-
1
-
-
84889299946
-
-
Challenge and Opportunity on the Critical Path to New Medical Products. US FDA March, Available from, accessed 29 January
-
Challenge and Opportunity on the Critical Path to New Medical Products. US FDA March 2004. Available from http://www.fda.gov/oc/initiatives/criticalpath/whitepaper.html(accessed 29 January 2007).
-
(2004)
-
-
-
2
-
-
33745915615
-
Guidance for Industry:Fast Track Drug Development Programs-Designation, Development, and Application Review
-
Rockvill, MD:US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research(CDER), Center for Biologics Evaluation and Research(CBER); January, Procedural Revision 2. Available from, accessed 29 January
-
Guidance for Industry:Fast Track Drug Development Programs-Designation, Development, and Application Review. Rockvill, MD:US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research(CDER), Center for Biologics Evaluation and Research(CBER); January 2006. Procedural Revision 2. Available from http://www.fda.gov/cber/gdlns/fsttrk.pdf(accessed 29 January 2007).
-
(2006)
-
-
-
3
-
-
33748750980
-
Regulating biopharmaceuticals under CDE versus CBER:an insider's perspective
-
Schwieterman WD. Regulating biopharmaceuticals under CDE versus CBER:an insider's perspective. Drug Discov Today 2006;11(19-20):945-951.
-
(2006)
Drug Discov Today
, vol.11
, Issue.19-20
, pp. 945-951
-
-
Schwieterman, W.D.1
-
4
-
-
84889422044
-
Organisation for Economic Co-operation and Development
-
Available from, accessed 29 January
-
Organisation for Economic Co-operation and Development. Chemcials Testing Guidelines. Section 4:Health Effects. Available from http://www.oecd.org/document/55/0,2340,en_2649_34377_2349687_1_1_1_1,00.html(accessed 29 January 2007).
-
(2007)
Chemcials Testing Guidelines. Section 4:Health Effects.
-
-
-
6
-
-
0033776857
-
Orphan G-protein coupled receptors:novel drug targets for the pharmaceutical industry
-
Wilson S, Bergsma D. Orphan G-protein coupled receptors:novel drug targets for the pharmaceutical industry. Drug Des Discov 2000; 17(2): 105-114.
-
(2000)
Drug Des Discov
, vol.17
, Issue.2
, pp. 105-114
-
-
Wilson, S.1
Bergsma, D.2
-
7
-
-
84889411407
-
-
Cancer Genome Anatomy Project:National Cancer Institute., Available from, accessed 29 January
-
Cancer Genome Anatomy Project:National Cancer Institute. Available from www.ncbi.nlm.nih.gov/CGAP(accessed 29 January 2007).
-
(2007)
-
-
-
8
-
-
84889296726
-
-
Genomes on-line database version 2. Available from, accessed 29 January
-
Genomes on-line database version 2. Available from http://www.genomesonline.org/(accessed 29 January 2007).
-
(2007)
-
-
-
9
-
-
14844326483
-
Computational prediction of human metabolic pathways from the complete human genome
-
accessed 29 January
-
Romero P, Wagg J, Green ML, Kaiser D, Krummenacker M, Karp PD. Computational prediction of human metabolic pathways from the complete human genome. Genome(Biol) 2004 ;6(1):http://genomebiology.com/2004/6/1/R2 (accessed 29 January 2007).
-
(2004)
Genome(Biol)
, vol.6
, Issue.1
-
-
Romero, P.1
Wagg, J.2
Green, M.L.3
Kaiser, D.4
Krummenacker, M.5
Karp, P.D.6
-
10
-
-
0035827328
-
Microbial genes in the human genome:lateral transfer or gene loss?
-
Salzberg SL, White O, Peterson J, Eisen JA. Microbial genes in the human genome:lateral transfer or gene loss? Science 2001; 292(5523): 1903-1906.
-
(2001)
Science
, vol.292
, Issue.5523
, pp. 1903-1906
-
-
Salzberg, S.L.1
White, O.2
Peterson, J.3
Eisen, J.A.4
-
11
-
-
0036699060
-
Systematic screen for human disease genes in yeast
-
Steinmetz LM, Scharfe C, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW. Systematic screen for human disease genes in yeast. Nat Genet 2002;31:400-404.
-
(2002)
Nat Genet
, vol.31
, pp. 400-404
-
-
Steinmetz, L.M.1
Scharfe, C.2
Deutschbauer, A.M.3
Mokranjac, D.4
Herman, Z.S.5
Jones, T.6
Chu, A.M.7
Giaever, G.8
Prokisch, H.9
Oefner, P.J.10
Davis, R.W.11
-
12
-
-
0034616930
-
Functional discovery via a compendium of expression profiles
-
Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, Armour CD, Bennett HA, Coffey E, Dai H, He YD, Kidd MJ, King AM, Meyer MR, Slade D, Lum PY, Stepaniants SB, Shoemaker DD, Gachotte D, Chakraburtty K, Simon J, Bard M, Friend SH. Functional discovery via a compendium of expression profiles. Cell 2000;102:109-126.
-
(2000)
Cell
, vol.102
, pp. 109-126
-
-
Hughes, T.R.1
Marton, M.J.2
Jones, A.R.3
Roberts, C.J.4
Stoughton, R.5
Armour, C.D.6
Bennett, H.A.7
Coffey, E.8
Dai, H.9
He, Y.D.10
Kidd, M.J.11
King, A.M.12
Meyer, M.R.13
Slade, D.14
Lum, P.Y.15
Stepaniants, S.B.16
Shoemaker, D.D.17
Gachotte, D.18
Chakraburtty, K.19
Simon, J.20
Bard, M.21
Friend, S.H.22
more..
-
13
-
-
0037087575
-
Subcellular localization of the yeast proteome
-
Kumar A, Agarwal S, Heyman JA, Matson S, Heidtman M, Piccirillo S, Umansky L, Drawid A, Jansen R, Liu Y, Cheung K-H, Miller P, Gerstein M, Roeder GS, Snyder M. Subcellular localization of the yeast proteome. Genes Dev 2002; 16(6): 707-719.
-
(2002)
Genes Dev
, vol.16
, Issue.6
, pp. 707-719
-
-
Kumar, A.1
Agarwal, S.2
Heyman, J.A.3
Matson, S.4
Heidtman, M.5
Piccirillo, S.6
Umansky, L.7
Drawid, A.8
Jansen, R.9
Liu, Y.10
Cheung, K.-H.11
Miller, P.12
Gerstein, M.13
Roeder, G.S.14
Snyder, M.15
-
14
-
-
0345189364
-
Yeast cells provide insight into alpha-synuclein biology and pathobiology
-
Outeiro TF, Lindquist S. Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 2003;302:1772-1775.
-
(2003)
Science
, vol.302
, pp. 1772-1775
-
-
Outeiro, T.F.1
Lindquist, S.2
-
15
-
-
31644443193
-
A yeast-based model of α-synucleinopathy identifies compounds with therapeutic potential
-
Griffioen G, Duhamel H, Van Damme N, Pellens K, Zabrocki P, Pannecouque C, van Leuven F, Winderickx J, Wera S. A yeast-based model of α-synucleinopathy identifies compounds with therapeutic potential. Biochem Biophys Acta 2006;1762:312-318.
-
(2006)
Biochem Biophys Acta
, vol.1762
, pp. 312-318
-
-
Griffioen, G.1
Duhamel, H.2
Van Damme, N.3
Pellens, K.4
Zabrocki, P.5
Pannecouque, C.6
Van Leuven, F.7
Winderickx, J.8
Wera, S.9
-
16
-
-
0034894495
-
Sex and sugar in yeast:two distinct GPCR systems
-
Versele M, Lemaire K, Thevelein JM. Sex and sugar in yeast:two distinct GPCR systems. EMBO Rep 2001;2:574-579.
