PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells

Biochemical and Biophysical Research Communications

Volumn 376, Issue 4, 2008, Pages 787-792

  Gonen, Nitzan ^a   Bram, Eran E ^a   Assaraf, Yehuda G ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Antifolates; Folates; Gene expression; Methylation; PCFT; Promoter

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; NUCLEOTIDE; TRICHOSTATIN A;

ARTICLE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTON COUPLED FOLATE TRANSPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

AZACITIDINE; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; GENE EXPRESSION; GENE EXPRESSION REGULATION, LEUKEMIC; GENE SILENCING; HUMANS; LEUKEMIA; MEMBRANE TRANSPORT PROTEINS; PROMOTER REGIONS (GENETICS);

EID: 53449097226     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.09.074     Document Type: Article

References (29)

1. Strahl B.D., and Allis C.D. The language of covalent histone modifications. Nature 403 (2000) 41-45
2. Zhang Y., and Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev. 15 (2001) 2343-2360
3. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 16 (2002) 6-21
4. Jones P.A., and Takai D. The role of DNA methylation in mammalian epigenetics. Science 293 (2001) 1068-1070
5. Baylin S.B., Esteller M., Rountree M.R., Bachman K.E., Schuebel K., and Herman J.G. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum. Mol. Genet. 10 (2001) 687-692
6. Amir R.E., Van den Veyver I.B., Wan M., Tran C.Q., Francke U., and Zoghbi H.Y. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23 (1999) 185-188
7. Qiu A., Jansen M., Sakaris A., Min S.H., Chattopadhyay S., Tsai E., Sandoval C., Zhao R., Akabas M.H., and Goldman I.D. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 127 (2006) 917-928
8. Henderson G.B., and Strauss B.P. Characteristics of a novel transport system for folate compounds in wild-type and methotrexate-resistant L1210 cells. Cancer Res. 50 (1990) 1709-1714
9. Sierra E.E., Brigle K.E., Spinella M.J., and Goldman I.D. pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH. Biochem. Pharmacol. 53 (1997) 223-231
10. Kumar C.K., Moyer M.P., Dudeja P.K., and Said H.M. A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460. J. Biol. Chem. 272 (1997) 6226-6231
11. Assaraf Y.G., Babani S., and Goldman I.D. Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in Chinese hamster ovary cells. J. Biol. Chem. 273 (1998) 8106-8111
12. Wang Y., Zhao R., and Goldman I.D. Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier. Clin. Cancer Res. 10 (2004) 6256-6264
13. Saier Jr. M.H., Beatty J.T., Goffeau A., Harley K.T., Heijne W.H., Huang S.C., Jack D.L., Jahn P.S., Lew K., Liu J., Pao S.S., Paulsen I.T., Tseng T.T., and Virk P.S. The major facilitator superfamily. J. Mol. Microbiol. Biotechnol. 1 (1999) 257-279
14. Boll M., Foltz M., Rubio-Aliaga I., Kottra G., and Daniel H. Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. J. Biol. Chem. 277 (2002) 22966-22973
15. Fei Y.J., Kanai Y., Nussberger S., Ganapathy V., Leibach F.H., Romero M.F., Singh S.K., Boron W.F., and Hediger M.A. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368 (1994) 563-566
16. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., and Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
17. Nozawa T., Imai K., Nezu J., Tsuji A., and Tamai I. Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J. Pharmacol. Exp. Ther. 308 (2004) 438-445
18. Lasry I., Berman B., Straussberg R., Sofer Y., Bessler H., Sharkia M., Glaser F., Jansen G., Drori S., and Assaraf Y.G. A novel loss of function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function. Blood 112 (2008) 2055-2061
19. Zhao R., Min S.H., Qiu A., Sakaris A., Goldberg G.L., Sandoval C., Malatack J.J., Rosenblatt D.S., and Goldman I.D. The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption. Blood 110 (2007) 1147-1152
20. Bram E.E., Ifergan I., Grimberg M., Lemke K., Skladanowski A., and Assaraf Y.G. C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells. Biochem. Pharmacol. 74 (2007) 41-53
21. Zhao R., and Goldman I.D. The molecular identity and characterization of a proton-coupled folate transporter-PCFT; biological ramifications and impact on the activity of pemetrexed. Cancer Metastasis Rev. 26 (2007) 129-139
22. Subramanian V.S., Reidling J.C., and Said H.M. Differentiation-dependent regulation of the intestinal folate uptake process: studies with Caco-2 cells and native mouse intestine. Am. J. Physiol. Cell Physiol. (2008)
23. Harada K., Toyooka S., Maitra A., Maruyama R., Toyooka K.O., Timmons C.F., Tomlinson G.E., Mastrangelo D., Hay R.J., Minna J.D., and Gazdar A.F. Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines. Oncogene 21 (2002) 4345-4349
24. Assaraf Y.G. Molecular basis of antifolate resistance. Cancer Metastasis Rev. 26 (2007) 153-181
25. Ifergan I., and Assaraf Y.G. Molecular mechanisms of adaptation to folate deficiency in mammalians. Vitam. Horm. 79 (2008) 99-143
26. Zhao R., Qiu A., Tsai E., Jansen M., Akabas M.H., and Goldman I.D. The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol. Pharmacol. 74 (2008) 854-862
27. Jones P.A., and Taylor S.M. Cellular differentiation, cytidine analogs and DNA methylation. Cell 20 (1980) 85-93
28. Oki Y., Aoki E., and Issa J.P. Decitabine-bedside to bench. Crit. Rev. Oncol. Hematol. 61 (2007) 140-152
29. Szyf M. The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Curr. Oncol. 15 (2008) 72-75