-
1
-
-
0027982786
-
A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells
-
K.H. Dixon, B.C. Lanpher, J. Chiu, K. Kelley, and K.H. Cowan A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells J Biol Chem 269 1994 17 20 (Pubitemid 24026611)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.1
, pp. 17-20
-
-
Dixon, K.H.1
Lanpher, B.C.2
Chiu, J.3
Kelley, K.4
Cowan, K.H.5
-
2
-
-
33751244559
-
Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption
-
DOI 10.1016/j.cell.2006.09.041, PII S009286740601347X
-
A. Qiu, M. Jansen, A. Sakaris, S.H. Min, S. Chattopadhyay, E. Tsai, C. Sandoval, R. Zhao, M.H. Akabas, and I.D. Goldman Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption Cell 127 2006 917 928 (Pubitemid 44792250)
-
(2006)
Cell
, vol.127
, Issue.5
, pp. 917-928
-
-
Qiu, A.1
Jansen, M.2
Sakaris, A.3
Min, S.H.4
Chattopadhyay, S.5
Tsai, E.6
Sandoval, C.7
Zhao, R.8
Akabas, M.H.9
Goldman, I.D.10
-
3
-
-
34347379290
-
+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
-
DOI 10.1113/expphysiol.2005.029959
-
D.T. Thwaites, and C.M.H. Anderson H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine Exp Physiol 92 2007 603 619 (Pubitemid 47024940)
-
(2007)
Experimental Physiology
, vol.92
, Issue.4
, pp. 603-619
-
-
Thwaites, D.T.1
Anderson, C.M.H.2
-
4
-
-
0842304934
-
A Prominent Low-pH Methotrexate Transport Activity in Human Solid Tumors: Contribution to the Preservation of Methotrexate Pharmacologic Activity in HeLa Cells Lacking the Reduced Folate Carrier
-
DOI 10.1158/1078-0432.CCR-1066-03
-
R. Zhao, F. Gao, M. Hanscom, and I.D. Goldman A prominent low-pH methotrexate transport activity in human solid tumor cells: contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier Clin Cancer Res 10 2004 718 727 (Pubitemid 38180440)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.2
, pp. 718-727
-
-
Zhao, R.1
Gao, F.2
Hanscom, M.3
Goldman, I.D.4
-
5
-
-
81555195479
-
Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter
-
S.K. Desmoulin, L. Wang, E. Hales, L. Polin, K. White, J. Kushner, M. Stout, Z. Hou, C. Cherian, and A. Gangjee Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter Mol Pharmacol 80 2011 1096 1107
-
(2011)
Mol Pharmacol
, vol.80
, pp. 1096-1107
-
-
Desmoulin, S.K.1
Wang, L.2
Hales, E.3
Polin, L.4
White, K.5
Kushner, J.6
Stout, M.7
Hou, Z.8
Cherian, C.9
Gangjee, A.10
-
6
-
-
79960481261
-
Mechanisms of membrane transport of folates into cells and across epithelia
-
R. Zhao, N. Diop-Bove, M. Visentin, and I.D. Goldman Mechanisms of membrane transport of folates into cells and across epithelia Annu Rev Nutr 31 2011 177 201
-
(2011)
Annu Rev Nutr
, vol.31
, pp. 177-201
-
-
Zhao, R.1
Diop-Bove, N.2
Visentin, M.3
Goldman, I.D.4
-
7
-
-
79952738916
-
The antifolates: Evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs
-
I.D. Goldman, S. Chattopadhyay, R. Zhao, and R.G. Moran The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs Curr Opin Investig Drugs 11 2010 1409 1423
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 1409-1423
-
-
Goldman, I.D.1
Chattopadhyay, S.2
Zhao, R.3
Moran, R.G.4
-
8
-
-
84870710332
-
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
-
S.K. Desmoulin, Z. Hou, A. Gangjee, and L.H. Matherly The human proton-coupled folate transporter: biology and therapeutic applications to cancer Cancer Biol Ther 13 2012 1355 1373
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 1355-1373
-
-
Desmoulin, S.K.1
Hou, Z.2
Gangjee, A.3
Matherly, L.H.4
-
9
-
-
84875168040
-
Hereditary folate malabsorption
-
R.A. Pagon, T.D. Bird, C.R. Dolan, K. Stephens, University of Washington, Seattle Seattle (WA) [Internet]
