메뉴 건너뛰기




Volumn 1, Issue 3, 2012, Pages 558-575

Autophagy and transporter-based multi-drug resistance

Author keywords

Apoptosis; Autophagy; MDR

Indexed keywords

ABC TRANSPORTER; BECLIN 1; CAFFEINE; CHLOROQUINE; CISPLATIN; DASATINIB; DOXORUBICIN; FLUOROURACIL; HIGH MOBILITY GROUP B1 PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53;

EID: 84888293859     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells1030558     Document Type: Review
Times cited : (61)

References (108)
  • 1
    • 84859161154 scopus 로고    scopus 로고
    • Microautophagy: Lesser-known self-eating
    • Li, W.W.; Li, J.; Bao, J.K. Microautophagy: Lesser-known self-eating. Cell. Mol. Life Sci. 2012, 69, 1125-1136.
    • (2012) Cell. Mol. Life Sci. , vol.69 , pp. 1125-1136
    • Li, W.W.1    Li, J.2    Bao, J.K.3
  • 3
    • 77950994646 scopus 로고    scopus 로고
    • Autophagy: Cellular and molecular mechanisms
    • Glick, D.; Barth, S.; Macleod, K.F. Autophagy: Cellular and molecular mechanisms. J. Pathol. 2010, 221, 3-12.
    • (2010) J. Pathol. , vol.221 , pp. 3-12
    • Glick, D.1    Barth, S.2    Macleod, K.F.3
  • 4
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: From phenomenology to molecular understanding
    • Klionsky, D.J. Autophagy: From phenomenology to molecular understanding. Mol. Cell Biol. 2007, 8, 931-937.
    • (2007) Mol. Cell Biol. , vol.8 , pp. 931-937
    • Klionsky, D.J.1
  • 5
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima, N.; Komatsu, M. Autophagy: Renovation of cells and tissues. Cell 2011, 147, 728-741.
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 7
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu, X. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Investig. 2003, 112, 1809-1820.
    • (2003) J. Clin. Investig. , vol.112 , pp. 1809-1820
    • Qu, X.1
  • 8
    • 77951228508 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy: Cell death or cell survival?
    • Mazure, N.M.; Pouyssegur, J. Hypoxia-induced autophagy: Cell death or cell survival? Curr. Opin. Cell Biol. 2010, 22, 177-180.
    • (2010) Curr. Opin. Cell Biol. , vol.22 , pp. 177-180
    • Mazure, N.M.1    Pouyssegur, J.2
  • 9
    • 77950509348 scopus 로고    scopus 로고
    • Autophagy and tumorigenesis
    • Chen, N.; Debnath, J. Autophagy and tumorigenesis. FEBS Lett. 2010, 584, 1427-1435.
    • (2010) FEBS Lett. , vol.584 , pp. 1427-1435
    • Chen, N.1    Debnath, J.2
  • 12
    • 84858690254 scopus 로고    scopus 로고
    • Tumor-cell death, autophagy, and immunity
    • Weiner, L.M.; Lotze, M.T. Tumor-cell death, autophagy, and immunity. New Engl. J. Med. 2012, 366, 1156-1158.
    • (2012) New Engl. J. Med. , vol.366 , pp. 1156-1158
    • Weiner, L.M.1    Lotze, M.T.2
  • 13
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: A history of macroautophagy
    • Yang, Z.; Klionsky, D.J. Eaten alive: A history of macroautophagy. Nat. Cell Biol. 2010, 12, 814-822.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 14
    • 77957660865 scopus 로고    scopus 로고
    • Dasatinib induces autophagic cell death in human ovarian cancer
    • Le, X.F.; Mao, W.; Lu, Z.; Carter, B.Z.; Bast, R.C., Jr. Dasatinib induces autophagic cell death in human ovarian cancer. Cancer 2010, 116, 4980-4990.
    • (2010) Cancer , vol.116 , pp. 4980-4990
    • Le, X.F.1    Mao, W.2    Lu, Z.3    Carter, B.Z.4    Bast Jr., R.C.5
  • 15
    • 84863292400 scopus 로고    scopus 로고
    • Role of ABC transporters in cancer chemotherapy
    • Sun, Y.L.; Patel, A.; Kumar, P.; Chen, Z.S. Role of ABC transporters in cancer chemotherapy. Chin. J. Cancer 2012, 31, 51-58.
