-
1
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
DiMasi, J.A., Hansen, R.W. & Grabowski, H.G. The price of innovation: new estimates of drug development costs. J. Health Econ. 22, 151-185 (2003).
-
(2003)
J. Health Econ.
, vol.22
, pp. 151-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
2
-
-
0035775725
-
A new approach to decoding life: Systems biology
-
Ideker, T., Galitski, T. & Hood, L. A new approach to decoding life: systems biology. Annu. Rev. Genomics Hum. Genet. 2, 343-372 (2001).
-
(2001)
Annu. Rev. Genomics Hum. Genet.
, vol.2
, pp. 343-372
-
-
Ideker, T.1
Galitski, T.2
Hood, L.3
-
3
-
-
0037716676
-
Building with a scaffold: Emerging strategies for high- to low-level cellular modeling
-
Ideker, T. & Lauffenburger, D. Building with a scaffold: emerging strategies for high- to low-level cellular modeling. Trends Biotechnol. 21, 255-262 (2003).
-
(2003)
Trends Biotechnol.
, vol.21
, pp. 255-262
-
-
Ideker, T.1
Lauffenburger, D.2
-
4
-
-
0037336350
-
Integration from proteins to organs: The Physiome Project
-
Hunter, P.J. & Borg, T.K. Integration from proteins to organs: the Physiome Project. Nat. Rev. Mol. Cell Biol. 4, 237-243 (2003).
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 237-243
-
-
Hunter, P.J.1
Borg, T.K.2
-
5
-
-
5044233947
-
Gene expression profiles classify different classes of bone therapies: PTH, Alendronate and SERMs
-
Poster 307, June 5, Nice, France
-
Kulkarni, N.H. et al. Gene expression profiles classify different classes of bone therapies: PTH, Alendronate and SERMs, Poster 307, 31st European Symposium on Calicified Tissue, June 5, 2004, Nice, France; http://www.ectsoc. org/nice2004/abstracts.htm#onl
-
(2004)
31st European Symposium on Calicified Tissue
-
-
Kulkarni, N.H.1
-
6
-
-
4644335402
-
Systems biology, proteomics, and the future of health care: Toward predictive, preventative, and personalized medicine
-
Weston, A.D. & Hood, L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J. Proteome. Res. 3, 179-196 (2004).
-
(2004)
J. Proteome. Res.
, vol.3
, pp. 179-196
-
-
Weston, A.D.1
Hood, L.2
-
7
-
-
11144355343
-
Integrative biological analysis of the APOE*5-leiden transgenic mouse
-
Clish, C.B. et al. Integrative biological analysis of the APOE*5-leiden transgenic mouse. Omics 8, 3-13 (2004).
-
(2004)
Omics
, vol.8
, pp. 3-13
-
-
Clish, C.B.1
-
8
-
-
2342517326
-
Biomarker discovery by comprehensive phenotyping for autoimmune diseases
-
Kantor, A.B. et al. Biomarker discovery by comprehensive phenotyping for autoimmune diseases. Clin. Immunol. 111, 186-195 (2004).
-
(2004)
Clin. Immunol.
, vol.111
, pp. 186-195
-
-
Kantor, A.B.1
-
9
-
-
0036500609
-
A genomic regulatory network for development
-
Davidson, E.H. et al. A genomic regulatory network for development. Science 295, 1669-1678 (2002).
-
(2002)
Science
, vol.295
, pp. 1669-1678
-
-
Davidson, E.H.1
-
10
-
-
0035805255
-
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
-
Ideker, T. et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 292, 929-934 (2001).
-
(2001)
Science
, vol.292
, pp. 929-934
-
-
Ideker, T.1
-
11
-
-
2342648924
-
Integrating high-throughput and computational data elucidates bacterial networks
-
Covert, M.W., Knight, E.M., Reed, J.L., Herrgard, M.J. & Palsson, B.O. Integrating high-throughput and computational data elucidates bacterial networks. Nature 429, 92-96 (2004).
-
(2004)
Nature
, vol.429
, pp. 92-96
-
-
Covert, M.W.1
Knight, E.M.2
Reed, J.L.3
Herrgard, M.J.4
Palsson, B.O.5
-
12
-
-
0034616930
-
Functional discovery via a compendium of expression profiles
-
Hughes, T.R. et al. Functional discovery via a compendium of expression profiles. Cell 102, 109-126 (2000).
-
(2000)
Cell
, vol.102
, pp. 109-126
-
-
Hughes, T.R.1
-
13
-
-
1642462948
-
Computational physiology and the Physiome Project
-
Crampin, E.J. et al. Computational physiology and the Physiome Project. Exp. Physiol 89, 1-26 (2004).
-
(2004)
Exp. Physiol.