-
N. Diop-Bove, D. Kronn, and I.D. Goldman Hereditary folate malabsorption R.A. Pagon, T.D. Bird, C.R. Dolan, K. Stephens, GeneReviews 2011 University of Washington, Seattle Seattle (WA) [Internet]
-
(2011)
GeneReviews
-
-
Diop-Bove, N.1
Kronn, D.2
Goldman, I.D.3
-
10
-
-
0036143484
-
Hereditary folate malabsorption: Family report and review of the literature
-
DOI 10.1097/00005792-200201000-00004
-
J. Geller, D. Kronn, S. Jayabose, and C. Sandoval Hereditary folate malabsorption: family report and review of the literature Medicine (Baltimore) 81 2002 51 68 (Pubitemid 34081287)
-
(2002)
Medicine
, vol.81
, Issue.1
, pp. 51-68
-
-
Geller, J.1
Kronn, D.2
Jayabose, S.3
Sandoval, C.4
-
11
-
-
79955963955
-
A mouse model of hereditary folate malabsorption: Deletion of the PCFT gene leads to systemic folate deficiency
-
K.V. Salojin, R.M. Cabrera, W. Sun, W.C. Chang, C. Lin, L. Duncan, K.A. Platt, R. Read, P. Vogel, and Q. Liu A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency Blood 117 2011 4895 4904
-
(2011)
Blood
, vol.117
, pp. 4895-4904
-
-
Salojin, K.V.1
Cabrera, R.M.2
Sun, W.3
Chang, W.C.4
Lin, C.5
Duncan, L.6
Platt, K.A.7
Read, R.8
Vogel, P.9
Liu, Q.10
-
12
-
-
84863697879
-
Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis
-
J.P. Gnana-Prakasam, S.K. Reddy, R. Veeranan-Karmegam, S.B. Smith, P.M. Martin, and V. Ganapathy Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis Invest Ophthalmol Vis Sci 52 2011 9279 9286
-
(2011)
Invest Ophthalmol Vis Sci
, vol.52
, pp. 9279-9286
-
-
Gnana-Prakasam, J.P.1
Reddy, S.K.2
Veeranan-Karmegam, R.3
Smith, S.B.4
Martin, P.M.5
Ganapathy, V.6
-
13
-
-
54349088976
-
Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3)
-
Y. Kitamura, M. Hirouchi, H. Kusuhara, J.D. Schuetz, and Y. Sugiyama Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3) J Pharmacol Exp Ther 327 2008 465 473
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 465-473
-
-
Kitamura, Y.1
Hirouchi, M.2
Kusuhara, H.3
Schuetz, J.D.4
Sugiyama, Y.5
-
14
-
-
77950400117
-
Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method
-
R. Zhao, E.S. Unal, D.S. Shin, and I.D. Goldman Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method Biochemistry 49 2010 2925 2931
-
(2010)
Biochemistry
, vol.49
, pp. 2925-2931
-
-
Zhao, R.1
Unal, E.S.2
Shin, D.S.3
Goldman, I.D.4
-
15
-
-
43649088482
-
N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT)
-
E.S. Unal, R. Zhao, A. Qiu, and I.D. Goldman N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT) Biochim Biophys Acta 1178 2008 1407 1414
-
(2008)
Biochim Biophys Acta
, vol.1178
, pp. 1407-1414
-
-
Unal, E.S.1
Zhao, R.2
Qiu, A.3
Goldman, I.D.4
-
16
-
-
36048936881
-
Rodent intestinal folate transporters (SLC46A1): Secondary structure, functional properties, and response to dietary folate restriction
-
A. Qiu, S.H. Min, M. Jansen, U. Malhotra, E. Tsai, D.C. Cabelof, L.H. Matherly, R. Zhao, M.H. Akabas, and I.D. Goldman Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction Am J Physiol Cell Physiol 293 2007 C1669 C1678
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Qiu, A.1
Min, S.H.2
Jansen, M.3
Malhotra, U.4
Tsai, E.5
Cabelof, D.C.6
Matherly, L.H.7
Zhao, R.8
Akabas, M.H.9
Goldman, I.D.10
-
17
-
-
79751535507
-
Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method
-
R. Zhao, D.S. Shin, and I.D. Goldman Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method Biochim Biophys Acta 1808 2011 1140 1145
-
(2011)
Biochim Biophys Acta
, vol.1808
, pp. 1140-1145
-
-
Zhao, R.1
Shin, D.S.2
Goldman, I.D.3
-
18
-
-
84866390080
-
Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter
