메뉴 건너뛰기




Volumn 280, Issue 12, 2013, Pages 2900-2915

The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane

Author keywords

BN PAGE; CHO cells; folic acid; proton coupled folate transporter; quaternary structure; transporter; two electrode voltage clamp; Xenopus laevis oocytes

Indexed keywords

ADIPIMIDIC ACID DIMETHYL ESTER; FOLIC ACID; GLUTARALDEHYDE; MONOMER; OLIGOMER; POLYACRYLIC ACID; PROTON COUPLED FOLATE TRANSPORTER; SEROTONIN 3A RECEPTOR; SILICON DIOXIDE;

EID: 84878761203     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12293     Document Type: Article
Times cited : (13)

References (66)
  • 2
    • 52649117496 scopus 로고    scopus 로고
    • A novel loss-of-function mutation in the protoncoupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function
    • Lasry I, Berman B, Straussberg R, Sofer Y, Bessler H, Sharkia M, Glaser F, Jansen G, Drori S & Assaraf YG (2008) A novel loss-of-function mutation in the protoncoupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function. Blood 112, 2055-2061.
    • (2008) Blood , vol.112 , pp. 2055-2061
    • Lasry, I.1    Berman, B.2    Straussberg, R.3    Sofer, Y.4    Bessler, H.5    Sharkia, M.6    Glaser, F.7    Jansen, G.8    Drori, S.9    Assaraf, Y.G.10
  • 3
    • 34548026299 scopus 로고    scopus 로고
    • The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption
    • Zhao R, Min SH, Qiu A, Sakaris A, Goldberg GL, Sandoval C, Malatack JJ, Rosenblatt DS & Goldman ID (2007) The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption. Blood 110, 1147-1152.
    • (2007) Blood , vol.110 , pp. 1147-1152
    • Zhao, R.1    Min, S.H.2    Qiu, A.3    Sakaris, A.4    Goldberg, G.L.5    Sandoval, C.6    Malatack, J.J.7    Rosenblatt, D.S.8    Goldman, I.D.9
  • 5
    • 79955149687 scopus 로고    scopus 로고
    • Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption
    • Shin DS, Mahadeo K, Min SH, Diop-Bove N, Clayton P, Zhao R & Goldman ID (2011) Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption. Mol Genet Metab 103, 33-37.
    • (2011) Mol Genet Metab , vol.103 , pp. 33-37
    • Shin, D.S.1    Mahadeo, K.2    Min, S.H.3    Diop-Bove, N.4    Clayton, P.5    Zhao, R.6    Goldman, I.D.7
  • 6
    • 78650055833 scopus 로고    scopus 로고
    • Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); A D156Y mutation causing hereditary folate malabsorption
    • Shin DS, Min SH, Russell L, Zhao R, Fiser A & Goldman ID (2010) Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption. Blood 116, 5162-5169.
    • (2010) Blood , vol.116 , pp. 5162-5169
    • Shin, D.S.1    Min, S.H.2    Russell, L.3    Zhao, R.4    Fiser, A.5    Goldman, I.D.6
  • 7
    • 84860528730 scopus 로고    scopus 로고
    • A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding
    • Shin DS, Zhao R, Yap EH, Fiser A & Goldman ID (2012) A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding. Am J Physiol Cell Physiol 302, C1405-C1412.
    • (2012) Am J Physiol Cell Physiol , vol.302
    • Shin, D.S.1    Zhao, R.2    Yap, E.H.3    Fiser, A.4    Goldman, I.D.5
  • 8
    • 27744438167 scopus 로고    scopus 로고
    • Pemetrexed: A multitargeted antifolate
    • Rollins KD & Lindley C (2005) Pemetrexed: a multitargeted antifolate. Clin Ther 27, 1343-1382.
    • (2005) Clin Ther , vol.27 , pp. 1343-1382
    • Rollins, K.D.1    Lindley, C.2
  • 9
    • 50549085728 scopus 로고    scopus 로고
    • The proton-coupled folate transporter: Impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier
    • Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH & Goldman ID (2008) The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol 74, 854-862.