    • (2012) Chin. J. Cancer , vol.31 , pp. 51-58
    • Sun, Y.L.1    Patel, A.2    Kumar, P.3    Chen, Z.S.4
  • 16
    • 33846799065 scopus 로고    scopus 로고
    • Autophagymediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells
    • Meschini, S.; Condello, M.; Marra, M.; Formisano, G.; Federici, E.; Arancia, G. Autophagymediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells. Toxicol. Vitro 2007, 21, 197-203.
    • (2007) Toxicol. Vitro , vol.21 , pp. 197-203
    • Meschini, S.1    Condello, M.2    Marra, M.3    Formisano, G.4    Federici, E.5    Arancia, G.6
  • 17
    • 0033799839 scopus 로고    scopus 로고
    • Multidrug resistance (MDR) in cancer Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
    • Krishna, R.; Mayer, L.D. Multidrug resistance (MDR) in cancer Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur. J. Pharmaceut. Sci. 2000, 11, 265-283.
    • (2000) Eur. J. Pharmaceut. Sci. , vol.11 , pp. 265-283
    • Krishna, R.1    Mayer, L.D.2
  • 18
    • 0023219734 scopus 로고
    • Transport of molecules in the tumor interstitium: A review
    • Jain, R.K. Transport of molecules in the tumor interstitium: A review. Cancer Res. 1987, 47, 3039-3051.
    • (1987) Cancer Res. , vol.47 , pp. 3039-3051
    • Jain, R.K.1
  • 19
    • 80052449326 scopus 로고    scopus 로고
    • Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
    • Chen, Z.S.; Tiwari, A.K. Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases. FEBS J. 2011, 278, 3226-3245.
    • (2011) FEBS J. , vol.278 , pp. 3226-3245
    • Chen, Z.S.1    Tiwari, A.K.2
  • 20
    • 84856687924 scopus 로고    scopus 로고
    • Molecular machinery of autophagy and its implication in cancer
    • Li, Y.; Zhang, J.; Chen, X.; Liu, T.; He, W.; Chen, Y.; Zeng, X. Molecular machinery of autophagy and its implication in cancer. Am. J. Med. Sci. 2012, 343, 155-161.
    • (2012) Am. J. Med. Sci. , vol.343 , pp. 155-161
    • Li, Y.1    Zhang, J.2    Chen, X.3    Liu, T.4    He, W.5    Chen, Y.6    Zeng, X.7
  • 24
    • 84862023791 scopus 로고    scopus 로고
    • Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
    • Li, X.; He, L.; Che, K.H.; Funderburk, S.F.; Pan, L.; Pan, N.; Zhang, M.; Yue, Z.; Zhao, Y. Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat. Commun. 2012, 3, 662.
    • (2012) Nat. Commun. , vol.3 , pp. 662
    • Li, X.1    He, L.2    Che, K.H.3    Funderburk, S.F.4    Pan, L.5    Pan, N.6    Zhang, M.7    Yue, Z.8    Zhao, Y.9
  • 25
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang, C.; Feng, P.; Ku, B.; Dotan, I.; Canaani, D.; Oh, B.H.; Jung, J.U. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 2006, 8, 688-699.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3    Dotan, I.4    Canaani, D.5    Oh, B.H.6    Jung, J.U.7
  • 26
    • 46449120732 scopus 로고    scopus 로고
    • Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
    • Liang, C.; Lee, J.S.; Inn, K.S.; Gack, M.U.; Li, Q.; Roberts, E.A.; Vergne, I.; Deretic, V.; Feng, P.; Akazawa, C.; et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 2008, 10, 776-787.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 776-787
    • Liang, C.1    Lee, J.S.2    Inn, K.S.3    Gack, M.U.4    Li, Q.5    Roberts, E.A.6    Vergne, I.7    Deretic, V.8    Feng, P.9    Akazawa, C.10
  • 27
    • 59249089394 scopus 로고    scopus 로고
    • Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
    • Itakura, E.; Kishi, C.; Inoue, K.; Mizushima, N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell 2008, 19, 5360-5372.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 28
    • 0031026639 scopus 로고    scopus 로고
    • Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150. Ptdins 3-kinase complex
    • Panaretou, C.; Domin, J.; Cockcroft, S.; Waterfield, M.D. Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150. Ptdins 3-kinase complex. J. Biol. Chem. 1997, 272, 2477-2485.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2477-2485
    • Panaretou, C.1    Domin, J.2    Cockcroft, S.3    Waterfield, M.D.4
  • 29
    • 67650305520 scopus 로고    scopus 로고
    • Regulation of Beclin 1 in autophagy
    • Sun, Q.; Fan, W.; Zhong, Q. Regulation of Beclin 1 in autophagy. Autophagy 2009, 5, 713-716.
