A Prominent Low-pH Methotrexate Transport Activity in Human Solid Tumors: Contribution to the Preservation of Methotrexate Pharmacologic Activity in HeLa Cells Lacking the Reduced Folate Carrier

Clinical Cancer Research

Volumn 10, Issue 2, 2004, Pages 718-727

  Zhao, Rongbao ^a   Gao, Feng ^a,b   Hanscom, Marie ^a   Goldman, I David ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c ALBERT EINSTEIN CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; FOLINIC ACID; METHOTREXATE; REDUCED FOLATE CARRIER;

ACIDITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG TRANSPORT; DRUG UPTAKE; GENE DELETION; HELA CELL; HUMAN; HUMAN CELL; IC 50; PH MEASUREMENT; PRIORITY JOURNAL; SOLID TUMOR; WILD TYPE;

ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CELL DIVISION; CELL LINE, TUMOR; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLIC ACID; GENE DELETION; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; LEUCOVORIN; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; NEOPLASMS; TIME FACTORS; TRANSFECTION;

EID: 0842304934     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-1066-03     Document Type: Article

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