    • (2008) Mol Pharmacol , vol.74 , pp. 854-862
    • Zhao, R.1    Qiu, A.2    Tsai, E.3    Jansen, M.4    Akabas, M.H.5    Goldman, I.D.6
  • 10
    • 59149107224 scopus 로고    scopus 로고
    • Oligomeric structure of the human reduced folate carrier: Identification of homo-oligomers and dominant-negative effects on carrier expression and function
    • Hou Z & Matherly LH (2009) Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function. J Biol Chem 284, 3285-3293.
    • (2009) J Biol Chem , vol.284 , pp. 3285-3293
    • Hou, Z.1    Matherly, L.H.2
  • 12
    • 77949321417 scopus 로고    scopus 로고
    • The prototypical H+/galactose symporter GalP assembles into functional trimers
    • Zheng H, Taraska J, Merz AJ & Gonen T (2010) The prototypical H+/galactose symporter GalP assembles into functional trimers. J Mol Biol 396, 593-601.
    • (2010) J Mol Biol , vol.396 , pp. 593-601
    • Zheng, H.1    Taraska, J.2    Merz, A.J.3    Gonen, T.4
  • 15
    • 0035810954 scopus 로고    scopus 로고
    • High-yield expression and functional analysis of Escherichia coli glycerol-3- phosphate transporter
    • Auer M, Kim MJ, Lemieux MJ, Villa A, Song J, Li XD & Wang DN (2001) High-yield expression and functional analysis of Escherichia coli glycerol-3- phosphate transporter. Biochemistry 40, 6628-6635.
    • (2001) Biochemistry , vol.40 , pp. 6628-6635
    • Auer, M.1    Kim, M.J.2    Lemieux, M.J.3    Villa, A.4    Song, J.5    Li, X.D.6    Wang, D.N.7
  • 16
    • 0024406418 scopus 로고
    • Characterization and functional reconstitution of a soluble form of the hydrophobic membrane protein lac permease from Escherichia coli
    • Roepe PD & Kaback HR (1989) Characterization and functional reconstitution of a soluble form of the hydrophobic membrane protein lac permease from Escherichia coli. Proc Natl Acad Sci USA 86, 6087- 6091.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 6087-6091
    • Roepe, P.D.1    Kaback, H.R.2
  • 17
    • 33646445156 scopus 로고    scopus 로고
    • Structure of the multidrug transporter EmrD from Escherichia coli
    • Yin Y, He X, Szewczyk P, Nguyen T & Chang G (2006) Structure of the multidrug transporter EmrD from Escherichia coli. Science 312, 741-744.
    • (2006) Science , vol.312 , pp. 741-744
    • Yin, Y.1    He, X.2    Szewczyk, P.3    Nguyen, T.4    Chang, G.5
  • 18
    • 0025332692 scopus 로고
    • UhpT, the sugar phosphate antiporter of Escherichia coli, functions as a monomer
    • Ambudkar SV, Anantharam V & Maloney PC (1990) UhpT, the sugar phosphate antiporter of Escherichia coli, functions as a monomer. J Biol Chem 265, 12287-12292.
    • (1990) J Biol Chem , vol.265 , pp. 12287-12292
    • Ambudkar, S.V.1    Anantharam, V.2    Maloney, P.C.3
  • 19
    • 0026447087 scopus 로고
    • Mammalian facilitative glucose transporters: Evidence for similar substrate recognition sites in functionally monomeric proteins
    • Burant CF & Bell GI (1992) Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins. Biochemistry 31, 10414-10420.
    • (1992) Biochemistry , vol.31 , pp. 10414-10420
    • Burant, C.F.1    Bell, G.I.2
  • 23
    • 33645320817 scopus 로고    scopus 로고
    • Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY
    • Mirza O, Guan L, Verner G, Iwata S & Kaback HR (2006) Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY. EMBO J 25, 1177-1183.
    • (2006) EMBO J , vol.25 , pp. 1177-1183
    • Mirza, O.1    Guan, L.2    Verner, G.3    Iwata, S.4    Kaback, H.R.5
  • 24
    • 0041489951 scopus 로고    scopus 로고
    • Structure and mechanism of the glycerol-3- phosphate transporter from Escherichia coli
    • Huang Y, Lemieux MJ, Song J, Auer M & Wang DN (2003) Structure and mechanism of the glycerol-3- phosphate transporter from Escherichia coli. Science 301, 616-620.
