The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1

Journal of Biological Chemistry

Volumn 284, Issue 26, 2009, Pages 17846-17857

  Unal, Ersin Selcuk ^a   Zhao, Rongbao ^a   Chang, Min Hwang ^b   Fiser, Andras ^a   Romero, Michael F ^b   Goldman, I David ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROPHYSIOLOGICAL STUDIES; EXTRACELLULAR REGION; FOLATE BINDING; FOLATE TRANSPORTER; FOLATES; FOLIC ACIDS; HIGH AFFINITY BINDING; HOMOLOGY MODELING; LOW LEVEL; PROTON COUPLING; PROTON TRANSLOCATION; PROTON TRANSPORT; TRANS-MEMBRANE DOMAINS; TRANSLOCATION PATHWAY; WILD TYPES; XENOPUS OOCYTE;

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; CELL MEMBRANES; ELECTRON TRANSITIONS; ENZYME ACTIVITY; HYDROGEN; ORGANIC ACIDS;

PROTONS;

FOLIC ACID; HISTIDINE; PROTEIN SLC46A1; REDUCED FOLATE CARRIER; UNCLASSIFIED DRUG; CARRIER PROTEIN; HEME CARRIER PROTEIN 1, HUMAN; PROTON; TUNICAMYCIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOPLASM; GENE MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTON TRANSPORT; WILD TYPE; XENOPUS; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ELECTROPHYSIOLOGY; ENZYME SPECIFICITY; GENETICS; HELA CELL; KINETICS; METABOLISM; SITE DIRECTED MUTAGENESIS; TRANSPORT AT THE CELLULAR LEVEL; WESTERN BLOTTING; XENOPUS LAEVIS;

AMINO ACID SUBSTITUTION; ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; ELECTROPHYSIOLOGY; FOLIC ACID; HELA CELLS; HISTIDINE; HUMANS; KINETICS; MEMBRANE TRANSPORT PROTEINS; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PROTONS; SUBSTRATE SPECIFICITY; TUNICAMYCIN; XENOPUS LAEVIS;

EID: 67650526040     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.008060     Document Type: Article

References (72)

