Systematic screen for human disease genes in yeast

Nature Genetics

Volumn 31, Issue 4, 2002, Pages 400-404

  Steinmetz, Lars M ^a   Scharfe, Curt ^a   Deutschbauer, Adam M ^a   Mokranjac, Dejana ^b   Herman, Zelek S ^a   Jones, Ted ^a   Chu, Angela M ^a   Giaever, Guri ^a   Prokisch, Holger ^b   Oefner, Peter J ^a   Davis, Ronald W ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN;

ARTICLE; DELETION MUTANT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE EXPRESSION; GENE MAPPING; GENE POOL; GENETIC LINKAGE; GENETIC SCREENING; GENOME; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

BIOLOGICAL TRANSPORT; CELL DIVISION; CITRIC ACID CYCLE; FUNGAL PROTEINS; GENE EXPRESSION PROFILING; GENOME, FUNGAL; GENOME, HUMAN; GENOMICS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; OPEN READING FRAMES; SACCHAROMYCES CEREVISIAE; SEQUENCE DELETION;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036699060     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng929     Document Type: Article

References (29)

1. Foury, F. Human genetic diseases: a cross-talk between man and yeast. Gene 195, 1-10 (1997).
2. DiMauro, S. & Schon, E.A. Nuclear power and mitochondrial disease. Nature Genet. 19, 214-215 (1998).
3. Wallace, D.C. Mitochondrial diseases in man and mouse. Science 283, 1482-1488 (1999).
4. Winzeler, E.A. et al. Functional characterization of the S. Cerevisiae genome by gene deletion and parallel analysis. Science 285, 901-906 (1999).
5. Birrell, G.W., Giaever, G., Chu, A.M., Davis, R.W & Brown, J.M. A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity. Proc. Natl Acad. Sci. USA 98, 12608-12613 (2001).
6. Ooi, S.L., Shoemaker, D.D. & Boeke, J.D. A DNA microarray-based genetic screen for nonhomologous end-joining mutants in Saccharomyces cerevisiae. Science 294, 2552-2556 (2001).
7. Shoemaker, D.D., Lashkari, D.A., Morris, D., Mittmann, M. & Davis, R.W. Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nature Genet. 14, 450-456 (1996).
8. Tzagoloff, A. & Myers, A.M. Genetics of mitochondrial biogenesis. Annu. Rev. Biochem. 55, 249-285 (1986).
9. Yaffe, M.P. in Methods in Enzymology Vol. 194 (eds Guthrie, C. & Fink, G.R.) 627-643 (Academic Press, San Diego, California, 1991).
10. Scharfe, C. et al. MITOP, the mitochondrial proteome database: 2000 update. Nucleic Acids Res. 28, 155-158 (2000).
11. Grivell, L.A. et al. Mitochondrial assembly in yeast. FEBS Lett. 452, 57-60 (1999).
12. Wood, V., Rutherford, K.M., Ivens, A., Rajandream, M.A. & Barrell, B. A reannotation of the Saccharomyces cerevisiae genome. Comp. Funct. Genom. 2, 143-154 (2001).
13. Claros, M.G. & Vincens, P. Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur. J. Biochem. 241, 779-786 (1996).
14. Andersson, S.G. et al. The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature 396, 133-140 (1998).
15. Schwikowski, B., Uetz, P. & Fields, S. A network of protein-protein interactions in yeast. Nature Biotechnol. 18, 1257-1261 (2000).
16. Kumar, A. et al. Subcellular localization of the yeast proteome. Genes Dev. 16, 707-719 (2002).
17. Nishino, I., Spinazzola, A. & Hirano, M. Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Science 283, 689-692 (1999).
18. Ashe, M.P., De Long, S.K. & Sachs, A.B. Glucose depletion rapidly inhibits translation initiation in yeast. Mol. Biol. Cell 11, 833-848 (2000).
19. DeRisi, J.L., Iyer, V.R. & Brown, P.O. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278, 680-686 (1997).
20. Hughes, T.R. et al. Functional discovery via a compendium of expression profiles. Cell 102, 109-126 (2000).
21. Boguski, M.S. & Schuler, G.D. ESTablishing a human transcript map. Nature Genet. 10, 369-371 (1995).
22. Mewes, H.W. et al. MIPS: a database for genomes and protein sequences. Nucleic Acids Res. 28, 37-40 (2000).
23. Hentati, A. et al. Linkage of 'pure' autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus heterogeneity. Hum. Mol. Genet. 3, 1263-1267 (1994).
24. Christodoulou, K. et at. Mapping of the second Friedreich's ataxia (FRDA2) locus to chromosome 9p23-p11: evidence for further locus heterogeneity. Neurogenetics 3, 127-132 (2001).
25. Kerrison, J.B. et al. Genetic heterogeneity of dominant optic atrophy, Kjer type: identification of a second locus on chromosome 18q12.2-12.3. Arch. Ophthalmol. 117, 805-810 (1999).
26. Assink, J.J. et al. A gene for X-linked optic atrophy is closely linked to the Xp11.4-Xp11.2 region of the X chromosome. Am. J. Hum. Genet. 61, 934-939 (1997).
27. Priest, J.M., Fischbeck, K.H., Nouri, N. & Keats, B.J. A locus for axonal motorsensory neuropathy with deafness and mental retardation maps to Xq24-q26. Genomics 29, 409-412 (1995).
28. McMullan, T.F., Collins, A.R., Tyers, A.G. & Robinson, D.O. A novel X-linked dominant condition: X-linked congenital isolated ptosis. Am. J. Hum. Genet. 66, 1455-1460 (2000).
29. Malmgren, H. et al. Linkage mapping of a severe X-linked mental retardation syndrome. Am. J. Hum. Genet. 52, 1046-1052 (1993).