    • (2003) Science , vol.301 , pp. 616-620
    • Huang, Y.1    Lemieux, M.J.2    Song, J.3    Auer, M.4    Wang, D.N.5
  • 26
    • 43649088482 scopus 로고    scopus 로고
    • N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT)
    • Selcuk Unal E, Zhao R, Qiu A & Goldman ID (2008) N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT). Biochim Biophys Acta 1778, 1407-1414.
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 1407-1414
    • Selcuk Unal, E.1    Zhao, R.2    Qiu, A.3    Goldman, I.D.4
  • 27
    • 77950400117 scopus 로고    scopus 로고
    • Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method
    • Zhao R, Unal ES, Shin DS & Goldman ID (2010) Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method. Biochemistry 49, 2925-2931.
    • (2010) Biochemistry , vol.49 , pp. 2925-2931
    • Zhao, R.1    Unal, E.S.2    Shin, D.S.3    Goldman, I.D.4
  • 28
    • 67650526040 scopus 로고    scopus 로고
    • The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1
    • Unal ES, Zhao R, Chang MH, Fiser A, Romero MF & Goldman ID (2009) The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1. J Biol Chem 284, 17846-17857.
    • (2009) J Biol Chem , vol.284 , pp. 17846-17857
    • Unal, E.S.1    Zhao, R.2    Chang, M.H.3    Fiser, A.4    Romero, M.F.5    Goldman, I.D.6
  • 33
    • 0033041549 scopus 로고    scopus 로고
    • Blue native PAGE as a useful method for the analysis of the assembly of distinct combinations of nicotinic acetylcholine receptor subunits
    • Nicke A, Rettinger J, Mutschler E & Schmalzing G (1999) Blue native PAGE as a useful method for the analysis of the assembly of distinct combinations of nicotinic acetylcholine receptor subunits. J Recept Signal Transduct Res 19, 493-507.
    • (1999) J Recept Signal Transduct Res , vol.19 , pp. 493-507
    • Nicke, A.1    Rettinger, J.2    Mutschler, E.3    Schmalzing, G.4
  • 34
    • 0035900794 scopus 로고    scopus 로고
    • Ubiquitination precedes internalization and proteolytic cleavage of FEBS Journal 280 (2013) 2900-2915 2013 FEBS 2913 P. K. Duddempudi et al. Monomeric PCFT on plasma membranes plasma membrane-bound glycine receptors
    • Buttner C, Sadtler S, Leyendecker A, Laube B, Griffon N, Betz H & Schmalzing G (2001) Ubiquitination precedes internalization and proteolytic cleavage of FEBS Journal 280 (2013) 2900-2915 2013 FEBS 2913 P. K. Duddempudi et al. Monomeric PCFT on plasma membranes plasma membrane-bound glycine receptors. J Biol Chem 276, 42978-42985.
    • (2001) J Biol Chem , vol.276 , pp. 42978-42985
    • Buttner, C.1    Sadtler, S.2    Leyendecker, A.3    Laube, B.4    Griffon, N.5    Betz, H.6    Schmalzing, G.7
  • 35
    • 4544336463 scopus 로고    scopus 로고
    • Assembly of nicotinic alpha7 subunits in Xenopus oocytes is partially blocked at the tetramer level
    • Nicke A, Thurau H, Sadtler S, Rettinger J & Schmalzing G (2004) Assembly of nicotinic alpha7 subunits in Xenopus oocytes is partially blocked at the tetramer level. FEBS Lett 575, 52-58.
    • (2004) FEBS Lett , vol.575 , pp. 52-58
    • Nicke, A.1    Thurau, H.2    Sadtler, S.3    Rettinger, J.4    Schmalzing, G.5
  • 36
    • 0037931744 scopus 로고    scopus 로고
    • A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha 1 subunit
    • Sadtler S, Laube B, Lashub A, Nicke A, Betz H & Schmalzing G (2003) A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha 1 subunit. J Biol Chem 278, 16782- 16790.
