Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line

Biochemical Pharmacology

Volumn 78, Issue 1, 2009, Pages 21-32

  Mazzanti, Roberto ^a   Platini, Francesca ^b   Bottini, Consuelo ^b   Fantappiè, Ornella ^a   Solazzo, Michela ^a   Tessitore, Luciana ^b  

^a CAREGGI UNIVERSITY HOSPITAL   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Autophagy; Celecoxib; HGF MET; MDR; P gp

Indexed keywords

BECLIN 1; CELECOXIB; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN E; DANSYLCADAVERINE; DOXORUBICIN; GLYCOPROTEIN P; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MULTIDRUG RESISTANCE PROTEIN 1; RETINOBLASTOMA PROTEIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; AUTOPHAGY; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; STATISTICAL ANALYSIS; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLOOXYGENASE INHIBITORS; DRUG RESISTANCE, MULTIPLE; G1 PHASE; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (NADP+); HEPATOCYTE GROWTH FACTOR; HUMANS; LIVER NEOPLASMS; P-GLYCOPROTEIN; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAZOLES; RNA, NEOPLASM; RNA, SMALL INTERFERING; SULFONAMIDES;

EID: 67349286024     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.03.013     Document Type: Article

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