    • (2009) Autophagy , vol.5 , pp. 713-716
    • Sun, Q.1    Fan, W.2    Zhong, Q.3
  • 31
    • 0037166241 scopus 로고    scopus 로고
    • Formation of the approximately 350-kDa Apg12-Apg5. Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
    • Kuma, A.; Mizushima, N.; Ishihara, N.; Ohsumi, Y. Formation of the approximately 350-kDa Apg12-Apg5. Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J. Biol. Chem. 2002, 277, 18619-18625.
    • (2002) J. Biol. Chem. , vol.277 , pp. 18619-18625
    • Kuma, A.1    Mizushima, N.2    Ishihara, N.3    Ohsumi, Y.4
  • 36
    • 0035971160 scopus 로고    scopus 로고
    • The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation
    • Komatsu, M.; Tanida, I.; Ueno, T.; Ohsumi, M.; Ohsumi, Y.; Kominami, E. The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation. J. Biol. Chem. 2001, 276, 9846-9854.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9846-9854
    • Komatsu, M.1    Tanida, I.2    Ueno, T.3    Ohsumi, M.4    Ohsumi, Y.5    Kominami, E.6
  • 38
    • 0035910423 scopus 로고    scopus 로고
    • The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3
    • Tanida, I.; Tanida-Miyake, E.; Ueno, T.; Kominami, E. The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. J. Biol. Chem. 2001, 276, 1701-1706.
    • (2001) J. Biol. Chem. , vol.276 , pp. 1701-1706
    • Tanida, I.1    Tanida-Miyake, E.2    Ueno, T.3    Kominami, E.4
  • 40
    • 0347695019 scopus 로고    scopus 로고
    • A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L
    • Hemelaar, J.; Lelyveld, V.S.; Kessler, B.M.; Ploegh, H.L. A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J. Biol. Chem. 2003, 278, 51841-51850.
    • (2003) J. Biol. Chem. , vol.278 , pp. 51841-51850
    • Hemelaar, J.1    Lelyveld, V.S.2    Kessler, B.M.3    Ploegh, H.L.4
  • 41
    • 0034676037 scopus 로고    scopus 로고
    • The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
    • Kirisako, T.; Ichimura, Y.; Okada, H.; Kabeya, Y.; Mizushima, N.; Yoshimori, T.; Ohsumi, M.; Takao, T.; Noda, T.; Ohsumi, Y. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J. Cell Biol. 2000, 151, 263-276.
    • (2000) J. Cell Biol. , vol.151 , pp. 263-276
    • Kirisako, T.1    Ichimura, Y.2    Okada, H.3    Kabeya, Y.4    Mizushima, N.5    Yoshimori, T.6    Ohsumi, M.7    Takao, T.8    Noda, T.9    Ohsumi, Y.10
  • 42
    • 82955247613 scopus 로고    scopus 로고
    • Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8
    • Hong, S.B.; Kim, B.W.; Lee, K.E.; Kim, S.W.; Jeon, H.; Kim, J.; Song, H.K. Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8. Nat. Struct. Mo. Biol. 2011, 18, 1323-1330.
    • (2011) Nat. Struct. Mo. Biol. , vol.18 , pp. 1323-1330
    • Hong, S.B.1    Kim, B.W.2    Lee, K.E.3    Kim, S.W.4    Jeon, H.5    Kim, J.6    Song, H.K.7
  • 43
    • 0035825175 scopus 로고    scopus 로고
    • Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex
    • Kim, J.; Huang, W.P.; Klionsky, D.J. Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex. J. Cell Biol. 2001, 152, 51-64.
    • (2001) J. Cell Biol. , vol.152 , pp. 51-64
    • Kim, J.1    Huang, W.P.2    Klionsky, D.J.3
  • 44
    • 84862777210 scopus 로고    scopus 로고
    • A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate
    • Chen, D.; Fan, W.; Lu, Y.; Ding, X.; Chen, S.; Zhong, Q. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol. Cell 2012, 45, 629-641.
