlenbeck, F.4
Schubert, G.5
Scheurich, P.6
-
103
-
-
47549097367
-
TWEAK-Fn14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNF-alpha
-
doi:10.1083/jcb.200801010
-
Vince JE, Chau D, Callus B, Wong WW, Hawkins CJ, Schneider P, et al. TWEAK-Fn14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNF-alpha. J Cell Biol (2008) 182:171-84. doi:10.1083/jcb.200801010
-
(2008)
J Cell Biol
, vol.182
, pp. 171-184
-
-
Vince, J.E.1
Chau, D.2
Callus, B.3
Wong, W.W.4
Hawkins, C.J.5
Schneider, P.6
-
104
-
-
70350007940
-
TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling
-
doi:10.1038/cdd.2009.80
-
Wicovsky A, Salzmann S, Roos C, Ehrenschwender M, Rosenthal T, Siegmund D, et al. TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling. Cell Death Differ (2009) 16:1445-59. doi:10.1038/cdd.2009.80
-
(2009)
Cell Death Differ
, vol.16
, pp. 1445-1459
-
-
Wicovsky, A.1
Salzmann, S.2
Roos, C.3
Ehrenschwender, M.4
Rosenthal, T.5
Siegmund, D.6
-
105
-
-
79958742849
-
TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8
-
doi:10.1074/jbc.M110.203745
-
Ikner A, Ashkenazi A. TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J Biol Chem (2011) 286:21546-54. doi:10.1074/jbc.M110.203745
-
(2011)
J Biol Chem
, vol.286
, pp. 21546-21554
-
-
Ikner, A.1
Ashkenazi, A.2
-
106
-
-
84869871676
-
TWEAK signals through JAK-STAT to induce tumor cell apoptosis
-
doi:10.1016/j.cyto.2012.09.020
-
Chapman MS, Wu L, Amatucci A, Ho SN, Michaelson JS. TWEAK signals through JAK-STAT to induce tumor cell apoptosis. Cytokine (2013) 61:210-7. doi:10.1016/j.cyto.2012.09.020
-
(2013)
Cytokine
, vol.61
, pp. 210-217
-
-
Chapman, M.S.1
Wu, L.2
Amatucci, A.3
Ho, S.N.4
Michaelson, J.S.5
-
107
-
-
84877697920
-
Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity
-
doi:10.1074/jbc.M112.435917
-
Salzmann S, Seher A, Trebing J, Weisenberger D, Rosenthal A, Siegmund D, et al. Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity. J Biol Chem (2013) 288:13455-66. doi:10.1074/jbc.M112.435917
-
(2013)
J Biol Chem
, vol.288
, pp. 13455-13466
-
-
Salzmann, S.1
Seher, A.2
Trebing, J.3
Weisenberger, D.4
Rosenthal, A.5
Siegmund, D.6
-
108
-
-
2442545541
-
Functional expression of TWEAK in human hepatocellular carcinoma: possible implication in cell proliferation and tumor angiogenesis
-
doi:10.1016/j.bbrc.2004.04.084
-
Kawakita T, Shiraki K, Yamanaka Y, Yamaguchi Y, Saitou Y, Enokimura N, et al. Functional expression of TWEAK in human hepatocellular carcinoma: possible implication in cell proliferation and tumor angiogenesis. Biochem Biophys Res Commun (2004) 318:726-33. doi:10.1016/j.bbrc.2004.04.084
-
(2004)
Biochem Biophys Res Commun
, vol.318
, pp. 726-733
-
-
Kawakita, T.1
Shiraki, K.2
Yamanaka, Y.3
Yamaguchi, Y.4
Saitou, Y.5
Enokimura, N.6
-
109
-
-
13544268326
-
The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NF-kappaB pathway activation and BCL-XL/BCL-W expression
-
doi:10.1074/jbc.M409906200
-
Tran NL, McDonough WS, Savitch BA, Sawyer TF, Winkles JA, Berens ME. The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NF-kappaB pathway activation and BCL-XL/BCL-W expression. J Biol Chem (2005) 280:3483-92. doi:10.1074/jbc.M409906200
-
(2005)
J Biol Chem
, vol.280
, pp. 3483-3492
-
-
Tran, N.L.1
McDonough, W.S.2
Savitch, B.A.3
Sawyer, T.F.4
Winkles, J.A.5
Berens, M.E.6
-
110
-
-
0037390762
-
TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity
-
doi:10.1161/01.ATV.0000062883.93715.37
