The TWEAK/Fn14 pathway in tissue remodeling: For better or for worse

Advances in Experimental Medicine and Biology

Volumn 691, Issue , 2011, Pages 305-322

  Burkly, Linda C ^a   Dohi, Taeko ^b  

^a BIOGEN   (United States)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR INDUCIBLE MOLECULE 14; MEMBRANE PROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR LIKE WEAK INDUCER OF APOPTOSIS; UNCLASSIFIED DRUG; TNFSF12 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR; TWEAK RECEPTOR;

ACUTE KIDNEY FAILURE; ADAPTIVE IMMUNITY; ANGIOGENESIS; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CELL GROWTH; CELL MIGRATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; COLITIS; CONFERENCE PAPER; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENTERITIS; HEART FAILURE; HEPATITIS; IMMUNOREGULATION; INFLAMMATION; INFLAMMATORY DISEASE; INFLAMMATORY INFILTRATE; LUPUS ERYTHEMATOSUS NEPHRITIS; MULTIPLE SCLEROSIS; MUSCLE ATROPHY; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TISSUE INJURY; TISSUE REGENERATION; UPREGULATION; ANIMAL; ANTIBODY SPECIFICITY; HUMAN; INTESTINE; METABOLISM; PATHOLOGY; REVIEW;

ANIMALS; HUMANS; INFLAMMATION; INTESTINES; ORGAN SPECIFICITY; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTORS;

EID: 79954449374     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-6612-4_32     Document Type: Conference Paper

References (50)