    • (2012) Mol. Cell , vol.45 , pp. 629-641
    • Chen, D.1    Fan, W.2    Lu, Y.3    Ding, X.4    Chen, S.5    Zhong, Q.6
  • 45
    • 64649085325 scopus 로고    scopus 로고
    • Autophagy and cancer: Dynamism of the metabolism of tumor cells and tissues
    • Tsuchihara, K.; Fujii, S.; Esumi, H. Autophagy and cancer: Dynamism of the metabolism of tumor cells and tissues. Cancer Lett. 2009, 278, 130-138.
    • (2009) Cancer Lett. , vol.278 , pp. 130-138
    • Tsuchihara, K.1    Fujii, S.2    Esumi, H.3
  • 46
    • 78649242978 scopus 로고    scopus 로고
    • HMGB1: A novel Beclin 1-binding protein active in autophagy
    • Kang, R.; Livesey, K.M.; Zeh, H.J.; Loze, M.T.; Tang, D. HMGB1: A novel Beclin 1-binding protein active in autophagy. Autophagy 2010, 6, 1209-1211.
    • (2010) Autophagy , vol.6 , pp. 1209-1211
    • Kang, R.1    Livesey, K.M.2    Zeh, H.J.3    Loze, M.T.4    Tang, D.5
  • 49
    • 33646371497 scopus 로고    scopus 로고
    • Hmgb-1 as a therapeutic target for infectious and inflammatory disorders
    • Mantell, L.L.; Parrish, W.R.; Ulloa, L. Hmgb-1 as a therapeutic target for infectious and inflammatory disorders. Shock 2006, 25, 4-11.
    • (2006) Shock , vol.25 , pp. 4-11
    • Mantell, L.L.1    Parrish, W.R.2    Ulloa, L.3
  • 50
    • 78649833334 scopus 로고    scopus 로고
    • p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation
    • Scherz-Shouval, R.; Weidberg, H.; Gonen, C.; Wilder, S.; Elazar, Z.; Oren, M. p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc. Natl. Acad. Sci. USA 2010, 107, 18511-18516.
    • (2010) Proc. Natl. Acad. Sci. , vol.107 , pp. 18511-18516
    • Scherz-Shouval, R.1    Weidberg, H.2    Gonen, C.3    Wilder, S.4    Elazar, Z.5    Oren, M.6
  • 52
    • 80053501671 scopus 로고    scopus 로고
    • Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
    • Liu, J.; Xia, H.; Kim, M.; Xu, L.; Li, Y.; Zhang, L.; Cai, Y.; Norberg, H.V.; Zhang, T.; Furuya, T.; et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 2011, 147, 223-234.
    • (2011) Cell , vol.147 , pp. 223-234
    • Liu, J.1    Xia, H.2    Kim, M.3    Xu, L.4    Li, Y.5    Zhang, L.6    Cai, Y.7    Norberg, H.V.8    Zhang, T.9    Furuya, T.10
  • 54
    • 0018731987 scopus 로고
    • Variation in susceptibility to oral infection with dengue viruses among geographic strains of Aedes aegypti
    • Gubler, D.J.; Nalim, S.; Tan, R.; Saipan, H.; Sulianti Saroso, J. Variation in susceptibility to oral infection with dengue viruses among geographic strains of Aedes aegypti. Am. J. Trop. Med. Hyg. 1979, 28, 1045-1052.
    • (1979) Am. J. Trop. Med. Hyg. , vol.28 , pp. 1045-1052
    • Gubler, D.J.1    Nalim, S.2    Tan, R.3    Saipan, H.4    Sulianti Saroso, J.5
  • 55
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White, E.; DiPaola, R.S. The double-edged sword of autophagy modulation in cancer. Clin. Cancer Res. 2009, 15, 5308-5316.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5308-5316
    • White, E.1    DiPaola, R.S.2
  • 57
    • 79551634458 scopus 로고    scopus 로고
    • Autophagy in tumorigenesis and energy metabolism: Friend by day, foe by night
    • Mathew, R.; White, E. Autophagy in tumorigenesis and energy metabolism: Friend by day, foe by night. Curr. Opin. Genet. Dev. 2011, 21, 113-119.
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 113-119
    • Mathew, R.1    White, E.2
  • 58
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz, J.D.; White, E. Autophagy and metabolism. Science 2010, 330, 1344-1348.
