Modelling tissue-specific signaling and organ function in three dimensions

Journal of Cell Science

Volumn 116, Issue 12, 2003, Pages 2377-2388

  Schmeichel, Karen L ^a   Bissell, Mina J ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Human epithelial cells; Organotypic models; Three dimensional; Tissue specific signaling

Indexed keywords

CANCER THERAPY; CARCINOGENESIS; CELL ACTIVITY; CELL ASSAY; CELL CULTURE; CELL FUNCTION; CELL TYPE; EPITHELIUM; EPITHELIUM CELL; FUNCTIONAL ASSESSMENT; HUMAN; IN VIVO STUDY; MODEL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; STROMA; TISSUE SPECIFICITY; ANIMAL; ANIMAL MODEL; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; BREAST TUMOR; CARCINOMA; CYTOLOGY; GENETICS; METABOLISM; METHODOLOGY; MOUSE; ORGAN CULTURE TECHNIQUE; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; STROMA CELL; VISCERA;

ANIMALIA;

ANIMALS; BREAST NEOPLASMS; CARCINOMA; EPITHELIAL CELLS; HUMANS; MICE; MODELS, ANIMAL; MODELS, BIOLOGICAL; ORGAN CULTURE TECHNIQUES; ORGAN SPECIFICITY; SIGNAL TRANSDUCTION; STROMAL CELLS; VISCERA;

EID: 0037484174     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00503     Document Type: Review

References (133)

1. Angel, P. and Szabowski, A. (2002). Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin. Biochem. Pharmacol. 64, 949-956.
2. Asselineau, D. and Prunieras, M. (1984). Reconstruction of 'simplified' skin: control of fabrication. Br. J. Dermatol. 111 Suppl. 27, 219-222.
3. Asselineau, D., Bernhard, B., Bailly, C. and Darmon, M. (1985). Epidermal morphogenesis and induction of the 67 kD keratin polypeptide by culture of human keratinocytes at the liquid-air interface. Exp. Cell Res. 159, 536-539.
4. Bader, A., Knop, E., Kern, A., Boker, K., Fruhauf, N., Crome, O., Esselmann, H., Pape, C., Kempka, G. and Sewing, K. F. (1996). 3-D coculture of hepatic sinusoidal cells with primary hepatocytes-design of an organotypical model. Exp. Cell Res. 226, 223-233.
5. Bagutti, C., Hutter, C., Chiquet-Ehrismann, R., Fassler, R. and Watt, F. M. (2001). Dermal fibroblast-derived growth factors restore the ability of beta(1) integrin-deficient embryonal stem cells to differentiate into keratinocytes. Dev. Biol. 231, 321-333.
6. Bagutti, C., Wobus, A. M., Fassler, R. and Watt, F. M. (1996). Differentiation of embryonal stem cells into keratinocytes: comparison of wild-type and beta 1 integrin-deficient cells. Dev. Biol. 179, 184-196.
7. Balis, F. M. (2002). Evolution of anticancer drug discovery and the role of cell-based screening. J. Natl. Cancer Inst. 94, 78-79.
8. Barcellos-Hoff, M. H. (2001). Three down and counting: the transformation of human mammary cells from normal to malignant in three steps. Trends Mol. Med. 7, 142-143.
9. Barcellos-Hoff, M. H. and Ravani, S. A. (2000). Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res. 60, 1254-1260.
10. Barcellos-Hoff, M. H., Aggeler, J., Ram, T. G. and Bissell, M. J. (1989). Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development 105, 223-235.
11. Bell, E., Ehrlich, H. P., Buttle, D. J. and Nakatsuji, T. (1981). Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness. Science 211, 1052-1054.
12. Bello-DeOcampo, D., Kleinman, H. K., Deocampo, N. D. and Webber, M. M. (2001). Laminin-1 and alpha6beta1 integrin regulate acinar morphogenesis of normal and malignant human prostate epithelial cells. Prostate 46, 142-153.