1. Burkly LC et al (2007) TWEAKing tissue remodeling by a multifunctional cytokine: Role of TWEAK/Fn14 pathway in health and disease. Cytokine 40(1):1-16
2. Winkles JA (2008) The TWEAK-Fn14 cytokine-receptor axis: Discovery, biology and therapeutic targeting. Nat Rev Drug Discov 7(5):411-425
3. Zheng TS, Burkly LC (2008) No end in site: TWEAK/Fn14 activation and autoimmunity associated- end-organ pathologies. J Leukoc Biol 84(2): 338-347
4. Dohi T et al (2009) TWEAK/Fn14 pathway: A nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis. Gastroenterology 136(3):912-923
5. Chicheportiche Y et al (1997) TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem 272(51):32401-32410
6. Felli N et al (2005) Multiple members of the TNF superfamily contribute to IFN-gammamediated inhibition of erythropoiesis. J Immunol 175(3):1464-1472
7. Kaplan MJ et al (2002) The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells. J Immunol 169(10):6020-6029
8. Kawakita T et al (2004) Functional expression of TWEAK in human hepatocellular carcinoma: Possible implication in cell proliferation and tumor angiogenesis. Biochem Biophys Res Commun 318(3):726-733
9. Desplat-Jego S et al (2009) TWEAK is expressed at the cell surface of monocytes during multiple sclerosis. J Leukoc Biol 85(1):132-135
10. van Kuijk AW et al (2009) TWEAK and its receptor Fn14 in the synovium of patients with rheumatoid arthritis compared to psoriatic arthritis and its response to TNF blockade. Ann Rheum Dis 69(1):301-304
11. Serafini B et al (2008) Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: Implications for inflammatory tissue injury. J Neuropathol Exp Neurol 67(12): 1137-1148
12. Inta I et al (2008) Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke. J Neurol Sci 275(1-2):117-120
13. Schwartz N et al (2006) Urinary TWEAK and the activity of lupus nephritis. J Autoimmun 27(4):242-250
14. Wiley SR et al (2001) A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15(5):837-846
15. Meighan-Mantha RL et al (1999) The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem 274(46):33166-33176
16. Perper SJ et al (2006) TWEAK is a novel arthritogenic mediator. J Immunol 177(4): 2610-2620
17. Zhao Z et al (2007) TWEAK/Fn14 Interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus. J Immunol 179(11):7949-7958
18. Jakubowski A et al (2002) Dual role for TWEAK in angiogenic regulation. J Cell Sci 115 (Pt 2):267-274
19. Chorianopoulos E et al (2009) FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK. Basic Res Cardiol 105(2):301-313
20. Munoz-Garcia B et al (2009) Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances vascular and renal damage induced by hyperlipidemic diet in ApoE-knockout mice. Arterioscler Thromb Vasc Biol
21. GirgenrathMet al (2006) TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. Embo J 25(24):5826-5839
22. Justo P et al (2006) Cytokine cooperation in renal tubular cell injury: The role of TWEAK. Kidney Int 70(10):1750-1758
23. Desplat-Jego S et al (2005) Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis. Clin Immunol 117(1):15-23
24. Potrovita I et al (2004) Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration. J Neurosci 24(38):8237-8244
25. Yepes M et al (2005) A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia. Am J Pathol 166(2):511-520
26. Jakubowski A et al (2005) TWEAK induces liver progenitor cell proliferation. J Clin Invest 115(9):2330-2340
27. Saitoh T et al (2003) TWEAK induces NF-kappaB2 p100 processing and long lasting NFkappaB activation. J Biol Chem 278(38):36005-36012
28. Nakayama M et al (2002) Multiple pathways of TWEAK-induced cell death. J Immunol 168(2):734-743
29. Vince CE et al (2008) TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1- TRAF2 complex to sensitize tumor cells to TNFa. J Cell Biol 182(1):171-184
30. Wicovsky A et al (2009) TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling. Cell Death Differ 16(11):1445-1459
31. Maecker H et al (2005) TWEAK attenuates the transition from innate to adaptive immunity. Cell 123(5):931-944
32. Jain M et al (2009) A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation 119(15): 2058-2068
33. Dogra C et al (2007) TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine. FASEB J 21(8):1857-1869
34. Desplat-Jego S et al (2002) TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity. J Neuroimmunol 133(1-2):116-123
35. Polavarapu R et al (2005) Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through nuclear factor-kappa B pathway activation. J Neurosci 25(44):10094-10100
36. Campbell S et al (2006) Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells. J Immunol 176(3):1889-1898
37. Gao HX et al (2009) TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells. Cytokine 46(1):24-35
38. Sanz AB et al (2008) The cytokine TWEAK modulates renal tubulointerstitial inflammation. J Am Soc Nephrol 19(4):695-703
39. Kamata K et al (2006) Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis. J Immunol 177(9):6433-6439
40. Mueller AM et al (2005) Targeting fibroblast growth factor-inducible-14 signaling protects from chronic relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol 159 (1-2):55-65
41. Schapira K et al (2009) Fn14-Fc fusion protein regulates atherosclerosis in ApoE-/- mice and inhibits macrophage lipid uptake in vitro. Arterioscler Thromb Vasc Biol 29(12):2021-2027
42. Sanz AB et al (2009) Tweak induces proliferation in renal tubular epithelium: A role in uninephrectomy-induced renal hyperplasia. J Cell Mol Med 13(9B):3329-3342
43. Iocca HA et al (2008) TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model. J Neuroimmunol 194(1-2):97-106
44. Zhang X et al (2007) TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia. J Cereb Blood Flow Metab 27(3):534-544
45. Abreu MT, Fukata M, Arditi M (2005) TLR signaling in the gut in health and disease. J Immunol 174(8):4453-4460
46. Artis D (2008) Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol 8(6):411-420
47. Gribar SC et al (2008) No longer an innocent bystander: Epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med 14(9-10):645-659
48. Galamb O et al (2008) Inflammation, adenoma and cancer: Objective classification of colon biopsy specimens with gene expression signature. Dis Markers 25(1):1-16
49. Gyorffy B et al (2009) Evaluation of microarray preprocessing algorithms based on concordance with RT-PCR in clinical samples. PLoS One 4(5):e5645
50. Kugathasan S et al (2008) Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet 40(10):1211-1215