, vol.89
, pp. 1-26
-
-
Crampin, E.J.1
-
14
-
-
0036499997
-
Modeling the heart-from genes to cells to the whole organ
-
Noble, D. Modeling the heart-from genes to cells to the whole organ. Science 295, 1678-1682 (2002).
-
(2002)
Science
, vol.295
, pp. 1678-1682
-
-
Noble, D.1
-
15
-
-
3042716105
-
The computational integrated myocyte: A view into the virtual heart
-
Bassingthwaighte, J.B. & Vinnakota, K.C. The computational integrated myocyte: a view into the virtual heart. Ann. NY Acad. Sci. 1015, 391-404 (2004).
-
(2004)
Ann. NY Acad. Sci.
, vol.1015
, pp. 391-404
-
-
Bassingthwaighte, J.B.1
Vinnakota, K.C.2
-
16
-
-
0037107986
-
Small- and large-scale biosimulation applied to drug discovery and development
-
Musante, C.J., Lewis, A.K. & Hall, K. Small- and large-scale biosimulation applied to drug discovery and development. Drug Discov. Today 7, S192-S196 (2002).
-
(2002)
Drug Discov. Today
, vol.7
-
-
Musante, C.J.1
Lewis, A.K.2
Hall, K.3
-
17
-
-
4243541856
-
A computer model of chronic asthma with application to clinical studies: Example of treatment of exercise-induced asthma
-
Stokes, C.L. et al. A computer model of chronic asthma with application to clinical studies: example of treatment of exercise-induced asthma. J. Allergy. Clin. Immunol. 107, 933 (2001).
-
(2001)
J. Allergy. Clin. Immunol.
, vol.107
, pp. 933
-
-
Stokes, C.L.1
-
18
-
-
0035044634
-
The roles of cells and mediators in a computer model of chronic asthma
-
Lewis, A.K. et al. The roles of cells and mediators in a computer model of chronic asthma. Inter. Arch. Allergy Immunol. 124, 282-286 (2001).
-
(2001)
Inter. Arch. Allergy Immunol.
, vol.124
, pp. 282-286
-
-
Lewis, A.K.1
-
19
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
-
Leckie, M.J. et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2144-2148 (2000).
-
(2000)
Lancet
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
-
20
-
-
0018487598
-
Quantitative estimation of insulin sensitivity
-
Bergman, R.N., Ider, Y.Z., Bowden, C.R. & Cobelli, C. Quantitative estimation of insulin sensitivity. Am. J. Physiol. 236, E667-E677 (1979).
-
(1979)
Am. J. Physiol.
, vol.236
-
-
Bergman, R.N.1
Ider, Y.Z.2
Bowden, C.R.3
Cobelli, C.4
-
21
-
-
1242298712
-
Modeling approaches to type 2 diabetes
-
Kansal, A.R. Modeling approaches to type 2 diabetes. Diabetes Technol. Ther. 6, 39-47 (2004).
-
(2004)
Diabetes Technol. Ther.
, vol.6
, pp. 39-47
-
-
Kansal, A.R.1
-
22
-
-
3042668008
-
Modeling cell signaling networks
-
Eungdamrong, N.J. & Iyengar, R. Modeling cell signaling networks. Biol. Cell 96, 355-362 (2004).
-
(2004)
Biol. Cell
, vol.96
, pp. 355-362
-
-
Eungdamrong, N.J.1
Iyengar, R.2
-
23
-
-
0033555859
-
Emergent properties of networks of biological signaling pathways
-
Bhalla, U.S. & Iyengar, R. Emergent properties of networks of biological signaling pathways. Science 283, 381-387 (1999).
-
(1999)
Science
, vol.283
, pp. 381-387
-
-
Bhalla, U.S.1
Iyengar, R.2
-
24
-
-
3442886313
-
PathBLAST: A tool for alignment of protein interaction networks
-
Kelley, B.P. et al. PathBLAST: a tool for alignment of protein interaction networks. Nucleic Acids Res. 32, W83-W88 (2004).
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Kelley, B.P.1
-
25
-
-
0035499939
-
Use of human tissue in ADME and safety profiling of development candidates
-
Coleman, R.A., Bowen, W.P., Baines, I.A., Woodrooffe, A.J. & Brown, A.M. Use of human tissue in ADME and safety profiling of development candidates. Drug Discov. Today 6, 1116-1126 (2001).