13. Ben-Ze'ev, A., Robinson, G. S., Bucher, N. L. and Farmer, S. R. (1988). Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc. Natl. Acad. Sci. USA 85, 2161-2165.
14. Bhadriraju, K. and Chen, C. S. (2002). Engineering cellular microenvironments to improve cell-based drug testing. Drug Discov. Today 7, 612-620.
15. Bissell, D. M., Arenson, D. M., Maher, J. J. and Roll, F. J. (1987). Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. J. Clin. Invest. 79, 801-812.
16. Bissell, M. J. (1981). The differentiated state of normal and malignant cells or how to define a "normal" cell in culture. Int. Rev. Cytol. 70, 27-100.
17. Bissell, M. and Bilder, D. (2003). Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin. Breast Cancer J. 2, 117-119.
18. Bissell, M. J. and Hall, H. G. (1987). Form and function in the mammary gland: the role of extracellular matrix. In The Mammary Gland (eds M. C. Neville and C. W. Daniel), pp. 97-146. New York: Plenum Press.
19. Bissell, M. J. and Radisky, D. (2001). Putting tumours in context. Nat. Rev. Cancer 1, 46-54.
20. Bissell, M. J., Radisky, D. C., Rizki, A., Weaver, V. M. and Petersen, O. W. (2002). The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 70, 537-546.
21. Blatchford, D. R., Quarrie, L. H., Tonner, E., McCarthy, C., Flint, D. J. and Wilde, C. J. (1999). Influence of microenvironment on mammary epithelial cell survival in primary culture. J. Cell Physiol. 181, 304-311.
22. Boudreau, N. and Bissell, M. J. (1998). Extracellular matrix signaling: integration of form and function in normal and malignant cells. Curr. Opin. Cell Biol. 10, 640-646.
23. Boudreau, N., Sympson, C. J., Werb, Z. and Bissell, M. J. (1995). Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267, 891-893.
24. Boyce, S. T. and Warden, G. D. (2002). Principles and practices for treatment of cutaneous wounds with cultured skin substitutes. Am. J. Surg. 183, 445-456.
25. Briand, P., Nielsen, K. V., Madsen, M. W. and Petersen, O. W. (1996). Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal. Cancer Res. 56, 2039-2044.
26. Briand, P., Petersen, O. W. and van Deurs, B. (1987). A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium. In Vitro Cell Dev. Biol. 23, 181-188.
27. Chen, H. M., Schmeichel, K. L., Mian, I. S., Lelievre, S., Petersen, O. W. and Bissell, M. J. (2000). AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression. Mol. Biol. Cell 11, 1357-1367.
28. Choi, Y. and Fuchs, E. (1990). TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells. Cell Regul. 1, 791-809.
29. Clejan, S., O'Connor, K. and Rosensweig, N. (2001). Tri-dimensional prostate cell cultures in simulated microgravity and induced changes in lipid second messengers and signal transduction. J. Cell Mol. Med. 5, 60-73.
30. Coucouvanis, E. and Martin, G. R. (1995). Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell 83, 279-287.
31. Coulomb, B., Lebreton, C. and Dubertret, L. (1989). Influence of human dermal fibroblasts on epidermalization. J. Invest. Dermatol. 92, 122-125.
32. Cukierman, E., Pankov, R., Stevens, D. R. and Yamada, K. M. (2001). Taking cell-matrix adhesions to the third dimension. Science 294, 1708-1712.
33. Cukierman, E., Pankov, R. and Yamada, K. (2002). Cell interactions with three-dimensional matrices. Curr. Opin. Cell Biol. 14, 633-639.
34. Cunha, G. R. (1994). Role of mesenchymal-epithelial interactions in normal and abnormal development of the mammary gland and prostate. Cancer 74, 1030-1044.