    • (2003) J Biol Chem , vol.278 , pp. 16782-16790
    • Sadtler, S.1    Laube, B.2    Lashub, A.3    Nicke, A.4    Betz, H.5    Schmalzing, G.6
  • 37
    • 84862537088 scopus 로고    scopus 로고
    • Emerging clinico-epidemiological trends in melioidosis: Analysis of 95 cases from western coastal India
    • Vidyalakshmi K, Lipika S, Vishal S, Damodar S & Chakrapani M (2012) Emerging clinico-epidemiological trends in melioidosis: analysis of 95 cases from western coastal India. Int J Infect Dis 16, e491-497.
    • (2012) Int J Infect Dis , vol.16
    • Vidyalakshmi, K.1    Lipika, S.2    Vishal, S.3    Damodar, S.4    Chakrapani, M.5
  • 39
    • 67650047730 scopus 로고    scopus 로고
    • Hereditary folate malabsorption: A positively charged amino acid at position 113 of the protoncoupled folate transporter (PCFT/SLC46A1) is required for folic acid binding
    • Lasry I, Berman B, Glaser F, Jansen G & Assaraf YG (2009) Hereditary folate malabsorption: a positively charged amino acid at position 113 of the protoncoupled folate transporter (PCFT/SLC46A1) is required for folic acid binding. Biochem Biophys Res Commun 386, 426-431.
    • (2009) Biochem Biophys Res Commun , vol.386 , pp. 426-431
    • Lasry, I.1    Berman, B.2    Glaser, F.3    Jansen, G.4    Assaraf, Y.G.5
  • 40
    • 0025275523 scopus 로고
    • Characteristics of a novel transport system for folate compounds in wildtype and methotrexate-resistant L1210 cells
    • Henderson GB & Strauss BP (1990) Characteristics of a novel transport system for folate compounds in wildtype and methotrexate-resistant L1210 cells. Cancer Res 50, 1709-1714.
    • (1990) Cancer Res , vol.50 , pp. 1709-1714
    • Henderson, G.B.1    Strauss, B.P.2
  • 41
    • 0028806397 scopus 로고
    • A method for determining the unitary functional capacity of cloned channels and transporters expressed in Xenopus laevis oocytes
    • Zampighi GA, Kreman M, Boorer KJ, Loo DD, Bezanilla F, Chandy G, Hall JE & Wright EM (1995) A method for determining the unitary functional capacity of cloned channels and transporters expressed in Xenopus laevis oocytes. J Membr Biol 148, 65-78.
    • (1995) J Membr Biol , vol.148 , pp. 65-78
    • Zampighi, G.A.1    Kreman, M.2    Boorer, K.J.3    Loo, D.D.4    Bezanilla, F.5    Chandy, G.6    Hall, J.E.7    Wright, E.M.8
  • 42
    • 77956513916 scopus 로고    scopus 로고
    • Mass estimation of native proteins by blue native electrophoresis: Principles and practical hints
    • Wittig I, Beckhaus T, Wumaier Z, Karas M & Schagger H (2010) Mass estimation of native proteins by blue native electrophoresis: principles and practical hints. Mol Cell Proteomics 9, 2149-2161.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 2149-2161
    • Wittig, I.1    Beckhaus, T.2    Wumaier, Z.3    Karas, M.4    Schagger, H.5
  • 43
    • 77956245795 scopus 로고    scopus 로고
    • RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits
    • Walstab J, Hammer C, Lasitschka F, Moller D, Connolly CN, Rappold G, Bruss M, Bonisch H & Niesler B (2010) RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits. J Biol Chem 285, 26956-26965.
    • (2010) J Biol Chem , vol.285 , pp. 26956-26965
    • Walstab, J.1    Hammer, C.2    Lasitschka, F.3    Moller, D.4    Connolly, C.N.5    Rappold, G.6    Bruss, M.7    Bonisch, H.8    Niesler, B.9
  • 44
    • 84867623729 scopus 로고    scopus 로고
    • Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption
    • Shin DS, Zhao R, Fiser A & Goldman DI (2012) Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption. Am J Physiol Cell Physiol 303, C834-842.
    • (2012) Am J Physiol Cell Physiol , vol.303
    • Shin, D.S.1    Zhao, R.2    Fiser, A.3    Goldman, D.I.4
  • 45
    • 84866352751 scopus 로고    scopus 로고
    • Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)
    • Zhao R, Shin DS, Fiser A & Goldman ID (2012) Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1). Am J Physiol Cell Physiol 303, C673-681.
