메뉴 건너뛰기




Volumn 11, Issue 4, 2013, Pages 393-404

The HER2- and heregulin b1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR INDUCIBLE 14; GELATINASE B; HEREGULIN BETA1; LAPATINIB; MESSENGER RNA; NEU DIFFERENTIATION FACTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; TUMOR NECROSIS FACTOR RECEPTOR; TWEAK RECEPTOR;

EID: 84876531010     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-12-0542     Document Type: Article
Times cited : (38)

References (50)
  • 2
    • 34547854801 scopus 로고    scopus 로고
    • The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
    • DOI 10.1038/sj.onc.1210477, PII 1210477
    • Moasser MM. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 2007;26:6469-87. (Pubitemid 47530601)
    • (2007) Oncogene , vol.26 , Issue.45 , pp. 6469-6487
    • Moasser, M.M.1
  • 3
    • 77649095719 scopus 로고    scopus 로고
    • HER3 comes of age: New insights into its functions and role in signaling, tumor biology, and cancer therapy
    • Campbell MR, Amin D, Moasser MM. HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapy. Clin Cancer Res 2010;16:1373-83.
    • (2010) Clin Cancer Res , vol.16 , pp. 1373-1383
    • Campbell, M.R.1    Amin, D.2    Moasser, M.M.3
  • 4
    • 0031730476 scopus 로고    scopus 로고
    • Expression of c-erbB3 protein in primary breast carcinomas
    • Naidu R, Yadav M, Nair S, Kutty MK. Expression of c-erbB3 protein in primary breast carcinomas. Br J Cancer 1998;78:1385-90. (Pubitemid 28495255)
    • (1998) British Journal of Cancer , vol.78 , Issue.10 , pp. 1385-1390
    • Naidu, R.1    Yadav, M.2    Nair, S.3    Kutty, M.K.4
  • 5
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: The biology of ErbB-2 and ErbB-3
    • DOI 10.1016/S0014-4827(02)00101-5
    • Citri A, Skaria KB, Yarden Y. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res 2003;284:54-65. (Pubitemid 36342255)
    • (2003) Experimental Cell Research , vol.284 , Issue.1 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 6
    • 48649092620 scopus 로고    scopus 로고
    • A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy
    • Lee-Hoeflich ST, Crocker L, Yao E, Pham T, Munroe X, Hoeflich KP, et al. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res 2008;68: 5878-87.
    • (2008) Cancer Res , vol.68 , pp. 5878-5887
    • Lee-Hoeflich, S.T.1    Crocker, L.2    Yao, E.3    Pham, T.4    Munroe, X.5    Hoeflich, K.P.6
  • 7
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
    • DOI 10.1038/nature05474, PII NATURE05474
    • Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, et al. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007;445:437-41. (Pubitemid 46160912)
    • (2007) Nature , vol.445 , Issue.7126 , pp. 437-441
    • Sergina, N.V.1    Rausch, M.2    Wang, D.3    Blair, J.4    Hann, B.5    Shokat, K.M.6    Moasser, M.M.7
  • 11
    • 66149134501 scopus 로고    scopus 로고
    • The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12
    • Hernandez L, Smirnova T, Kedrin D, Wyckoff J, Zhu L, Stanley ER, et al. The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res 2009;69:3221-7.
    • (2009) Cancer Res , vol.69 , pp. 3221-3227
    • Hernandez, L.1    Smirnova, T.2    Kedrin, D.3    Wyckoff, J.4    Zhu, L.5    Stanley, E.R.6
  • 12
    • 66749093527 scopus 로고    scopus 로고
    • Inhibitory effect of (-)-epigallocatechin and (-)-epigalloca-techin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line
    • Kushima Y, Iida K, Nagaoka Y, Kawaratani Y, Shirahama T, Sakaguch M, et al. Inhibitory effect of (-)-epigallocatechin and (-)-epigalloca-techin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line. Biol Pharm Bull 2009;32: 899-904.
    • (2009) Biol Pharm Bull , vol.32 , pp. 899-904
    • Kushima, Y.1    Iida, K.2    Nagaoka, Y.3    Kawaratani, Y.4    Shirahama, T.5    Sakaguch, M.6
  • 13
    • 0037226817 scopus 로고    scopus 로고
    • Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo
    • Atlas E, Cardillo M, Mehmi I, Zahedkargaran H, Tang C, Lupu R. Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo. Mol Cancer Res 2003; 1:165-75. (Pubitemid 36330198)
    • (2003) Molecular Cancer Research , vol.1 , Issue.3 , pp. 165-175
    • Atlas, E.1    Cardillo, M.2    Mehmi, I.3    Zahedkargaran, H.4    Tang, C.5    Lupu, R.6
  • 14
    • 81855169565 scopus 로고    scopus 로고
    • Cancer invasion and the microenvironment: Plasticity and reciprocity
    • Friedl P, Alexander S. Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 2011;147:992-1009.