-
(2001)
EMBO Rep
, vol.2
, pp. 574-579
-
-
Versele, M.1
Lemaire, K.2
Thevelein, J.M.3
-
17
-
-
4944258780
-
Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiae
-
Pausch MH, Lai M, Tseng E, Paulsen J, Bates B, Kwak S. Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiae. Biochem Biophys Res Commun 2004;324:171-177.
-
(2004)
Biochem Biophys Res Commun
, vol.324
, pp. 171-177
-
-
Pausch, M.H.1
Lai, M.2
Tseng, E.3
Paulsen, J.4
Bates, B.5
Kwak, S.6
-
18
-
-
0032545933
-
Potent and specific genetic interference by double stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-811.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
19
-
-
0031731989
-
Genetics of programmed cell death in C. elegans:past, present and future
-
Metzstein MM, Stanfield GM, Horvitz HR. Genetics of programmed cell death in C. elegans:past, present and future. Trends Genet 1998; 14(10): 410-416.
-
(1998)
Trends Genet
, vol.14
, Issue.10
, pp. 410-416
-
-
Metzstein, M.M.1
Stanfield, G.M.2
Horvitz, H.R.3
-
20
-
-
33750006528
-
Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery
-
Nichols CD. Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery. Pharmacol Ther 2006; 112(3): 677-700.
-
(2006)
Pharmacol Ther
, vol.112
, Issue.3
, pp. 677-700
-
-
Nichols, C.D.1
-
21
-
-
33646228824
-
Sc-PDB:an annotated database of druggable binding sites from the protein data bank
-
Kellenberger E, Muller P, Schalon C, Bret G, Foata N, Rognan D. Sc- PDB:an annotated database of druggable binding sites from the protein data bank. J Chem Inf Model 2006;46:717-727.
-
(2006)
J Chem Inf Model
, vol.46
, pp. 717-727
-
-
Kellenberger, E.1
Muller, P.2
Schalon, C.3
Bret, G.4
Foata, N.5
Rognan, D.6
-
23
-
-
0034678033
-
Target-oriented and diversity-oriented organis synthesis in drug discovery
-
Schreiber SL. Target-oriented and diversity-oriented organis synthesis in drug discovery. Science 2000; 287(5460): 1964-1969.
-
(2000)
Science
, vol.287
, Issue.5460
, pp. 1964-1969
-
-
Schreiber, S.L.1
-
24
-
-
3342966009
-
Using NMR for ligand discovery and optimization
-
Villar HO, Yan J, Hansen MR. Using NMR for ligand discovery and optimization. Curr Opin Chem Biol 2004; 8(4): 387-391.
-
(2004)
Curr Opin Chem Biol
, vol.8
, Issue.4
, pp. 387-391
-
-
Villar, H.O.1
Yan, J.2
Hansen, M.R.3
-
25
-
-
0037194620
-
SAR by MS:a ligand-based technique for drug lead discovery against RNA targets
-
Swayze EE, Jefferson EA, Sannes-Lowery KA, Blyn LB, Risen LM, Arakawa S, Osgood SA, Hofstadler SA, Griffey RH. SAR by MS:a ligand-based technique for drug lead discovery against RNA targets. J Med Chem 2002; 45(18): 3816-3819.
-
(2002)
J Med Chem
, vol.45
, Issue.18
, pp. 3816-3819
-
-
Swayze, E.E.1
Jefferson, E.A.2
Sannes-Lowery, K.A.3
Blyn, L.B.4
Risen, L.M.5
Arakawa, S.6
Osgood, S.A.7
Hofstadler, S.A.8
Griffey, R.H.9
-
26
-
-
12344318177
-
Fragment-based lead discovery using X-ray crystallography
-
Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H. Fragment-based lead discovery using X-ray crystallography. J Med Chem 2005; 48(2): 403-413.
-
(2005)
J Med Chem
, vol.48
, Issue.2
, pp. 403-413
-
-
Hartshorn, M.J.1
Murray, C.W.2
Cleasby, A.3
Frederickson, M.4
Tickle, I.J.5
Jhoti, H.6
-
27
-
-
4644324195
-
Optimizing the hit-to-lead process using SPR analysis
-
Lofas S. Optimizing the hit-to-lead process using SPR analysis. Assay Drug Dev Technol 2004;4:407-415.
-
(2004)
Assay Drug Dev Technol
, vol.4
, pp. 407-415
-
-
Lofas, S.1
-
31
-
-
0034460074
-
HTS in the new millennium. The role of pharmacology and flexibility
-
Landro JA, Taylor ICA, Stirtan WG, Osterman DG, Kristie J, Hunnicutt EJ, Rae PMM, Sweetnam PM. HTS in the new millennium. The role of pharmacology and flexibility. J Pharmacol Toxicol Methods 2000;44:273-289.
-
(2000)
J Pharmacol Toxicol Methods
, vol.44
, pp. 273-289
-
-
Landro, J.A.1
Taylor, I.C.A.2
Stirtan, W.G.3
Osterman, D.G.4
Kristie, J.5
Hunnicutt, E.J.6
Rae, P.M.M.7
Sweetnam, P.M.8
-
32
-
-
20444410379
-
Enzyme inihibitor screening using a homogenous proximity-based immunoassay for estradiol
-
Kokko L, Johansson N, Lovgren T, Soukka T. Enzyme inihibitor screening using a homogenous proximity-based immunoassay for estradiol. J Biomol Screen 2005;10:348-354.
-
(2005)
J Biomol Screen
, vol.10
, pp. 348-354
-
-
Kokko, L.1
Johansson, N.2
Lovgren, T.3
Soukka, T.4
-
33
-
-
22144495695
-
A human immunodeficiency virus type 1 protease biosensor using bioluminescence resonance energy transfer
-
Kimberly H, Clement, JF, Abrahamyan L, Strebel K, Bouvier M, Kleinman L, Mouland AJ. A human immunodeficiency virus type 1 protease biosensor using bioluminescence resonance energy transfer. J Virol Methods 2005;128:93-103.
-
(2005)
J Virol Methods
, vol.128
, pp. 93-103
-
-
Kimberly, H.1
Clement, J.F.2
Abrahamyan, L.3
Strebel, K.4
Bouvier, M.5
Kleinman, L.6
Mouland, A.J.7
-
35
-
-
24344470951
-
Cell-based and biochemical screening approaches for the discovery of novel HIV-1 inihibitors
-
Westby M, Nakayama GR, Butler SL, Blair WS. Cell-based and biochemical screening approaches for the discovery of novel HIV-1 inihibitors. Antiviral Res 2005;67:121-140.
-
(2005)
Antiviral Res
, vol.67
, pp. 121-140
-
-
Westby, M.1
Nakayama, G.R.2
Butler, S.L.3
Blair, W.S.4
-
36
-
-
33745991806
-
Electrochemical biosensor evaluation of the interaction between DNA and metallo-drugs
-
Mascini M, Bagni G, Di Pietro ML, Ravera M, Baracco S, Osella D. Electrochemical biosensor evaluation of the interaction between DNA and metallo-drugs. Biometals 2006;19:409-418.
-
(2006)
Biometals
, vol.19
, pp. 409-418
-
-
Mascini, M.1
Bagni, G.2
Di Pietro, M.L.3
Ravera, M.4
Baracco, S.5
Osella, D.6
-
37
-
-
23044463650
-
New strategy for improved secondary screening and lead optimization using high-resolution SPR characterization of compound-target interactions
-
Huber W. New strategy for improved secondary screening and lead optimization using high-resolution SPR characterization of compound-target interactions. J Mol Recognition 2005;18:273-281.
-
(2005)
J Mol Recognition
, vol.18
, pp. 273-281
-
-
Huber, W.1
-
38
-
-
0030974119
-
In vitro selection and evolution of functional proteins by using ribosomal display
-
Hanes J, Pluckhun A. In vitro selection and evolution of functional proteins by using ribosomal display. Proc Natl Acad Sci USA 1997;94:4937-4942.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4937-4942
-
-
Hanes, J.1
Pluckhun, A.2
-
39
-
-
20644469912
-
Design, construction, and characterization of a large synthetic human antibody phage display library
-
Silacci M, Brack S, Schirru G, Marlind J, Ettorre A, Merlo A, Viti F, Neri D. Design, construction, and characterization of a large synthetic human antibody phage display library. Proteomics 2005;5:2340-2350.