35. Cunha, G. R., Hayward, S. W. and Wang, Y. Z. (2002). Role of stroma in carcinogenesis of the prostate. Differentiation 70, 473-485.
36. Debnath, J., Mills, K., Collins, N., Reginato, M., Muthuswamy, S. and Brugge, J. (2002). The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111, 29-40.
37. Eccles, S. A. (2001). The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis. J. Mammary Gland Biol. Neoplasia 6, 393-406.
38. Elenbaas, B., Spirio, L., Koerner, F., Fleming, M. D., Zimonjic, D. B., Donaher, J. L., Popescu, N. C., Hahn, W. C. and Weinberg, R. A. (2001). Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 15, 50-65.
39. Elsdale, T. and Bard, J. (1972). Collagen substrata for studies on cell behavior. J. Cell Biol. 54, 626-637.
40. Emerman, J. T. and Pitelka, D. R. (1977). Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes. In Vitro 13, 316-328.
41. Emerman, J. T., Enami, J., Pitelka, D. R. and Nandi, S. (1977). Hormonal effects on intracellular and secreted casein in cultures of mouse mammary epithelial cells on floating collagen membranes. Proc. Natl. Acad. Sci. USA 74, 4466-4470.
42. Fartasch, M. and Ponec, M. (1994). Improved barrier structure formation in air-exposed human keratinocyte culture systems. J. Invest. Dermatol. 102, 366-374.
43. Frisch, S. M. and Francis, H. (1994). Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626.
44. Fuchs, E. and Raghavan, S. (2002). Getting under the skin of epidermal morphogenesis. Nat. Rev. Genet. 3, 199-209.
45. Fusenig, N. E. (1994). Epithelial-mesenchymal interactions regulate keratinocyte growth and differentiation in vitro. In The Keratinocyte Handbook (eds I. Leigh B. Lane and F. Watt), pp. 71-94. Cambridge: Cambridge University Press.
46. Fusenig, N. E. and Boukamp, P. (1998). Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes. Mol. Carcinog. 23, 144-158.
47. Gay, R., Swiderek, M., Nelson, D. and Ernesti, A. (1992). The living skin equivalent as a model in vitro for ranking the toxic potential of dermal irritants. Toxic In Vitro 6.
48. Gittes, G. K., Galante, P. E., Hanahan, D., Rutter, W. J. and Debase, H. T. (1996). Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors. Development 122, 439-447.
49. Grant, D. S., Tashiro, K., Segui-Real, B., Yamada, Y., Martin, G. R. and Kleinman, H. K. (1989). Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro. Cell 58, 933-943.
50. Gudjonsson, T., Ronnov-Jessen, L., Villadsen, R., Rank, F., Bissell, M. J. and Petersen, O. W. (2002a). Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J. Cell Sci. 115, 39-50.
51. Gudjonsson, T., Villadsen, R., Nielsen, H. L., Ronnov-Jessen, L., Bissell, M. J. and Petersen, O. W. (2002b). Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev. 16, 693-706.
52. Hall, H. G., Farson, D. A. and Bissell, M. J. (1982). Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture. Proc. Natl. Acad. Sci. USA 79, 4672-4676.
53. Harkin, D. G. and Hay, E. D. (1996). Effects of electroporation on the tubulin cytoskeleton and directed migration of corneal fibroblasts cultured within collagen matrices. Cell Motil. Cytoskeleton 35, 345-357.
54. Hay, E. D. and Dodson, J. W. (1973). Secretion of collagen by corneal epithelium. I. Morphology of the collagenous products produced by isolated epithelia grown on frozen-killed lens. J. Cell Biol. 57, 190-213.
55. Hertle, M. D., Adams, J. C. and Watt, F. M. (1991). Integrin expression during human epidermal development in vivo and in vitro. Development 112, 193-206.
56. Hoffman, M. P., Kibbey, M. C., Letterio, J. J. and Kleinman, H. K. (1996). Role of laminin-1 and TGF-beta 3 in acinar differentiation of a human submandibular gland cell line (HSG). J. Cell Sci. 109, 2013-2021.