    • (2011) Cell , vol.147 , pp. 992-1009
    • Friedl, P.1    Alexander, S.2
  • 15
    • 0032561206 scopus 로고    scopus 로고
    • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
    • DOI 10.1074/jbc.273.43.28238
    • Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, Kumar R. Heregulin regulates cytoskeletal reorganization and cel migration through the p21-activated kinase-1 via phosphatidylinosi-tol-3 kinase. J Biol Chem 1998;273:28238-46. (Pubitemid 28496122)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.43 , pp. 28238-28246
    • Adam, L.1    Vadlamudi, R.2    Kondapaka, S.B.3    Chernoff, J.4    Mendelsohn, J.5    Kumar, R.6
  • 17
    • 0035819050 scopus 로고    scopus 로고
    • Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-β1 in human breast cancer cells
    • DOI 10.1038/sj.onc.1204944
    • Yao J, Xiong S, Klos K, Nguyen N, Grijalva R, Li P, et al. Multiple signaling pathways involved in activation of matrix metalloproteinase-9(MMP-9) byheregulin-beta1 in human breast cancer cells. Oncogene 2001;20:8066-74. (Pubitemid 34028331)
    • (2001) Oncogene , vol.20 , Issue.56 , pp. 8066-8074
    • Yao, J.1    Xiong, S.2    Klos, K.3    Nguyen, N.4    Grijalva, R.5    Li, P.6    Yu, D.7
  • 18
    • 77950931419 scopus 로고    scopus 로고
    • Matrixmetalloproteinases: Regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V, Werb Z. Matrixmetalloproteinases: regulators of the tumor microenvironment. Cell 2010;141:52-67.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 19
    • 0035959808 scopus 로고    scopus 로고
    • HER2/neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1
    • DOI 10.1038/sj.onc.1204820
    • Bosc DG, Goueli BS, Janknecht R. HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1. Oncogene 2001;20:6215-24. (Pubitemid 32964434)
    • (2001) Oncogene , vol.20 , Issue.43 , pp. 6215-6224
    • Bosc, D.G.1    Goueli, B.S.2    Janknecht, R.3
  • 20
    • 54949088624 scopus 로고    scopus 로고
    • Heregulin-beta promotes matrix metalloproteinase-7 expression via HER2-mediated AP-1 activation in MCF-7 cells
    • Yuan G, Qian L, Song L, Shi M, Li D, Yu M, et al. Heregulin-beta promotes matrix metalloproteinase-7 expression via HER2-mediated AP-1 activation in MCF-7 cells. Mol Cell Biochem 2008;318:73-9.
    • (2008) Mol Cell Biochem , vol.318 , pp. 73-79
    • Yuan, G.1    Qian, L.2    Song, L.3    Shi, M.4    Li, D.5    Yu, M.6
  • 21
    • 42949160019 scopus 로고    scopus 로고
    • The TWEAK-Fn14 cytokine-receptor axis: Discovery, biology and therapeutic targeting
    • DOI 10.1038/nrd2488, PII NRD2488
    • Winkles JA. The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting. Nat Rev Drug Discov 2008;7: 411-25. (Pubitemid 351619113)
    • (2008) Nature Reviews Drug Discovery , vol.7 , Issue.5 , pp. 411-425
    • Winkles, J.A.1
  • 22
    • 80054865852 scopus 로고    scopus 로고
    • TWEAK/Fn14 pathway: An immunological switch for shaping tissue responses
    • Burkly LC, Michaelson JS, Zheng TS. TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses. Immunol Rev 2011;244:99-114.
    • (2011) Immunol Rev , vol.244 , pp. 99-114
    • Burkly, L.C.1    Michaelson, J.S.2    Zheng, T.S.3
  • 23
    • 82355175278 scopus 로고    scopus 로고
    • Elevated fibroblast growth factor-inducible 14 expression promotes gastric cancergrowth via nuclear factor-kB and is associated with poor patient outcome
    • Kwon OH, Park SJ, Kang TW, Kim M, Kim JH, Noh SM, et al. Elevated fibroblast growth factor-inducible 14 expression promotes gastric cancergrowth via nuclear factor-kB and is associated with poor patient outcome. Cancer Lett 2012;314:73-81.
