메뉴 건너뛰기




Volumn 107, Issue 43, 2010, Pages 18511-18516

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

Author keywords

Apoptosis; Posttranscriptional regulation

Indexed keywords

MEMBRANE PROTEIN; MEMBRANE PROTEIN LC3; MESSENGER RNA; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 78649833334     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1006124107     Document Type: Article
Times cited : (206)

References (37)
  • 1
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: The growing complexity of p53
    • Vousden KH, Prives C (2009) Blinded by the light: The growing complexity of p53. Cell 137:413-431.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 2
    • 70349442548 scopus 로고    scopus 로고
    • The first 30 years of p53: Growing ever more complex
    • Levine AJ, Oren M (2009) The first 30 years of p53: Growing ever more complex. Nat Rev Cancer 9:749-758.
    • (2009) Nat Rev Cancer , vol.9 , pp. 749-758
    • Levine, A.J.1    Oren, M.2
  • 4
    • 56649117454 scopus 로고    scopus 로고
    • Wild-type p53 in cancer cells: When a guardian turns into a blackguard
    • Kim E, Giese A, Deppert W (2009) Wild-type p53 in cancer cells: When a guardian turns into a blackguard. Biochem Pharmacol 77:11-20.
    • (2009) Biochem Pharmacol , vol.77 , pp. 11-20
    • Kim, E.1    Giese, A.2    Deppert, W.3
  • 5
    • 72949111893 scopus 로고    scopus 로고
    • Physiological functions of autophagy
    • Mizushima N (2009) Physiological functions of autophagy. Curr Top Microbiol Immunol 335:71-84.
    • (2009) Curr Top Microbiol Immunol , vol.335 , pp. 71-84
    • Mizushima, N.1
  • 6
    • 74949090299 scopus 로고    scopus 로고
    • An overview of the molecular mechanism of autophagy
    • Yang Z, Klionsky DJ (2009) An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol 335:1-32.
    • (2009) Curr Top Microbiol Immunol , vol.335 , pp. 1-32
    • Yang, Z.1    Klionsky, D.J.2
  • 7
    • 0034707036 scopus 로고    scopus 로고
    • A ubiquitin-like system mediates protein lipidation
    • Ichimura Y, et al. (2000) A ubiquitin-like system mediates protein lipidation. Nature 408:488-492.
    • (2000) Nature , vol.408 , pp. 488-492
    • Ichimura, Y.1
  • 8
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19:5720-5728.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1
  • 9
    • 3242888703 scopus 로고    scopus 로고
    • LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
    • Kabeya Y, et al. (2004) LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 117:2805-2812.
    • (2004) J Cell Sci , vol.117 , pp. 2805-2812
    • Kabeya, Y.1
  • 10
    • 70349969648 scopus 로고    scopus 로고
    • Apoptosis and autophagy: Targeting autophagy signalling in cancer cells - 'trick or treats'?
    • Corcelle EA, Puustinen P, Jäättelä M (2009) Apoptosis and autophagy: Targeting autophagy signalling in cancer cells - 'trick or treats'? FEBS J 276:6084-6096.
    • (2009) FEBS J , vol.276 , pp. 6084-6096
    • Corcelle, E.A.1    Puustinen, P.2    Jäättelä, M.3
  • 11
    • 62449287501 scopus 로고    scopus 로고
    • The paradox of autophagy and its implication in cancer etiology and therapy
    • Eisenberg-Lerner A, Kimchi A (2009) The paradox of autophagy and its implication in cancer etiology and therapy. Apoptosis 14:376-391.
    • (2009) Apoptosis , vol.14 , pp. 376-391
    • Eisenberg-Lerner, A.1    Kimchi, A.2
  • 12
    • 61849135453 scopus 로고    scopus 로고
    • Tumor suppressors and cell metabolism: A recipe for cancer growth
    • Jones RG, Thompson CB (2009) Tumor suppressors and cell metabolism: A recipe for cancer growth. Genes Dev 23:537-548.
    • (2009) Genes Dev , vol.23 , pp. 537-548
    • Jones, R.G.1    Thompson, C.B.2
  • 13
    • 77951243028 scopus 로고    scopus 로고
    • Autophagy regulation by p53
    • Maiuri MC, et al. (2010) Autophagy regulation by p53. Curr Opin Cell Biol 22:181-185.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 181-185
    • Maiuri, M.C.1
  • 14
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White E, DiPaola RS (2009) The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 15:5308-5316.
    • (2009) Clin Cancer Res , vol.15 , pp. 5308-5316
    • White, E.1    DiPaola, R.S.2
  • 15
    • 64349123107 scopus 로고    scopus 로고
    • Autophagy mediates the mitotic senescence transition
    • Young AR, et al. (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23:798-803.
    • (2009) Genes Dev , vol.23 , pp. 798-803
    • Young, A.R.1
  • 16
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, Jin S (2005) The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA 102:8204-8209.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 17
    • 48449101433 scopus 로고    scopus 로고
    • p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov AV, Karin M (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134:451-460.