-
Z. Hou, S.K. Desmoulin, E. Etnyre, M. Olive, B. Hsiung, C. Cherian, P.A. Wloszczynski, K. Moin, and L.H. Matherly Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter J Biol Chem 2011
-
(2011)
J Biol Chem
-
-
Hou, Z.1
Desmoulin, S.K.2
Etnyre, E.3
Olive, M.4
Hsiung, B.5
Cherian, C.6
Wloszczynski, P.A.7
Moin, K.8
Matherly, L.H.9
-
19
-
-
84866352751
-
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)
-
R. Zhao, D.S. Shin, A. Fiser, and I.D. Goldman Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1) Am J Physiol Cell Physiol 303 2012 C673 C681
-
(2012)
Am J Physiol Cell Physiol
, vol.303
-
-
Zhao, R.1
Shin, D.S.2
Fiser, A.3
Goldman, I.D.4
-
20
-
-
84878761203
-
The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane
-
P.K. Duddempudi, P. Nakashe, M.P. Blanton, and M. Jansen The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane FEBS J 280 2013 2900 2915
-
(2013)
FEBS J
, vol.280
, pp. 2900-2915
-
-
Duddempudi, P.K.1
Nakashe, P.2
Blanton, M.P.3
Jansen, M.4
-
21
-
-
67650526040
-
The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1
-
E.S. Unal, R. Zhao, M.H. Chang, A. Fiser, M.F. Romero, and I.D. Goldman The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1 J Biol Chem 284 2009 17846 17857
-
(2009)
J Biol Chem
, vol.284
, pp. 17846-17857
-
-
Unal, E.S.1
Zhao, R.2
Chang, M.H.3
Fiser, A.4
Romero, M.F.5
Goldman, I.D.6
-
22
-
-
67650073369
-
Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1
-
E.S. Unal, R. Zhao, and I.D. Goldman Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1 Am J Physiol Cell Physiol 297 2009 C66 C74
-
(2009)
Am J Physiol Cell Physiol
, vol.297
-
-
Unal, E.S.1
Zhao, R.2
Goldman, I.D.3
-
23
-
-
78650055833
-
Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT; SLC46A1); a D156Y mutation causing hereditary folate malabsorption
-
D.S. Shin, S.H. Min, L. Russell, R. Zhao, A. Fiser, and I.D. Goldman Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT; SLC46A1); a D156Y mutation causing hereditary folate malabsorption Blood 116 2010 5162 5169
-
(2010)
Blood
, vol.116
, pp. 5162-5169
-
-
Shin, D.S.1
Min, S.H.2
Russell, L.3
Zhao, R.4
Fiser, A.5
Goldman, I.D.6
-
24
-
-
84860528730
-
A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding
-
D.S. Shin, R. Zhao, E.H. Yap, A. Fiser, and I.D. Goldman A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding Am J Physiol Cell Physiol 302 2012 C1405 C1412
-
(2012)
Am J Physiol Cell Physiol
, vol.302
-
-
Shin, D.S.1
Zhao, R.2
Yap, E.H.3
Fiser, A.4
Goldman, I.D.5
-
25
-
-
84867623729
-
Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption
-
D.S. Shin, R. Zhao, A. Fiser, and D.I. Goldman Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption Am J Physiol Cell Physiol 303 2012 C834 C842
-
(2012)
Am J Physiol Cell Physiol
, vol.303
-
-
Shin, D.S.1
Zhao, R.2
Fiser, A.3
Goldman, D.I.4
-
26
-
-
78349241039
-
Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption
-
K. Mahadeo, N. Diop-Bove, D. Shin, E. Unal, J. Teo, R. Zhao, M.H. Chang, A. Fulterer, M.F. Romero, and I.D. Goldman Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption Am J Physiol Cell Physiol 299 2010 C1153 C1161
-
(2010)
Am J Physiol Cell Physiol
, vol.299
-
-
Mahadeo, K.1
Diop-Bove, N.2
Shin, D.3
Unal, E.4
Teo, J.5
Zhao, R.6
Chang, M.H.7
Fulterer, A.8
Romero, M.F.9
Goldman, I.D.10
-
27
-
-
79959873628
-
Random mutagenesis of the proton-coupled folate transporter (PCFT, SLC46A1), clustering of mutations and the bases for associated losses of function
-
R. Zhao, D.S. Shin, N. Diop-Bove, C.G. Ovits, and I.D. Goldman Random mutagenesis of the proton-coupled folate transporter (PCFT, SLC46A1), clustering of mutations and the bases for associated losses of function J Biol Chem 286 2011 24150 24158
