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Volumn 22, Issue 10, 2004, Pages 1253-1259

Systems biology in drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; COMPUTER SIMULATION; DECISION MAKING; DISEASE CONTROL; DRUG DOSAGE; GENES; METABOLITES; MOLECULAR BIOLOGY; PROTEINS; SYSTEMS ANALYSIS; TISSUE;

EID: 5044226336     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt1017     Document Type: Review
Times cited : (518)

References (39)
  • 1
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi, J.A., Hansen, R.W. & Grabowski, H.G. The price of innovation: new estimates of drug development costs. J. Health Econ. 22, 151-185 (2003).
    • (2003) J. Health Econ. , vol.22 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 3
    • 0037716676 scopus 로고    scopus 로고
    • Building with a scaffold: Emerging strategies for high- to low-level cellular modeling
    • Ideker, T. & Lauffenburger, D. Building with a scaffold: emerging strategies for high- to low-level cellular modeling. Trends Biotechnol. 21, 255-262 (2003).
    • (2003) Trends Biotechnol. , vol.21 , pp. 255-262
    • Ideker, T.1    Lauffenburger, D.2
  • 4
    • 0037336350 scopus 로고    scopus 로고
    • Integration from proteins to organs: The Physiome Project
    • Hunter, P.J. & Borg, T.K. Integration from proteins to organs: the Physiome Project. Nat. Rev. Mol. Cell Biol. 4, 237-243 (2003).
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 237-243
    • Hunter, P.J.1    Borg, T.K.2
  • 5
    • 5044233947 scopus 로고    scopus 로고
    • Gene expression profiles classify different classes of bone therapies: PTH, Alendronate and SERMs
    • Poster 307, June 5, Nice, France
    • Kulkarni, N.H. et al. Gene expression profiles classify different classes of bone therapies: PTH, Alendronate and SERMs, Poster 307, 31st European Symposium on Calicified Tissue, June 5, 2004, Nice, France; http://www.ectsoc. org/nice2004/abstracts.htm#onl
    • (2004) 31st European Symposium on Calicified Tissue
    • Kulkarni, N.H.1
  • 6
    • 4644335402 scopus 로고    scopus 로고
    • Systems biology, proteomics, and the future of health care: Toward predictive, preventative, and personalized medicine
    • Weston, A.D. & Hood, L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J. Proteome. Res. 3, 179-196 (2004).
    • (2004) J. Proteome. Res. , vol.3 , pp. 179-196
    • Weston, A.D.1    Hood, L.2
  • 7
    • 11144355343 scopus 로고    scopus 로고
    • Integrative biological analysis of the APOE*5-leiden transgenic mouse
    • Clish, C.B. et al. Integrative biological analysis of the APOE*5-leiden transgenic mouse. Omics 8, 3-13 (2004).
    • (2004) Omics , vol.8 , pp. 3-13
    • Clish, C.B.1
  • 8
    • 2342517326 scopus 로고    scopus 로고
    • Biomarker discovery by comprehensive phenotyping for autoimmune diseases
    • Kantor, A.B. et al. Biomarker discovery by comprehensive phenotyping for autoimmune diseases. Clin. Immunol. 111, 186-195 (2004).
    • (2004) Clin. Immunol. , vol.111 , pp. 186-195
    • Kantor, A.B.1
  • 9
    • 0036500609 scopus 로고    scopus 로고
    • A genomic regulatory network for development
    • Davidson, E.H. et al. A genomic regulatory network for development. Science 295, 1669-1678 (2002).
    • (2002) Science , vol.295 , pp. 1669-1678
    • Davidson, E.H.1
  • 10
    • 0035805255 scopus 로고    scopus 로고
    • Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
    • Ideker, T. et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 292, 929-934 (2001).
    • (2001) Science , vol.292 , pp. 929-934
    • Ideker, T.1
  • 11
    • 2342648924 scopus 로고    scopus 로고
    • Integrating high-throughput and computational data elucidates bacterial networks
    • Covert, M.W., Knight, E.M., Reed, J.L., Herrgard, M.J. & Palsson, B.O. Integrating high-throughput and computational data elucidates bacterial networks. Nature 429, 92-96 (2004).
    • (2004) Nature , vol.429 , pp. 92-96
    • Covert, M.W.1    Knight, E.M.2    Reed, J.L.3    Herrgard, M.J.4    Palsson, B.O.5
  • 12
    • 0034616930 scopus 로고    scopus 로고
    • Functional discovery via a compendium of expression profiles
    • Hughes, T.R. et al. Functional discovery via a compendium of expression profiles. Cell 102, 109-126 (2000).