1. Qiu, A., Jansen, M., Sakaris, A., Min, S. H., Chattopadhyay, S., Tsai, E., Sandoval, C., Zhao, R., Akabas, M. H., and Goldman, I. D. (2006) Cell 127, 917-928
2. Zhao, R., Min, S. H., Qiu, A., Sakaris, A., Goldberg, G. L., Sandoval, C., Malatack, J. J., Rosenblatt, D. S., and Goldman, I. D. (2007) Blood 110, 1147-1152
3. Geller, J., Kronn, D., Jayabose, S., and Sandoval, C. (2002) Medicine (Baltimore) 81, 51-68
4. Zhao, R., Qiu, A., Tsai, E., Jansen, M., Akabas, M. H., and Goldman, I. D. (2008) Mol. Pharmacol. 74, 854-862
5. Helmlinger, G., Yuan, F., Dellian, M., and Jain, R. K. (1997) Nat. Med. 3, 177-182
6. Raghunand, N., Altbach, M. I., van Sluis, R., Baggett, B., Taylor, C. W., Bhujwalla, Z. M., and Gillies, R. J. (1999) Biochem. Pharmacol. 57, 309-312
7. Yang, J., Chen, H., Vlahov, I. R., Cheng, J. X., and Low, P. S. (2007) J. Pharmacol. Exp. Ther. 321, 462-468
8. Andrews, N. C. (2007) Cell Metab. 5, 5-6
9. Zhao, R., Min, S. H., Wang, Y., Campanella, E., Low, P. S., and Goldman, I. D. (2009) J. Biol. Chem. 284, 4267-4274
10. Pao, S. S., Paulsen, I. T., and Saier, M. H., Jr. (1998) Microbiol. Mol. Biol. Rev. 62, 1-34
11. Thwaites, D. T., and Anderson, C. M. (2007) Exp. Physiol. 92, 603-619
12. Lam-Yuk-Tseung, S., Govoni, G., Forbes, J., and Gros, P. (2003) Blood 101, 3699-3707
13. Metzner, L., Natho, K., Zebisch, K., Dorn, M., Bosse-Doenecke, E., Ganapathy, V., and Brandsch, M. (2008) Biochim. Biophys. Acta 1778, 1042-1050
14. Fei, Y. J., Liu, W., Prasad, P. D., Kekuda, R., Oblak, T. G., Ganapathy, V., and Leibach, F. H. (1997) Biochemistry 36, 452-460
15. Horne, D. W., and Reed, K. A. (1992) Arch. Biochem. Biophys. 298, 121-128
16. Schron, C. M. (1991) J. Membr. Biol. 120, 192-200
17. Schron, C. M., Washington, C., Jr., and Blitzer, B. L. (1985) J. Clin. Invest. 76, 2030-2033
18. Said, H. M., and Mohammadkhani, R. (1993) Biochem. J. 290, 237-240
19. Miles, E. W. (1977) Methods Enzymol. 47, 431-442
20. Cohen, L. A. (1968) Annu. Rev. Biochem. 37, 695-726
21. Fry, D. W., Yalowich, J. C., and Goldman, I. D. (1982) J. Biol. Chem. 257, 1890-1896
22. Zhao, R., Chattopadhyay, S., Hanscom, M., and Goldman, I. D. (2004) Clin. Cancer Res. 10, 8735-8742
23. Unal, E. S., Zhao, R., Qiu, A., and Goldman, I. D. (2008) Biochim. Biophys. Acta 1778, 1407-1414
24. Liman, E. R., Tytgat, J., and Hess, P. (1992) Neuron 9, 861-871
25. Chang, M. H., DiPiero, J., Sönnichsen, F. D., and Romero, M. F. (2008) J. Biol. Chem. 283, 18402-18410
26. Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., and Hediger, M. A. (1997) Nature 388, 482-488
27. Mackenzie, B., Ujwal, M. L., Chang, M. H., Romero, M. F., and Hediger, M. A. (2006) Pflugers Arch. 451, 544-558
28. McGuffin, L. J., Bryson, K., and Jones, D. T. (2000) Bioinformatics 16, 404-405
29. Huang, Y., Lemieux, M. J., Song, J., Auer, M., and Wang, D. N. (2003) Science 301, 616-620
30. Rai, B. K., Madrid-Aliste, C. J., Fajardo, J. E., and Fiser, A. (2006) Bioinformatics 22, 2691-2692
31. Rai, B. K., and Fiser, A. (2006) Proteins 63, 644-661
32. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
33. Fiser, A., and Sali, A. (2003) Methods Enzymol. 374, 461-491
34. Sippl, M. J. (1993) Proteins 17, 355-362
35. Honig, B., and Nicholls, A. (1995) Science 268, 1144-1149
36. Petrey, D., and Honig, B. (2003) Methods Enzymol. 374, 492-509, 492-509
37. Alexov, E. G., and Gunner, M. R. (1997) Biophys. J. 72, 2075-2093
38. Georgescu, R. E., Alexov, E. G., and Gunner, M. R. (2002) Biophys. J. 83, 1731-1748