    • (2012) Am J Physiol Cell Physiol , vol.303
    • Zhao, R.1    Shin, D.S.2    Fiser, A.3    Goldman, I.D.4
  • 46
    • 0021112527 scopus 로고
    • Coating cells with colloidal silica for high yield isolation of plasma membrane sheets and identification of transmembrane proteins
    • Chaney LK & Jacobson BS (1983) Coating cells with colloidal silica for high yield isolation of plasma membrane sheets and identification of transmembrane proteins. J Biol Chem 258, 10062-10072.
    • (1983) J Biol Chem , vol.258 , pp. 10062-10072
    • Chaney, L.K.1    Jacobson, B.S.2
  • 47
    • 56449086663 scopus 로고    scopus 로고
    • Evaluation of two cell surface modification methods for proteomic analysis of plasma membrane from isolated mouse hepatocytes
    • Li X, Jin Q, Cao J, Xie C, Cao R, Liu Z, Xiong J, Li J, Yang X, Chen P et al. (2009) Evaluation of two cell surface modification methods for proteomic analysis of plasma membrane from isolated mouse hepatocytes. Biochim Biophys Acta 1794, 32-41.
    • (2009) Biochim Biophys Acta , vol.1794 , pp. 32-41
    • Li, X.1    Jin, Q.2    Cao, J.3    Xie, C.4    Cao, R.5    Liu, Z.6    Xiong, J.7    Li, J.8    Yang, X.9    Chen, P.10
  • 49
    • 0035852734 scopus 로고    scopus 로고
    • Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes
    • Horiuchi M, Nicke A, Gomeza J, Aschrafi A, Schmalzing G & Betz H (2001) Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes. Proc Natl Acad Sci USA 98, 1448-1453.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1448-1453
    • Horiuchi, M.1    Nicke, A.2    Gomeza, J.3    Aschrafi, A.4    Schmalzing, G.5    Betz, H.6
  • 51
    • 0036299012 scopus 로고    scopus 로고
    • Oligomeric state of membrane transport proteins analyzed with blue native electrophoresis and analytical ultracentrifugation
    • Heuberger EH, Veenhoff LM, Duurkens RH, Friesen RH & Poolman B (2002) Oligomeric state of membrane transport proteins analyzed with blue native electrophoresis and analytical ultracentrifugation. J Mol Biol 317, 591-600.
    • (2002) J Mol Biol , vol.317 , pp. 591-600
    • Heuberger, E.H.1    Veenhoff, L.M.2    Duurkens, R.H.3    Friesen, R.H.4    Poolman, B.5
  • 52
    • 4644219565 scopus 로고    scopus 로고
    • Identification and importance of N-glycosylation of the human 5-hydroxytryptamine3A receptor subunit
    • Monk SA, Williams JM, Hope AG & Barnes NM (2004) Identification and importance of N-glycosylation of the human 5-hydroxytryptamine3A receptor subunit. Biochem Pharmacol 68, 1787-1796.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1787-1796
    • Monk, S.A.1    Williams, J.M.2    Hope, A.G.3    Barnes, N.M.4
  • 53
    • 0031029915 scopus 로고    scopus 로고
    • Isoformspecific interactions of Na, K-ATPase subunits are mediated via extracellular domains and carbohydrates
    • Schmalzing G, Ruhl K & Gloor SM (1997) Isoformspecific interactions of Na, K-ATPase subunits are mediated via extracellular domains and carbohydrates. Proc Natl Acad Sci USA 94, 1136-1141.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1136-1141
    • Schmalzing, G.1    Ruhl, K.2    Gloor, S.M.3
  • 56
    • 0020417260 scopus 로고
    • Beta-D-galactoside transport in Escherichia coli: Mr determination of the transport protein in organic solvent
    • Konig B & Sandermann H Jr (1982) Beta-D-galactoside transport in Escherichia coli: Mr determination of the transport protein in organic solvent. FEBS Lett 147, 31-34.