57. Howlett, A. R., Bailey, N., Damsky, C., Petersen, O. W. and Bissell, M. J. (1995). Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma. J. Cell Sci. 108, 1945-1957.
58. Howlett, A. R., Petersen, O. W., Steeg, P. S. and Bissell, M. J. (1994). A novel function for the nm23-H1 gene: overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest. J. Natl. Cancer Inst. 86, 1838-1844.
59. Huang, J., Hardy, J. D., Sun, Y. and Shively, J. E. (1999). Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. J. Cell Sci. 112, 4193-4205.
60. Huss, F. R. and Kratz, G. (2001). Mammary epithelial cell and adipocyte coculture in a 3-D matrix: the first step towards tissue-engineered human breast tissue. Cells Tissues Organs 169, 361-367.
61. Ingber, D. E. (2002). Cancer as a disease of epithelial-mesenchymal interactions and extracellular matrix regulation. Differentiation 70, 547-560.
62. Ingber, D. E. and Folkman, J. (1989). How does extracellular matrix control capillary morphogenesis? Cell 58, 803-805.
63. Ingber, D. E., Madri, J. A. and Jamieson, J. D. (1986). Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro. Am. J. Pathol. 122, 129-139.
64. Jacks, T. and Weinberg, R. A. (2002). Taking the study of cancer cell survival to a new dimension. Cell 111, 923-925.
65. Kaur, P. and Carter, W. G. (1992). Integrin expression and differentiation in transformed human epidermal cells is regulated by fibroblasts. J. Cell Sci. 103, 755-763.
66. Kirshner, J., Chen, C. J., Liu, P., Huang, J. and Shively, J. E. (2003). CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture. Proc. Natl. Acad. Sci. USA 100, 521-526.
67. Kleinman, H. K., McGarvey, M. L., Hassel, J. R., Star, V. L., Cannon, F. B., Laurie, G. W. and Martin, G. R. (1986). Basement membrane complexes with biological activity. Biochemistry 25, 312-318.
68. Kopan, R. and Fuchs, E. (1989). A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes Dev. 3, 1-15.
69. Kopan, R., Traska, G. and Fuchs, E. (1987). Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. J. Cell Biol. 105, 427-440.
70. Kubota, Y., Kleinman, H. K., Martin, G. R. and Lawley, T. J. (1988). Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J. Cell Biol. 107, 1589-1598.
71. Lelievre, S. A., Bissell, M. J. and Pujuguet, P. (2000). Cell nucleus in context. Crit. Rev. Eukaryot. Gene Expr. 10, 13-20.
72. Lelievre, S. A., Weaver, V. M., Nickerson, J. A., Larabell, C. A., Bhaumik, A., Petersen, O. W. and Bissell, M. J. (1998). Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc. Natl. Acad Sci. USA 95, 14711-14716.
73. Leone, A., Flatow, U., VanHoutte, K. and Steeg, P. S. (1993). Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity. Oncogene 8, 2325-2333.
74. Li, M. L., Aggeler, J., Farson, D. A., Hatier, C., Hassell, J. and Bissell, M. J. (1987). Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells. Proc. Natl. Acad. Sci. USA 84, 136-140.
75. Lin, C. Q. and Bissell, M. J. (1993). Multi-faceted regulation of cell differentiation by extracellular matrix. FASEB J. 7, 737-743.
76. Liotta, L. A. and Kohn, E. C. (2001). The microenvironment of the tumour-host interface. Nature 411, 375-379.
77. Maas-Szabowski, N., Stark, H. J. and Fusenig, N. E. (2000). Keratinocyte growth regulation in defined organotypic cultures through IL-1-induced keratinocyte growth factor expression in resting fibroblasts. J. Invest. Dermatol. 114, 1075-1084.