    • (2012) Cancer Lett , vol.314 , pp. 73-81
    • Kwon, O.H.1    Park, S.J.2    Kang, T.W.3    Kim, M.4    Kim, J.H.5    Noh, S.M.6
  • 24
    • 13544268326 scopus 로고    scopus 로고
    • L/BCL-W expression
    • DOI 10.1074/jbc.M409906200
    • Tran NL, McDonough WS, Savitch BA, Sawyer TF, Winkles JA, Berens ME. The tumor necrosis factor-like weak inducer of apo-ptosis (TWEAK)-fibroblast growth factor-inducible 14(Fn14) signaling system regulates glioma cell survival via NF-kappaB pathway activation and BCL-XL/BCL-W expression. J Biol Chem 2005;280: 3483-92. (Pubitemid 40223813)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.5 , pp. 3483-3492
    • Tran, N.L.1    McDonough, W.S.2    Savitch, B.A.3    Sawyer, T.F.4    Winkles, J.A.5    Berens, M.E.6
  • 26
    • 51049115805 scopus 로고    scopus 로고
    • The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity
    • Willis AL, Tran NL, Chatigny JM, Charlton N, Vu H, Brown SAN, et al. The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity. Mol Cancer Res 2008;6:725-34.
    • (2008) Mol Cancer Res , vol.6 , pp. 725-734
    • Willis, A.L.1    Tran, N.L.2    Chatigny, J.M.3    Charlton, N.4    Vu, H.5    Brown, S.A.N.6
  • 27
    • 84862698136 scopus 로고    scopus 로고
    • Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion
    • Whitsett TG, Cheng E, Inge L, Asrani K, Nathan M, Hostetter G, et al. Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. Am J Pathol 2012;181:111-20.
    • (2012) Am J Pathol , vol.181 , pp. 111-120
    • Whitsett, T.G.1    Cheng, E.2    Inge, L.3    Asrani, K.4    Nathan, M.5    Hostetter, G.6
  • 28
    • 80755144050 scopus 로고    scopus 로고
    • Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome
    • Huang M, Narita S, Tsuchiya N, Ma Z, Numakura K, Obara T, et al. Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome. Carcinogenesis 2011;32:1589-96.
    • (2011) Carcinogenesis , vol.32 , pp. 1589-1596
    • Huang, M.1    Narita, S.2    Tsuchiya, N.3    Ma, Z.4    Numakura, K.5    Obara, T.6
  • 29
    • 10844249434 scopus 로고    scopus 로고
    • Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice
    • DOI 10.1158/0008-5472.CAN-04-1879
    • Ho DH, Vu H, Brown SAN, Donohue PJ, Hanscom HN, Winkles JA. Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice. Cancer Res 2004;64: 8968-72. (Pubitemid 39665505)
    • (2004) Cancer Research , vol.64 , Issue.24 , pp. 8968-8972
    • Ho, D.H.1    Vu, H.2    Brown, S.A.N.3    Donohue, P.J.4    Hanscom, H.N.5    Winkles, J.A.6
  • 31
    • 23444434936 scopus 로고    scopus 로고
    • Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice
    • DOI 10.1038/sj.onc.1208712
    • Landis MD, Seachrist DD, Monta~nez-Wiscovich ME, Danielpour D, Keri RA. Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-beta signaling in ErbB2/Neu-induced tumors from transgenic mice. Oncogene 2005; 24:5173-90. (Pubitemid 41192434)
    • (2005) Oncogene , vol.24 , Issue.33 , pp. 5173-5190
    • Landis, M.D.1    Seachrist, D.D.2    Montanez-Wiscovich, M.E.3    Danielpour, D.4    Keri, R.A.5
  • 32
    • 0026587657 scopus 로고
    • Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
    • Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 1992;12:954-61.
    • (1992) Mol Cell Biol , vol.12 , pp. 954-961
    • Guy, C.T.1    Cardiff, R.D.2    Muller, W.J.3
  • 33
    • 0142244181 scopus 로고    scopus 로고
    • Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases
    • Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ, et al. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 2003;163:2113-26. (Pubitemid 37310040)
    • (2003) American Journal of Pathology , vol.163 , Issue.5 , pp. 2113-2126
    • Lin, E.Y.1    Jones, J.G.2    Li, P.3    Zhu, L.4    Whitney, K.D.5    Muller, W.J.6    Pollard, J.W.7
  • 34
    • 20644465808 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole
    • DOI 10.1158/0008-5472.CAN-04-4502
    • Jelovac D, Sabnis G, Long BJ, Macedo L, Goloubeva OG, Brodie AMH. Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole. Cancer Res 2005;65:5380-9. (Pubitemid 40834290)
    • (2005) Cancer Research , vol.65 , Issue.12 , pp. 5380-5389
    • Jelovac, D.1    Sabnis, G.2    Long, B.J.3    Macedo, L.4    Goloubeva, O.G.5    Brodie, A.M.H.6
  • 35
    • 77952892382 scopus 로고    scopus 로고
    • Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway
    • Brown SAN, Ghosh A, Winkles JA. Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. J Biol Chem 2010;285: 17432-41.