-
(2011)
J Biol Chem
, vol.286
, pp. 24150-24158
-
-
Zhao, R.1
Shin, D.S.2
Diop-Bove, N.3
Ovits, C.G.4
Goldman, I.D.5
-
28
-
-
84879128872
-
The role of the fourth transmembrane domain in proton-coupled folate transporter (PCFT) function as assessed by the substituted cysteine accessibility method
-
D.S. Shin, R. Zhao, A. Fiser, and I.D. Goldman The role of the fourth transmembrane domain in proton-coupled folate transporter (PCFT) function as assessed by the substituted cysteine accessibility method Am J Physiol Cell Physiol 304 2013 C1159 C1167
-
(2013)
Am J Physiol Cell Physiol
, vol.304
-
-
Shin, D.S.1
Zhao, R.2
Fiser, A.3
Goldman, I.D.4
-
29
-
-
68849117681
-
Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line
-
N.K. Diop-Bove, J. Wu, R. Zhao, J. Locker, and I.D. Goldman Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line Molecular Cancer Therapeutics 8 2009 2424 2431
-
(2009)
Molecular Cancer Therapeutics
, vol.8
, pp. 2424-2431
-
-
Diop-Bove, N.K.1
Wu, J.2
Zhao, R.3
Locker, J.4
Goldman, I.D.5
-
30
-
-
68949159799
-
Functional elements in the minimal promoter of the human proton-coupled folate transporter
-
M. Stark, N. Gonen, and Y.G. Assaraf Functional elements in the minimal promoter of the human proton-coupled folate transporter Biochem Biophys Res Commun 388 2009 79 85
-
(2009)
Biochem Biophys Res Commun
, vol.388
, pp. 79-85
-
-
Stark, M.1
Gonen, N.2
Assaraf, Y.G.3
-
31
-
-
77958577386
-
The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1
-
N. Gonen, and Y.G. Assaraf The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1 J Biol Chem 285 2010 33602 33613
-
(2010)
J Biol Chem
, vol.285
, pp. 33602-33613
-
-
Gonen, N.1
Assaraf, Y.G.2
-
32
-
-
70350440282
-
Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter
-
J.J. Eloranta, Z.M. Zair, C. Hiller, S. Hausler, B. Stieger, and G.A. Kullak-Ublick Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter Mol Pharmacol 76 2009 1062 1071
-
(2009)
Mol Pharmacol
, vol.76
, pp. 1062-1071
-
-
Eloranta, J.J.1
Zair, Z.M.2
Hiller, C.3
Hausler, S.4
Stieger, B.5
Kullak-Ublick, G.A.6
-
33
-
-
53449097226
-
PCFT promoter methylation and restoration of gene expression in human leukemia cells
-
N. Gonen, E.E. Bram, and Y.G. Assaraf PCFT promoter methylation and restoration of gene expression in human leukemia cells Biochem Biophys Res Commun 376 2008 787 792
-
(2008)
Biochem Biophys Res Commun
, vol.376
, pp. 787-792
-
-
Gonen, N.1
Bram, E.E.2
Assaraf, Y.G.3
-
34
-
-
14044262904
-
Structure and regulation of the murine reduced folate carrier gene: Identification of four noncoding exons and promoters and regulation by dietary folates
-
DOI 10.1074/jbc.M412662200
-
M. Liu, Y. Ge, D.C. Cabelof, A. Aboukameel, A.R. Heydari, R. Mohammad, and L.H. Matherly Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates J Biol Chem 280 2005 5588 5597 (Pubitemid 40280037)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.7
, pp. 5588-5597
-
-
Liu, M.1
Ge, Y.2
Cabelof, D.C.3
Aboukameel, A.4
Heydari, A.R.5
Mohammad, R.6
Matherly, L.H.7
-
35
-
-
2342461116
-
Selective Preservation of Pemetrexed Pharmacological Activity in HeLa Cells Lacking the Reduced Folate Carrier: Association with the Presence of a Secondary Transport Pathway
-
DOI 10.1158/0008-5472.CAN-03-3953
-
R. Zhao, M. Hanscom, S. Chattopadhyay, and I.D. Goldman Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier; association with the presence of a secondary transport pathway Cancer Res 64 2004 3313 3319 (Pubitemid 38581438)
-
(2004)
