메뉴 건너뛰기




Volumn 310, Issue 2, 2011, Pages 188-197

Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2

Author keywords

Apoptosis; Autophagy; Multi drug resistance; PP2; Src tyrosine kinase inhibitor

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; BECLIN 1; CASPASE 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BCL 2; RAF PROTEIN; TYROSINE;

EID: 80051696767     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.06.034     Document Type: Article
Times cited : (33)

References (47)
  • 2
    • 67650656774 scopus 로고    scopus 로고
    • Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies
    • Wu C.P., Calcagno A.M., Ambudkar S.V. Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies. Curr. Mol. Pharmacol. 2008, 1:93-105.
    • (2008) Curr. Mol. Pharmacol. , vol.1 , pp. 93-105
    • Wu, C.P.1    Calcagno, A.M.2    Ambudkar, S.V.3
  • 3
    • 34648823750 scopus 로고    scopus 로고
    • Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy
    • Moretti L., Yang E.S., Kim K.W., Lu B. Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy. Drug Resist. Update. 2007, 10:135-143.
    • (2007) Drug Resist. Update. , vol.10 , pp. 135-143
    • Moretti, L.1    Yang, E.S.2    Kim, K.W.3    Lu, B.4
  • 4
    • 48249090416 scopus 로고    scopus 로고
    • Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer
    • Kim K.W., Hwang M., Moretti L., Jaboin J.J., Cha Y.I., Lu B. Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 2008, 4:659-668.
    • (2008) Autophagy , vol.4 , pp. 659-668
    • Kim, K.W.1    Hwang, M.2    Moretti, L.3    Jaboin, J.J.4    Cha, Y.I.5    Lu, B.6
  • 5
  • 7
    • 65549167833 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network for cancer therapy
    • Meric-Bernstam F., Gonzalez-Angulo A.M. Targeting the mTOR signaling network for cancer therapy. J. Clin. Oncol. 2009, 27:2278-2287.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2278-2287
    • Meric-Bernstam, F.1    Gonzalez-Angulo, A.M.2
  • 8
    • 79959937240 scopus 로고    scopus 로고
    • Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras transformed NIH3T3 cells
    • Eum K.-H., Lee M. Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras transformed NIH3T3 cells. Mol. Cells 2010, 31:231-238.
    • (2010) Mol. Cells , vol.31 , pp. 231-238
    • Eum, K.-H.1    Lee, M.2
  • 9
    • 67549142261 scopus 로고    scopus 로고
    • Life and death partners: apoptosis, autophagy and the cross-talk between them
    • Eisenberg-Lerner A., Bialik S., Simon H.U., Kimchi A. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 2009, 16:966-975.
    • (2009) Cell Death Differ. , vol.16 , pp. 966-975
    • Eisenberg-Lerner, A.1    Bialik, S.2    Simon, H.U.3    Kimchi, A.4
  • 11
    • 0034693806 scopus 로고    scopus 로고
    • Selected glimpses into the activation and function of Src kinase
    • Bjorge J.D., Jakymiw A., Fujita D.J. Selected glimpses into the activation and function of Src kinase. Oncogene 2000, 19:5620-5635.
    • (2000) Oncogene , vol.19 , pp. 5620-5635
    • Bjorge, J.D.1    Jakymiw, A.2    Fujita, D.J.3
  • 12
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for SRC
    • Yeatman T.J. A renaissance for SRC. Nat. Rev. Cancer 2004, 4:470-480.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 470-480
    • Yeatman, T.J.1
  • 16
    • 79956121823 scopus 로고    scopus 로고
    • Decreased interaction of Raf-1 with its negative regulator Spry2 as a mechanism for acquired drug resistance
    • Ahn J.-H., Kim Y.-K., Lee M. Decreased interaction of Raf-1 with its negative regulator Spry2 as a mechanism for acquired drug resistance. Biomol. Ther. 2011, 19:174-180.
    • (2011) Biomol. Ther. , vol.19 , pp. 174-180
    • Ahn, J.-H.1    Kim, Y.-K.2    Lee, M.3
  • 17
    • 77957851560 scopus 로고    scopus 로고
    • The differences in biological properties between parental and v-Ha-ras transformed NIH3T3 cells