-
(2005)
Proteomics
, vol.5
, pp. 2340-2350
-
-
Silacci, M.1
Brack, S.2
Schirru, G.3
Marlind, J.4
Ettorre, A.5
Merlo, A.6
Viti, F.7
Neri, D.8
-
40
-
-
0030994634
-
Yeast surface display for screening combinatorial polypeptide libraries
-
Boder ET, Wittrup KD. Yeast surface display for screening combinatorial polypeptide libraries. Nat Biotechnol 1997;15:553-557.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 553-557
-
-
Boder, E.T.1
Wittrup, K.D.2
-
41
-
-
19444375104
-
DNA- based therapeutics and DNA delivery systems:a comprehensive review
-
Patil SD, Rhodes DG, Burgess DJ. DNA- based therapeutics and DNA delivery systems:a comprehensive review. AAPS 2005;7(1):E61-E77.
-
(2005)
AAPS
, vol.7
, Issue.1
-
-
Patil, S.D.1
Rhodes, D.G.2
Burgess, D.J.3
-
42
-
-
33646534455
-
Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics
-
Klumpp C, Kostarelos K, Prato M, Bianco A. Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics. Biochim Biophys Acta 2006;1758:404-412.
-
(2006)
Biochim Biophys Acta
, vol.1758
, pp. 404-412
-
-
Klumpp, C.1
Kostarelos, K.2
Prato, M.3
Bianco, A.4
-
43
-
-
0037124196
-
Drugs, leads and drug-likeness:an analysis of some recently launched drugs
-
Proudfoot JR. Drugs, leads and drug-likeness:an analysis of some recently launched drugs. Bioorg Med Chem Lett 2002; 12(12): 1647-1650.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, Issue.12
, pp. 1647-1650
-
-
Proudfoot, J.R.1
-
44
-
-
27844463050
-
Ligand affinity binding in improving success-rates for lead generation
-
Makara GM, Athanasopoulos J. Ligand affinity binding in improving success-rates for lead generation. Curr Opin Biotechnol 2005;16:666-673.
-
(2005)
Curr Opin Biotechnol
, vol.16
, pp. 666-673
-
-
Makara, G.M.1
Athanasopoulos, J.2
-
46
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 2004;3:711-715.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
47
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lambardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 1997;23:3-25.
-
(1997)
Adv Drug Deliv Rev
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lambardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
48
-
-
0028948839
-
A theoretical basis for a biopharmaceutic drug classification:the correlation of in vitro drug product dissolution and in vivo bioavailability
-
Amidon GLH, Lennernäs H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification:the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 1995; 12(3): 413-420.
-
(1995)
Pharm Res
, vol.12
, Issue.3
, pp. 413-420
-
-
Amidon, G.L.H.1
Lennernäs, H.2
Shah, V.P.3
Crison, J.R.4
-
49
-
-
0037484174
-
Modeling tissue-specific signaling and organ function in three dimensions
-
Schmeichel KL, Bissell MJ. Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci 2003; 116(12): 2377-2388.
-
(2003)
J Cell Sci
, vol.116
, Issue.12
, pp. 2377-2388
-
-
Schmeichel, K.L.1
Bissell, M.J.2
-
50
-
-
0028243664
-
Use of everted intestinal rings for in vitro examination of oral absorption potential
-
Leppert PS, Fix JA. Use of everted intestinal rings for in vitro examination of oral absorption potential. J Pharm Sci 1994;8:976-981.
-
(1994)
J Pharm Sci
, vol.8
, pp. 976-981
-
-
Leppert, P.S.1
Fix, J.A.2
-
51
-
-
0023715382
-
Estimating human oral fraction dose absorbed:a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds
-
Amidon GL, Sinko PJ, Fleisher D. Estimating human oral fraction dose absorbed:a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds. Pharm Res 1988;10:651-654.
-
(1988)
Pharm Res
, vol.10
, pp. 651-654
-
-
Amidon, G.L.1
Sinko, P.J.2
Fleisher, D.3
-
52
-
-
0029692559
-
Cultured intestinal epithelial cell models
-
Hidalgo IJ. Cultured intestinal epithelial cell models. Pharm Biotechnol 1996;8:35-50.
-
(1996)
Pharm Biotechnol
, vol.8
, pp. 35-50
-
-
Hidalgo, I.J.1
-
53
-
-
0032949615
-
MDCK(Madin-Darby canine kidney) cells:a tool for membrane permeability screening
-
Irvine JD, Takahashi L, Lockhart K, Cheong J, Tolan JW, Selick HE, Grove JR. MDCK(Madin-Darby canine kidney) cells:a tool for membrane permeability screening. J Pharm Sci 1999;88:28-33.
-
(1999)
J Pharm Sci
, vol.88
, pp. 28-33
-
-
Irvine, J.D.1
Takahashi, L.2
Lockhart, K.3
Cheong, J.4
Tolan, J.W.5
Selick, H.E.6
Grove, J.R.7
-
54
-
-
0029020035
-
Comparison of intestinal permeabilities determined in multiple in vitro and in situ models:relationship to absorption in humans
-
Stewart BH, Chan OH, Lu RH, Rener EL, Schmid HL, Hamilton HW, Steinbaugh BA, Taylor MD. Comparison of intestinal permeabilities determined in multiple in vitro and in situ models:relationship to absorption in humans. Pharm Res 1995;12:693-699.
-
(1995)
Pharm Res
, vol.12
, pp. 693-699
-
-
Stewart, B.H.1
Chan, O.H.2
Lu, R.H.3
Rener, E.L.4
Schmid, H.L.5
Hamilton, H.W.6
Steinbaugh, B.A.7
Taylor, M.D.8
-
55
-
-
0034034259
-
High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery
-
White RE. High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery. Annu Rev Pharmacol Toxicol 2000;40:133-157.
-
(2000)
Annu Rev Pharmacol Toxicol
, vol.40
, pp. 133-157
-
-
White, R.E.1
-
56
-
-
0029058745
-
IAM chromatography:an in vitro screen for predicting drug membrane permeability
-
Pidgeon C, Ong S, Munroe J, Hornback WJ, Kasher JS, Grunz L, Liu H, Qiu X, Pidgeon M, Dantzig A. IAM chromatography:an in vitro screen for predicting drug membrane permeability. Med Chem 1995;38:590-594.
-
(1995)
Med Chem
, vol.38
, pp. 590-594
-
-
Pidgeon, C.1
Ong, S.2
Munroe, J.3
Hornback, W.J.4
Kasher, J.S.5
Grunz, L.6
Liu, H.7
Qiu, X.8
Pidgeon, M.9
Dantzig, A.10
-
57
-
-
0032568397
-
Physicochemical high throughput screening:parallel artificial membrane permeation assay in the description of passive absorption processes
-
Kansy M, Senner F, Gubernator K. Physicochemical high throughput screening:parallel artificial membrane permeation assay in the description of passive absorption processes. J Med Chem 1998;41:1007-1010.
-
(1998)
J Med Chem
, vol.41
, pp. 1007-1010
-
-
Kansy, M.1
Senner, F.2
Gubernator, K.3
-
58
-
-
33749440072
-
Rapid assessment of P-glycoprotein-drug interactions at the blood-brain barrier
-
Bubik M, Ott M, Mahringer A, Fricker G. Rapid assessment of P-glycoprotein-drug interactions at the blood-brain barrier. Anal Biochem 2006;358:51-58.
-
(2006)
Anal Biochem
, vol.358
, pp. 51-58
-
-
Bubik, M.1
Ott, M.2
Mahringer, A.3
Fricker, G.4
-
59
-
-
3342900203
-
The development of a standardised protocol to measure squamous differentiation in stratified epithelia, by using the fluorescein cadaverine incorporation technique
-
Gray AC, Malton J, Clothier RH. The development of a standardised protocol to measure squamous differentiation in stratified epithelia, by using the fluorescein cadaverine incorporation technique Altern Lab Anim 2004; 32(2): 91-100.