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 18
    • 77749264562 scopus 로고    scopus 로고
    • Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
    • Lee JH, et al. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327:1223-1228.
    • (2010) Science , vol.327 , pp. 1223-1228
    • Lee, J.H.1
  • 19
    • 66849111716 scopus 로고    scopus 로고
    • Stimulation of autophagy by the p53 target gene Sestrin2
    • Maiuri MC, et al. (2009) Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle 8:1571-1576.
    • (2009) Cell Cycle , vol.8 , pp. 1571-1576
    • Maiuri, M.C.1
  • 21
    • 44649141966 scopus 로고    scopus 로고
    • Regulation of autophagy by cytoplasmic p53
    • Tasdemir E, et al. (2008) Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 10:676-687.
    • (2008) Nat Cell Biol , vol.10 , pp. 676-687
    • Tasdemir, E.1
  • 22
    • 77954310492 scopus 로고    scopus 로고
    • The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
    • Feng Z, Levine AJ (2010) The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol 20:427-434.
    • (2010) Trends Cell Biol , vol.20 , pp. 427-434
    • Feng, Z.1    Levine, A.J.2
  • 23
    • 53549084325 scopus 로고    scopus 로고
    • Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?
    • Klionsky DJ, Elazar Z, Seglen PO, Rubinsztein DC (2008) Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy 4:849-950.
    • (2008) Autophagy , vol.4 , pp. 849-950
    • Klionsky, D.J.1    Elazar, Z.2    Seglen, P.O.3    Rubinsztein, D.C.4
  • 24
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • Klionsky DJ, et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151-175.
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1
  • 25
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • DOI 10.1038/sj.emboj.7601623, PII 7601623
    • Scherz-Shouval R, et al. (2007) Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26:1749-1760. (Pubitemid 46624042)
    • (2007) EMBO Journal , vol.26 , Issue.7 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 27
    • 33644851212 scopus 로고    scopus 로고
    • Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells
    • Phelps ED, Updike DL, Bullen EC, Grammas P, Howard EW (2006) Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells. Am J Physiol Cell Physiol 290:C352-C361.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Phelps, E.D.1    Updike, D.L.2    Bullen, E.C.3    Grammas, P.4    Howard, E.W.5
  • 28
    • 53549112774 scopus 로고    scopus 로고
    • The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression
    • Shema E, et al. (2008) The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev 22:2664-2676.
    • (2008) Genes Dev , vol.22 , pp. 2664-2676
    • Shema, E.1
  • 30
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R, et al. (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell 137:1062-1075.
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1
  • 31
    • 34347404887 scopus 로고    scopus 로고
    • Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    • Karantza-Wadsworth V, et al. (2007) Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 21:1621-1635.
    • (2007) Genes Dev , vol.21 , pp. 1621-1635
    • Karantza-Wadsworth, V.1
  • 32
    • 70350575440 scopus 로고    scopus 로고
    • Modulation of intracellular ROS levels by TIGAR controls autophagy
    • Bensaad K, Cheung EC, Vousden KH (2009) Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J 28:3015-3026.
    • (2009) EMBO J , vol.28 , pp. 3015-3026
    • Bensaad, K.1    Cheung, E.C.2    Vousden, K.H.3
  • 33
    • 0029814061 scopus 로고    scopus 로고
    • Anti-apoptotic activity of low levels of wild-type p53
    • Lassus P, Ferlin M, Piette J, Hibner U (1996) Anti-apoptotic activity of low levels of wild-type p53. EMBO J 15:4566-4573.
    • (1996) EMBO J , vol.15 , pp. 4566-4573
    • Lassus, P.1    Ferlin, M.2    Piette, J.3    Hibner, U.4
  • 34
    • 28644447272 scopus 로고    scopus 로고
    • The antioxidant function of the p53 tumor suppressor
    • Sablina AA, et al. (2005) The antioxidant function of the p53 tumor suppressor. Nat Med 11:1306-1313.
    • (2005) Nat Med , vol.11 , pp. 1306-1313
    • Sablina, A.A.1
  • 36
    • 0029115918 scopus 로고
    • Negative feedback regulation of wild-type p53 biosynthesis
    • Mosner J, et al. (1995) Negative feedback regulation of wild-type p53 biosynthesis. EMBO J 14:4442-4449.
    • (1995) EMBO J , vol.14 , pp. 4442-4449
    • Mosner, J.1
  • 37
    • 33749334018 scopus 로고    scopus 로고
    • A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
    • Aylon Y, et al. (2006) A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev 20:2687-2700.
    • (2006) Genes Dev , vol.20 , pp. 2687-2700
    • Aylon, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.