    • Lee M., Ahn J.-H., Eum K.-H. The differences in biological properties between parental and v-Ha-ras transformed NIH3T3 cells. Cancer Res. Treat. 2009, 41:93-99.
    • (2009) Cancer Res. Treat. , vol.41 , pp. 93-99
    • Lee, M.1    Ahn, J.-H.2    Eum, K.-H.3
  • 18
    • 28544449918 scopus 로고    scopus 로고
    • SRC tyrosine kinase and multidrug resistance protein-1 inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian cancer cells
    • George J.A., Chen T., Taylor C.C. SRC tyrosine kinase and multidrug resistance protein-1 inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian cancer cells. Cancer Res. 2005, 65:10381-10388.
    • (2005) Cancer Res. , vol.65 , pp. 10381-10388
    • George, J.A.1    Chen, T.2    Taylor, C.C.3
  • 19
    • 70450257737 scopus 로고    scopus 로고
    • The enhancement of Raf-1 kinase activity by knockdown of Spry2 is associated with high sensitivity to paclitaxel in v-Ha-ras-transformed NIH 3T3 fibroblasts
    • Ahn J.-H., Eum K.-H., Lee M. The enhancement of Raf-1 kinase activity by knockdown of Spry2 is associated with high sensitivity to paclitaxel in v-Ha-ras-transformed NIH 3T3 fibroblasts. Mol. Cell. Biochem. 2009, 332:189-197.
    • (2009) Mol. Cell. Biochem. , vol.332 , pp. 189-197
    • Ahn, J.-H.1    Eum, K.-H.2    Lee, M.3
  • 20
  • 21
    • 0005677775 scopus 로고
    • 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
    • Seglen P.O., Gordon P.B. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl. Acad. Sci. USA 1982, 79:1889-1892.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 1889-1892
    • Seglen, P.O.1    Gordon, P.B.2
  • 22
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: molecular mechanisms and biological functions of autophagy
    • Levine B., Klionsky D.J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 2004, 6:463-477.
    • (2004) Dev. Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 23
    • 75749086084 scopus 로고    scopus 로고
    • The PI3K/Akt and mTOR/P70S6K signaling pathways in human uveal melanoma cells: interaction with B-Raf/ERK
    • Babchia N., Calipel A., Mouriaux F., Faussat A.M., Mascarelli F. The PI3K/Akt and mTOR/P70S6K signaling pathways in human uveal melanoma cells: interaction with B-Raf/ERK. Invest. Ophthalmol. Vis. Sci. 2010, 51:421-429.
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51 , pp. 421-429
    • Babchia, N.1    Calipel, A.2    Mouriaux, F.3    Faussat, A.M.4    Mascarelli, F.5
  • 24
    • 58649110598 scopus 로고    scopus 로고
    • Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
    • Zheng B., Jeong J.H., Asara J.M., Yuan Y.Y., Granter S.R., Chin L., Cantley L.C. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol. Cell 2009, 33:237-247.
    • (2009) Mol. Cell , vol.33 , pp. 237-247
    • Zheng, B.1    Jeong, J.H.2    Asara, J.M.3    Yuan, Y.Y.4    Granter, S.R.5    Chin, L.6    Cantley, L.C.7
  • 25
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell 2000, 103:253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 27
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • Gottesman M.M. Mechanisms of cancer drug resistance. Annu. Rev. Med. 2002, 53:615-627.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 29
    • 60849137218 scopus 로고    scopus 로고
    • Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma
    • Milano V., Piao Y., LaFortune T., de Groot J. Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma. Mol. Cancer Ther. 2009, 8:394-406.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 394-406
    • Milano, V.1    Piao, Y.2    LaFortune, T.3    de Groot, J.4
  • 30
    • 54549086723 scopus 로고    scopus 로고
    • Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530
    • Chang Y.M., Bai L., Liu S., Yang J.C., Kung H.J., Evans C.P. Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene 2008, 27:6365-6375.