-
(2004)
Altern Lab Anim
, vol.32
, Issue.2
, pp. 91-100
-
-
Gray, A.C.1
Malton, J.2
Clothier, R.H.3
-
60
-
-
0029685785
-
Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells
-
Gray TE, Guzman K, Davis CW, Abdullah LH, Nettesheim P. Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol 1996; 14(1): 104-112.
-
(1996)
Am J Respir Cell Mol Biol
, vol.14
, Issue.1
, pp. 104-112
-
-
Gray, T.E.1
Guzman, K.2
Davis, C.W.3
Abdullah, L.H.4
Nettesheim, P.5
-
61
-
-
17444406065
-
P ermeability studies on in vitro blood-brain barrier models:physiology, pathology and pharmacology
-
Deli MAM, Abraham CS, Kataoka Y, Niwa M. P ermeability studies on in vitro blood-brain barrier models:physiology, pathology and pharmacology. Cell Mol Neurobiol 2005;25:59-126.
-
(2005)
Cell Mol Neurobiol
, vol.25
, pp. 59-126
-
-
Deli, M.A.M.1
Abraham, C.S.2
Kataoka, Y.3
Niwa, M.4
-
62
-
-
3042569619
-
The Third FRAME Toxicity Committee:Working Toward Greater Implementation of Alternatives in Toxicity Testing
-
Combes RD, Balls M, Bansil L, Barratt M, Bell D, Botham P, Broadhead C, Clothier R, George E, Fentem J, Jackson M, Indans I, Loizou G, Navaratnam V, Pentreath V, Phillips B, Stemplewski H, Stewart J. The Third FRAME Toxicity Committee:Working Toward Greater Implementation of Alternatives in Toxicity Testing. Altern Lab Anim 2002;32(S1):635-642.
-
(2002)
Altern Lab Anim
, vol.32
, Issue.S1
, pp. 635-642
-
-
Combes, R.D.1
Balls, M.2
Bansil, L.3
Barratt, M.4
Bell, D.5
Botham, P.6
Broadhead, C.7
Clothier, R.8
George, E.9
Fentem, J.10
Jackson, M.11
Indans, I.12
Loizou, G.13
Navaratnam, V.14
Pentreath, V.15
Phillips, B.16
Stemplewski, H.17
Stewart, J.18
-
63
-
-
0035156232
-
Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier
-
Gumbleton M, Audus KL. Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier. J Pharm Sci 2001;90:1681-1698.
-
(2001)
J Pharm Sci
, vol.90
, pp. 1681-1698
-
-
Gumbleton, M.1
Audus, K.L.2
-
64
-
-
0001855566
-
Brain spheroid and other organotypic culture systems in in vitro neurotoxicology
-
Pentreath VW, Ed., Washington DC:Taylor and Francis
-
Atterwill CK, Purcell WM. Brain spheroid and other organotypic culture systems in in vitro neurotoxicology. In Pentreath VW, Ed., Neurotoxicology In vitro Washington DC:Taylor and Francis;1999, pp 213-238.
-
(1999)
Neurotoxicology In vitro
, pp. 213-238
-
-
Atterwill, C.K.1
Purcell, W.M.2
-
65
-
-
9944235585
-
Comparative structure, function and toxicity of the nasal airways. Predicting human effects from animal studies
-
Gardner DE, Crapo JD, McCellan RO, Eds., Washington DC:Taylor and Francis
-
Harkema JR. Comparative structure, function and toxicity of the nasal airways. Predicting human effects from animal studies. In Gardner DE, Crapo JD, McCellan RO, Eds. Toxicology of the Lung. Washington DC:Taylor and Francis;1999, pp 55-83.
-
(1999)
Toxicology of the Lung.
, pp. 55-83
-
-
Harkema, J.R.1
-
66
-
-
9944256233
-
The use of human nasal in vitro cell systems during drug discovery and development
-
Dimova S, Brewster ME, Noppe M, Jorissen M, Augustijns P. The use of human nasal in vitro cell systems during drug discovery and development. Toxicol In Vitro 2005;19:107-122.
-
(2005)
Toxicol In Vitro
, vol.19
, pp. 107-122
-
-
Dimova, S.1
Brewster, M.E.2
Noppe, M.3
Jorissen, M.4
Augustijns, P.5
-
67
-
-
8944256082
-
Nomenclature for human CYP2D6 alleles
-
Daly AK. Nomenclature for human CYP2D6 alleles. Pharmacogenetics 1996;6:193-201.
-
(1996)
Pharmacogenetics
, vol.6
, pp. 193-201
-
-
Daly, A.K.1
-
68
-
-
0032838532
-
The use of long-term hepatocyte cultures for detecting induction of drug metabolising enzymes:the current status:ECVAM Hepatocytes and Metabolically Competent Systems Task Force Report 1
-
Coecke S, Rogiers V, Bayliss M, Castell JM, Doehmer J, Fabre G, Fry J, Kern A, Westmoreland C. The use of long-term hepatocyte cultures for detecting induction of drug metabolising enzymes:the current status:ECVAM Hepatocytes and Metabolically Competent Systems Task Force Report 1. Altern Lab Anim 1999; 27(4): 579-638.
-
(1999)
Altern Lab Anim
, vol.27
, Issue.4
, pp. 579-638
-
-
Coecke, S.1
Rogiers, V.2
Bayliss, M.3
Castell, J.M.4
Doehmer, J.5
Fabre, G.6
Fry, J.7
Kern, A.8
Westmoreland, C.9
-
69
-
-
33750201621
-
On-line drug metabolism in capillary electrophoresis 1. Glucuronidation using rat liver microsomes
-
Kim HS, Wainer IW. On-line drug metabolism in capillary electrophoresis. 1. Glucuronidation using rat liver microsomes. Anal Chem 2006;78:7071-7077.
-
(2006)
Anal Chem
, vol.78
, pp. 7071-7077
-
-
Kim, H.S.1
Wainer, I.W.2
-
70
-
-
0026158432
-
Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration
-
Dunn JC, Tompkins RG, Yarmush ML. Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Prog 1991;7:237-245.
-
(1991)
Biotechnol Prog
, vol.7
, pp. 237-245
-
-
Dunn, J.C.1
Tompkins, R.G.2
Yarmush, M.L.3
-
71
-
-
33746736816
-
A membrane-based small-scale bioreactor for accelerated in vitro drug screenings with primary hepatocytes
-
Scmitmeier S, Langsch A, Bader A. A membrane-based small-scale bioreactor for accelerated in vitro drug screenings with primary hepatocytes. Desalination 2006;199:258-260.
-
(2006)
Desalination
, vol.199
, pp. 258-260
-
-
Scmitmeier, S.1
Langsch, A.2
Bader, A.3
-
72
-
-
31544463781
-
Predicting oral drug absorption and hepatobiliary clearance:human intestinal and hepatic in vitro cell models
-
Fearn RA, Hirst BH. Predicting oral drug absorption and hepatobiliary clearance:human intestinal and hepatic in vitro cell models. Environ Toxicol Pharmacol 2006;21:168-178.
-
(2006)
Environ Toxicol Pharmacol
, vol.21
, pp. 168-178
-
-
Fearn, R.A.1
Hirst, B.H.2
-
73
-
-
0642366710
-
V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans
-
Krebsfaenger N, Murdter TE, Zanger UM, Eichelbaum MF, Doehmer J. V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans. ALTEX 2003; 20(3): 143-154.
-
(2003)
ALTEX
, vol.20
, Issue.3
, pp. 143-154
-
-
Krebsfaenger, N.1
Murdter, T.E.2
Zanger, U.M.3
Eichelbaum, M.F.4
Doehmer, J.5
-
74
-
-
3242752786
-
Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells
-
Boonstra J, Post JA. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 2004;337:1-13.