78. Maas-Szabowski, N., Szabowski, A., Stark, H. J., Andrecht, S., Kolbus, A., Schorpp-Kistner, M., Angel, P. and Fusenig, N. E. (2001). Organotypic cocultures with genetically modified mouse fibroblasts as a tool to dissect molecular mechanisms regulating keratinocyte growth and differentiation. J. Invest. Dermatol. 116, 816-820.
79. Man, Y. G., Shekitka, K. M, Bratthauer, G. L. and Tavassoli, F A. (2002). Immunohistochemical and genetic alterations in mammary epithelial cells immediately overlying focally disrupted myoepithelial cell layers. Breast Cancer Research Treatment 76 (Supplement 1), S143.
80. Mauchamp, J., Mirrione, A., Alquier, C. and Andre, F. (1998). Follicle-like structure and polarized monolayer: role of the extracellular matrix on thyroid cell organization in primary culture. Biol. Cell 90, 369-380.
81. McCance, D. J., Kopan, R., Fuchs, E. and Laimins, L. A. (1988). Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc. Natl. Acad. Sci. USA 85, 7169-7173.
82. Michalopoulos, G. and Pitot, H. C. (1975). Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. Exp. Cell Res. 94, 70-78.
83. Miller, F. R., Medina, D. and Heppner, G. H. (1981). Preferential growth of mammary tumors in intact mammary fatpads. Cancer Res. 41, 3863-3867.
84. Moinfar, F., Man, Y. G., Arnould, L., Bratthauer, G. L., Ratschek, M. and Tavassoli, F. A. (2000). Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res. 60, 2562-2566.
85. Mueller, M. M. and Fusenig, N. E. (2002). Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells. Differentiation 70, 486-497.
86. Muschler, J., Levy, D., Boudreau, R., Henry, M., Campbell, K. and Bissell, M. J. (2002). A Role for dystroglycan in epithelial polarization: loss of function in breast tumor cells. Cancer Res. 62, 7102-7109.
87. Muthuswamy, S. K., Li, D., Lelievre, S., Bissell, M. J. and Brugge, J. S. (2001). ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat. Cell Biol. 3, 785-792.
88. Neville, M. C., Medina, D., Monks, J. and Hovey, R. C. (1998). The mammary fat pad. J. Mammary Gland Biol. Neoplasia 3, 109-116.
89. Nickerson, J. (2001). Experimental observations of a nuclear matrix. J. Cell Sci. 114, 463-474.
90. Nielsen, K. V., Madsen, M. W. and Briand, P. (1994). In vitro karyotype evolution and cytogenetic instability in the non-tumorigenic human breast epithelial cell line HMT-3522. Cancer Genet. Cytogenet. 78, 189-199.
91. O'Brien, L. E., Jou, T. S., Pollack, A. L., Zhang, Q., Hansen, S. H., Yurchenco, P. and Mostov, K. E. (2001). Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly. Nat. Cell Biol. 3, 831-838.
92. O'Brien, L. E., Zegers, M. M. and Mostov, K. E. (2002). Opinion: Building epithelial architecture: insights from three-dimensional culture models. Nat. Rev. Mol. Cell Biol. 3, 531-537.
93. Oliver, C., Waters, J. F., Tolbert, C. L. and Kleinman, H. K. (1987). Growth of exocrine acinar cells on a reconstituted basement membrane gel. In Vitro Cell Dev. Biol. 23, 465-473.
94. Olumi, A. F., Grossfeld, G. D., Hayward, S. W., Carroll, P. R., Tlsty, T. D. and Cunha, G. R. (1999). Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59, 5002-5011.
95. Parenteau, N., Nolte, C., Bilbo, P., Rosenberg, M., Wilkins, L., Johnson, E., Watson, S., Mason, V. and Bell, E. (1991). Epidermis generated in vitro: practical considerations and applications. J Cell Biochem. 45, 245-251.
