Engineering stereoselectivity of ThDP-dependent enzymes

FEBS Journal

Volumn 280, Issue 24, 2013, Pages 6374-6394

  Hailes, Helen C ^a   Rother, Dörte ^b   Müller, Michael ^c   Westphal, Robert ^b   Ward, John M ^a   Pleiss, Jürgen ^d   Vogel, Constantin ^d   Pohl, Martina ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF STUTTGART   (Germany)

Author keywords

, dihydroxyketone; hydroxyketone; 2 hydroxypropiophenone; acetoin; acyloins; asymmetric synthesis; benzoin; catalysis; phenylacetylcarbinol; protein engineering

Indexed keywords

2 OXOGLUTARIC ACID; 2 SUCCINYL 5 ENOLPYRUVYL 6 HYDROXY 3 CYCLOHEXENE 1 CARBOXYLATE; BENZOYLFORMATE DECARBOXYLASE; CARBOXYLYASE; COCARBOXYLASE; PYRUVATE DECARBOXYLASE; THIAMINE DIPHOSPHATE DEPENDENT ENZYME; TRANSKETOLASE; UNCLASSIFIED DRUG;

AZOARCUS; BINDING SITE; DECARBOXYLATION; ECTK GENE; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; ESCHERICHIA COLI; GENE; GENETIC VARIABILITY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PSEUDOMONAS FLUORESCENS; REVIEW; SACCHAROMYCES CEREVISIAE; STEREOCHEMISTRY; STRUCTURE ANALYSIS; YERSINIA PSEUDOTUBERCULOSIS;

Α,Α′-DIHYDROXYKETONE; Α-HYDROXYKETONE; 2-HYDROXYPROPIOPHENONE; ACETOIN; ACYLOINS; ASYMMETRIC SYNTHESIS; BENZOIN; CATALYSIS; PHENYLACETYLCARBINOL; PROTEIN ENGINEERING;

ANIMALS; CARBOXY-LYASES; CATALYSIS; HUMANS; STEREOISOMERISM; THIAMINE PYROPHOSPHATE; TRANSKETOLASE;

EID: 84889671065     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12496     Document Type: Review

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