Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function

Journal of Biological Chemistry

Volumn 286, Issue 27, 2011, Pages 24150-24158

  Zhao, Rongbao ^a   Shin, Daniel Sanghoon ^a   Diop Bove, Ndeye ^a   Ovits, Channa Gila ^a   Goldman, I David ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; FOLATE TRANSPORTER; FRAMESHIFT; HUMAN DISORDERS; RANDOM MUTAGENESIS; RECESSIVE DISORDER; STRUCTURE-FUNCTION RELATIONSHIP; WEALTH OF INFORMATION;

CELL MEMBRANES; GENES; MUTAGENESIS;

PROTONS;

PROTON COUPLED FOLATE TRANSPORTER;

ARTICLE; CELL MEMBRANE; CODON; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FRAMESHIFT MUTATION; GENE; GENE DELETION; GENE INSERTION; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; MUTAGENESIS; NUCLEIC ACID BASE SUBSTITUTION; PCFT GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA TRANSLATION; SATURATION MUTAGENESIS; SIMULATION; STRUCTURE ACTIVITY RELATION;

HELA CELLS; HUMANS; METABOLISM, INBORN ERRORS; MUTAGENESIS; MUTATION; PROTON-COUPLED FOLATE TRANSPORTER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959873628     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.236539     Document Type: Article

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