-
Donohue PJ, Richards CM, Brown SA, Hanscom HN, Buschman J, Thangada S, et al. TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity. Arterioscler Thromb Vasc Biol (2003) 23:594-600. doi:10.1161/01.ATV.0000062883.93715.37
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 594-600
-
-
Donohue, P.J.1
Richards, C.M.2
Brown, S.A.3
Hanscom, H.N.4
Buschman, J.5
Thangada, S.6
-
111
-
-
3042607901
-
Immunotoxins and other conjugates: pre-clinical studies
-
doi:10.2174/1389557043403864
-
Bolognesi A, Polito L. Immunotoxins and other conjugates: pre-clinical studies. Mini-Rev Med Chem (2004) 4:563-83. doi:10.2174/1389557043403864
-
(2004)
Mini-Rev Med Chem
, vol.4
, pp. 563-583
-
-
Bolognesi, A.1
Polito, L.2
-
112
-
-
34047136785
-
Immunotoxin treatment of cancer
-
doi:10.1146/annurev.med.58.070605.115320
-
Pastan I, Hassan R, Fitzgerald DJ, Kreitman RJ. Immunotoxin treatment of cancer. Annu Rev Med (2007) 58:221-37. doi:10.1146/annurev.med.58.070605.115320
-
(2007)
Annu Rev Med
, vol.58
, pp. 221-237
-
-
Pastan, I.1
Hassan, R.2
Fitzgerald, D.J.3
Kreitman, R.J.4
-
113
-
-
0037223197
-
Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death
-
Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, et al. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol (2003) 170:341-8.
-
(2003)
J Immunol
, vol.170
, pp. 341-348
-
-
Nakayama, M.1
Ishidoh, K.2
Kojima, Y.3
Harada, N.4
Kominami, E.5
Okumura, K.6
-
114
-
-
0037757754
-
Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies
-
doi:10.1016/S0006-291X(03)01051-9
-
Nakayama M, Harada N, Okumura K, Yagita H. Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies. Biochem Biophys Res Commun (2003) 306:819-25. doi:10.1016/S0006-291X(03)01051-9
-
(2003)
Biochem Biophys Res Commun
, vol.306
, pp. 819-825
-
-
Nakayama, M.1
Harada, N.2
Okumura, K.3
Yagita, H.4
-
115
-
-
33747229123
-
Ribosome-inactivating proteins: progress and problems
-
doi:10.1007/s00018-006-6078-7
-
Stirpe F, Battelli MG. Ribosome-inactivating proteins: progress and problems. Cell Mol Life Sci (2006) 63:1850-66. doi:10.1007/s00018-006-6078-7
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 1850-1866
-
-
Stirpe, F.1
Battelli, M.G.2
-
116
-
-
77951687835
-
Delivery and therapeutic potential of human granzyme B
-
doi:10.1111/j.0105-2896.2010.00894.x
-
Kurschus FC, Jenne DE. Delivery and therapeutic potential of human granzyme B. Immunol Rev (2010) 235:159-71. doi:10.1111/j.0105-2896.2010.00894.x
-
(2010)
Immunol Rev
, vol.235
, pp. 159-171
-
-
Kurschus, F.C.1
Jenne, D.E.2
-
117
-
-
77951681958
-
Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B
-
doi:10.1111/j.0105-2896.2010.00908.x
-
Afonina IS, Cullen SP, Martin SJ. Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B. Immunol Rev (2010) 235:105-16. doi:10.1111/j.0105-2896.2010.00908.x
-
(2010)
Immunol Rev
, vol.235
, pp. 105-116
-
-
Afonina, I.S.1
Cullen, S.P.2
Martin, S.J.3
-
119
-
-
84875233141
-
Phase 1 study of an anti-CD33 immunotoxin, humanized monoclonal antibody M195 conjugated to recombinant gelonin (HUM-195/rGEL), in patients with advanced myeloid malignancies
-
doi:10.3324/haematol.2012.071092
-
Borthakur G, Rosenblum MG, Talpaz M, Daver N, Ravandi F, Faderl S, et al. Phase 1 study of an anti-CD33 immunotoxin, humanized monoclonal antibody M195 conjugated to recombinant gelonin (HUM-195/rGEL), in patients with advanced myeloid malignancies. Haematologica (2013) 98:217-21. doi:10.3324/haematol.2012.071092