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 59
    • 84857723095 scopus 로고    scopus 로고
    • Here, there be dragons: Charting autophagy-related alterations in human tumors
    • Lebovitz, C.B.; Bortnik, S.B.; Gorski, S.M. Here, there be dragons: Charting autophagy-related alterations in human tumors. Clin. Cancer Res. 2012, 18, 1214-1226.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1214-1226
    • Lebovitz, C.B.1    Bortnik, S.B.2    Gorski, S.M.3
  • 63
    • 83455225635 scopus 로고    scopus 로고
    • The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis
    • Rubinstein, A.D.; Eisenstein, M.; Ber, Y.; Bialik, S.; Kimchi, A. The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis. Mol. Cell 2011, 44, 698-709.
    • (2011) Mol. Cell , vol.44 , pp. 698-709
    • Rubinstein, A.D.1    Eisenstein, M.2    Ber, Y.3    Bialik, S.4    Kimchi, A.5
  • 68
    • 77949542302 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival
    • Kang, R.; Tang, D.; Schapiro, N.E.; Livesey, K.M.; Farkas, A.; Loughran, P.; Bierhaus, A.; Lotze, M.T.; Zeh, H.J. The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. Cell Death Differ. 2009, 17, 666-676.
    • (2009) Cell Death Differ. , vol.17 , pp. 666-676
    • Kang, R.1    Tang, D.2    Schapiro, N.E.3    Livesey, K.M.4    Farkas, A.5    Loughran, P.6    Bierhaus, A.7    Lotze, M.T.8    Zeh, H.J.9
  • 70
    • 84860135029 scopus 로고    scopus 로고
    • Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death
    • Gammoh, N.; Lam, D.; Puente, C.; Ganley, I.; Marks, P.A.; Jiang, X. Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc. Natl. Acad. Sci. USA 2012, 109, 6561-6565.
    • (2012) Proc. Natl. Acad. Sci. , vol.109 , pp. 6561-6565
    • Gammoh, N.1    Lam, D.2    Puente, C.3    Ganley, I.4    Marks, P.A.5    Jiang, X.6
  • 74
    • 79959626436 scopus 로고    scopus 로고
    • Autophagy and apoptosis: What is the connection?
    • Gump, J.M.; Thorburn, A. Autophagy and apoptosis: What is the connection? Trends Cell Biol. 2011, 21, 387-392.
    • (2011) Trends Cell Biol. , vol.21 , pp. 387-392
    • Gump, J.M.1    Thorburn, A.2
  • 77
    • 81055140893 scopus 로고    scopus 로고
    • Feedback on fat: P62-mTORC1-autophagy connections
    • Moscat, J.; Diaz-Meco, M.T. Feedback on fat: p62-mTORC1-autophagy connections. Cell 2011, 147, 724-727.
    • (2011) Cell , vol.147 , pp. 724-727
    • Moscat, J.1    Diaz-Meco, M.T.2
  • 78
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri, M.C.; Zalckvar, E.; Kimchi, A.; Kroemer, G. Self-eating and self-killing: Crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 2007, 8, 741-752.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 79
    • 67549142261 scopus 로고    scopus 로고
    • Life and death partners: Apoptosis, autophagy and the cross-talk between them
    • Eisenberg-Lerner, A.; Bialik, S.; Simon, H.U.; Kimchi, A. Life and death partners: Apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 2009, 16, 966-975.
    • (2009) Cell Death Differ. , vol.16 , pp. 966-975
    • Eisenberg-Lerner, A.1    Bialik, S.2    Simon, H.U.3    Kimchi, A.4
  • 81
    • 72949115495 scopus 로고    scopus 로고
    • Alpha-eleostearic acid induces autophagy-dependent cell death through targeting AKT/mTOR and ERK1/2 signal together with the generation of reactive oxygen species
    • Eom, J.M.; Seo, M.J.; Baek, J.Y.; Chu, H.; Han, S.H.; Min, T.S.; Cho, C.S.; Yun, C.H. Alpha-eleostearic acid induces autophagy-dependent cell death through targeting AKT/mTOR and ERK1/2 signal together with the generation of reactive oxygen species. Biochem. Biophys. Res. Comm. 2010, 391, 903-908.
    • (2010) Biochem. Biophys. Res. Comm. , vol.391 , pp. 903-908
    • Eom, J.M.1    Seo, M.J.2    Baek, J.Y.3    Chu, H.4    Han, S.H.5    Min, T.S.6    Cho, C.S.7    Yun, C.H.8
  • 82
    • 79251593832 scopus 로고    scopus 로고
    • Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells
    • Wang, Q.; Chen, Z.; Diao, X.; Huang, S. Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells. Cancer Lett. 2011, 302, 29-36.
