Modular microfluidic reactor and inline filtration system for the biocatalytic synthesis of chiral metabolites

Journal of Molecular Catalysis B: Enzymatic

Volumn 77, Issue , 2012, Pages 1-8

  O'Sullivan, Brian ^a   Al Bahrani, Homam ^a   Lawrence, James ^a   Campos, Maria ^a   Cázares, Armando ^a   Baganz, Frank ^a   Wohlgemuth, Roland ^b   Hailes, Helen C ^a   Szita, Nicolas ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Sigma Aldrich   (Switzerland)

Author keywords

Bioprocess microfluidics; Chiral metabolites; Filtration; Microfluidic downstream processing; Microfluidic reactor; Transketolase

Indexed keywords

BIOCATALYTIC PROCESS; BIOCATALYTIC REACTION; BIOCATALYTIC SYNTHESIS; FILTRATION SYSTEMS; FREE SOLUTIONS; GLYCOLALDEHYDES; IN-LINE; INDUSTRIAL SYNTHESIS; MICRO FLUIDIC SYSTEM; MICRO-FLUIDIC REACTORS; MICROFLUIDIC REACTOR; ORGANIC SYNTHESIS; PROPANAL; SMALL-SCALE EVALUATION; TRANSKETOLASE; TWO-COMPONENT;

ALDEHYDES; FILTRATION; METABOLISM; METABOLITES; SYNTHESIS (CHEMICAL);

MICROFLUIDICS;

1,3 DIHYDROXYPENTAN 2 ONE; ENZYME; ERYTHRULOSE; PROPIONALDEHYDE; TRANSKETOLASE; UNCLASSIFIED DRUG;

ARTICLE; BIOCATALYSIS; CHIRALITY; CONTINUOUS FLOW REACTOR; ENZYME ACTIVITY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; FILTRATION; HYDROPHOBICITY; INCUBATION TIME; INLINE FILTRATION SYSTEM; MICROFLUIDIC ANALYSIS; MICROFLUIDIC REACTOR; REACTION TIME; SEPARATION TECHNIQUE;

EID: 84857861459     PISSN: 13811177     EISSN: 18733158     Source Type: Journal    
DOI: 10.1016/j.molcatb.2011.12.010     Document Type: Article

References (47)