    • (2000) Cell , vol.102 , pp. 109-126
    • Hughes, T.R.1
  • 13
    • 1642462948 scopus 로고    scopus 로고
    • Computational physiology and the Physiome Project
    • Crampin, E.J. et al. Computational physiology and the Physiome Project. Exp. Physiol 89, 1-26 (2004).
    • (2004) Exp. Physiol. , vol.89 , pp. 1-26
    • Crampin, E.J.1
  • 14
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart-from genes to cells to the whole organ
    • Noble, D. Modeling the heart-from genes to cells to the whole organ. Science 295, 1678-1682 (2002).
    • (2002) Science , vol.295 , pp. 1678-1682
    • Noble, D.1
  • 15
    • 3042716105 scopus 로고    scopus 로고
    • The computational integrated myocyte: A view into the virtual heart
    • Bassingthwaighte, J.B. & Vinnakota, K.C. The computational integrated myocyte: a view into the virtual heart. Ann. NY Acad. Sci. 1015, 391-404 (2004).
    • (2004) Ann. NY Acad. Sci. , vol.1015 , pp. 391-404
    • Bassingthwaighte, J.B.1    Vinnakota, K.C.2
  • 16
    • 0037107986 scopus 로고    scopus 로고
    • Small- and large-scale biosimulation applied to drug discovery and development
    • Musante, C.J., Lewis, A.K. & Hall, K. Small- and large-scale biosimulation applied to drug discovery and development. Drug Discov. Today 7, S192-S196 (2002).
    • (2002) Drug Discov. Today , vol.7
    • Musante, C.J.1    Lewis, A.K.2    Hall, K.3
  • 17
    • 4243541856 scopus 로고    scopus 로고
    • A computer model of chronic asthma with application to clinical studies: Example of treatment of exercise-induced asthma
    • Stokes, C.L. et al. A computer model of chronic asthma with application to clinical studies: example of treatment of exercise-induced asthma. J. Allergy. Clin. Immunol. 107, 933 (2001).
    • (2001) J. Allergy. Clin. Immunol. , vol.107 , pp. 933
    • Stokes, C.L.1
  • 18
    • 0035044634 scopus 로고    scopus 로고
    • The roles of cells and mediators in a computer model of chronic asthma
    • Lewis, A.K. et al. The roles of cells and mediators in a computer model of chronic asthma. Inter. Arch. Allergy Immunol. 124, 282-286 (2001).
    • (2001) Inter. Arch. Allergy Immunol. , vol.124 , pp. 282-286
    • Lewis, A.K.1
  • 19
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie, M.J. et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2144-2148 (2000).
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1
  • 21
    • 1242298712 scopus 로고    scopus 로고
    • Modeling approaches to type 2 diabetes
    • Kansal, A.R. Modeling approaches to type 2 diabetes. Diabetes Technol. Ther. 6, 39-47 (2004).
    • (2004) Diabetes Technol. Ther. , vol.6 , pp. 39-47
    • Kansal, A.R.1
  • 22
    • 3042668008 scopus 로고    scopus 로고
    • Modeling cell signaling networks
    • Eungdamrong, N.J. & Iyengar, R. Modeling cell signaling networks. Biol. Cell 96, 355-362 (2004).
    • (2004) Biol. Cell , vol.96 , pp. 355-362
    • Eungdamrong, N.J.1    Iyengar, R.2
  • 23
    • 0033555859 scopus 로고    scopus 로고
    • Emergent properties of networks of biological signaling pathways
    • Bhalla, U.S. & Iyengar, R. Emergent properties of networks of biological signaling pathways. Science 283, 381-387 (1999).
    • (1999) Science , vol.283 , pp. 381-387
    • Bhalla, U.S.1    Iyengar, R.2
  • 24
    • 3442886313 scopus 로고    scopus 로고
    • PathBLAST: A tool for alignment of protein interaction networks
    • Kelley, B.P. et al. PathBLAST: a tool for alignment of protein interaction networks. Nucleic Acids Res. 32, W83-W88 (2004).
    • (2004) Nucleic Acids Res. , vol.32
    • Kelley, B.P.1
  • 26
    • 0142059834 scopus 로고    scopus 로고
    • Genome-scale functional profiling of the mammalian AP-1 signaling pathway
    • Chanda, S.K. et al. Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc. Natl. Acad. Sci. USA 100, 12153-12158 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12153-12158
    • Chanda, S.K.1
  • 27
    • 0038522853 scopus 로고    scopus 로고
    • Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays
    • Haggarty, S.J., Koeller, K.M., Wong, J.C., Butcher, R.A. & Schreiber, S.L. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chem. Biol. 10, 383-396 (2003).
