A membrane-based small-scale bioreactor for accelerated in vitro drug screenings with primary hepatocytes

Desalination

Volumn 199, Issue 1-3, 2006, Pages 258-260

  Schmitmeier, Stephanie ^a   Langsch, Angelika ^b   Bader, Augustinus ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b LEIBNIZ UNIVERSITY HANNOVER   (Germany)

Author keywords

Culture systems; Hepatocytes; Liver specific functions; Oxygenation; Small scale bioreactor

Indexed keywords

CELL MEMBRANES; DETOXIFICATION; DRUG INTERACTIONS; SYNTHESIS (CHEMICAL);

CULTURE SYSTEMS; HEPATOCYTES; LIVER-SPECIFIC FUNCTIONS; OXYGENATION; SMALL-SCALE BIOREACTOR;

BIOREACTORS;

BIOREACTORS; CELL MEMBRANES; DETOXIFICATION; DRUG INTERACTIONS; SYNTHESIS (CHEMICAL);

BIOREACTOR; DRUG; MEMBRANE;

EID: 33746736816     PISSN: 00119164     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.desal.2006.03.062     Document Type: Article

References (3)

1. Dunn J.C., Yarmush M.L., Koebe H.G., and Tompkins R.G. Hepatocyte function and extra-cellular matrix geometry: long-term culture in a sandwich configuration. FASEB J. 3 (1989) 174-177
2. Dunn J.C., Tompkins R.G., and Yarmush M.L. Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol. Progr. 7 (1991) 237-245
3. Bader A., Fruhauf N., Zech K., Haverich A., and Borlak J.T. Development of a small-scale bioreactor for drug metabolism studies maintaining hepatospecific functions. Xenobiotica 28 (1998) 815-825