Cancer Research
, vol.64
, Issue.9
, pp. 3313-3319
-
-
Zhao, R.1
Hanscom, M.2
Chattopadhyay, S.3
Goldman, I.D.4
-
36
-
-
4644224936
-
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier
-
DOI 10.1158/1078-0432.CCR-04-0645
-
Y. Wang, R. Zhao, and I.D. Goldman Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier Clin Cancer Res 10 2004 6256 6264 (Pubitemid 39287534)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.18
, pp. 6256-6264
-
-
Wang, Y.1
Zhao, R.2
Goldman, I.D.3
-
37
-
-
50549085728
-
The proton-coupled folate transporter (PCFT): Impact on pemetrexed transport and on antifolate activities as compared to the reduced folate carrier
-
R. Zhao, A. Qiu, E. Tsai, M. Jansen, M.H. Akabas, and I.D. Goldman The proton-coupled folate transporter (PCFT): impact on pemetrexed transport and on antifolate activities as compared to the reduced folate carrier Mol Pharmacol 74 2008 854 862
-
(2008)
Mol Pharmacol
, vol.74
, pp. 854-862
-
-
Zhao, R.1
Qiu, A.2
Tsai, E.3
Jansen, M.4
Akabas, M.H.5
Goldman, I.D.6
-
38
-
-
33644975527
-
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line
-
S. Chattopadhyay, R. Zhao, S.A. Krupenko, N. Krupenko, and I.D. Goldman The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line Mol Cancer Ther 5 2006 438 449
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 438-449
-
-
Chattopadhyay, S.1
Zhao, R.2
Krupenko, S.A.3
Krupenko, N.4
Goldman, I.D.5
-
39
-
-
84866844783
-
Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter
-
S.K. Desmoulin, L. Wang, L. Polin, K. White, J. Kushner, M. Stout, Z. Hou, C. Cherian, A. Gangjee, and L.H. Matherly Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter Mol Pharmacol 82 2012 591 600
-
(2012)
Mol Pharmacol
, vol.82
, pp. 591-600
-
-
Desmoulin, S.K.1
Wang, L.2
Polin, L.3
White, K.4
Kushner, J.5
Stout, M.6
Hou, Z.7
Cherian, C.8
Gangjee, A.9
Matherly, L.H.10
-
40
-
-
77957921048
-
Folate-targeted therapies for cancer
-
W. Xia, and P.S. Low Folate-targeted therapies for cancer J Med Chem 53 2010 6811 6824
-
(2010)
J Med Chem
, vol.53
, pp. 6811-6824
-
-
Xia, W.1
Low, P.S.2
-
41
-
-
77953266081
-
Molecular and biochemical characterization of folate transport proteins in retinal Muller cells
-
B.R. Bozard, P. Ganapathy, J.N. Duplantier, B. Mysona, Y. Ha, P. Roon, R. Smith, I.D. Goldman, P.D. Prasad, and P.M. Martin Molecular and biochemical characterization of folate transport proteins in retinal Muller cells Invest Ophthalmol Vis Sci 51 2010 3226 3235
-
(2010)
Invest Ophthalmol Vis Sci
, vol.51
, pp. 3226-3235
-
-
Bozard, B.R.1
Ganapathy, P.2
Duplantier, J.N.3
Mysona, B.4
Ha, Y.5
Roon, P.6
Smith, R.7
Goldman, I.D.8
Prasad, P.D.9
Martin, P.M.10
-
42
-
-
63249102414
-
A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis
-
R. Zhao, S.H. Min, Y. Wang, E. Campanella, P.S. Low, and I.D. Goldman A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis J Biol Chem 284 2009 4267 4274
-
(2009)
J Biol Chem
, vol.284
, pp. 4267-4274
-
-
Zhao, R.1
Min, S.H.2
Wang, Y.3
Campanella, E.4
Low, P.S.5
Goldman, I.D.6
-
43
-
-
77249090272
-
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry
-
L. Wang, C. Cherian, S.K. Desmoulin, L. Polin, Y. Deng, J. Wu, Z. Hou, K. White, J. Kushner, and L.H. Matherly Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry J Med Chem 53 2010 1306 1318
-
(2010)
J Med Chem
, vol.53
, pp. 1306-1318
-
-
Wang, L.1
Cherian, C.2
Desmoulin, S.K.3
Polin, L.4
Deng, Y.5
Wu, J.6
Hou, Z.7
White, K.8
Kushner, J.9
Matherly, L.H.10
-
44
-
-
80054932788
-
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits beta-glycinamide ribonucleotide formyltransferase
-