    • (2003) Chem. Biol. , vol.10 , pp. 383-396
    • Haggarty, S.J.1    Koeller, K.M.2    Wong, J.C.3    Butcher, R.A.4    Schreiber, S.L.5
  • 28
    • 0038610570 scopus 로고    scopus 로고
    • Systematic discovery of multicomponent therapeutics
    • Borisy, A.A. et al. Systematic discovery of multicomponent therapeutics. Proc. Natl. Acad. Sci. USA 100, 7977-7982 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7977-7982
    • Borisy, A.A.1
  • 29
    • 0031730097 scopus 로고    scopus 로고
    • Drug target validation and identification of secondary drug target effects using DNA microarrays
    • Marton, M.J. et al. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat. Med. 4, 1293-1301 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 1293-1301
    • Marton, M.J.1
  • 30
    • 4644264129 scopus 로고    scopus 로고
    • An integrative biology approach for analysis of drug action in models of human vascular inflammation
    • Kunkel, E.J. et al. An integrative biology approach for analysis of drug action in models of human vascular inflammation. FASEB J. 18, 1279-1281 (2004).
    • (2004) FASEB J. , vol.18 , pp. 1279-1281
    • Kunkel, E.J.1
  • 31
    • 4644356849 scopus 로고    scopus 로고
    • Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models
    • Kunkel, E.J. et al. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Assay Drug Dev. Technol. 2, 431-441 (2004).
    • (2004) Assay Drug Dev. Technol. , vol.2 , pp. 431-441
    • Kunkel, E.J.1
  • 32
    • 10744233471 scopus 로고    scopus 로고
    • Method for analyzing signaling networks in complex cellular systems
    • Plavec, I. et al. Method for analyzing signaling networks in complex cellular systems. Proc. Natl. Acad. Sci. USA 101, 1223-1228 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1223-1228
    • Plavec, I.1
  • 33
    • 0142092591 scopus 로고    scopus 로고
    • Statins as novel immunomodulators: From cell to potential clinical benefit
    • Mach, F. Statins as novel immunomodulators: from cell to potential clinical benefit. Thromb. Haemost. 90, 607-610 (2003).
    • (2003) Thromb. Haemost. , vol.90 , pp. 607-610
    • Mach, F.1
  • 34
    • 2942576105 scopus 로고    scopus 로고
    • Data-driven computer simulation of human cancer cell
    • Christopher, R. et al. Data-driven computer simulation of human cancer cell. Ann. NY Acad. Sci. 1020, 132-153 (2004).
    • (2004) Ann. NY Acad. Sci. , vol.1020 , pp. 132-153
    • Christopher, R.1
  • 35
    • 0037213006 scopus 로고    scopus 로고
    • Computational modeling of the EGF-receptor system: A paradigm for systems biology
    • Wiley, H.S., Shvartsman, S.Y. & Lauffenburger, D.A. Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends Cell Biol. 13, 43-50 (2003).
    • (2003) Trends Cell Biol. , vol.13 , pp. 43-50
    • Wiley, H.S.1    Shvartsman, S.Y.2    Lauffenburger, D.A.3
  • 36
    • 0036212767 scopus 로고    scopus 로고
    • Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
    • Schoeberl, B., Eichler-Jonsson, C., Gilles, E.D. & Muller, G. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat. Biotechnol. 20, 370-375 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 370-375
    • Schoeberl, B.1    Eichler-Jonsson, C.2    Gilles, E.D.3    Muller, G.4
  • 37
    • 0036364829 scopus 로고    scopus 로고
    • Pathway logic: Symbolic analysis of biological signaling
    • Eker, S. et al. Pathway logic: symbolic analysis of biological signaling. Pac. Symp. Biocomput. 7, 400-412 (2002).
    • (2002) Pac. Symp. Biocomput. , vol.7 , pp. 400-412
    • Eker, S.1
  • 38
    • 0242574987 scopus 로고    scopus 로고
    • Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway
    • Cho, K.H., Shin, S.Y., Lee, H.W. & Wolkenhauer, O. Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway. Genome Res. 13, 2413-2422 (2003).
    • (2003) Genome Res. , vol.13 , pp. 2413-2422
    • Cho, K.H.1    Shin, S.Y.2    Lee, H.W.3    Wolkenhauer, O.4
  • 39
    • 0037044575 scopus 로고    scopus 로고
    • The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation
    • Hoffmann, A., Levchenko, A., Scott, M.L. & Baltimore, D. The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298, 1241-1245 (2002).
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.