96. Parmar, H., Young, P., Emerman, J. T., Neve, R. M., Dairkee, S. and Cunha, G. R. (2002). A novel method for growing human breast epithelium in vivo using mouse and human mammary fibroblasts. Endocrinology 143, 4886-4896.
97. Petersen, O. W., Ronnov-Jessen, L., Howlett, A. R. and Bissell, M. J. (1992). Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc. Natl. Acad. Sci. USA 89, 9064-9068.
98. Petersen, O. W., Lind Nielsen, H., Gudjonsson, T., Villadsen, R., Ronnov-Jessen, L. and Bissell, M. J. (2001). The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion. Breast Cancer Res. 3, 213-217.
99. Radisky, D., Muschler, J. and Bissell, M. J. (2002). Order and disorder: the role of extracellular matrix in epithelial cancer. Cancer Invest. 20, 139-153.
100. Regnier, M., Prunieras, M. and Woodley, D. (1981). Growth and differentiation of adult human epidermal cells on dermal substrates. Frontiers Matrix Biol. 9, 4-35.
101. Ronnov-Jessen, L., Petersen, O. W. and Bissell, M. J. (1996). Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol. Rev. 76, 69-125.
102. Roskelley, C. D., Desprez, P. Y. and Bissell, M. J. (1994). Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc. Natl. Acad. Sci. USA 91, 12378-12382.
103. Roskelley, C. D., Srebrow, A. and Bissell, M. J. (1995). A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Curr. Opin. Cell Biol. 7, 736-747.
104. Runswick, S. K., O'Hare, M. J., Jones, L., Streuli, C. H. and Garrod, D. R. (2001). Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat. Cell Biol. 3, 823-830.
105. Sakamoto, T., Hirano, K., Morishima, Y., Masuyama, K., Ishii, Y., Nomura, A., Uchida, Y., Ohtsuka, M. and Sekizawa, K. (2001). Maintenance of the differentiated type II cell characteristics by culture on an acellular human amnion membrane. In Vitro Cell Dev. Biol. Anim. 37, 471-479.
106. Sakurai, H., Barros, E. J., Tsukamoto, T., Barasch, J. and Nigam, S. K. (1997). An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors. Proc. Natl. Acad. Sci. USA 94, 6279-6284.
107. Sanderson, I. R., Ezzell, R. M., Kedinger, M., Erlanger, M., Xu, Z. X., Pringault, E., Leon-Robine, S., Louvard, D. and Walker, W. A. (1996). Human fetal enterocytes in vitro: modulation of the phenotype by extracellular matrix. Proc. Natl. Acad. Sci. USA 93, 7717-7722.
108. Schmeichel, K. L., Weaver, V. M. and Bissell, M. J. (1998). Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype. J. Mammary Gland Biol. Neoplasia 3, 201-213.
109. Schuger, L., O'Shea, K. S., Nelson, B. B. and Varani, J. (1990). Organotypic arrangement of mouse embryonic lung cells on a basement membrane extract: involvement of laminin. Development 110, 1091-1099.
110. Sheffield, L. G. (1988). Organization and growth of mammary epithelia in the mammary gland fat pad. J. Dairy Sci. 71, 2855-2874.
111. Silberstein, G. B. (2001). Tumour-stromal interactions. Role of the stroma in mammary development. Breast Cancer Res. 3, 218-223.
112. Smalley, M. J., Titley, J., Paterson, H., Perusinghe, N., Clarke, C. and O'Hare, M. J. (1999). Differentiation of separated mouse mammary luminal epithelial and myoepithelial cells cultured on EHS matrix analyzed by indirect immunofluorescence of cytoskeletal antigens. J. Histochem. Cytochem. 47, 1513-1524.
113. Smith, G. H. (1996). Experimental mammary epithelial morphogenesis in an in vivo model: evidence for distinct cellular progenitors of the ductal and lobular phenotype. Breast Cancer Res. Treat. 39, 21-31.