-
(2004)
Gene
, vol.337
, pp. 1-13
-
-
Boonstra, J.1
Post, J.A.2
-
75
-
-
0842328727
-
Neuroblastoma survival and death:an in vitro model of hypoxia and metabolic stress
-
Prabhakaran K, Sampson DA, Hoehner JC. Neuroblastoma survival and death:an in vitro model of hypoxia and metabolic stress. J Surg Res 2004;116:288-296.
-
(2004)
J Surg Res
, vol.116
, pp. 288-296
-
-
Prabhakaran, K.1
Sampson, D.A.2
Hoehner, J.C.3
-
76
-
-
1942451939
-
Evaluation of a flat membrane hepatocyte bioreactor for pharmacotoxicological applications:evidence that inhibition of spontaneously produced nitric oxide improves cell functionality
-
Canova N, Kmonickova E, Lincova D, Vitek L, Farghali H. Evaluation of a flat membrane hepatocyte bioreactor for pharmacotoxicological applications:evidence that inhibition of spontaneously produced nitric oxide improves cell functionality. Altern Lab Anim 2004;32:25-35.
-
(2004)
Altern Lab Anim
, vol.32
, pp. 25-35
-
-
Canova, N.1
Kmonickova, E.2
Lincova, D.3
Vitek, L.4
Farghali, H.5
-
77
-
-
84889366586
-
Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro
-
Wong JM, Harper PA, Meyer UA, Bock KW, Morike K, Lagueux J, Ayotte P, Tyndale RF, Sellers EM, Manchester DK, Okey AB. Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro. Pharmacogenetics 1991;1:66-67.
-
(1991)
Pharmacogenetics
, vol.1
, pp. 66-67
-
-
Wong, J.M.1
Harper, P.A.2
Meyer, U.A.3
Bock, K.W.4
Morike, K.5
Lagueux, J.6
Ayotte, P.7
Tyndale, R.F.8
Sellers, E.M.9
Manchester, D.K.10
Okey, A.B.11
-
78
-
-
0242543259
-
Clinical relevance of genetic polymorphisms in the human CYP2C9 gene
-
Schwarz UI. Clinical relevance of genetic polymorphisms in the human CYP2C9 gene. Eur J Clin Invest 2003;33:23-30.
-
(2003)
Eur J Clin Invest
, vol.33
, pp. 23-30
-
-
Schwarz, U.I.1
-
79
-
-
33749015188
-
In silico prediction of cytochrome P450 inihibitors
-
Refsgaard HHF, Jensen BF, Christensen IT, Hagen N, Brockhoff PB. In silico prediction of cytochrome P450 inihibitors. Drug Dev Res 2006;67:417-429.
-
(2006)
Drug Dev Res
, vol.67
, pp. 417-429
-
-
Refsgaard, H.H.F.1
Jensen, B.F.2
Christensen, I.T.3
Hagen, N.4
Brockhoff, P.B.5
-
80
-
-
0037431382
-
A model for predicting likely sites of CYP3A4-mediated metabolism on drug-like molecules
-
Singh SB, Shen LQ, Walker MJ, Sheridan RP. A model for predicting likely sites of CYP3A4-mediated metabolism on drug-like molecules. J Med Chem 2003;46:1330-1336.
-
(2003)
J Med Chem
, vol.46
, pp. 1330-1336
-
-
Singh, S.B.1
Shen, L.Q.2
Walker, M.J.3
Sheridan, R.P.4
-
81
-
-
33745741280
-
Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs
-
Crivori P, Pogessi I. Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs. Eur J Med Chem 2006;41:795-808.
-
(2006)
Eur J Med Chem
, vol.41
, pp. 795-808
-
-
Crivori, P.1
Pogessi, I.2
-
82
-
-
10844283579
-
Automatic mass spectrometry method development for drug discovery:application in metabolic stability assays
-
Chovan LE, Black-Schaefer C, Dandliker PJ, Lau YY. Automatic mass spectrometry method development for drug discovery:application in metabolic stability assays. Rapid Commun Mass Spectrom 2004;18:3105-3112.
-
(2004)
Rapid Commun Mass Spectrom
, vol.18
, pp. 3105-3112
-
-
Chovan, L.E.1
Black-Schaefer, C.2
Dandliker, P.J.3
Lau, Y.Y.4
-
83
-
-
13544276336
-
Glycosylation of recombinant antibody therapeutics
-
Jefferis R. Glycosylation of recombinant antibody therapeutics. Biotechnol Prog 2005;21:11-16.
-
(2005)
Biotechnol Prog
, vol.21
, pp. 11-16
-
-
Jefferis, R.1
-
84
-
-
33744922424
-
TGN1412:time to change the paradigm for the testing of new pharmaceuticals
-
Bhogal N, Combes R. TGN1412:time to change the paradigm for the testing of new pharmaceuticals. Altern Lab Anim 2006; 34(2): 225-239.
-
(2006)
Altern Lab Anim
, vol.34
, Issue.2
, pp. 225-239
-
-
Bhogal, N.1
Combes, R.2
-
85
-
-
0036268893
-
Enhancing the predictive validity of Frog Embryo Teratogenesis Assay-Xenopus(FETAX)
-
Fort DJ, Paul RR. Enhancing the predictive validity of Frog Embryo Teratogenesis Assay-Xenopus(FETAX). J Appl Toxicol 2002;22:185-191.
-
(2002)
J Appl Toxicol
, vol.22
, pp. 185-191
-
-
Fort, D.J.1
Paul, R.R.2
-
86
-
-
84889463571
-
ICH Considerations:General Principles to Address the Risk of Inadvertent Germline Integration of Gene Therapy Vectors
-
International Conference on Harmonisation of technical requirements for registration of pharmaceuticals for human use(25 October, Available from, accessed 29 January
-
International Conference on Harmonisation of technical requirements for registration of pharmaceuticals for human use(25 October 2006). ICH Considerations:General Principles to Address the Risk of Inadvertent Germline Integration of Gene Therapy Vectors. Available from http://www.ich.org/LOB/media/MEDIA3363.pdf(accessed 29 January 2007).
-
(2006)
-
-
-
87
-
-
1842684996
-
Nanoparticles for overcoming biological barriers
-
Alonso MJ. Nanoparticles for overcoming biological barriers. Biomed Pharmacother 2004;58:168-172.
-
(2004)
Biomed Pharmacother
, vol.58
, pp. 168-172
-
-
Alonso, M.J.1
-
88
-
-
84889434989
-
Nanaotechnology:regulatory perspective for drug development
-
accessed 29 January
-
Sadrieh N. Nanaotechnology:regulatory perspective for drug development http://www.fda.gov/nanotechnology/powerpoint_conversions/regulatory_perspective_files/outline/index.html(accessed 29 January 2007).
-
(2007)
-
-
Sadrieh, N.1
-
89
-
-
33845214358
-
Principles of characterizing the potential health effects from exposure to nanomaterials:elements of a screening strategy. A report from ILSI Research Foundation/Risk Science Instate Nanomaterial Toxicity Screening Working Groups
-
Oberdörster G, Maynard A, Donaldson K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit S, Yang H. Principles of characterizing the potential health effects from exposure to nanomaterials:elements of a screening strategy. A report from ILSI Research Foundation/Risk Science Instate Nanomaterial Toxicity Screening Working Groups. Particle Fibre Toxicol 2005;2:1-36.
-
(2005)
Particle Fibre Toxicol
, vol.2
, pp. 1-36
-
-
Oberdörster, G.1
Maynard, A.2
Donaldson, K.3
Carter, J.4
Karn, B.5
Kreyling, W.6
Lai, D.7
Olin, S.8
Monteiro-Riviere, N.9
Warheit, S.10
Yang, H.11
-
90
-
-
0031709640
-
Arterial uptake of biodegradable nanoparticles:effects of surface modifications
-
Labhesetwar V, Song C, Humphrey W, Shebucki R, Levy RJ. Arterial uptake of biodegradable nanoparticles:effects of surface modifications. J Pharm Sci 2000;87:1229-1234.
