Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate

Biochemistry

Volumn 46, Issue 43, 2007, Pages 12037-12052

  Asztalos, Peter ^e   Parthier, Christoph ^e   Golbik, Ralph ^a   Kleinschmidt, Martin ^c   Hübner, Gerhard ^a   Weiss, Manfred S ^b   Friedemann, Rudolf ^a   Wille, Georg ^d   Tittmann, Kai ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c PROBIODRUG AG   (Germany)

^d GOETHE UNIVERSITY   (Germany)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TRANSKETOLASE; HYDROXYL GROUPS; TETRAHEDRAL COFACTOR; THIAZOLIUM RING;

ENZYME ACTIVITY; ESCHERICHIA COLI; HYDROGEN BONDS; NITROGEN COMPOUNDS; SUGAR (SUCROSE);

CATALYSIS;

ALDEHYDE DERIVATIVE; ALDOSE RIBOSE 5 PHOSPHATE; ARGININE; ASPARTIC ACID; ENAMINE; ERYTHROSE 4 PHOSPHATE; FRUCTOSE 6 PHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE; HISTIDINE; HYDROXYL GROUP; KETOSE; PYRIMIDINE DERIVATIVE; PYROPHOSPHATE; SERINE; THIAMINE; THIAZOLE DERIVATIVE; TRANSKETOLASE; UNCLASSIFIED DRUG; XYLULOSE 5 PHOSPHATE;

ARTICLE; CARBOHYDRATE METABOLISM; COMPLEX FORMATION; CONFORMATION; COVALENT BOND; CRYSTAL STRUCTURE; DENSITY FUNCTIONAL THEORY; ENZYME ACTIVE SITE; ENZYME MECHANISM; ESCHERICHIA COLI; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; ESCHERICHIA COLI; FRUCTOSEPHOSPHATES; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PENTOSEPHOSPHATES; THIAMINE; TRANSKETOLASE;

BACTERIA (MICROORGANISMS);

EID: 35648979411     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700844m     Document Type: Article

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