L. Wang, S.K. Desmoulin, C. Cherian, L. Polin, K. White, J. Kushner, A. Fulterer, M.H. Chang, S. Mitchell-Ryan, and M. Stout Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits beta-glycinamide ribonucleotide formyltransferase J Med Chem 54 2011 7150 7164
-
(2011)
J Med Chem
, vol.54
, pp. 7150-7164
-
-
Wang, L.1
Desmoulin, S.K.2
Cherian, C.3
Polin, L.4
White, K.5
Kushner, J.6
Fulterer, A.7
Chang, M.H.8
Mitchell-Ryan, S.9
Stout, M.10
-
46
-
-
59649117206
-
Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1)
-
S.E. van de, C.M. van der Kruijssen, E. Wagenaar, J.E. Burggraaff, E. Mesman, K.E. Kenworthy, and A.H. Schinkel Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1) Drug Metab Dispos 37 2009 277 281
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 277-281
-
-
Van De, S.E.1
Van Der Kruijssen, C.M.2
Wagenaar, E.3
Burggraaff, J.E.4
Mesman, E.5
Kenworthy, K.E.6
Schinkel, A.H.7
-
47
-
-
65649094824
-
Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo
-
M.L. Vlaming, Z. Pala, E.A. van, E. Wagenaar, D.R. de Waart, K. van de Wetering, C.M. van der Kruijssen, R.P. Oude Elferink, T.O. van, and A.H. Schinkel Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo Clin Cancer Res 15 2009 3084 3093
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3084-3093
-
-
Vlaming, M.L.1
Pala, Z.2
Van, E.A.3
Wagenaar, E.4
De Waart, D.R.5
Van De Wetering, K.6
Van Der Kruijssen, C.M.7
Oude Elferink, R.P.8
Van, T.O.9
Schinkel, A.H.10
-
48
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
W.H. Koppenol, P.L. Bounds, and C.V. Dang Otto Warburg's contributions to current concepts of cancer metabolism Nat Rev Cancer 11 2011 325 337
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
49
-
-
84878840411
-
Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter
-
C. Cherian, D.S. Kugel, L. Wang, L. Polin, K. White, J. Kushner, M. Stout, Z. Hou, A. Gangjee, and L.H. Matherly Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter Cancer Chemother Pharmacol 71 2013 999 1011
-
(2013)
Cancer Chemother Pharmacol
, vol.71
, pp. 999-1011
-
-
Cherian, C.1
Kugel, D.S.2
Wang, L.3
Polin, L.4
White, K.5
Kushner, J.6
Stout, M.7
Hou, Z.8
Gangjee, A.9
Matherly, L.H.10
-
50
-
-
84879107962
-
Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions
-
R. Zhao, M. Visentin, S.O. Suadicani, and I.D. Goldman Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions Mol Pharm 84 2013 95 103
-
(2013)
Mol Pharm
, vol.84
, pp. 95-103
-
-
Zhao, R.1
Visentin, M.2
Suadicani, S.O.3
Goldman, I.D.4
-
51
-
-
34547138910
-
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter
-
DOI 10.1124/jpet.107.122606
-
Y. Nakai, K. Inoue, N. Abe, M. Hatakeyama, K.Y. Ohta, M. Otagiri, Y. Hayashi, and H. Yuasa Functional characterization of human PCFT/HCP1 heterologously expressed in mammalian cells as a folate transporter J Pharmacol Exp Ther 322 2007 469 476 (Pubitemid 47105788)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.322
, Issue.2
, pp. 469-476
-
-
Nakai, Y.1
Inoue, K.2
Abe, N.3
Hatakeyama, M.4
Ohta, K.-Y.5
Otagiri, M.6
Hayashi, Y.7
Yuasa, H.8
-
52
-
-
76749135846
-
The human proton-coupled folate transporter (hPCFT): Modulation of intestinal expression and function by drugs
-
B.L. Urquhart, J.C. Gregor, N. Chande, M.J. Knauer, R.G. Tirona, and R.B. Kim The human proton-coupled folate transporter (hPCFT): modulation of intestinal expression and function by drugs Am J Physiol Gastrointest Liver Physiol 298 2010 G248 G254
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
-
-
Urquhart, B.L.1
Gregor, J.C.2
Chande, N.3
Knauer, M.J.4
Tirona, R.G.5
Kim, R.B.6
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