    • (2010) J Biol Chem , vol.285 , pp. 17432-17441
    • Brown, S.A.N.1    Ghosh, A.2    Winkles, J.A.3
  • 37
    • 0038708366 scopus 로고    scopus 로고
    • The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor- associated factors 1, 2, 3 and 5 and mediates nuclear factor-κB activation
    • DOI 10.1042/BJ20021730
    • Brown SAN, Richards CM, Hanscom HN, Feng SL, Winkles JA. The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kB activation. Biochem J 2003;371:395-403. (Pubitemid 36547622)
    • (2003) Biochemical Journal , vol.371 , Issue.2 , pp. 395-403
    • Brown, S.A.N.1    Richards, C.M.2    Hanscom, H.N.3    Feng, S.-L.Y.4    Winkles, J.A.5
  • 39
    • 84875000590 scopus 로고    scopus 로고
    • Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb
    • Chao DT, Su M, Tanlimco S, Sho M, Choi D, Fox M, et al. Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb. J Cancer Res Clin Oncol 2013;139: 315-25.
    • (2013) J Cancer Res Clin Oncol , vol.139 , pp. 315-325
    • Chao, D.T.1    Su, M.2    Tanlimco, S.3    Sho, M.4    Choi, D.5    Fox, M.6
  • 40
    • 0033561296 scopus 로고    scopus 로고
    • Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: Implications for human breast cancer
    • Siegel PM, Ryan ED, Cardiff RD, Muller WJ. Elevated expression of activatedformsofNeu/ErbB-2 andErbB-3are involvedinthe induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J 1999;18:2149-64. (Pubitemid 29179172)
    • (1999) EMBO Journal , vol.18 , Issue.8 , pp. 2149-2164
    • Siegel, P.M.1    Ryan, E.D.2    Cardiff, R.D.3    Muller, W.J.4
  • 42
    • 0029162564 scopus 로고
    • Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3
    • Wallasch C, Weiss FU, Niederfellner G, Jallal B, Issing W, Ullrich A. Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. EMBO J 1995;14:4267-75.
    • (1995) EMBO J , vol.14 , pp. 4267-4275
    • Wallasch, C.1    Weiss, F.U.2    Niederfellner, G.3    Jallal, B.4    Issing, W.5    Ullrich, A.6
  • 43
    • 49849103925 scopus 로고    scopus 로고
    • Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9
    • Lin CW, Shen SC, Hou WC, Yang LY, Chen YC. Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9. Mol Cancer Ther 2008;7:1195-206.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1195-1206
    • Lin, C.W.1    Shen, S.C.2    Hou, W.C.3    Yang, L.Y.4    Chen, Y.C.5
  • 44
    • 33847715433 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 regulates angiopoietin-2 expression in breast cancer via AKT and mitogen-activated protein kinase pathways
    • DOI 10.1158/0008-5472.CAN-06-3155
    • Niu G, Carter WB. Human epidermal growth factor receptor 2 regulates angiopoietin-2 expression in breast cancer via AKT and mitogen-activated protein kinase pathways. Cancer Res 2007;67: 1487-93. (Pubitemid 46383372)
    • (2007) Cancer Research , vol.67 , Issue.4 , pp. 1487-1493
    • Niu, G.1    Carter, W.B.2
  • 45
    • 77649190700 scopus 로고    scopus 로고
    • Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKal-pha
    • Merkhofer EC, Cogswell P, Baldwin AS. Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKal-pha. Oncogene 2010;29:1238-48.
    • (2010) Oncogene , vol.29 , pp. 1238-1248
    • Merkhofer, E.C.1    Cogswell, P.2    Baldwin, A.S.3
  • 47
    • 68849092790 scopus 로고    scopus 로고
    • An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance
    • Mitra D, Brumlik MJ, Okamgba SU, Zhu Y, Duplessis TT, Parvani JG, et al. An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance. Mol Cancer Ther 2009;8:2152-62.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2152-2162
    • Mitra, D.1    Brumlik, M.J.2    Okamgba, S.U.3    Zhu, Y.4    Duplessis, T.T.5    Parvani, J.G.6
  • 48
    • 33645851656 scopus 로고    scopus 로고
    • TWEAK and Fn14: New molecular targets for cancer therapy?
    • Winkles JA, Tran NL, Berens ME. TWEAK and Fn14: new molecular targets for cancer therapy? Cancer Lett 2006;235:11-7.
    • (2006) Cancer Lett , vol.235 , pp. 11-17
    • Winkles, J.A.1    Tran, N.L.2    Berens, M.E.3
  • 50
    • 58149250652 scopus 로고    scopus 로고
    • Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors
    • Chen FL, Xia W, Spector NL. Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors. Clin Cancer Res 2008;14:6730-4.
    • (2008) Clin Cancer Res , vol.14 , pp. 6730-6734
    • Chen, F.L.1    Xia, W.2    Spector, N.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.