39. Qiu, A., Min, S. H., Jansen, M., Malhotra, U., Tsai, E., Cabelof, D. C., Matherly, L. H., Zhao, R., Akabas, M. H., and Goldman, I. D. (2007) Am. J. Physiol. Cell Physiol. 293, C1669-1678
40. Sharina, I. G., Zhao, R., Wang, Y., Babani, S., and Goldman, I. D. (2002) Biochem. Pharmacol. 63, 1717-1724
41. Galić, S., Schneider, H. P., Bröer, A., Deitmer, J. W., and Bröer, S. (2003) Biochem. J. 376, 413-422
42. Boll, M., Foltz, M., Rubio-Aliaga, I., and Daniel, H. (2003) Genomics 82, 47-56
43. Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H. R., and Iwata, S. (2003) Science 301, 610-615
44. Lemieux, M. J. (2007) Mol. Membr. Biol. 24, 333-341
45. Lasry, I., Berman, B., Straussberg, R., Sofer, Y., Bessler, H., Sharkia, M., Glaser, F., Jansen, G., Drori, S., and Assaraf, Y. G. (2008) Blood 112, 2055-2061
46. Jardetzky, O. (1966) Nature 211, 969-970
47. Crane, R. K. (1977) Rev. Physiol. Biochem. Pharmacol. 78, 99 -159
48. Widdas, W. F. (1952) J. Physiol. 118, 23-39
49. Guan, L., and Kaback, H. R. (2006) Annu. Rev. Biophys. Biomol. Struct. 35, 67-91, 67-91
50. Meredith, D., and Price, R. A. (2006) J. Membr. Biol. 213, 79-88
51. Kjelsberg, M. A., Cotecchia, S., Ostrowski, J., Caron, M. G., and Lefkowitz, R. J. (1992) J. Biol. Chem. 267, 1430-1433
52. Loland, C. J., Norregaard, L., Litman, T., and Gether, U. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 1683-1688
53. Decoursey, T. E. (2003) Physiol. Rev. 83, 475-579
54. DeFelice, L. J., and Goswami, T. (2007) Annu. Rev. Physiol. 69, 87-112, 87-112
55. Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaugh, M. P., and Amara, S. G. (1995) Nature 375, 599-603
56. Galli, A., Blakely, R. D., and DeFelice, L. J. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 8671-8676
57. Sonders, M. S., and Amara, S. G. (1996) Curr. Opin. Neurobiol. 6, 294-302
58. Galli, A., Blakely, R. D., and DeFelice, L. J. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 13260-13265
59. Carvelli, L., Blakely, R. D., and DeFelice, L. J. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 14192-14197
60. Fairman, W. A., Sonders, M. S., Murdoch, G. H., and Amara, S. G. (1998) Nat. Neurosci. 1, 105-113
61. Fei, Y. J., Romero, M. F., Krause, M., Liu, J. C., Huang, W., Ganapathy, V., and Leibach, F. H. (2000) J. Biol. Chem. 275, 9563-9571
62. Choi, I., Aalkjaer, C., Boulpaep, E. L., and Boron, W. F. (2000) Nature 405, 571-575
63. Yang, H. S., Kim, E., Lee, S., Park, H. J., Cooper, D. S., Rajbhandari, I., and Choi, I. (2009) J. Biol. Chem. 284, 15970-15979
64. Chang, M. H., Plata, C., Zandi-Nejad, K., Sindić, A., Sussman, C. R., Mercado, A., Broumand, V., Raghuram, V., Mount, D. B., and Romero, M. F. (2009) J. Membr. Biol. 228, 125-140
65. Chen, X. Z., Peng, J. B., Cohen, A., Nelson, H., Nelson, N., and Hediger, M. A. (1999) J. Biol. Chem. 274, 35089-35094
66. Xu, H., Jin, J., DeFelice, L. J., Andrews, N. C., and Clapham, D. E. (2004) PLoS. Biol. 2, E50
67. Tao, Z., and Grewer, C. (2005) Biochemistry 44, 3466-3476
68. Steel, A., Nussberger, S., Romero, M. F., Boron, W. F., Boyd, C. A., and Hediger, M. A. (1997) J. Physiol. 498, 563-569
69. Foltz, M., Mertl, M., Dietz, V., Boll, M., Kottra, G., and Daniel, H. (2005) Biochem. J. 386, 607-616
70. Müller-Berger, S., Karbach, D., Kang, D., Aranibar, N., Wood, P. G., Rüterjans, H., and Passow, H. (1995) Biochemistry 34, 9325-9332
71. Müller-Berger, S., Karbach, D., König, J., Lepke, S., Wood, P. G., Appelhans, H., and Passow, H. (1995) Biochemistry 34, 9315-9324
72. Humphrey, W., Dalke, A., and Schulten, K. (1996) J. Mol. Graph. 14, (33-8, 27-8)