Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Lammens, Alfred ^a,b,e   Baehner, Monika ^c   Kohnert, Ulrich ^c   Niewoehner, Jens ^c   von Proff, Leopold ^d   Schraeml, Michael ^d   Lammens, Katja ^b   Hopfner, Karl Peter ^a,b  

^a Munich Center for Integrated Protein Science   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c ROCHE INNOVATION CENTER MUNICH   (Germany)

^d Research and Development Gambro Dialysatoren   (Germany)

^e PROTEROS BIOSTRUCTURES GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 8; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR LIKE WEAK INDUCER OF APOPTOSIS; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE RELEASE; HYDROGEN BOND; NONHUMAN; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RECEPTOR BINDING; STRUCTURE ANALYSIS;

ANTIBODIES, NEUTRALIZING; CRYSTALLOGRAPHY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; TUMOR NECROSIS FACTORS;

EID: 84877256304     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062697     Document Type: Article

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