-
(2001)
Drug Discov. Today
, vol.6
, pp. 1116-1126
-
-
Coleman, R.A.1
Bowen, W.P.2
Baines, I.A.3
Woodrooffe, A.J.4
Brown, A.M.5
-
26
-
-
0142059834
-
Genome-scale functional profiling of the mammalian AP-1 signaling pathway
-
Chanda, S.K. et al. Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc. Natl. Acad. Sci. USA 100, 12153-12158 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12153-12158
-
-
Chanda, S.K.1
-
27
-
-
0038522853
-
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays
-
Haggarty, S.J., Koeller, K.M., Wong, J.C., Butcher, R.A. & Schreiber, S.L. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chem. Biol. 10, 383-396 (2003).
-
(2003)
Chem. Biol.
, vol.10
, pp. 383-396
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Butcher, R.A.4
Schreiber, S.L.5
-
28
-
-
0038610570
-
Systematic discovery of multicomponent therapeutics
-
Borisy, A.A. et al. Systematic discovery of multicomponent therapeutics. Proc. Natl. Acad. Sci. USA 100, 7977-7982 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 7977-7982
-
-
Borisy, A.A.1
-
29
-
-
0031730097
-
Drug target validation and identification of secondary drug target effects using DNA microarrays
-
Marton, M.J. et al. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat. Med. 4, 1293-1301 (1998).
-
(1998)
Nat. Med.
, vol.4
, pp. 1293-1301
-
-
Marton, M.J.1
-
30
-
-
4644264129
-
An integrative biology approach for analysis of drug action in models of human vascular inflammation
-
Kunkel, E.J. et al. An integrative biology approach for analysis of drug action in models of human vascular inflammation. FASEB J. 18, 1279-1281 (2004).
-
(2004)
FASEB J.
, vol.18
, pp. 1279-1281
-
-
Kunkel, E.J.1
-
31
-
-
4644356849
-
Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models
-
Kunkel, E.J. et al. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Assay Drug Dev. Technol. 2, 431-441 (2004).
-
(2004)
Assay Drug Dev. Technol.
, vol.2
, pp. 431-441
-
-
Kunkel, E.J.1
-
32
-
-
10744233471
-
Method for analyzing signaling networks in complex cellular systems
-
Plavec, I. et al. Method for analyzing signaling networks in complex cellular systems. Proc. Natl. Acad. Sci. USA 101, 1223-1228 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 1223-1228
-
-
Plavec, I.1
-
33
-
-
0142092591
-
Statins as novel immunomodulators: From cell to potential clinical benefit
-
Mach, F. Statins as novel immunomodulators: from cell to potential clinical benefit. Thromb. Haemost. 90, 607-610 (2003).
-
(2003)
Thromb. Haemost.
, vol.90
, pp. 607-610
-
-
Mach, F.1
-
34
-
-
2942576105
-
Data-driven computer simulation of human cancer cell
-
Christopher, R. et al. Data-driven computer simulation of human cancer cell. Ann. NY Acad. Sci. 1020, 132-153 (2004).
-
(2004)
Ann. NY Acad. Sci.
, vol.1020
, pp. 132-153
-
-
Christopher, R.1
-
35
-
-
0037213006
-
Computational modeling of the EGF-receptor system: A paradigm for systems biology
-
Wiley, H.S., Shvartsman, S.Y. & Lauffenburger, D.A. Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends Cell Biol. 13, 43-50 (2003).
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 43-50
-
-
Wiley, H.S.1
Shvartsman, S.Y.2
Lauffenburger, D.A.3
-
36
-
-
0036212767
-
Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
-
Schoeberl, B., Eichler-Jonsson, C., Gilles, E.D. & Muller, G. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat. Biotechnol. 20, 370-375 (2002).
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 370-375
-
-
Schoeberl, B.1
Eichler-Jonsson, C.2
Gilles, E.D.3
Muller, G.4
-
37
-
-
0036364829
-
Pathway logic: Symbolic analysis of biological signaling
-
Eker, S. et al. Pathway logic: symbolic analysis of biological signaling. Pac. Symp. Biocomput. 7, 400-412 (2002).
-
(2002)
Pac. Symp. Biocomput.
, vol.7
, pp. 400-412
-
-
Eker, S.1
-
38
-
-
0242574987
-
Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway
-
Cho, K.H., Shin, S.Y., Lee, H.W. & Wolkenhauer, O. Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway. Genome Res. 13, 2413-2422 (2003).
-
(2003)
Genome Res.
, vol.13
, pp. 2413-2422
-
-
Cho, K.H.1
Shin, S.Y.2
Lee, H.W.3
Wolkenhauer, O.4
-
39
-
-
0037044575
-
The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation
-
Hoffmann, A., Levchenko, A., Scott, M.L. & Baltimore, D. The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298, 1241-1245 (2002).
-
(2002)
Science
, vol.298
, pp. 1241-1245
-
-
Hoffmann, A.1
Levchenko, A.2
Scott, M.L.3
Baltimore, D.4
|