-
(2000)
J Pharm Sci
, vol.87
, pp. 1229-1234
-
-
Labhesetwar, V.1
Song, C.2
Humphrey, W.3
Shebucki, R.4
Levy, R.J.5
-
91
-
-
84889412803
-
-
Environmental Toxicity Council(ETC) Group:Size matters! The case for a global moratorium. 2003 /04. Occasional paper series vol 7 no 1. Available from, accessed 10 September
-
Environmental Toxicity Council(ETC) Group:Size matters! The case for a global moratorium. 2003 /04. Occasional paper series vol 7 no 1. Available from http://etcgroup.org/en/materials/publications.html?id=165(accessed 10 September 2007).
-
(2007)
-
-
-
92
-
-
34248208920
-
Carbon nanotubes as nanomedicines:from toxicology to pharmacology
-
Lacerda L, Bianco A, Prato M, Kostarelos K. Carbon nanotubes as nanomedicines:from toxicology to pharmacology. Adv Drug Dev Rev 2006;58:1460-1470.
-
(2006)
Adv Drug Dev Rev
, vol.58
, pp. 1460-1470
-
-
Lacerda, L.1
Bianco, A.2
Prato, M.3
Kostarelos, K.4
-
93
-
-
31944451232
-
Toxic potential of materials at the nanolevel
-
Nel A, Xia T, Maedler L, Li N. Toxic potential of materials at the nanolevel. Science 2006;311:622-627.
-
(2006)
Science
, vol.311
, pp. 622-627
-
-
Nel, A.1
Xia, T.2
Maedler, L.3
Li, N.4
-
95
-
-
0034917323
-
Organising evidence on QT prolongation and occurrence of torsades des pointes with non-antiarrhythmic drugs:a call for consensus
-
De Pont FI, Poluzzi E, Montanaro N. Organising evidence on QT prolongation and occurrence of torsades des pointes with non-antiarrhythmic drugs:a call for consensus. Eur J Clin Pharmacol 2001;57:185-209.
-
(2001)
Eur J Clin Pharmacol
, vol.57
, pp. 185-209
-
-
De Pont, F.I.1
Poluzzi, E.2
Montanaro, N.3
-
96
-
-
14544268139
-
QT prolongation through hERG K + channel blockade:current knowledge and strategies for the early prediction during drug development
-
Recanatini M, Poluzzi E, Masetti M, Cavalli A, De Ponti F. QT prolongation through hERG K + channel blockade:current knowledge and strategies for the early prediction during drug development. Med Res Rev 2005;25:133-166.
-
(2005)
Med Res Rev
, vol.25
, pp. 133-166
-
-
Recanatini, M.1
Poluzzi, E.2
Masetti, M.3
Cavalli, A.4
De Ponti, F.5
-
97
-
-
0037312345
-
Differentiation and genetic manipulation of human embryonic stem cells and the analysis of the cardiovascular system
-
Lavon N, Bevenisty N. Differentiation and genetic manipulation of human embryonic stem cells and the analysis of the cardiovascular system. Trends Cardiovasc Med 2003;13:47-52.
-
(2003)
Trends Cardiovasc Med
, vol.13
, pp. 47-52
-
-
Lavon, N.1
Bevenisty, N.2
-
98
-
-
0038300672
-
Human embryonic stem cells develop into multiple types of cardiac myocytes:action potential characterisation
-
He JQ, Ma Y, Lee Y, Thompson JA, Kamp T. Human embryonic stem cells develop into multiple types of cardiac myocytes:action potential characterisation. Circ Res 2003;93:1-9.
-
(2003)
Circ Res
, vol.93
, pp. 1-9
-
-
He, J.Q.1
Ma, Y.2
Lee, Y.3
Thompson, J.A.4
Kamp, T.5
-
99
-
-
84889431465
-
Cardiomyocytes can be generated from marrow stromal cells in vitro
-
Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J, Umezawa A, Ogawa S. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Bioeng Biomembr 1999;28:379-385.
-
(1999)
J Bioeng Biomembr
, vol.28
, pp. 379-385
-
-
Makino, S.1
Fukuda, K.2
Miyoshi, S.3
Konishi, F.4
Kodama, H.5
Pan, J.6
Sano, M.7
Takahashi, T.8
Hori, S.9
Abe, H.10
Hata, J.11
Umezawa, A.12
Ogawa, S.13
-
100
-
-
84889461384
-
In Vitro Pyrogenicity Test Methods
-
Draft ICCVAM test method recommendations, December, Available from, accessed 29 January
-
Draft ICCVAM test method recommendations:In Vitro Pyrogenicity Test Methods(December 2006). Available from http://iccvam.niehs.nih.gov/methods/pyrodocs/supp/PWGrec12016.pdf(accessed 29 January 2007).
-
(2006)
-
-
-
101
-
-
24644481406
-
A strategy for probing the function of noncoding RNAs finds a repressor of NFAT
-
Willingham AT, Orth OP, Batalov S, Eters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Sculz PG. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science 2005;309:1570-1573.
-
(2005)
Science
, vol.309
, pp. 1570-1573
-
-
Willingham, A.T.1
Orth, O.P.2
Batalov, S.3
Eters, E.C.4
Wen, B.G.5
Aza-Blanc, P.6
Hogenesch, J.B.7
Sculz, P.G.8
-
102
-
-
10744222470
-
Mechanisms of benzene-induced hematotoxicity and leukemogenicity:cDNA microarray analyses using mouse bone marrow tissue
-
Yoon BI, Li GX, Kitada K, Kawasaki Y, Igarashi K, Kodama Y, Inoue T, Kobayashi K, Kanno J, Kim DY, Inoue T, Hirabayashi Y. Mechanisms of benzene-induced hematotoxicity and leukemogenicity:cDNA microarray analyses using mouse bone marrow tissue. Environ Health Perspect 2003;111:1411-1420.
-
(2003)
Environ Health Perspect
, vol.111
, pp. 1411-1420
-
-
Yoon, B.I.1
Li, G.X.2
Kitada, K.3
Kawasaki, Y.4
Igarashi, K.5
Kodama, Y.6
Inoue, T.7
Kobayashi, K.8
Kanno, J.9
Kim, D.Y.10
Inoue, T.11
Hirabayashi, Y.12
-
103
-
-
1942453842
-
Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profiling
-
Kramer JA, Curtiss SW, Kolaja KL, Alden CL, Blomme EA, Curtiss WC, Davila JC, Jackson CJ, Bunch RT. Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profiling. Chem Res Toxciol 2004;17:463-470.
-
(2004)
Chem Res Toxciol
, vol.17
, pp. 463-470
-
-
Kramer, J.A.1
Curtiss, S.W.2
Kolaja, K.L.3
Alden, C.L.4
Blomme, E.A.5
Curtiss, W.C.6
Davila, J.C.7
Jackson, C.J.8
Bunch, R.T.9
-
104
-
-
28444433078
-
Towards a human proteome atlas:high-throughput generation of mono-specific antibodies for tissue profiling
-
Nilsson P, Paavilainen L, Larsson K, Odling J, Sundberg M, Andersson AC, Kampf C, Persson A, Al-Khalili Szigyarto C, Ottosson J, Bjorling E, Hober S, Wernerus H, Wester K, Ponten F, Uhlen M. Towards a human proteome atlas:high-throughput generation of mono-specific antibodies for tissue profiling. Proteomics 2005;5:4327-4337.
-
(2005)
Proteomics
, vol.5
, pp. 4327-4337
-
-
Nilsson, P.1
Paavilainen, L.2
Larsson, K.3
Odling, J.4
Sundberg, M.5
Andersson, A.C.6
Kampf, C.7
Persson, A.8
Al-Khalili Szigyarto, C.9
Ottosson, J.10
Bjorling, E.11
Hober, S.12
Wernerus, H.13
Wester, K.14
Ponten, F.15
Uhlen, M.16
-
105
-
-
0032694577
-
" Metabonomics ":understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
-
Nicholson JK, Lindon JC, Holmes E. " Metabonomics ":understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999;29:1181-1189.