    • (2008) Oncogene , vol.27 , pp. 6365-6375
    • Chang, Y.M.1    Bai, L.2    Liu, S.3    Yang, J.C.4    Kung, H.J.5    Evans, C.P.6
  • 31
    • 0028363519 scopus 로고
    • P27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima H., Huter T. P27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 1994, 78:67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Huter, T.2
  • 35
    • 77953483885 scopus 로고    scopus 로고
    • MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy
    • Balakumaran B.S., Herbert J.T., Febbo P.G. MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy. Autophagy 2010, 6:281-282.
    • (2010) Autophagy , vol.6 , pp. 281-282
    • Balakumaran, B.S.1    Herbert, J.T.2    Febbo, P.G.3
  • 37
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • Scott R.C., Schuldiner O., Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 2004, 7:167-178.
    • (2004) Dev. Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 38
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
    • Pause A., Belsham G.J., Gingras A.C., Donzé O., Lin T.A., Lawrence J.C.J., Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature 1994, 371:762-767.
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.C.3    Donzé, O.4    Lin, T.A.5    Lawrence, J.C.J.6    Sonenberg, N.7
  • 39
    • 3142757865 scopus 로고    scopus 로고
    • Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
    • Karbowniczek M., Cash T., Cheung M., Robertson G.P., Astrinidis A., Henske E.P. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. J. Biol. Chem. 2004, 279:29930-29937.
    • (2004) J. Biol. Chem. , vol.279 , pp. 29930-29937
    • Karbowniczek, M.1    Cash, T.2    Cheung, M.3    Robertson, G.P.4    Astrinidis, A.5    Henske, E.P.6
  • 40
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
    • Shackelford D.B., Shaw R.J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer 2009, 9:563-575.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 41
    • 34250894388 scopus 로고    scopus 로고
    • BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
    • Maiuri M.C., Criollo A., Tasdemir E., Vicencio J.M., Tajeddine N., Hickman J.A., Geneste O., Kroemer G. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007, 3:374-376.
    • (2007) Autophagy , vol.3 , pp. 374-376
    • Maiuri, M.C.1    Criollo, A.2    Tasdemir, E.3    Vicencio, J.M.4    Tajeddine, N.5    Hickman, J.A.6    Geneste, O.7    Kroemer, G.8
  • 42
    • 1842472069 scopus 로고    scopus 로고
    • Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis
    • Bassik M.C., Scorrano L., Oakes S.A., Pozzan T., Korsmeyer S.J. Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J. 2004, 23:1207-1216.
    • (2004) EMBO J. , vol.23 , pp. 1207-1216
    • Bassik, M.C.1    Scorrano, L.2    Oakes, S.A.3    Pozzan, T.4    Korsmeyer, S.J.5
  • 43
    • 0032129272 scopus 로고    scopus 로고
    • Bcl-xL is phosphorylated in malignant cells following microtubule disruption
    • Poruchynsky M.S., Wang E.W., Rudin C.M., Blagosklonny M.V., Fojo T. Bcl-xL is phosphorylated in malignant cells following microtubule disruption. Cancer Res. 1998, 58:3331-3338.
    • (1998) Cancer Res. , vol.58 , pp. 3331-3338
    • Poruchynsky, M.S.1    Wang, E.W.2    Rudin, C.M.3    Blagosklonny, M.V.4    Fojo, T.5
  • 45
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: the story of a misnomer
    • Kroemer G., Levine B. Autophagic cell death: the story of a misnomer. Nat. Rev. Mol. Cell Biol. 2008, 9:1004-1010.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 46
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • Kondo Y., Kanzawa T., Sawaya R., Kondo S. The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer 2005, 5:726-734.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.