    • (2011) Cancer Lett. , vol.302 , pp. 29-36
    • Wang, Q.1    Chen, Z.2    Diao, X.3    Huang, S.4
  • 83
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death?
    • Baehrecke, E.H. Autophagy: Dual roles in life and death? Nat. Rev. Mol. Cell Biol. 2005, 6, 505-510.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 84
    • 79953306808 scopus 로고    scopus 로고
    • Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival
    • Elgendy, M.; Sheridan, C.; Brumatti, G.; Martin, S.J. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol. Cell 2011, 42, 23-35.
    • (2011) Mol. Cell , vol.42 , pp. 23-35
    • Elgendy, M.1    Sheridan, C.2    Brumatti, G.3    Martin, S.J.4
  • 85
    • 82855181979 scopus 로고    scopus 로고
    • E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells
    • Hatchi, E.; Rodier, G.; Sardet, C.; Le Cam, L. E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells. Autophagy 2011, 7, 1566-1567.
    • (2011) Autophagy , vol.7 , pp. 1566-1567
    • Hatchi, E.1    Rodier, G.2    Sardet, C.3    Le Cam, L.4
  • 87
    • 84855424390 scopus 로고    scopus 로고
    • Interplay between histone deacetylases and autophagy From cancer therapy to neurodegeneration
    • True, O.; Matthias, P. Interplay between histone deacetylases and autophagy From cancer therapy to neurodegeneration. Immunol. Cell Biol. 2012, 90, 78-84.
    • (2012) Immunol. Cell Biol. , vol.90 , pp. 78-84
    • True, O.1    Matthias, P.2
  • 88
    • 84862777402 scopus 로고    scopus 로고
    • Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor
    • Wu, M.Y.; Fu, J.; Xu, J.; O'Malley, B.W.; Wu, R.C. Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor. Cell Res. 2012, 22, 1003-1021.
    • (2012) Cell Res. , vol.22 , pp. 1003-1021
    • Wu, M.Y.1    Fu, J.2    Xu, J.3    O'Malley, B.W.4    Wu, R.C.5
  • 89
    • 79955677000 scopus 로고    scopus 로고
    • Autophagic cell death: Loch Ness monster or endangered species?
    • Shen, H.M.; Codogno, P. Autophagic cell death: Loch Ness monster or endangered species? Autophagy 2011, 7, 457-465.
    • (2011) Autophagy , vol.7 , pp. 457-465
    • Shen, H.M.1    Codogno, P.2
  • 90
    • 84856431622 scopus 로고    scopus 로고
    • The end of autophagic cell death?
    • Shen, S.; Kepp, O.; Kroemer, G. The end of autophagic cell death? Autophagy 2012, 8, 1-3.
    • (2012) Autophagy , vol.8 , pp. 1-3
    • Shen, S.1    Kepp, O.2    Kroemer, G.3
  • 91
    • 34648823750 scopus 로고    scopus 로고
    • Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy
    • Moretti, L.; Yang, E.S.; Kim, K.W.; Lu, B. Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy. Drug Resist. Updat. 2007, 10, 135-143.
    • (2007) Drug Resist. Updat. , vol.10 , pp. 135-143
    • Moretti, L.1    Yang, E.S.2    Kim, K.W.3    Lu, B.4
  • 92
    • 48249090416 scopus 로고    scopus 로고
    • Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer
    • Kim, K.W.; Hwang, M.; Moretti, L.; Jaboin, J.J.; Cha, Y.I.; Lu, B. Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 2008, 4, 659-668.
    • (2008) Autophagy , vol.4 , pp. 659-668
    • Kim, K.W.1    Hwang, M.2    Moretti, L.3    Jaboin, J.J.4    Cha, Y.I.5    Lu, B.6
  • 93
  • 95
    • 65549167833 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network for cancer therapy
    • Meric-Bernstam, F.; Gonzalez-Angulo, A.M. Targeting the mTOR signaling network for cancer therapy. J. Clin. Oncol. 2009, 27, 2278-2287.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2278-2287
    • Meric-Bernstam, F.1    Gonzalez-Angulo, A.M.2
  • 96
    • 79959937240 scopus 로고    scopus 로고
    • Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras-transformed NIH 3T3 cells
    • Eum, K.H.; Lee, M. Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras-transformed NIH 3T3 cells. Mol. Cell. 2011, 31, 231-238.