-
(1999)
Xenobiotica
, vol.29
, pp. 1181-1189
-
-
Nicholson, J.K.1
Lindon, J.C.2
Holmes, E.3
-
106
-
-
0141794522
-
A study of metabolic compartmentation in the rat heart and cardiac mitochondritiss using high resolution magic angle spinning 1 H NMR spectroscopy
-
Bollard ME, Murray AJ, Clarke K, Nicholson JK, Griffin JL. A study of metabolic compartmentation in the rat heart and cardiac mitochondritiss using high resolution magic angle spinning 1 H NMR spectroscopy. FEBS Lett 2003;553:73-78.
-
(2003)
FEBS Lett
, vol.553
, pp. 73-78
-
-
Bollard, M.E.1
Murray, A.J.2
Clarke, K.3
Nicholson, J.K.4
Griffin, J.L.5
-
107
-
-
19144371287
-
NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
-
Bollard ME, Stanley EG, Lindon JC, Nicholson JK, Holmes E. NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed 2005;18:143-162.
-
(2005)
NMR Biomed
, vol.18
, pp. 143-162
-
-
Bollard, M.E.1
Stanley, E.G.2
Lindon, J.C.3
Nicholson, J.K.4
Holmes, E.5
-
108
-
-
1142305959
-
Development of a microscale cell culture analog to probe naphthalene toxicity
-
Viravaidya K, Sin A, Shuler ML. Development of a microscale cell culture analog to probe naphthalene toxicity. Biotechnol Prog 2004;20:316-323.
-
(2004)
Biotechnol Prog
, vol.20
, pp. 316-323
-
-
Viravaidya, K.1
Sin, A.2
Shuler, M.L.3
-
109
-
-
0035799654
-
Microarrays of cells expressing defined cDNAs
-
Ziauddin J, Sabatini DM. Microarrays of cells expressing defined cDNAs. Nature 2001;411:107-110.
-
(2001)
Nature
, vol.411
, pp. 107-110
-
-
Ziauddin, J.1
Sabatini, D.M.2
-
110
-
-
12144263348
-
Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays
-
Hung PJ, Lee PJ, Sabouchi P, Lin R, Lee P. Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays. Biotechnol Bioeng 2005;89:1-8.
-
(2005)
Biotechnol Bioeng
, vol.89
, pp. 1-8
-
-
Hung, P.J.1
Lee, P.J.2
Sabouchi, P.3
Lin, R.4
Lee, P.5
-
111
-
-
28444480986
-
Metabonomic modelling of drug toxicity
-
Keun HC. Metabonomic modelling of drug toxicity. J Pharmacol Exp Ther 2006;109:92-106.
-
(2006)
J Pharmacol Exp Ther
, vol.109
, pp. 92-106
-
-
Keun, H.C.1
-
113
-
-
15944425080
-
Techniques:application of systems biology to absorption, distribution, metabolism, excretion and toxicity
-
Ekins S, Nikolsky Y, Nikolskaya T. Techniques:application of systems biology to absorption, distribution, metabolism, excretion and toxicity. Trends Pharm Sci 2005;26:202-209.
-
(2005)
Trends Pharm Sci
, vol.26
, pp. 202-209
-
-
Ekins, S.1
Nikolsky, Y.2
Nikolskaya, T.3
-
114
-
-
84889447063
-
Role of predictive metabolism and toxicity modelling in drug discovery-a summary of some recent advancements
-
Wilson AG, White AC, Mueller RA. Role of predictive metabolism and toxicity modelling in drug discovery-a summary of some recent advancements. Curr Opin Drug Discov Dev 2003;9:74-83.
-
(2003)
Curr Opin Drug Discov Dev
, vol.9
, pp. 74-83
-
-
Wilson, A.G.1
White, A.C.2
Mueller, R.A.3
-
115
-
-
33746465842
-
Dock around the clock-current status of small molecule docking and scoring
-
Rester U. Dock around the clock-current status of small molecule docking and scoring. QSAR Comb Sci 2006;25:605-615.
-
(2006)
QSAR Comb Sci
, vol.25
, pp. 605-615
-
-
Rester, U.1
-
116
-
-
0002022798
-
Validation and development of the DEREK skin sensitisation rulebase by anaylsis of the BgVV list of contact allergens
-
Balls M, Zeller AM, Halder M, Eds., New York:Elsevier
-
Barratt M, Langowski J. Validation and development of the DEREK skin sensitisation rulebase by anaylsis of the BgVV list of contact allergens. In Balls M, Zeller AM, Halder M, Eds. Progress in the Reduction Refinement and Replacement of Animal Experimentation. New York:Elsevier;2000, pp 493-512.
-
(2000)
Progress in the Reduction Refinement and Replacement of Animal Experimentation.
, pp. 493-512
-
-
Barratt, M.1
Langowski, J.2
-
117
-
-
0036323878
-
Evaluation of a rule base for identifying contact allergens by using a regulatory database:comparison of data on chemicals notified in the European Union with " structural alerts " used in the DEREK expert system
-
Zinke S, Gerner I, Schlede E. Evaluation of a rule base for identifying contact allergens by using a regulatory database:comparison of data on chemicals notified in the European Union with " structural alerts " used in the DEREK expert system. Altern Lab Anim 2002;30:285-298.
-
(2002)
Altern Lab Anim
, vol.30
, pp. 285-298
-
-
Zinke, S.1
Gerner, I.2
Schlede, E.3
-
118
-
-
0001383515
-
The development and validation of expert systems for predicting toxicity
-
Dearden JC, Barratt MD, Benigni R, Bristol DW, Combes RD, Cronin MTD, Judson PN, Payne MP, Richard AM, Tichy N, Worth AP, Yourick JJ. The development and validation of expert systems for predicting toxicity. Altern Lab Anim 1997;25:223-252.
-
(1997)
Altern Lab Anim
, vol.25
, pp. 223-252
-
-
Dearden, J.C.1
Barratt, M.D.2
Benigni, R.3
Bristol, D.W.4
Combes, R.D.5
Cronin, M.T.D.6
Judson, P.N.7
Payne, M.P.8
Richard, A.M.9
Tichy, N.10
Worth, A.P.11
Yourick, J.J.12
-
119
-
-
0032458218
-
A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software
-
Matthews EJ, Contrera JF. A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software. Regul Toxicol Pharmacol 1998;28:242.
-
(1998)
Regul Toxicol Pharmacol
, vol.28
, pp. 242
-
-
Matthews, E.J.1
Contrera, J.F.2
-
120
-
-
0027954402
-
International Commission for Protection Against Environmental Mutagens and Carcinogens. Use of SAR in computer-assisted prediction of carcinogenicity and mutagenicity of chemicals by the TOPKAT program
-
Enslein K, Gombar VK, Blake BW. International Commission for Protection Against Environmental Mutagens and Carcinogens. Use of SAR in computer-assisted prediction of carcinogenicity and mutagenicity of chemicals by the TOPKAT program. Mutat Res 1994;305:47.
-
(1994)
Mutat Res
, vol.305
, pp. 47
-
-
Enslein, K.1
Gombar, V.K.2
Blake, B.W.3
-
121
-
-
0029153221
-
Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals
-
Woo YT, Lai D, Argus A, Arcos JC. Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals. Toxicol Lett 1995;79:219.
-
(1995)
Toxicol Lett
, vol.79
, pp. 219
-
-
Woo, Y.T.1
Lai, D.2
Argus, A.3
Arcos, J.C.4
-
122
-
-
0036015529
-
Human carcinogens:an evaluation study via the COMPACT and HazardExpert procedures
-
Lewis DFV, Bird MG, Jacobs MN. Human carcinogens:an evaluation study via the COMPACT and HazardExpert procedures. Hum Exp Toxicol 2002;21:115.