-
(2013)
Haematologica
, vol.98
, pp. 217-221
-
-
Borthakur, G.1
Rosenblum, M.G.2
Talpaz, M.3
Daver, N.4
Ravandi, F.5
Faderl, S.6
-
120
-
-
33747855481
-
Comparing antibody and small-molecule therapies for cancer
-
doi:10.1038/nrc1913
-
Imai K, Takaoka A. Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer (2006) 6:714-27. doi:10.1038/nrc1913
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 714-727
-
-
Imai, K.1
Takaoka, A.2
-
121
-
-
77952043572
-
RNAi-based therapeutics-current status, challenges and prospects
-
doi:10.1002/emmm.200900023
-
Tiemann K, Rossi JJ. RNAi-based therapeutics-current status, challenges and prospects. EMBO Mol Med (2009) 1:142-51. doi:10.1002/emmm.200900023
-
(2009)
EMBO Mol Med
, vol.1
, pp. 142-151
-
-
Tiemann, K.1
Rossi, J.J.2
-
122
-
-
78650624101
-
RNA interference in the clinic: challenges and future directions
-
doi:10.1038/nrc2966
-
Pecot CV, Calin GA, Coleman RL, Lopez-Berestein G, Sood AK. RNA interference in the clinic: challenges and future directions. Nat Rev Cancer (2011) 11:59-67. doi:10.1038/nrc2966
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 59-67
-
-
Pecot, C.V.1
Calin, G.A.2
Coleman, R.L.3
Lopez-Berestein, G.4
Sood, A.K.5
-
123
-
-
80052627990
-
Current progress of siRNA/shRNA therapeutics in clinical trials
-
doi:10.1002/biot.201100054
-
Burnett JC, Rossi JJ, Tiemann K. Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol J (2011) 6:1130-46. doi:10.1002/biot.201100054
-
(2011)
Biotechnol J
, vol.6
, pp. 1130-1146
-
-
Burnett, J.C.1
Rossi, J.J.2
Tiemann, K.3
-
124
-
-
74049124186
-
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
-
doi:10.1038/nrd3010
-
Jackson AL, Linsley PS. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov (2010) 9:57-67. doi:10.1038/nrd3010
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 57-67
-
-
Jackson, A.L.1
Linsley, P.S.2
-
125
-
-
76149109071
-
Targeting protein-protein interactions for therapeutic intervention: a challenge for the future
-
doi:10.4155/fmc.09.12
-
Zinzalla G, Thurston DE. Targeting protein-protein interactions for therapeutic intervention: a challenge for the future. Future Med Chem (2009) 1:65-93. doi:10.4155/fmc.09.12
-
(2009)
Future Med Chem
, vol.1
, pp. 65-93
-
-
Zinzalla, G.1
Thurston, D.E.2
-
126
-
-
27744586067
-
Small-molecule inhibition of TNF-alpha
-
doi:10.1126/science.1116304
-
He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, et al. Small-molecule inhibition of TNF-alpha. Science (2005) 310:1022-5. doi:10.1126/science.1116304
-
(2005)
Science
, vol.310
, pp. 1022-1025
-
-
He, M.M.1
Smith, A.S.2
Oslob, J.D.3
Flanagan, W.M.4
Braisted, A.C.5
Whitty, A.6
-
127
-
-
79961092776
-
Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism
-
doi:10.1021/cb2000346
-
Silvian LF, Friedman JE, Strauch K, Cachero TG, Day ES, Qian F, et al. Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism. ACS Chem Biol (2011) 6:636-47. doi:10.1021/cb2000346
-
(2011)
ACS Chem Biol
, vol.6
, pp. 636-647
-
-
Silvian, L.F.1
Friedman, J.E.2
Strauch, K.3
Cachero, T.G.4
Day, E.S.5
Qian, F.6
-
128
-
-
0035834057
-
Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha
-
doi:10.1073/pnas.211178398
-
Carter PH, Scherle PA, Muckelbauer JK, Voss ME, Liu RQ, Thompson LA, et al. Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha. Proc Natl Acad Sci U S A (2001) 98:11879-84. doi:10.1073/pnas.211178398