    • (2011) Mol. Cell. , vol.31 , pp. 231-238
    • Eum, K.H.1    Lee, M.2
  • 97
    • 67349286024 scopus 로고    scopus 로고
    • Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line
    • Mazzanti, R.; Platini, F.; Bottini, C.; Fantappie, O.; Solazzo, M.; Tessitore, L. Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line. Biochem. Pharmacol. 2009, 78, 21-32.
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 21-32
    • Mazzanti, R.1    Platini, F.2    Bottini, C.3    Fantappie, O.4    Solazzo, M.5    Tessitore, L.6
  • 98
    • 84856857494 scopus 로고    scopus 로고
    • Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells
    • Ajabnoor, G.M.; Crook, T.; Coley, H.M. Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells. Cell Death Dis. 2012, 3, 1-9.
    • (2012) Cell Death Dis. , vol.3 , pp. 1-9
    • Ajabnoor, G.M.1    Crook, T.2    Coley, H.M.3
  • 99
    • 0028920467 scopus 로고
    • Characterisation of highlevel cisplatin-resistant cell lines established from a human hepatomacell line and human KB adenocarcinomacells: Cross-resistance and protein changes
    • Shen, D.W.; Akiyama, S.; Schoenlein, P.; Pastan, I.; Gottesman, M.M. Characterisation of highlevel cisplatin-resistant cell lines established from a human hepatomacell line and human KB adenocarcinomacells: Cross-resistance and protein changes. Br. J. Canc. 1995, 71, 676-683.
    • (1995) Br. J. Canc. , vol.71 , pp. 676-683
    • Shen, D.W.1    Akiyama, S.2    Schoenlein, P.3    Pastan, I.4    Gottesman, M.M.5
  • 101
    • 84863985893 scopus 로고    scopus 로고
    • Long-term cisplatin exposure impairs autophagy and causes cisplatin resistance in human lung cancer cells
    • Sirichanchuen, B.; Pengsuparp, T.; Chanvorachote, P. Long-term cisplatin exposure impairs autophagy and causes cisplatin resistance in human lung cancer cells. Mol. Cell. Biochem. 2012, 364, 11-18.
    • (2012) Mol. Cell. Biochem. , vol.364 , pp. 11-18
    • Sirichanchuen, B.1    Pengsuparp, T.2    Chanvorachote, P.3
  • 102
    • 80051696767 scopus 로고    scopus 로고
    • Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2
    • Ahn, J.H.; Lee, M. Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2. Cancer Lett. 2011, 310, 188-197.
    • (2011) Cancer Lett. , vol.310 , pp. 188-197
    • Ahn, J.H.1    Lee, M.2
  • 103
    • 77953289524 scopus 로고    scopus 로고
    • Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
    • Li, J.; Hou, N.; Faried, A.; Tsutsumi, S.; Kuwano, H. Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur. J. Cancer 2010, 46, 1900-1909.
    • (2010) Eur. J. Cancer , vol.46 , pp. 1900-1909
    • Li, J.1    Hou, N.2    Faried, A.3    Tsutsumi, S.4    Kuwano, H.5
  • 104
    • 60449092595 scopus 로고    scopus 로고
    • Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells
    • Li, J.; Hou, N.; Faried, A.; Tsutsumi, S.; Takeuchi, T.; Kuwano, H. Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells. Ann. Surg. Oncol. 2009, 16, 761-771.
    • (2009) Ann. Surg. Oncol. , vol.16 , pp. 761-771
    • Li, J.1    Hou, N.2    Faried, A.3    Tsutsumi, S.4    Takeuchi, T.5    Kuwano, H.6
  • 107
    • 84862494695 scopus 로고    scopus 로고
    • The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells
    • Kong, D.; Ma, S.; Liang, B.; Yi, H.; Zhao, Y.; Xin, R.; Cui, L.; Jia, L.; Liu, X.; Liu, X. The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells. Biomed. Pharmacother. 2012, 66, 271-278.
    • (2012) Biomed. Pharmacother. , vol.66 , pp. 271-278
    • Kong, D.1    Ma, S.2    Liang, B.3    Yi, H.4    Zhao, Y.5    Xin, R.6    Cui, L.7    Jia, L.8    Liu, X.9    Liu, X.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.