    • (1982) FEBS Lett , vol.147 , pp. 31-34
    • Konig, B.1    Sandermann Jr., H.2
  • 57
    • 0028291250 scopus 로고
    • Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli
    • Sahin-Toth M, Lawrence MC & Kaback HR (1994) Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli. Proc Natl Acad Sci USA 91, 5421- 5425.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5421-5425
    • Sahin-Toth, M.1    Lawrence, M.C.2    Kaback, H.R.3
  • 58
    • 78650476908 scopus 로고    scopus 로고
    • S. Aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: Implications for detergent-solubilized membrane proteins
    • Dorwart MR, Wray R, Brautigam CA, Jiang Y & Blount P (2010) S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins. PLoS Biol 8, e1000555.
    • (2010) PLoS Biol , vol.8
    • Dorwart, M.R.1    Wray, R.2    Brautigam, C.A.3    Jiang, Y.4    Blount, P.5
  • 59
    • 4143136452 scopus 로고    scopus 로고
    • Trimeric architecture of homomeric P2X2 and heteromeric P2X1 + 2 receptor subtypes
    • Aschrafi A, Sadtler S, Niculescu C, Rettinger J & Schmalzing G (2004) Trimeric architecture of homomeric P2X2 and heteromeric P2X1 + 2 receptor subtypes. J Mol Biol 342, 333-343.
    • (2004) J Mol Biol , vol.342 , pp. 333-343
    • Aschrafi, A.1    Sadtler, S.2    Niculescu, C.3    Rettinger, J.4    Schmalzing, G.5
  • 60
    • 0028950155 scopus 로고
    • Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies
    • Qian Y, Melikian HE, Rye DB, Levey AI & Blakely RD (1995) Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J Neurosci 15, 1261-1274.
    • (1995) J Neurosci , vol.15 , pp. 1261-1274
    • Qian, Y.1    Melikian, H.E.2    Rye, D.B.3    Levey, A.I.4    Blakely, R.D.5
  • 61
    • 0036186510 scopus 로고    scopus 로고
    • Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes
    • Jespersen T, Grunnet M, Angelo K, Klaerke DA & Olesen SP (2002) Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes. Biotechniques 32, 536-538, 540.
    • (2002) Biotechniques , vol.32 , Issue.536-538 , pp. 540
    • Jespersen, T.1    Grunnet, M.2    Angelo, K.3    Klaerke, D.A.4    Olesen, S.P.5
  • 62
    • 33646828912 scopus 로고    scopus 로고
    • State-dependent cross-linking of the M2 and M3 segments: Functional basis for the alignment of GABAA and acetylcholine receptor M3 segments
    • Jansen M & Akabas MH (2006) State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments. J Neurosci 26, 4492-4499.
    • (2006) J Neurosci , vol.26 , pp. 4492-4499
    • Jansen, M.1    Akabas, M.H.2
  • 63
    • 79957851357 scopus 로고    scopus 로고
    • Quantum chemical investigation on the mechanism and kinetics of PBDE photooxidation by OH: A case study for BDE-15
    • Zhou J, Chen J, Liang CH, Xie Q, Wang YN, Zhang S, Qiao X & Li X (2011) Quantum chemical investigation on the mechanism and kinetics of PBDE photooxidation by OH: a case study for BDE-15. Environm Sci Technol 45, 4839-4845.
    • (2011) Environm Sci Technol , vol.45 , pp. 4839-4845
    • Zhou, J.1    Chen, J.2    Liang, C.H.3    Xie, Q.4    Wang, Y.N.5    Zhang, S.6    Qiao, X.7    Li, X.8
  • 64
    • 23144452044 scopus 로고    scopus 로고
    • The HHpred interactive server for protein homology detection and structure prediction
    • Soding J, Biegert A & Lupas AN (2005) The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res 33, W244-248.
    • (2005) Nucleic Acids Res , vol.33
    • Soding, J.1    Biegert, A.2    Lupas, A.N.3
  • 65
    • 16344373015 scopus 로고    scopus 로고
    • Protein homology detection by HMM- HMM comparison
    • Soding J (2005) Protein homology detection by HMM- HMM comparison. Bioinformatics 21, 951-960.
    • (2005) Bioinformatics , vol.21 , pp. 951-960
    • Soding, J.1
  • 66
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • Sali A & Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234, 779-815.
    • (1993) J Mol Biol , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.