-
(2002)
Hum Exp Toxicol
, vol.21
, pp. 115
-
-
Lewis, D.F.V.1
Bird, M.G.2
Jacobs, M.N.3
-
123
-
-
33646198766
-
In silico search of putative adverse drug reaction related proteins as a potential tool for facilitating drug adverse effect prediction
-
Ji ZL, Wang Y, Yu L, Ha LH, Zheng CJ, Chen YZ. In silico search of putative adverse drug reaction related proteins as a potential tool for facilitating drug adverse effect prediction. Toxicol Lett 2006;164:104-112.
-
(2006)
Toxicol Lett
, vol.164
, pp. 104-112
-
-
Ji, Z.L.1
Wang, Y.2
Yu, L.3
Ha, L.H.4
Zheng, C.J.5
Chen, Y.Z.6
-
124
-
-
0037452421
-
The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamics modelling as a tool in hazard and risk assessment:a commentary
-
Blaauboer BJ. The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamics modelling as a tool in hazard and risk assessment:a commentary. Toxicol Lett 2003;138:161-171.
-
(2003)
Toxicol Lett
, vol.138
, pp. 161-171
-
-
Blaauboer, B.J.1
-
125
-
-
4744342922
-
Protein binding capacity in vitro changes metabolism of substrates and influences the predictability of metabolic pathways in vivo
-
Deglmann CJ, Ebner T, Ludwig E, Happich S, Schildberg FW, Koebe HG. Protein binding capacity in vitro changes metabolism of substrates and influences the predictability of metabolic pathways in vivo. Toxicol In Vitro 2004;18:835-840.
-
(2004)
Toxicol In Vitro
, vol.18
, pp. 835-840
-
-
Deglmann, C.J.1
Ebner, T.2
Ludwig, E.3
Happich, S.4
Schildberg, F.W.5
Koebe, H.G.6
-
126
-
-
18944373550
-
In silico strategies for modelling membrane transporter function
-
Chang C, Ray A, Swaan P. In silico strategies for modelling membrane transporter function. Drug Discov Today 2005;10:663-671.
-
(2005)
Drug Discov Today
, vol.10
, pp. 663-671
-
-
Chang, C.1
Ray, A.2
Swaan, P.3
-
127
-
-
0003756012
-
The UFAW Handbook on the Care and Management of Laboratory Animals
-
London:UFAW
-
Poole TB, Ed. The UFAW Handbook on the Care and Management of Laboratory Animals. London:UFAW;1999.
-
(1999)
-
-
Poole, T.B.1
-
128
-
-
0347824360
-
Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modelling
-
Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modelling. Mol Pharmacol 2003; 64(6): 1295-1308.
-
(2003)
Mol Pharmacol
, vol.64
, Issue.6
, pp. 1295-1308
-
-
Hirst, W.D.1
Abrahamsen, B.2
Blaney, F.E.3
Calver, A.R.4
Aloj, L.5
Price, G.W.6
Medhurst, A.D.7
-
129
-
-
4243813744
-
Importance of species selection in drug toxicity testing
-
Morton DM. Importance of species selection in drug toxicity testing. Toxicol Lett 1998;102-103:545-550.
-
(1998)
Toxicol Lett
, vol.102-103
, pp. 545-550
-
-
Morton, D.M.1
-
130
-
-
0028961304
-
Human(MDR1) and mouse(mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators
-
Tang-Wai DF, Kajiji S, diCapua F, de Graff D, Roninson IB, Gros P. Human(MDR1) and mouse(mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. Biochemistry 1995;34:32-39.
-
(1995)
Biochemistry
, vol.34
, pp. 32-39
-
-
Tang-Wai, D.F.1
Kajiji, S.2
DiCapua, F.3
De Graff, D.4
Roninson, I.B.5
Gros, P.6
-
131
-
-
23944475573
-
Accuracy of allometrically predicted pharmacokinetic parameters in humans:role of species selection
-
Tang H, Mayersohn M. Accuracy of allometrically predicted pharmacokinetic parameters in humans:role of species selection. Drug Metab Dispos 2005;33:1288-1295.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 1288-1295
-
-
Tang, H.1
Mayersohn, M.2
-
132
-
-
0003626484
-
The Design of Animal Experiments:Reducing the Use of Animals in Research Through Better Experimental Design
-
London:Royal Society of Medicine Press Ltd
-
Festing M, Ed. The Design of Animal Experiments:Reducing the Use of Animals in Research Through Better Experimental Design. London:Royal Society of Medicine Press Ltd, 2002.
-
(2002)
-
-
Festing, M.1
-
133
-
-
0036049423
-
The International Symposium on Regulatory Testing and Animal Welfare:recommendations on best scientific practices for animal care in regulatory toxicology
-
Morris T, Goulet S, Morton D. The International Symposium on Regulatory Testing and Animal Welfare:recommendations on best scientific practices for animal care in regulatory toxicology. ILAR J 2002;43(Suppl):S123-S125.
-
(2002)
ILAR J
, vol.43
, Issue.SUPPL
-
-
Morris, T.1
Goulet, S.2
Morton, D.3
-
134
-
-
0024319712
-
Inter-species extrapolation in carcinogenesis:prediction between rats and mice
-
Gold LS, Bernstein L, Magaw R, Slone TH. Inter-species extrapolation in carcinogenesis:prediction between rats and mice. Environ Health Perspect 1989;81:211-219.
-
(1989)
Environ Health Perspect
, vol.81
, pp. 211-219
-
-
Gold, L.S.1
Bernstein, L.2
Magaw, R.3
Slone, T.H.4
-
135
-
-
6344229209
-
Molecular triangulation:bridging linkage and molecular-network information for identifying candidate genes in Azheimer's disease
-
Krauthammer M, Kaufmann CA, Gilliam TC, Rzhietsky A. Molecular triangulation:bridging linkage and molecular-network information for identifying candidate genes in Azheimer's disease. Proc Natl Acad Sci USA 2004;101:15148-15153.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 15148-15153
-
-
Krauthammer, M.1
Kaufmann, C.A.2
Gilliam, T.C.3
Rzhietsky, A.4
-
136
-
-
84889427500
-
-
TM. Elsevier MDL. Available from, accessed 29 January
-
TM. Elsevier MDL. Available from http://www.mdl.com/products/knowledge/pharmapendium/index.jsp(accessed 29 January 2007).
-
(2007)
-
-
-
137
-
-
84889476979
-
-
TM. Wolters-Kluwer Health. Medi-Span Available from, accessed 29 January
-
TM. Wolters-Kluwer Health. Medi-Span Available from http://www.medispan.com/Products/index.aspx?id=18(accessed 29 January 2007).
-
(2007)
-
-
-
138
-
-
0019083071
-
Evaluating the mutagenic potential of chemicals:the minimal battery and extrapolation problems
-
Sobels FH. Evaluating the mutagenic potential of chemicals:the minimal battery and extrapolation problems. Arch Toxicol 1980;46:21-30.
-
(1980)
Arch Toxicol
, vol.46
, pp. 21-30
-
-
Sobels, F.H.1
-
139
-
-
0029059540
-
Molecular and cellular approaches to extrapolation for risk assessment
-
Sutter TR. Molecular and cellular approaches to extrapolation for risk assessment. Environ Health Perspect 1995;103:386.
-
(1995)
Environ Health Perspect
, vol.103
, pp. 386
-
-
Sutter, T.R.1
-
140
-
-
1642534398
-
The significance of in vitro rat skin absorption studies to human risk assessment
-
Van Ravenzwaay B, Leibold E. The significance of in vitro rat skin absorption studies to human risk assessment. Toxicol In Vitro 2004;18:219-225.
-
(2004)
Toxicol In Vitro
, vol.18
, pp. 219-225
-
-
Van Ravenzwaay, B.1
Leibold, E.2
-
141
-
-
1642282158
-
First dose of potential new medicines to humans:how animals help
-
Greaves P, Williams A, Eve M. First dose of potential new medicines to humans:how animals help. Nat Rev Drug Discov 2004;3:226-236.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 226-236
-
-
Greaves, P.1
Williams, A.2
Eve, M.3
|