114. Smola, H., Stark, H. J., Thiekotter, G., Mirancea, N., Krieg, T. and Fusenig, N. E. (1998). Dynamics of basement membrane formation by keratinocyte-fibroblast interactions in organotypic skin culture. Exp. Cell Res. 239, 399-410.
115. Spancake, K. M., Anderson, C. B., Weaver, V. M., Matsunami, N., Bissell, M. J. and White, R. L. (1999). E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture. Cancer Res. 59, 6042-6045.
116. Sternlicht, M. D., Kedeshian, P., Shao, Z. M., Safarians, S. and Barsky, S. H. (1997). The human myoepithelial cell is a natural tumor suppressor. Clin. Cancer Res. 3, 1949-1958.
117. Still, I. H., Hamilton, M., Vince, P., Wolfman, A. and Cowell, J. K. (1999). Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. Oncogene 18, 4032-4038.
118. Stingl, J., Eaves, C. J., Kuusk, U. and Emerman, J. T. (1998). Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast. Differentiation 63, 201-213.
119. Stoker, A. W., Streuli, C. H., Martins-Green, M. and Bissell, M. J. (1990). Designer microenvironments for the analysis of cell and tissue function. Curr. Opin. Cell Biol. 2, 864-874.
120. Szabowski, A., Maas-Szabowski, N., Andrecht, S., Kolbus, A., Schorpp-Kistner, M., Fusenig, N. E. and Angel, P. (2000). c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell 103, 745-755.
121. Tlsty, T. D. and Hein, P. W. (2001). Know thy neighbor: stromal cells can contribute oncogenic signals. Curr. Opin. Genet. Dev. 11, 54-59.
122. Troxell, M. L., Loftus, D. J., Nelson, W. J. and Marrs, J. A. (2001). Mutant cadherin affects epithelial morphogenesis and invasion, but not transformation. J. Cell Sci. 114, 1237-1246.
123. Turksen, K., Choi, Y. and Fuchs, E. (1991). Transforming growth factor alpha induces collagen degradation and cell migration in differentiating human epidermal raft cultures. Cell Regul. 2, 613-625.
124. Vukicevic, S., Luyten, F. P., Kleinman, H. K. and Reddi, A. H. (1990). Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: regulation by discrete domains of laminin. Cell 63, 437-445.
125. Walpita, D. and Hay, E. (2002). Studying actin-dependent processes in tissue culture. Nat. Rev. Mol. Cell Biol. 3, 137-141.
126. Wang, F., Weaver, V. M., Petersen, O. W., Larabell, C. A., Dedhar, S., Briand, P., Lupu, R. and Bissell, M. J. (1998). Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc. Natl. Acad. Sci. USA 95, 14821-14826.
127. Wang, F., Hansen, R. K., Radisky, D., Yoneda, T., Barcellos-Hoff, M. H., Petersen, O. W., Turley, E. A. and Bissell, M. J. (2002). Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J. Natl. Cancer Inst. 94, 1494-1503.
128. Watt, F. M. (1988). Proliferation and terminal differentiation of human epidermal keratinocytes in culture. Biochem. Soc. Trans. 16, 666-668.
129. Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C. and Bissell, M. J. (1997). Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J. Cell Biol. 137, 231-245.
130. Weaver, V., Lelievre, S., Lakins, J., Chrenek, M., Jones, J., Giancotti, F., Werb, Z. and Bissell, M. (2002). beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2, 205-216.
131. Yamada, K. M. and Clark, K. (2002). Cell biology: Survival in three dimensions. Nature 419, 790-791.
132. Yarden, Y. (2001). Biology of HER2 and its importance in breast cancer. Oncology 61 Suppl. 2, 1-13.
133. Zou, Z., Anisowicz, A., Hendrix, M. J., Thor, A., Neveu, M., Sheng, S., Rafidi, K., Seftor, E. and Sager, R. (1994). Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science 263, 526-529.