1. C. Wiles, and P. Watts Eur. J. Org. Chem. 10 2008 1655 1671
2. P.L. Urban, D.M. Goodall, and N.C. Bruce Biotechnol. Adv. 24 2006 42 57
3. M.S. Thomsen, P. Polt, and B. Nidetzky Chem. Commun. 24 2007 2527 2529
4. M. Tišma, B. Zelić,. Vasić-Rački, P. Žnidaršič-Plazl, and I. Plazl Chem. Eng. J. 149 2009 383 388
5. P. He, G. Greenway, and S.J. Haswell Process Biochem. 45 2010 593 597
6. H.R. Luckarift, B.S. Ku, J.S. Dordick, and J.C. Spain Biotechnol. Bioeng. 98 2007 701 705
7. B. Ngamsom, A.M. Hickey, G.M. Greenway, J.A. Littlechild, P. Watts, and C. Wiles J. Mol. Catal. B: Enzym. 63 2010 81 86
8. M.N.H.Z. Alam, M. Pinelo, K. Samanta, G. Jonsson, A. Meyer, and K.V. Gernaey Chem. Eng. J. 167 2011 418 426
9. K. Koch, R.J.F. van den Berg, P.J. Nieuwland, R. Wijtmans, H.E. Schoemaker, J.C.M. van Hest, and F.P.J.T. Rutjes Biotechnol. Bioeng. 99 2008 1028 1033
10. M. Miyazaki, and H. Maeda Trends Biotechnol. 24 2006 463 470
11. H.R. Sahoo, J.G. Kralj, and K.F. Jensen Angew. Chem. Int. Ed. 119 2007 5806 5810
12. R.L. Hartman, J.R. Naber, S.L. Buchwald, and K.F. Jensen Angew. Chem. Int. Ed. 49 2010 899 903
13. R. Wohlgemuth Chem. Biochem. Eng. Q. 25 2011 125 134
14. R. Wohlgemuth M. Moo-Young, M. Butler, C. Webb, A. Moreira, B. Grodzinski, Z.F. Cui, S. Agathos, Comprehensive Biotechnology 2011 Elsevier Amsterdam, Netherlands 591 601
15. A. Schwarz, M.S. Thomsen, and B. Nidetzky Biotechnol. Bioeng. 103 2009 865 872
16. S. Matosevic, G.J. Lye, and F. Baganz Biotechnol. Prog. 26 2010 118 126
17. K.F. Schilke, K.L. Wilson, T. Cantrell, G. Corti, D.N. McIlroy, and C. Kelly Biotechnol. Prog. 26 2010 1597 1605
18. R. Moser, T. Chappuis, E. Vannioli, S. Crefier, and O. Naef Chimia 64 2010 799 802
19. M.A. Holden, S.Y. Jung, and P.S. Cremer Anal. Chem. 76 2004 1838 1843
20. A. Srinivasan, H. Bach, D.H. Sherman, and J.S. Dordick Biotechnol. Bioeng. 88 2004 528 535
21. R. van Reis, and A. Zydney J. Membr. Sci. 297 2007 16 50
22. J. de Jong, R.G.H. Lammertink, and M. Wessling Lab Chip 6 2006 1125 1139
23. M. Kalyanpur Mol. Biotechnol. 22 2002 87 98
24. I.S. Ngene, R.G.H. Lammertink, M. Wessling, and W. van der Meer J. Membr. Sci. 346 2010 202 207
25. R. Wohlgemuth, M.E.B. Smith, P.A. Dalby, and J.M. Woodley M.C. Flickinger, Encyclopaedia of Industrial Biotechnology: Bioprocess, Bioseparation and Cell Technology 2010 Wiley Hoboken, USA 4746 4752
26. A. Cázares, J.L. Galman, L.G. Crago, M.E.B. Smith, J. Strafford, L. Ríos-Solís, G.J. Lye, P.A. Dalby, and H.C. Hailes Org. Biomol. Chem. 8 2010 1301 1309
27. E.G. Hibbert, T. Senussi, S.J. Costelloe, W. Lei, M.E.B. Smith, J.M. Ward, H.C. Hailes, and P.A. Dalby J. Biotechnol. 131 2007 425 432
28. E.G. Hibbert, T. Senussi, M.E.B. Smith, S.J. Costelloe, J.M. Ward, H.C. Hailes, and P.A. Dalby J. Biotechnol. 134 2008 240 245
29. F. Charmantray, V. Helaine, B. Legeret, and L. Hecquet J. Mol. Catal. B: Enzym. 57 2009 6 9
30. R. Wohlgemuth J. Mol. Catal. B: Enzym. 61 2009 23 29
31. C.U. Ingram, M. Bommer, M.E.B. Smith, P.A. Dalby, J.M. Ward, H.C. Hailes, and G.J. Lye Biotechnol. Bioeng. 96 2007 559 569
32. J. Shaeri, I. Wright, E. Rathbone, R. Wohlgemuth, and J.M. Woodley Biotechnol. Bioeng. 101 2008 761 767
33. M.E.B. Smith, E.G. Hibbert, A.B. Jones, P.A. Dalby, and H.C. Hailes Adv. Synth. Catal. 350 2008 2631 2638
34. M.E.B. Smith, K. Smithies, T. Senussi, P.A. Dalby, and H.C. Hailes Eur. J. Org. Chem. 5 2006 1121 1123
35. S. Matosevic, M. Micheletti, J.M. Woodley, G. Lye, and F. Baganz Biotechnol. Lett. 30 2008 995 1000
36. H.A. Stone, A.D. Stroock, and A. Ajdari Annu. Rev. Fluid Mech. 36 2004 381 411
37. A.D. Stroock, S.K.W. Dertinger, A. Ajdari, I. Mezic, H.A. Stone, and G.M. Whitesides Science 295 2002 647 651
38. M.A. Ansari, and K.Y. Kim Chem. Eng. Sci. 62 2007 6687 6695
39. W.D. Ristenpart, J. Wan, and H.A. Stone Anal. Chem. 80 2008 3270 3276
40. G.J. Lye, P. Ayazi-Shamlou, F. Baganz, P.A. Dalby, and J.M. Woodley Trends Biotechnol. 21 2003 29 37
41. M.B. Kerby, R.S. Legge, and A. Tripathi Anal. Chem. 78 2006 8273 8280
42. J. Shaeri, R. Wohlgemuth, and J.M. Woodley Org. Proc. Res. Dev. 10 2006 605 610
43. M.P.C. Marques, J.M.S. Cabral, and P. Fernandes Recent Pat. Biotechnol. 3 2009 124 140
44. G.M. Whitesides Nature 442 2006 368 373
45. A.J. DeMello Nature 442 2006 394 402
46. J.M. Bolivar, J. Wiesbauer, and B. Nidetzky Trends Biotechnol. 29 2011 333 342
47. R. Wohlgemuth Biotechnol. J. 4 2009 1253 1265