MTOR drives its own activation via SCF βTrCP-dependent degradation of the mTOR inhibitor DEPTOR

Molecular Cell

Volumn 44, Issue 2, 2011, Pages 290-303

  Gao, Daming ^a   Inuzuka, Hiroyuki ^a   Tan, Meng Kwang Marcus ^a   Fukushima, Hidefumi ^a   Locasale, Jason W ^a,b   Liu, Pengda ^a   Wan, Lixin ^a   Zhai, Bo ^a   Chin, Y Rebecca ^a   Shaik, Shavali ^a   Lyssiotis, Costas A ^a,b   Gygi, Steven P ^a   Toker, Alex ^a   Cantley, Lewis C ^a,b   Asara, John M ^a   Harper, J Wade ^a   Wei, Wenyi ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; CASEIN KINASE II; DEPTOR PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN INHIBITOR; S6 KINASE; STEM CELL FACTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; POSITIVE FEEDBACK; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

AUTOPHAGY; HELA CELLS; HUMANS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; TOR SERINE-THREONINE KINASES; TRANSFECTION;

EID: 81855181738     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2011.08.030     Document Type: Article

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