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 11879-11884
-
-
Carter, P.H.1
Scherle, P.A.2
Muckelbauer, J.K.3
Voss, M.E.4
Liu, R.Q.5
Thompson, L.A.6
-
129
-
-
84863827333
-
A homogeneous HTRF assay for the identification of inhibitors of the TWEAK-Fn14 protein interaction
-
doi:10.1177/1087057112447873
-
Benicchi T, Iozzi S, Svahn A, Axelsson H, Mori E, Bernocco S, et al. A homogeneous HTRF assay for the identification of inhibitors of the TWEAK-Fn14 protein interaction. J Biomol Screen (2012) 17:933-45. doi:10.1177/1087057112447873
-
(2012)
J Biomol Screen
, vol.17
, pp. 933-945
-
-
Benicchi, T.1
Iozzi, S.2
Svahn, A.3
Axelsson, H.4
Mori, E.5
Bernocco, S.6
-
130
-
-
61449199479
-
Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily
-
doi:10.1002/pro.49
-
He F, Dang W, Saito K, Watanabe S, Kobayashi N, Guntert P, et al. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. Protein Sci (2009) 18:650-6. doi:10.1002/pro.49
-
(2009)
Protein Sci
, vol.18
, pp. 650-656
-
-
He, F.1
Dang, W.2
Saito, K.3
Watanabe, S.4
Kobayashi, N.5
Guntert, P.6
-
131
-
-
84876288017
-
Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions
-
doi:10.1111/febs.12206
-
Pellegrini M, Willen L, Perroud M, Krushinskie D, Strauch K, Cuervo H, et al. Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions. FEBS J (2013) 280:1818-29. doi:10.1111/febs.12206
-
(2013)
FEBS J
, vol.280
, pp. 1818-1829
-
-
Pellegrini, M.1
Willen, L.2
Perroud, M.3
Krushinskie, D.4
Strauch, K.5
Cuervo, H.6
-
132
-
-
84877256304
-
Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding
-
doi:10.1371/journal.pone.0062697
-
Lammens A, Baehner M, Kohnert U, Niewoehner J, von Proff L, Schraeml M, et al. Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding. PLoS One (2013) 8:e62697. doi:10.1371/journal.pone.0062697
-
(2013)
PLoS One
, vol.8
-
-
Lammens, A.1
Baehner, M.2
Kohnert, U.3
Niewoehner, J.4
von Proff, L.5
Schraeml, M.6
-
133
-
-
84887496644
-
Structural basis and targeting of the interaction between fibroblast growth factor-inducible-14 and tumor necrosis factor-like weak inducer of apoptosis
-
doi:10.1074/jbc.M113.493536
-
Dhruv H, Loftus JC, Narang P, Petit JL, Fameree M, Burton J, et al. Structural basis and targeting of the interaction between fibroblast growth factor-inducible-14 and tumor necrosis factor-like weak inducer of apoptosis. J Biol Chem (2013) 288:32261-76. doi:10.1074/jbc.M113.493536
-
(2013)
J Biol Chem
, vol.288
, pp. 32261-32276
-
-
Dhruv, H.1
Loftus, J.C.2
Narang, P.3
Petit, J.L.4
Fameree, M.5
Burton, J.6
-
134
-
-
33746093941
-
TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules
-
doi:10.1042/BJ20051362
-
Brown SA, Hanscom HN, Vu H, Brew SA, Winkles JA. TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules. Biochem J (2006) 397:297-304. doi:10.1042/BJ20051362
-
(2006)
Biochem J
, vol.397
, pp. 297-304
-
-
Brown, S.A.1
Hanscom, H.N.2
Vu, H.3
Brew, S.A.4
Winkles, J.A.5
-
135
-
-
34347240363
-
TWEAK and Fn14. New players in the pathogenesis of atherosclerosis
-
doi:10.2741/2341
-
Blanco-Colio LM, Martin-Ventura JL, Munoz-Garcia B, Moreno JA, Meilhac O, Ortiz A, et al. TWEAK and Fn14. New players in the pathogenesis of atherosclerosis. Front Biosci (2007) 12:3648-55. doi:10.2741/2341
-
(2007)
Front Biosci
, vol.12
, pp. 3648-3655
-
-
Blanco-Colio, L.M.1
Martin-Ventura, J.L.2
Munoz-Garcia, B.3
Moreno, J.A.4
Meilhac, O.5
Ortiz, A.6
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